Fulvestrant_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fulvestrant perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fulvestrant_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.0444851
ELL2 elongation factor, RNA polymerase II, 2 0.0381537
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0375721
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0367951
PM20D1 peptidase M20 domain containing 1 0.0358245
PDE4D phosphodiesterase 4D, cAMP-specific 0.031218
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0304366
FNDC3B fibronectin type III domain containing 3B 0.0304222
SPAG9 sperm associated antigen 9 0.0298038
FNDC3A fibronectin type III domain containing 3A 0.0288997
UBC ubiquitin C 0.0282308
PDLIM5 PDZ and LIM domain 5 0.0279429
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0256864
FMNL2 formin-like 2 0.0251764
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0245355
STC1 stanniocalcin 1 0.0242158
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0239174
ESYT2 extended synaptotagmin-like protein 2 0.0228042
KMT2E lysine (K)-specific methyltransferase 2E 0.0208059
ERRFI1 ERBB receptor feedback inhibitor 1 0.0202811
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0201871
CDH13 cadherin 13 0.0201537
ZEB2 zinc finger E-box binding homeobox 2 0.0201342
DST dystonin 0.0191777
KDM6A lysine (K)-specific demethylase 6A 0.0191597
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0191335
SMOC1 SPARC related modular calcium binding 1 0.0187772
ATP13A3 ATPase type 13A3 0.0181917
UBA6 ubiquitin-like modifier activating enzyme 6 0.0176967
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0176663
FAM13A family with sequence similarity 13, member A 0.0172699
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0170256
IGFBP3 insulin-like growth factor binding protein 3 0.0168268
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0166732
BIRC6 baculoviral IAP repeat containing 6 0.0164607
COPA coatomer protein complex, subunit alpha 0.0162115
KMT2C lysine (K)-specific methyltransferase 2C 0.0157461
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0156891
RNF145 ring finger protein 145 0.0151556
OGA O-GlcNAcase 0.0149351
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.014762
CD109 CD109 molecule 0.0147327
PUM2 pumilio RNA-binding family member 2 0.0144298
DGKD diacylglycerol kinase, delta 130kDa 0.0144013
TRIO trio Rho guanine nucleotide exchange factor 0.0142602
PCBP3 poly(rC) binding protein 3 0.0141049
HELZ helicase with zinc finger 0.0140242
DNER delta/notch-like EGF repeat containing 0.0140108
COL4A6 collagen, type IV, alpha 6 0.0138601
ITPRID2 ITPR interacting domain containing 2 0.0136081
CDC73 cell division cycle 73 0.0136028
AUTS2 autism susceptibility candidate 2 0.0135995
MCL1 myeloid cell leukemia 1 0.0134043
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0133411
GRB10 growth factor receptor-bound protein 10 0.0131719
CHD1 chromodomain helicase DNA binding protein 1 0.0130661
PTEN phosphatase and tensin homolog 0.012647
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.012539
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0124403
GOLGA4 golgin A4 0.0123465
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0123192
RLIM ring finger protein, LIM domain interacting 0.0122809
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0121904
SRPK2 SRSF protein kinase 2 0.0121385
USP34 ubiquitin specific peptidase 34 0.0121027
CANX calnexin 0.011858
NBAS neuroblastoma amplified sequence 0.0118244
P3H2 prolyl 3-hydroxylase 2 0.0117927
WAC WW domain containing adaptor with coiled-coil 0.0117282
EFNA5 ephrin-A5 0.0116828
NEK7 NIMA-related kinase 7 0.0116781
CHL1 cell adhesion molecule L1-like 0.0116287
SAMD4A sterile alpha motif domain containing 4A 0.011622
TENT5A terminal nucleotidyltransferase 5A 0.0116188
AKAP13 A kinase (PRKA) anchor protein 13 0.011452
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0114024
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0113804
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0113226
TPD52 tumor protein D52 0.0112857
COL8A1 collagen, type VIII, alpha 1 0.0112583
AGFG1 ArfGAP with FG repeats 1 0.0112582
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0111666
SBF2 SET binding factor 2 0.0111347
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0110627
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0110101
TGFBR1 transforming growth factor, beta receptor 1 0.01098
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0108603
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0108513
BZW1 basic leucine zipper and W2 domains 1 0.0108241
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0107276
SLC16A6 solute carrier family 16, member 6 0.0106539
PDIA6 protein disulfide isomerase family A, member 6 0.0106422
NGLY1 N-glycanase 1 0.0106142
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0105612
GPRIN3 GPRIN family member 3 0.0105511
USP9X ubiquitin specific peptidase 9, X-linked 0.010491
SPTBN1 spectrin, beta, non-erythrocytic 1 0.010284
VCL vinculin 0.0102592
NCKAP1 NCK-associated protein 1 0.0102185
SOD2 superoxide dismutase 2, mitochondrial 0.0101486

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.158616
TMSB10 thymosin beta 10 -0.112122
RPLP1 ribosomal protein, large, P1 -0.0849719
FTL ferritin, light polypeptide -0.0727413
VIM vimentin -0.070682
TPT1 tumor protein, translationally-controlled 1 -0.0642322
RPL35A ribosomal protein L35a -0.0620775
RPS6 ribosomal protein S6 -0.0612636
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0569722
RPL12 ribosomal protein L12 -0.0530693
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0528635
RPL23 ribosomal protein L23 -0.0516528
RPL26 ribosomal protein L26 -0.0513631
RPL31 ribosomal protein L31 -0.051265
TXNRD1 thioredoxin reductase 1 -0.0505352
MT2A metallothionein 2A -0.0499135
RPS24 ribosomal protein S24 -0.0498592
RPS19 ribosomal protein S19 -0.0493751
PTMA prothymosin, alpha -0.0487894
RPL37A ribosomal protein L37a -0.0464173
RPS8 ribosomal protein S8 -0.0463555
RPS23 ribosomal protein S23 -0.0428804
RPL19 ribosomal protein L19 -0.0423933
RPLP0 ribosomal protein, large, P0 -0.0411397
RPL9 ribosomal protein L9 -0.0407658
EIF1 eukaryotic translation initiation factor 1 -0.0400233
RPLP2 ribosomal protein, large, P2 -0.0393928
ACTG1 actin gamma 1 -0.0385311
RPS12 ribosomal protein S12 -0.0374938
RPS4X ribosomal protein S4, X-linked -0.0351129
RPS29 ribosomal protein S29 -0.0337266
RPL34 ribosomal protein L34 -0.0333888
RPL7A ribosomal protein L7a -0.0332944
RPL36A ribosomal protein L36a -0.0332037
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0331299
ASPH aspartate beta-hydroxylase -0.032581
RPL11 ribosomal protein L11 -0.0313302
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0308902
GRAMD1B GRAM domain containing 1B -0.0304694
RPS21 ribosomal protein S21 -0.0297141
RPL36 ribosomal protein L36 -0.0295335
RPS3 ribosomal protein S3 -0.0294477
RPL38 ribosomal protein L38 -0.0284591
RPS16 ribosomal protein S16 -0.0281227
RPL37 ribosomal protein L37 -0.0279543
S100A10 S100 calcium binding protein A10 -0.0276925
RPS14 ribosomal protein S14 -0.0267129
RPL35 ribosomal protein L35 -0.0261528
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0260982
RPS27 ribosomal protein S27 -0.0255098
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0252437
EEF2 eukaryotic translation elongation factor 2 -0.0251307
PRDX1 peroxiredoxin 1 -0.0251283
RACK1 receptor for activated C kinase 1 -0.0251036
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.024801
RPL28 ribosomal protein L28 -0.0246531
RPS13 ribosomal protein S13 -0.0244273
RPS27A ribosomal protein S27a -0.0242581
RPL32 ribosomal protein L32 -0.0237384
NAP1L1 nucleosome assembly protein 1-like 1 -0.0228551
RPL7 ribosomal protein L7 -0.022266
RPS25 ribosomal protein S25 -0.0221702
RPL5 ribosomal protein L5 -0.0218471
RPL13A ribosomal protein L13a -0.0217325
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0209505
LOC112694756 uncharaterized LOC112694756 -0.0209453
ATP5F1E ATP synthase F1 subunit epsilon -0.0208015
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0206136
RPL27 ribosomal protein L27 -0.0200399
PDE10A phosphodiesterase 10A -0.0199603
RPS17 ribosomal protein S17 -0.0198153
B2M beta-2-microglobulin -0.0196864
RPS28 ribosomal protein S28 -0.0194678
S100A6 S100 calcium binding protein A6 -0.0192703
RPS20 ribosomal protein S20 -0.0190557
SRGN serglycin -0.0188582
KRT19 keratin 19, type I -0.0184917
AKR1C1 aldo-keto reductase family 1, member C1 -0.0184131
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0183359
TFPI2 tissue factor pathway inhibitor 2 -0.0178211
RPL30 ribosomal protein L30 -0.0176946
RPS15 ribosomal protein S15 -0.0173385
RPS5 ribosomal protein S5 -0.0170742
POTEF POTE ankyrin domain family, member F -0.0168812
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0168024
LDHA lactate dehydrogenase A -0.0166907
RPS11 ribosomal protein S11 -0.0164838
RPS10 ribosomal protein S10 -0.0160818
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0160213
GNAS GNAS complex locus -0.0158394
VDAC1 voltage-dependent anion channel 1 -0.0158169
RPL27A ribosomal protein L27a -0.0156538
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0152686
LMNA lamin A/C -0.0151128
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0150755
HLA-B major histocompatibility complex, class I, B -0.0150333
RPL18 ribosomal protein L18 -0.0147292
RPL10A ribosomal protein L10a -0.0145872
NAMPT nicotinamide phosphoribosyltransferase -0.0144723
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0143714