Fulvestrant_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fulvestrant perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Fulvestrant_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.0449558
TRIO trio Rho guanine nucleotide exchange factor 0.0407741
RAD51B RAD51 paralog B 0.0326628
TXNRD1 thioredoxin reductase 1 0.0252628
TPM3 tropomyosin 3 0.0244389
ANO6 anoctamin 6 0.0240672
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0236708
USP34 ubiquitin specific peptidase 34 0.0232559
AKAP12 A kinase (PRKA) anchor protein 12 0.022765
ZCCHC7 zinc finger, CCHC domain containing 7 0.0221241
TAS2R14 taste receptor, type 2, member 14 0.0215662
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0215532
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0213618
NF1 neurofibromin 1 0.0211174
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0200005
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0194123
PUM2 pumilio RNA-binding family member 2 0.0192725
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0190585
AHNAK AHNAK nucleoprotein 0.0188824
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0188768
EXOC4 exocyst complex component 4 0.0187811
OGA O-GlcNAcase 0.01877
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0182839
PCLO piccolo presynaptic cytomatrix protein 0.0180996
SMAD3 SMAD family member 3 0.0179985
NABP1 nucleic acid binding protein 1 0.0179721
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0177207
ZFAND3 zinc finger, AN1-type domain 3 0.0175817
NIPBL Nipped-B homolog (Drosophila) 0.0173348
H1-0 H1.0 linker histone 0.0165077
IGF1R insulin-like growth factor 1 receptor 0.0164837
JMJD1C jumonji domain containing 1C 0.0162826
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0161142
KDM3A lysine (K)-specific demethylase 3A 0.016014
COPA coatomer protein complex, subunit alpha 0.0159853
TRIP12 thyroid hormone receptor interactor 12 0.0159842
SENP6 SUMO1/sentrin specific peptidase 6 0.0159663
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0156092
THSD4 thrombospondin, type I, domain containing 4 0.0155731
RPL4 ribosomal protein L4 0.0153982
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0150978
RICTOR RPTOR independent companion of MTOR, complex 2 0.0149642
KDM2A lysine (K)-specific demethylase 2A 0.0147619
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.014723
MACF1 microtubule-actin crosslinking factor 1 0.014706
ANKRD36 ankyrin repeat domain 36 0.0146359
UBC ubiquitin C 0.0146037
NUP153 nucleoporin 153kDa 0.0143534
SAMD4A sterile alpha motif domain containing 4A 0.0141343
MMP12 matrix metallopeptidase 12 0.0139897
DOCK5 dedicator of cytokinesis 5 0.0138888
CLTC clathrin, heavy chain (Hc) 0.013886
EIF4B eukaryotic translation initiation factor 4B 0.0137964
GSK3B glycogen synthase kinase 3 beta 0.0137788
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.013685
FMNL2 formin-like 2 0.0135613
BIRC6 baculoviral IAP repeat containing 6 0.0135554
ETNK1 ethanolamine kinase 1 0.0134391
ZNF638 zinc finger protein 638 0.0133827
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0133436
EML4 echinoderm microtubule associated protein like 4 0.0133253
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0133229
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0131718
CSNK1A1 casein kinase 1, alpha 1 0.0130338
WDR70 WD repeat domain 70 0.0129408
BIRC2 baculoviral IAP repeat containing 2 0.0128004
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0127734
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0127485
SPAG9 sperm associated antigen 9 0.0127189
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0126941
RLIM ring finger protein, LIM domain interacting 0.0126446
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0125669
ACTN1 actinin, alpha 1 0.0124035
NBAS neuroblastoma amplified sequence 0.0121951
KIAA1328 KIAA1328 0.012192
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0121703
ATP11A ATPase, class VI, type 11A 0.0121691
LARP4B La ribonucleoprotein domain family, member 4B 0.0121595
XPO1 exportin 1 0.0119874
DIDO1 death inducer-obliterator 1 0.0118818
WDPCP WD repeat containing planar cell polarity effector 0.0118455
RBM39 RNA binding motif protein 39 0.0118098
SRBD1 S1 RNA binding domain 1 0.0117121
VMP1 vacuole membrane protein 1 0.0116271
BBX bobby sox homolog (Drosophila) 0.0115115
CAMKMT calmodulin-lysine N-methyltransferase 0.011497
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0114955
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0113657
FAF1 Fas (TNFRSF6) associated factor 1 0.0111583
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0111401
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0110644
PTK2 protein tyrosine kinase 2 0.0110312
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0109014
CDK17 cyclin-dependent kinase 17 0.010881
ZFC3H1 zinc finger, C3H1-type containing 0.0108421
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0108397
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0108271
CSDE1 cold shock domain containing E1, RNA-binding 0.0108104
MARCHF4 membrane associated ring-CH-type finger 4 0.0107516
EHBP1 EH domain binding protein 1 0.0106977

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.261944
TMSB10 thymosin beta 10 -0.138191
PTMA prothymosin, alpha -0.0859564
VIM vimentin -0.0819448
RPS3 ribosomal protein S3 -0.0651499
RPL35A ribosomal protein L35a -0.0634709
RPS8 ribosomal protein S8 -0.0582605
TPI1 triosephosphate isomerase 1 -0.0576959
RPLP1 ribosomal protein, large, P1 -0.0576469
RPL37A ribosomal protein L37a -0.0546573
MT2A metallothionein 2A -0.0528161
RPL23 ribosomal protein L23 -0.0518986
RPS19 ribosomal protein S19 -0.0494863
RPS21 ribosomal protein S21 -0.0471661
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0450052
FTL ferritin, light polypeptide -0.0429475
RPL37 ribosomal protein L37 -0.0427381
RPS27 ribosomal protein S27 -0.0422914
RPS29 ribosomal protein S29 -0.0409775
RPL26 ribosomal protein L26 -0.040816
RPL12 ribosomal protein L12 -0.0400327
RPL31 ribosomal protein L31 -0.0394906
RPL34 ribosomal protein L34 -0.0392068
RPS15 ribosomal protein S15 -0.0387453
TFPI2 tissue factor pathway inhibitor 2 -0.0379731
RPS10 ribosomal protein S10 -0.0364195
RPLP2 ribosomal protein, large, P2 -0.0359511
ACTG1 actin gamma 1 -0.0358244
RPL36 ribosomal protein L36 -0.0356598
HLA-B major histocompatibility complex, class I, B -0.0354346
TPT1 tumor protein, translationally-controlled 1 -0.0352417
RPS6 ribosomal protein S6 -0.0344233
RPL8 ribosomal protein L8 -0.0336012
RPL19 ribosomal protein L19 -0.033507
RPL11 ribosomal protein L11 -0.033276
EGR1 early growth response 1 -0.0331184
PFN1 profilin 1 -0.0327847
RPS12 ribosomal protein S12 -0.0321875
MYL12B myosin, light chain 12B, regulatory -0.0317194
RPL5 ribosomal protein L5 -0.0311479
RPL9 ribosomal protein L9 -0.0306449
EIF5B eukaryotic translation initiation factor 5B -0.0305696
KTN1 kinectin 1 (kinesin receptor) -0.03037
RPL38 ribosomal protein L38 -0.0302443
YBX1 Y box binding protein 1 -0.029351
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0285014
RPS14 ribosomal protein S14 -0.0277611
IFI6 interferon, alpha-inducible protein 6 -0.027169
POTEF POTE ankyrin domain family, member F -0.027113
RPLP0 ribosomal protein, large, P0 -0.0270514
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0262995
RACK1 receptor for activated C kinase 1 -0.0262376
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0262303
RPL28 ribosomal protein L28 -0.0261325
RPS17 ribosomal protein S17 -0.0250007
RPL32 ribosomal protein L32 -0.0249887
RPS27A ribosomal protein S27a -0.0248522
YBX3 Y box binding protein 3 -0.0243036
ATP5F1E ATP synthase F1 subunit epsilon -0.0235133
RPL27 ribosomal protein L27 -0.0232615
RPL36A ribosomal protein L36a -0.0231824
RPL35 ribosomal protein L35 -0.0230296
NAP1L1 nucleosome assembly protein 1-like 1 -0.0229184
RPS13 ribosomal protein S13 -0.0228402
TPM2 tropomyosin 2 (beta) -0.0228039
RPS23 ribosomal protein S23 -0.0222432
RPS4X ribosomal protein S4, X-linked -0.0220853
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0220277
GSTP1 glutathione S-transferase pi 1 -0.0209872
RPS25 ribosomal protein S25 -0.0209116
HMGA1 high mobility group AT-hook 1 -0.0206417
S100A11 S100 calcium binding protein A11 -0.0205354
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0203685
LDHB lactate dehydrogenase B -0.0201639
RPL7A ribosomal protein L7a -0.0200806
S100A10 S100 calcium binding protein A10 -0.0196283
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0194988
RPS24 ribosomal protein S24 -0.0194365
S100A6 S100 calcium binding protein A6 -0.0193223
PKM pyruvate kinase, muscle -0.0192369
RPL30 ribosomal protein L30 -0.0191043
EEF2 eukaryotic translation elongation factor 2 -0.019083
GNAS GNAS complex locus -0.018826
DEK DEK proto-oncogene -0.0180203
SEC61G Sec61 gamma subunit -0.0179918
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0176682
RPL18 ribosomal protein L18 -0.017668
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0176224
TUBA1B tubulin, alpha 1b -0.0173673
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.0171722
EIF1 eukaryotic translation initiation factor 1 -0.0169481
RPS16 ribosomal protein S16 -0.0169227
RPS20 ribosomal protein S20 -0.0168577
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0164974
CBX3 chromobox homolog 3 -0.0162799
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.016142
WSB1 WD repeat and SOCS box containing 1 -0.0160689
NACA nascent polypeptide-associated complex alpha subunit -0.0160658
GPX4 glutathione peroxidase 4 -0.01542
B2M beta-2-microglobulin -0.0153383