Fulvestrant_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fulvestrant perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fulvestrant_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 0.0856081
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.063833
PUM1 pumilio RNA-binding family member 1 0.0431776
QKI QKI, KH domain containing, RNA binding 0.0370708
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0364191
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0357826
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0356218
NOP58 NOP58 ribonucleoprotein 0.034248
HDAC9 histone deacetylase 9 0.0337096
ZNF292 zinc finger protein 292 0.0332643
ADAM9 ADAM metallopeptidase domain 9 0.0314158
FNDC3B fibronectin type III domain containing 3B 0.0308947
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0306142
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0296028
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0287476
TRPS1 trichorhinophalangeal syndrome I 0.0282786
KMT2E lysine (K)-specific methyltransferase 2E 0.0281885
RLF rearranged L-myc fusion 0.0279935
RHEB Ras homolog enriched in brain 0.0277286
ZFAND3 zinc finger, AN1-type domain 3 0.0274894
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0271809
NCKAP1 NCK-associated protein 1 0.0270577
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0266187
TRIO trio Rho guanine nucleotide exchange factor 0.026211
KDM3A lysine (K)-specific demethylase 3A 0.0256541
KMT2C lysine (K)-specific methyltransferase 2C 0.025591
H1-0 H1.0 linker histone 0.0253799
WDR43 WD repeat domain 43 0.0243957
RPL4 ribosomal protein L4 0.0242538
CDC73 cell division cycle 73 0.0236633
GLS2 glutaminase 2 (liver, mitochondrial) 0.023548
TRA2A transformer 2 alpha homolog (Drosophila) 0.0230915
OSBPL8 oxysterol binding protein-like 8 0.0227563
MATR3 matrin 3 0.0226812
BCLAF1 BCL2-associated transcription factor 1 0.0218862
RBM39 RNA binding motif protein 39 0.0218511
ANKRD33B ankyrin repeat domain 33B 0.0218374
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0217509
USP3 ubiquitin specific peptidase 3 0.0217455
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0217426
CXADR coxsackie virus and adenovirus receptor 0.0212555
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0209769
EMP1 epithelial membrane protein 1 0.0209126
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0208543
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.020826
PDS5B PDS5 cohesin associated factor B 0.0206168
SFPQ splicing factor proline/glutamine-rich 0.0204968
ORC4 origin recognition complex, subunit 4 0.0202384
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0201985
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0201293
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0200186
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0198262
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0198233
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0196645
ZNF217 zinc finger protein 217 0.0195909
KAT6A K(lysine) acetyltransferase 6A 0.0193922
CENPF centromere protein F, 350/400kDa 0.0193156
FBXO11 F-box protein 11 0.0192975
FNBP1L formin binding protein 1-like 0.0190176
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0189412
PICALM phosphatidylinositol binding clathrin assembly protein 0.0188778
MKI67 marker of proliferation Ki-67 0.0187152
RAB1A RAB1A, member RAS oncogene family 0.0184552
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.018454
MARCHF6 membrane associated ring-CH-type finger 6 0.0183264
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0181599
SMG7 SMG7 nonsense mediated mRNA decay factor 0.01807
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0179263
STRN3 striatin, calmodulin binding protein 3 0.0178255
RBM33 RNA binding motif protein 33 0.0178099
MED13L mediator complex subunit 13-like 0.0176691
CKAP5 cytoskeleton associated protein 5 0.01752
THBS1 thrombospondin 1 0.0173724
H1-4 H1.4 linker histone, cluster member 0.0172718
SRP72 signal recognition particle 72kDa 0.017267
YAP1 Yes-associated protein 1 0.0169209
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0168839
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0168106
IGF1R insulin-like growth factor 1 receptor 0.0165917
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0164667
SRP54 signal recognition particle 54kDa 0.0164312
NAMPT nicotinamide phosphoribosyltransferase 0.0163066
FXR1 fragile X mental retardation, autosomal homolog 1 0.0159711
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0159674
URI1 URI1, prefoldin-like chaperone 0.0159257
HSPH1 heat shock 105kDa/110kDa protein 1 0.0158293
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.015745
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0157347
RTN4 reticulon 4 0.0157318
MCTP1 multiple C2 domains, transmembrane 1 0.0156181
PUM2 pumilio RNA-binding family member 2 0.0155837
CALCR calcitonin receptor 0.0152853
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0152801
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0152629
FUBP1 far upstream element (FUSE) binding protein 1 0.0152501
PAWR PRKC, apoptosis, WT1, regulator 0.0152275
ABI2 abl-interactor 2 0.0152
AHNAK AHNAK nucleoprotein 0.0151605
CDC14A cell division cycle 14A 0.0148909
NEK7 NIMA-related kinase 7 0.0148573

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.118972
TMSB10 thymosin beta 10 -0.101343
COL11A1 collagen, type XI, alpha 1 -0.0922715
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0838303
CADM2 cell adhesion molecule 2 -0.0592128
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0569532
PTMA prothymosin, alpha -0.0534487
RPS16 ribosomal protein S16 -0.0525405
RPS6 ribosomal protein S6 -0.0500535
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0491942
COL5A2 collagen, type V, alpha 2 -0.0489359
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0466296
RPL35A ribosomal protein L35a -0.0422922
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0414244
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0393466
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0392453
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0387056
PCLO piccolo presynaptic cytomatrix protein -0.0347943
B2M beta-2-microglobulin -0.0337242
RPS8 ribosomal protein S8 -0.0332309
RPS19 ribosomal protein S19 -0.0326951
MDK midkine (neurite growth-promoting factor 2) -0.0326196
ISG15 ISG15 ubiquitin-like modifier -0.0321667
ENO1 enolase 1, (alpha) -0.0319507
PCDH9 protocadherin 9 -0.0307514
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0302872
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0287233
LDHA lactate dehydrogenase A -0.0284254
HSPB1 heat shock 27kDa protein 1 -0.0273891
RPLP1 ribosomal protein, large, P1 -0.0273025
RPL9 ribosomal protein L9 -0.0272964
COL1A2 collagen, type I, alpha 2 -0.0270735
PFN1 profilin 1 -0.0268491
PGK1 phosphoglycerate kinase 1 -0.0264801
ACTG1 actin gamma 1 -0.025535
PARD3B par-3 family cell polarity regulator beta -0.0244944
RPL31 ribosomal protein L31 -0.0241058
S100A9 S100 calcium binding protein A9 -0.0238905
TPT1 tumor protein, translationally-controlled 1 -0.0237349
FTL ferritin, light polypeptide -0.0233349
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0232662
RPL37A ribosomal protein L37a -0.0231523
LRRC4C leucine rich repeat containing 4C -0.0222337
WSB1 WD repeat and SOCS box containing 1 -0.0219419
RPS3 ribosomal protein S3 -0.0216751
NCAM2 neural cell adhesion molecule 2 -0.0216187
RPL12 ribosomal protein L12 -0.0209239
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0208543
RPL19 ribosomal protein L19 -0.0205738
MEIS2 Meis homeobox 2 -0.0205063
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0197364
RPS21 ribosomal protein S21 -0.0196541
RPL36A ribosomal protein L36a -0.0194306
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0194276
MYL12B myosin, light chain 12B, regulatory -0.0191044
RPS27 ribosomal protein S27 -0.018911
RPL23 ribosomal protein L23 -0.0187037
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0186303
MRPS6 mitochondrial ribosomal protein S6 -0.0185424
RAI1 retinoic acid induced 1 -0.0185224
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0185219
CSMD3 CUB and Sushi multiple domains 3 -0.018425
CNRIP1 cannabinoid receptor interacting protein 1 -0.0183814
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0183786
RPL11 ribosomal protein L11 -0.0183237
EIF1 eukaryotic translation initiation factor 1 -0.0182764
MT2A metallothionein 2A -0.0180395
COL3A1 collagen, type III, alpha 1 -0.0179111
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0177288
RPL37 ribosomal protein L37 -0.0175882
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0174694
RPS12 ribosomal protein S12 -0.0174143
FBXO17 F-box protein 17 -0.0174048
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0173277
RAD51B RAD51 paralog B -0.0172769
LOC112694756 uncharaterized LOC112694756 -0.017271
DOCK5 dedicator of cytokinesis 5 -0.0171079
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0169253
GPC3 glypican 3 -0.0165986
TUBA1B tubulin, alpha 1b -0.0165709
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0163455
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0163225
ANKRD12 ankyrin repeat domain 12 -0.0161754
S100A10 S100 calcium binding protein A10 -0.0161671
NRG1 neuregulin 1 -0.0161268
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.01606
RPL30 ribosomal protein L30 -0.0160272
TENM2 teneurin transmembrane protein 2 -0.015981
RPLP0 ribosomal protein, large, P0 -0.0158291
SNX6 sorting nexin 6 -0.0156621
TENM3 teneurin transmembrane protein 3 -0.0156343
RNF213 ring finger protein 213 -0.0156156
APOE apolipoprotein E -0.0154719
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0151556
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0148318
RPS13 ribosomal protein S13 -0.0148019
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0147931
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0146978
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0144739
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0144698