Fulvestrant_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fulvestrant perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

179 genes differentially expressed following the Fulvestrant_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
OGA O-GlcNAcase 0.0921718
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.082019
PDE4D phosphodiesterase 4D, cAMP-specific 0.0682222
PDE10A phosphodiesterase 10A 0.0674574
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0649245
GOLGA4 golgin A4 0.0648487
EXT1 exostosin glycosyltransferase 1 0.06193
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0618795
H1-0 H1.0 linker histone 0.0614208
SPAG9 sperm associated antigen 9 0.0596681
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.057554
TXNRD1 thioredoxin reductase 1 0.0565411
PGK1 phosphoglycerate kinase 1 0.055254
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0540274
MYOF myoferlin 0.0539598
AFF4 AF4/FMR2 family, member 4 0.0523009
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0517958
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0504853
RICTOR RPTOR independent companion of MTOR, complex 2 0.0503416
KMT2C lysine (K)-specific methyltransferase 2C 0.0482363
COPA coatomer protein complex, subunit alpha 0.0479505
KMT2E lysine (K)-specific methyltransferase 2E 0.0478712
NCOR1 nuclear receptor corepressor 1 0.0459541
WSB1 WD repeat and SOCS box containing 1 0.0446259
NDRG1 N-myc downstream regulated 1 0.044589
DCAF6 DDB1 and CUL4 associated factor 6 0.0440147
MRTFA myocardin related transcription factor A 0.0438102
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0435949
SBF2 SET binding factor 2 0.0430892
MED13 mediator complex subunit 13 0.0429473
RAB7A RAB7A, member RAS oncogene family 0.0420113
NKTR natural killer cell triggering receptor 0.0416653
PUM2 pumilio RNA-binding family member 2 0.0406031
SOD2 superoxide dismutase 2, mitochondrial 0.0399611
MATR3 matrin 3 0.0382001
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0378603
SCAPER S-phase cyclin A-associated protein in the ER 0.0375089
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.037377
UBE2H ubiquitin-conjugating enzyme E2H 0.0357943
TSC22D2 TSC22 domain family, member 2 0.0356652
KDM6A lysine (K)-specific demethylase 6A 0.0355477
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0345708
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0341017
RBM39 RNA binding motif protein 39 0.0338782
CD109 CD109 molecule 0.0333688
SETD5 SET domain containing 5 0.0330467
ITSN2 intersectin 2 0.0326938
SUCO SUN domain containing ossification factor 0.0318774
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.031683
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0308797
AGO3 argonaute RISC catalytic component 3 0.0301659
EEF2 eukaryotic translation elongation factor 2 0.0291085
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0287471
PSD3 pleckstrin and Sec7 domain containing 3 0.0285525
RAB1A RAB1A, member RAS oncogene family 0.028495
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.028339
ETNK1 ethanolamine kinase 1 0.0280334
MARCHF6 membrane associated ring-CH-type finger 6 0.0276811
TRIO trio Rho guanine nucleotide exchange factor 0.027472
ARHGAP32 Rho GTPase activating protein 32 0.02634
BIRC6 baculoviral IAP repeat containing 6 0.0249482
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.024875
HDLBP high density lipoprotein binding protein 0.0247538
DST dystonin 0.0244486
BHLHE40 basic helix-loop-helix family, member e40 0.0240558
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0240525
FLNB filamin B, beta 0.0239998
SMAD3 SMAD family member 3 0.023684
FBXO11 F-box protein 11 0.0234586
PTK2 protein tyrosine kinase 2 0.0232622
MAP4 microtubule-associated protein 4 0.0217517
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0216372
EPS8 epidermal growth factor receptor pathway substrate 8 0.0201913
LDHA lactate dehydrogenase A 0.0189515
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0183751
PTPRM protein tyrosine phosphatase, receptor type, M 0.0176581
ZNF292 zinc finger protein 292 0.0172085
ITPRID2 ITPR interacting domain containing 2 0.0171264
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0167522
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0155447
NAMPT nicotinamide phosphoribosyltransferase 0.0149062
PRELID2 PRELI domain containing 2 0.0142105
TM4SF1 transmembrane 4 L six family member 1 0.014162
NAP1L1 nucleosome assembly protein 1-like 1 0.0139267
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0138762
YAP1 Yes-associated protein 1 0.0129393
ELL2 elongation factor, RNA polymerase II, 2 0.0124925
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0123589
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0113334
MEF2A myocyte enhancer factor 2A 0.0105542
BPTF bromodomain PHD finger transcription factor 0.0104945
SND1 staphylococcal nuclease and tudor domain containing 1 0.0102636
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.00946049
GNAS GNAS complex locus 0.00704598
EIF1 eukaryotic translation initiation factor 1 0.00693651
IER3 immediate early response 3 0.0068217
LAMA4 laminin, alpha 4 0.00673251
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.00576617
RPS3 ribosomal protein S3 0.00560106
NEBL nebulette 0.00512544

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.155218
TMSB10 thymosin beta 10 -0.120143
PTMA prothymosin, alpha -0.119706
FN1 fibronectin 1 -0.118903
PRKCA protein kinase C, alpha -0.109452
MYO10 myosin X -0.0816531
ITGA6 integrin, alpha 6 -0.0779728
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0756553
LPP LIM domain containing preferred translocation partner in lipoma -0.0749661
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.074538
RPS6 ribosomal protein S6 -0.0744245
MT2A metallothionein 2A -0.073136
FNDC3B fibronectin type III domain containing 3B -0.0713599
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0705659
TTC3 tetratricopeptide repeat domain 3 -0.0705315
ANKRD12 ankyrin repeat domain 12 -0.0652369
SLTM SAFB-like, transcription modulator -0.0651819
MCL1 myeloid cell leukemia 1 -0.0638023
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0625844
HMGA2 high mobility group AT-hook 2 -0.0613172
AKAP12 A kinase (PRKA) anchor protein 12 -0.0606949
EGFR epidermal growth factor receptor -0.0588329
TPT1 tumor protein, translationally-controlled 1 -0.0578991
ARHGAP26 Rho GTPase activating protein 26 -0.0574458
MACF1 microtubule-actin crosslinking factor 1 -0.0549114
ACTG1 actin gamma 1 -0.0544217
THSD4 thrombospondin, type I, domain containing 4 -0.0528689
ALCAM activated leukocyte cell adhesion molecule -0.051456
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0512087
ANXA2 annexin A2 -0.0502596
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0492612
EGR1 early growth response 1 -0.049101
RPL15 ribosomal protein L15 -0.0474331
RPLP1 ribosomal protein, large, P1 -0.0452198
VIM vimentin -0.0437745
ENO1 enolase 1, (alpha) -0.0411978
MYO1E myosin IE -0.0409071
DSCAM Down syndrome cell adhesion molecule -0.0407688
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0402385
FHIT fragile histidine triad -0.0390139
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0382406
LMO7 LIM domain 7 -0.0363465
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0354237
TM9SF3 transmembrane 9 superfamily member 3 -0.0351643
RPS13 ribosomal protein S13 -0.0335334
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0335147
RPS8 ribosomal protein S8 -0.0306765
KPNB1 karyopherin (importin) beta 1 -0.028709
RPL37 ribosomal protein L37 -0.0285166
RAD51B RAD51 paralog B -0.0282837
KTN1 kinectin 1 (kinesin receptor) -0.0280369
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0271732
TAS2R14 taste receptor, type 2, member 14 -0.0266519
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0233812
SEC31A SEC31 homolog A (S. cerevisiae) -0.020228
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0172251
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0171713
PDE8A phosphodiesterase 8A -0.0163217
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0146861
VCL vinculin -0.0126708
RPL31 ribosomal protein L31 -0.0126569
CANX calnexin -0.0123235
RPS19 ribosomal protein S19 -0.0110296
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0107723
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.00971759
TBC1D22A TBC1 domain family, member 22A -0.00948279
EFNA5 ephrin-A5 -0.00894119
PTPRJ protein tyrosine phosphatase, receptor type, J -0.00787134
ZSWIM6 zinc finger, SWIM-type containing 6 -0.00764209
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.00762681
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.00697012
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.00496005
ZBTB20 zinc finger and BTB domain containing 20 -0.0043244
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.00426656
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.00343752
OXR1 oxidation resistance 1 -0.00271668
JMJD1C jumonji domain containing 1C -0.0024132
ASPH aspartate beta-hydroxylase -0.0019752
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.00146242