| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fulvestrant perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Fulvestrant_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TPM3 | tropomyosin 3 | 0.0763134 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0743294 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0699678 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0693658 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0677546 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0653415 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0532407 |
| RPL4 | ribosomal protein L4 | 0.0518999 |
| UBC | ubiquitin C | 0.0511696 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0481939 |
| POTEF | POTE ankyrin domain family, member F | 0.0468634 |
| ERBIN | erbb2 interacting protein | 0.0464029 |
| WDR43 | WD repeat domain 43 | 0.0459328 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0428882 |
| RNF145 | ring finger protein 145 | 0.0423351 |
| BRD2 | bromodomain containing 2 | 0.0408559 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0401716 |
| COPA | coatomer protein complex, subunit alpha | 0.0401449 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0398177 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0390398 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0377997 |
| MSN | moesin | 0.0376033 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0358863 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0343974 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0332768 |
| HDGF | hepatoma-derived growth factor | 0.0324864 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.031599 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0315233 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0314082 |
| FMNL2 | formin-like 2 | 0.031329 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0311557 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0311085 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0310554 |
| PLS3 | plastin 3 | 0.0308394 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0307455 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0306029 |
| MAX | MYC associated factor X | 0.0306005 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0298078 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0297797 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0297179 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0293426 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.028894 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0284669 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0281377 |
| GON4L | gon-4-like (C. elegans) | 0.0274786 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0271098 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.026931 |
| EGR1 | early growth response 1 | 0.0268807 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0268674 |
| TOP1 | topoisomerase (DNA) I | 0.0266094 |
| GTDC1 | glycosyltransferase-like domain containing 1 | 0.0265342 |
| NUP98 | nucleoporin 98kDa | 0.0255337 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0254797 |
| CASC3 | cancer susceptibility candidate 3 | 0.0254689 |
| PNN | pinin, desmosome associated protein | 0.0254183 |
| RCOR1 | REST corepressor 1 | 0.0252892 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0251873 |
| RPS2 | ribosomal protein S2 | 0.0250548 |
| NOP58 | NOP58 ribonucleoprotein | 0.0249544 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0248654 |
| FGB | fibrinogen beta chain | 0.0248552 |
| CABIN1 | calcineurin binding protein 1 | 0.0246646 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 0.024623 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0245154 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0243801 |
| USP36 | ubiquitin specific peptidase 36 | 0.0236643 |
| FAM193A | family with sequence similarity 193, member A | 0.0231884 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.023129 |
| TPX2 | TPX2, microtubule-associated | 0.0228842 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0226297 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0223175 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0220995 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0220089 |
| GOLGA4 | golgin A4 | 0.022001 |
| WBP11 | WW domain binding protein 11 | 0.0219962 |
| SETD5 | SET domain containing 5 | 0.0218456 |
| INO80 | INO80 complex subunit | 0.0215998 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0215662 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.021293 |
| PDE8A | phosphodiesterase 8A | 0.0212144 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.021139 |
| PYGL | phosphorylase, glycogen, liver | 0.0210008 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0209872 |
| ENO1 | enolase 1, (alpha) | 0.0209468 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0208197 |
| DDX24 | DEAD (Asp-Glu-Ala-Asp) box helicase 24 | 0.0208089 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0207476 |
| RPS27A | ribosomal protein S27a | 0.0206916 |
| FLNB | filamin B, beta | 0.0206043 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0205795 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0205555 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0205533 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0205014 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0202813 |
| HAT1 | histone acetyltransferase 1 | 0.0202808 |
| PHF20 | PHD finger protein 20 | 0.020263 |
| BRD4 | bromodomain containing 4 | 0.0201846 |
| FERMT2 | fermitin family member 2 | 0.0201646 |
| PUM1 | pumilio RNA-binding family member 1 | 0.020098 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0200127 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.228548 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.201928 |
| TXNRD1 | thioredoxin reductase 1 | -0.186862 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.149041 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.136464 |
| FTL | ferritin, light polypeptide | -0.124359 |
| TMSB10 | thymosin beta 10 | -0.112923 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.109297 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.107086 |
| RPL23 | ribosomal protein L23 | -0.0967904 |
| VIM | vimentin | -0.0882259 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0829321 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0802456 |
| GRAMD1B | GRAM domain containing 1B | -0.07831 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0775569 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0761955 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.075896 |
| RPL35A | ribosomal protein L35a | -0.0746799 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0713147 |
| ASPH | aspartate beta-hydroxylase | -0.0675249 |
| RPL19 | ribosomal protein L19 | -0.0608719 |
| BICC1 | BicC family RNA binding protein 1 | -0.0584514 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0550898 |
| IER3 | immediate early response 3 | -0.0549091 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0543546 |
| NRG1 | neuregulin 1 | -0.0535126 |
| RPLP1 | ribosomal protein, large, P1 | -0.050044 |
| RPS21 | ribosomal protein S21 | -0.0484995 |
| S100A10 | S100 calcium binding protein A10 | -0.0483827 |
| ANXA2 | annexin A2 | -0.0483423 |
| RPS24 | ribosomal protein S24 | -0.0468844 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0448666 |
| WWOX | WW domain containing oxidoreductase | -0.0448624 |
| RPLP0 | ribosomal protein, large, P0 | -0.0446085 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0443637 |
| MYOF | myoferlin | -0.0442113 |
| RPL34 | ribosomal protein L34 | -0.0433959 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.043298 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0427757 |
| DST | dystonin | -0.0407759 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0405994 |
| EFNA5 | ephrin-A5 | -0.0400484 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0392336 |
| TUBB | tubulin, beta class I | -0.0384206 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0363033 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0354719 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0341158 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0338812 |
| PTMA | prothymosin, alpha | -0.0323975 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0323417 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0319964 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0316536 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0315753 |
| AHNAK | AHNAK nucleoprotein | -0.0309005 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0307779 |
| RPS5 | ribosomal protein S5 | -0.0302277 |
| TMEM123 | transmembrane protein 123 | -0.0302136 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0298841 |
| NEGR1 | neuronal growth regulator 1 | -0.0293437 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0293262 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0291776 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0290433 |
| DENND4A | DENN/MADD domain containing 4A | -0.0290253 |
| RPL11 | ribosomal protein L11 | -0.028566 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0282666 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0282267 |
| RPS19 | ribosomal protein S19 | -0.0277296 |
| GSTP1 | glutathione S-transferase pi 1 | -0.027271 |
| RNF213 | ring finger protein 213 | -0.0271806 |
| RPL12 | ribosomal protein L12 | -0.0271667 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0270917 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0267844 |
| RPS25 | ribosomal protein S25 | -0.0267303 |
| TNPO1 | transportin 1 | -0.0263843 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0259951 |
| RPL38 | ribosomal protein L38 | -0.0257333 |
| YBX1 | Y box binding protein 1 | -0.0257215 |
| RPL31 | ribosomal protein L31 | -0.0255562 |
| TMSB4X | thymosin beta 4, X-linked | -0.0255505 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0254647 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0253879 |
| TKT | transketolase | -0.0253707 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0251737 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.024971 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0246411 |
| RPS20 | ribosomal protein S20 | -0.0245915 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0239469 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.02369 |
| HMGA1 | high mobility group AT-hook 1 | -0.0231449 |
| RAD21 | RAD21 homolog (S. pombe) | -0.023068 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0230135 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0225645 |
| RPS11 | ribosomal protein S11 | -0.0223408 |
| FHIT | fragile histidine triad | -0.0222722 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0220668 |
| NAV3 | neuron navigator 3 | -0.022016 |
| RPL30 | ribosomal protein L30 | -0.022005 |
| RPL9 | ribosomal protein L9 | -0.0219791 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0219604 |
| NNMT | nicotinamide N-methyltransferase | -0.0218155 |
