Fulvestrant_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fulvestrant perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fulvestrant_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RNF145 ring finger protein 145 0.0598101
NAMPT nicotinamide phosphoribosyltransferase 0.0552291
BHLHE40 basic helix-loop-helix family, member e40 0.0488898
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0478211
FXR1 fragile X mental retardation, autosomal homolog 1 0.04664
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0447258
TSC22D2 TSC22 domain family, member 2 0.0421495
CCNL1 cyclin L1 0.0414311
ADAM9 ADAM metallopeptidase domain 9 0.0411743
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0398988
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0394744
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0392387
TFG TRK-fused gene 0.0377736
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0370195
MSMO1 methylsterol monooxygenase 1 0.0366142
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0337648
ASPH aspartate beta-hydroxylase 0.033363
NDRG1 N-myc downstream regulated 1 0.0323085
MARCHF6 membrane associated ring-CH-type finger 6 0.0322169
RPL4 ribosomal protein L4 0.0318022
UBC ubiquitin C 0.0310605
YTHDC1 YTH domain containing 1 0.0306969
UBA6 ubiquitin-like modifier activating enzyme 6 0.0304089
MATR3 matrin 3 0.0301409
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0297144
RHEB Ras homolog enriched in brain 0.0290955
RAD21 RAD21 homolog (S. pombe) 0.0268594
NCKAP1 NCK-associated protein 1 0.0264844
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0261958
MSN moesin 0.0255451
GARS1 glycyl-tRNA synthetase 1 0.0251398
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0247577
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0247169
USP3 ubiquitin specific peptidase 3 0.0246629
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0243801
RYBP RING1 and YY1 binding protein 0.0235787
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0234013
PAPOLA poly(A) polymerase alpha 0.0234006
MIS18BP1 MIS18 binding protein 1 0.0229247
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0223278
WAC WW domain containing adaptor with coiled-coil 0.0222711
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.022217
ZNF292 zinc finger protein 292 0.0216266
DSCAM Down syndrome cell adhesion molecule 0.0216144
NUP58 nucleoporin 58 0.0213597
RBM25 RNA binding motif protein 25 0.0212435
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0210726
CDK17 cyclin-dependent kinase 17 0.0210093
ECT2 epithelial cell transforming 2 0.0208893
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0208197
KMT2E lysine (K)-specific methyltransferase 2E 0.0207968
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0206307
RAD23B RAD23 homolog B (S. cerevisiae) 0.0203374
UGCG UDP-glucose ceramide glucosyltransferase 0.0203034
TPM3 tropomyosin 3 0.020052
FAM13A family with sequence similarity 13, member A 0.0196055
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.019505
ANLN anillin, actin binding protein 0.0194781
RLF rearranged L-myc fusion 0.0194308
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0193832
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0190848
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0189782
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0188931
HMGB2 high mobility group box 2 0.0188514
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0188218
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0185262
BCLAF1 BCL2-associated transcription factor 1 0.0184796
CLINT1 clathrin interactor 1 0.0181651
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0178507
CHD1 chromodomain helicase DNA binding protein 1 0.0178161
SCEL sciellin 0.0176829
MORF4L1 mortality factor 4 like 1 0.0173277
FAM3C family with sequence similarity 3, member C 0.017093
QKI QKI, KH domain containing, RNA binding 0.0170446
PEG10 paternally expressed 10 0.0169456
KDM6A lysine (K)-specific demethylase 6A 0.0169367
MTMR3 myotubularin related protein 3 0.0168768
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0168526
ATP13A3 ATPase type 13A3 0.0166651
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0165734
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0163595
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0162758
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0161614
TPX2 TPX2, microtubule-associated 0.0160472
CD46 CD46 molecule, complement regulatory protein 0.0160269
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0159858
NPEPPS aminopeptidase puromycin sensitive 0.0159841
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0157772
PELI1 pellino E3 ubiquitin protein ligase 1 0.0157368
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0156316
SRRM1 serine/arginine repetitive matrix 1 0.015198
ANXA5 annexin A5 0.0151423
WDR43 WD repeat domain 43 0.0149705
TRA2B transformer 2 beta homolog (Drosophila) 0.0148366
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.014781
CDC73 cell division cycle 73 0.0147614
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0144332
DDIT4 DNA-damage-inducible transcript 4 0.0144094
SSBP2 single-stranded DNA binding protein 2 0.0143873
SDC4 syndecan 4 0.0143735

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.2
ACTG1 actin gamma 1 -0.173916
FTL ferritin, light polypeptide -0.138245
TMSB10 thymosin beta 10 -0.137596
PTMA prothymosin, alpha -0.115611
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.110625
EXT1 exostosin glycosyltransferase 1 -0.108747
FBXO32 F-box protein 32 -0.0933894
SAMD4A sterile alpha motif domain containing 4A -0.0907903
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0868103
IGFBP3 insulin-like growth factor binding protein 3 -0.0837229
RPLP1 ribosomal protein, large, P1 -0.0819991
RPL35A ribosomal protein L35a -0.0806733
IFI27 interferon, alpha-inducible protein 27 -0.0799307
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0788575
TPT1 tumor protein, translationally-controlled 1 -0.077644
IFI6 interferon, alpha-inducible protein 6 -0.0764678
RPL34 ribosomal protein L34 -0.073544
RPS8 ribosomal protein S8 -0.0713812
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0713031
S100A6 S100 calcium binding protein A6 -0.069125
LPP LIM domain containing preferred translocation partner in lipoma -0.068403
EIF1 eukaryotic translation initiation factor 1 -0.0674379
S100A10 S100 calcium binding protein A10 -0.0654859
RPL23 ribosomal protein L23 -0.0654685
LAMB3 laminin, beta 3 -0.0640826
ISG15 ISG15 ubiquitin-like modifier -0.0639932
EFNA5 ephrin-A5 -0.0628967
LIMCH1 LIM and calponin homology domains 1 -0.0599679
TMSB4X thymosin beta 4, X-linked -0.0582276
IFITM3 interferon induced transmembrane protein 3 -0.0553994
CSTB cystatin B (stefin B) -0.0537032
RPLP2 ribosomal protein, large, P2 -0.0533354
IFI16 interferon, gamma-inducible protein 16 -0.0531337
RPS29 ribosomal protein S29 -0.0510863
RPS19 ribosomal protein S19 -0.0507513
RPL12 ribosomal protein L12 -0.0500806
RACK1 receptor for activated C kinase 1 -0.0500575
RPS6 ribosomal protein S6 -0.0494391
WSB1 WD repeat and SOCS box containing 1 -0.0490849
RPL37A ribosomal protein L37a -0.0484684
RPS23 ribosomal protein S23 -0.0472898
LMO7 LIM domain 7 -0.0466956
TPM4 tropomyosin 4 -0.0462481
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0462259
RNF213 ring finger protein 213 -0.0434607
SH3KBP1 SH3-domain kinase binding protein 1 -0.0430719
GOLGB1 golgin B1 -0.0428429
RPL8 ribosomal protein L8 -0.0421429
SQSTM1 sequestosome 1 -0.0416645
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0415567
ENO1 enolase 1, (alpha) -0.0413946
RPS13 ribosomal protein S13 -0.0411606
IFITM1 interferon induced transmembrane protein 1 -0.0411597
RPL9 ribosomal protein L9 -0.0404461
MYO1E myosin IE -0.0402221
RPS27 ribosomal protein S27 -0.039608
HMGA1 high mobility group AT-hook 1 -0.0390628
RPL19 ribosomal protein L19 -0.038722
SOX4 SRY (sex determining region Y)-box 4 -0.0384418
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0382407
RPS3 ribosomal protein S3 -0.0381549
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0374194
SP100 SP100 nuclear antigen -0.0368194
HLA-A major histocompatibility complex, class I, A -0.0366271
HLA-B major histocompatibility complex, class I, B -0.036552
KRT7 keratin 7, type II -0.0365116
ARHGAP5 Rho GTPase activating protein 5 -0.0362167
RPL30 ribosomal protein L30 -0.0357457
C15ORF48 chromosome 15 open reading frame 48 -0.035609
RPS25 ribosomal protein S25 -0.0356085
MX2 MX dynamin-like GTPase 2 -0.0354041
RPS17 ribosomal protein S17 -0.0351827
RPS14 ribosomal protein S14 -0.0347562
DSPP dentin sialophosphoprotein -0.0346396
VCL vinculin -0.034629
VIM vimentin -0.0344989
MX1 MX dynamin-like GTPase 1 -0.0344639
RAI14 retinoic acid induced 14 -0.0342546
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0341409
RPL31 ribosomal protein L31 -0.0336963
ZBTB20 zinc finger and BTB domain containing 20 -0.0336244
RPL37 ribosomal protein L37 -0.0330622
RPL36 ribosomal protein L36 -0.0330594
IFIH1 interferon induced with helicase C domain 1 -0.0329832
AHNAK AHNAK nucleoprotein -0.0323949
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0320525
RIGI RNA sensor RIG-I -0.0318347
NAV2 neuron navigator 2 -0.0316472
CANX calnexin -0.0314456
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0311203
RAB7A RAB7A, member RAS oncogene family -0.0310217
TTC3 tetratricopeptide repeat domain 3 -0.0308183
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0303562
RPS27A ribosomal protein S27a -0.0302436
F3 coagulation factor III (thromboplastin, tissue factor) -0.0302182
FTH1 ferritin, heavy polypeptide 1 -0.0301041
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0298828
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0296112
PLSCR1 phospholipid scramblase 1 -0.0295696