Fulvestrant_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fulvestrant perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fulvestrant_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.113151
EREG epiregulin 0.072176
RNF145 ring finger protein 145 0.0710796
TXNIP thioredoxin interacting protein 0.0644859
FAM13A family with sequence similarity 13, member A 0.0611724
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.056123
GOLGA4 golgin A4 0.0533755
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0485526
SETD5 SET domain containing 5 0.046806
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0456971
WAC WW domain containing adaptor with coiled-coil 0.0447786
KDM3A lysine (K)-specific demethylase 3A 0.0431919
RBM39 RNA binding motif protein 39 0.0430017
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.041
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0409014
KMT2E lysine (K)-specific methyltransferase 2E 0.0391732
DSCAM Down syndrome cell adhesion molecule 0.0391549
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0386733
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0384602
GARS1 glycyl-tRNA synthetase 1 0.0379764
NCOR1 nuclear receptor corepressor 1 0.0378668
TFG TRK-fused gene 0.0370144
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0361772
UBA6 ubiquitin-like modifier activating enzyme 6 0.0355443
ZFAND3 zinc finger, AN1-type domain 3 0.0354128
ANKRD11 ankyrin repeat domain 11 0.0343972
SEC31A SEC31 homolog A (S. cerevisiae) 0.033844
FNBP1L formin binding protein 1-like 0.0338012
MED13L mediator complex subunit 13-like 0.0330678
USP3 ubiquitin specific peptidase 3 0.0328958
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0325281
COPA coatomer protein complex, subunit alpha 0.0324124
IARS1 isoleucyl-tRNA synthetase 1 0.0319626
LMO7 LIM domain 7 0.0318179
OGA O-GlcNAcase 0.0315508
ESYT2 extended synaptotagmin-like protein 2 0.0311045
PNISR PNN-interacting serine/arginine-rich protein 0.0310844
H1-0 H1.0 linker histone 0.0308008
PICALM phosphatidylinositol binding clathrin assembly protein 0.0305468
ZNF292 zinc finger protein 292 0.0302738
RAB6A RAB6A, member RAS oncogene family 0.0300137
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0299464
YTHDC1 YTH domain containing 1 0.0298524
CCNL1 cyclin L1 0.029636
PUM2 pumilio RNA-binding family member 2 0.0295999
COG5 component of oligomeric golgi complex 5 0.0291704
RAB1A RAB1A, member RAS oncogene family 0.0290848
EPS8 epidermal growth factor receptor pathway substrate 8 0.0288338
STRN3 striatin, calmodulin binding protein 3 0.0286164
WDR45B WD repeat domain 45B 0.0285768
ZFC3H1 zinc finger, C3H1-type containing 0.0283031
KDM6A lysine (K)-specific demethylase 6A 0.0273945
GSK3B glycogen synthase kinase 3 beta 0.0273031
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0272566
NUP58 nucleoporin 58 0.0272021
SREBF2 sterol regulatory element binding transcription factor 2 0.0269645
RNF43 ring finger protein 43 0.0266544
NDRG1 N-myc downstream regulated 1 0.0266044
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0262411
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0261058
SPAG9 sperm associated antigen 9 0.0254496
SUCO SUN domain containing ossification factor 0.025334
HELZ helicase with zinc finger 0.025092
PRRC1 proline-rich coiled-coil 1 0.0250425
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0249111
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0247279
MARCHF6 membrane associated ring-CH-type finger 6 0.0244072
NEK7 NIMA-related kinase 7 0.0241262
NCKAP1 NCK-associated protein 1 0.0239438
ESRP1 epithelial splicing regulatory protein 1 0.0238962
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0234649
ADAM17 ADAM metallopeptidase domain 17 0.0231756
SPRED2 sprouty-related, EVH1 domain containing 2 0.0229153
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0229139
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0228779
TSC22D2 TSC22 domain family, member 2 0.0228552
RAB5A RAB5A, member RAS oncogene family 0.0227021
SPPL3 signal peptide peptidase like 3 0.0224553
CTNND1 catenin (cadherin-associated protein), delta 1 0.022427
RLF rearranged L-myc fusion 0.0223902
ZMYM2 zinc finger, MYM-type 2 0.0222335
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0222233
FUBP1 far upstream element (FUSE) binding protein 1 0.0221662
SENP6 SUMO1/sentrin specific peptidase 6 0.0220729
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0220386
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0218672
SRP54 signal recognition particle 54kDa 0.0218198
NOP58 NOP58 ribonucleoprotein 0.0217635
EWSR1 EWS RNA-binding protein 1 0.0211035
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0210757
TRA2A transformer 2 alpha homolog (Drosophila) 0.0209594
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0207993
TPD52 tumor protein D52 0.0206568
KCMF1 potassium channel modulatory factor 1 0.0206311
CSNK1A1 casein kinase 1, alpha 1 0.0205778
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0204684
ACBD3 acyl-CoA binding domain containing 3 0.0204286
ZNF654 zinc finger protein 654 0.0202297
KDM2A lysine (K)-specific demethylase 2A 0.020223
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0196186

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.174872
NPSR1 neuropeptide S receptor 1 -0.147382
PTMA prothymosin, alpha -0.14682
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.126331
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.122909
RPS6 ribosomal protein S6 -0.119391
TPT1 tumor protein, translationally-controlled 1 -0.107441
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104877
RPS8 ribosomal protein S8 -0.0938292
ACTG1 actin gamma 1 -0.0778973
NALF1 NALCN channel auxiliary factor 1 -0.076681
RPLP1 ribosomal protein, large, P1 -0.0742068
RPS19 ribosomal protein S19 -0.0718682
KRT18 keratin 18, type I -0.0688372
ALCAM activated leukocyte cell adhesion molecule -0.0684634
RPL23 ribosomal protein L23 -0.0676094
RPL35A ribosomal protein L35a -0.0673903
RPL34 ribosomal protein L34 -0.0668822
RPS12 ribosomal protein S12 -0.0622703
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0613897
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0600465
GMDS GDP-mannose 4,6-dehydratase -0.059512
S100A6 S100 calcium binding protein A6 -0.0583293
RPL37A ribosomal protein L37a -0.0568803
CEMIP cell migration inducing protein, hyaluronan binding -0.0556841
PDE4D phosphodiesterase 4D, cAMP-specific -0.0552476
MT2A metallothionein 2A -0.0552124
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0530014
RPLP2 ribosomal protein, large, P2 -0.0518111
RPL36 ribosomal protein L36 -0.0516429
RPL12 ribosomal protein L12 -0.0506212
RPL31 ribosomal protein L31 -0.0499543
FHIT fragile histidine triad -0.0497406
RPL26 ribosomal protein L26 -0.0487674
RPL9 ribosomal protein L9 -0.0482633
PTPRK protein tyrosine phosphatase, receptor type, K -0.0475208
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0445141
RPS24 ribosomal protein S24 -0.0443026
ASPH aspartate beta-hydroxylase -0.0424459
POTEF POTE ankyrin domain family, member F -0.0419339
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0417566
PKM pyruvate kinase, muscle -0.0416705
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0414814
RPS23 ribosomal protein S23 -0.0413801
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0412874
RPS25 ribosomal protein S25 -0.0411552
GREB1L growth regulation by estrogen in breast cancer-like -0.0406312
RPL19 ribosomal protein L19 -0.0397405
RPS29 ribosomal protein S29 -0.0394904
EXT1 exostosin glycosyltransferase 1 -0.0386361
RPS27 ribosomal protein S27 -0.0382841
RPS27A ribosomal protein S27a -0.0374419
SMYD3 SET and MYND domain containing 3 -0.0373827
FAT1 FAT atypical cadherin 1 -0.0370503
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0364218
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0361187
RPL11 ribosomal protein L11 -0.0361036
SLC35F3 solute carrier family 35, member F3 -0.0353161
TPM4 tropomyosin 4 -0.0352645
RPS3 ribosomal protein S3 -0.0352324
S100A9 S100 calcium binding protein A9 -0.0350781
MUC17 mucin 17, cell surface associated -0.0348138
HMGA1 high mobility group AT-hook 1 -0.0346716
RNF217 ring finger protein 217 -0.0345032
MYO1E myosin IE -0.0344325
KRT19 keratin 19, type I -0.034245
RPL7A ribosomal protein L7a -0.0340532
RPS17 ribosomal protein S17 -0.034039
TUBB4B tubulin, beta 4B class IVb -0.033891
RPS21 ribosomal protein S21 -0.0337624
PSD3 pleckstrin and Sec7 domain containing 3 -0.0337107
RPS13 ribosomal protein S13 -0.0336843
RAD51B RAD51 paralog B -0.033494
S100A10 S100 calcium binding protein A10 -0.0333688
RPS14 ribosomal protein S14 -0.03327
CCND1 cyclin D1 -0.0332266
ZBTB20 zinc finger and BTB domain containing 20 -0.0331344
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0328016
KRT8 keratin 8, type II -0.0326828
CCSER1 coiled-coil serine-rich protein 1 -0.0326462
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.032556
TFF1 trefoil factor 1 -0.0323921
EGFR epidermal growth factor receptor -0.0323604
MAML3 mastermind-like 3 (Drosophila) -0.0320295
RPS11 ribosomal protein S11 -0.0310048
RPL35 ribosomal protein L35 -0.0309491
ENO1 enolase 1, (alpha) -0.0308463
LDHA lactate dehydrogenase A -0.0304438
RPL28 ribosomal protein L28 -0.0303695
RPS20 ribosomal protein S20 -0.0300522
RPL37 ribosomal protein L37 -0.0297174
RPLP0 ribosomal protein, large, P0 -0.0292984
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0291549
RPL5 ribosomal protein L5 -0.0289169
ACTN4 actinin, alpha 4 -0.0287109
FTL ferritin, light polypeptide -0.0283674
HMGB1 high mobility group box 1 -0.0281146
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0280845
MAML2 mastermind-like 2 (Drosophila) -0.0280498
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0280301