| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A meroterpenoid resulting from the formal condensation of the hydroxy group of fumagillol with the carboxylic acid group of (all-E)-deca-2,4,6,8-tetraenedioic acid. Originally isolated from the fungus Aspergillus fumigatus, it is used for the control of Nosema infection in honey bees. (Chemical Entities of Biological Interest Ontology, CHEBI_48635) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/6917655 |
| Similar Terms | |
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200 proteins with high or low expression in Fumagillin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KMT2B | lysine (K)-specific methyltransferase 2B | 1.38 |
| ITM2C | integral membrane protein 2C | 1.27 |
| ITM2B | integral membrane protein 2B | 1.19 |
| USP19 | ubiquitin specific peptidase 19 | 1.11 |
| ADCY10 | adenylate cyclase 10 (soluble) | 1.1 |
| CCDC28A | coiled-coil domain containing 28A | 1.04 |
| HMOX1 | heme oxygenase 1 | 1.0 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.81 |
| ZNF239 | zinc finger protein 239 | 0.8 |
| CASKIN1 | CASK interacting protein 1 | 0.8 |
| GPANK1 | G patch domain and ankyrin repeats 1 | 0.79 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.76 |
| DUSP14 | dual specificity phosphatase 14 | 0.76 |
| ATAD2B | ATPase family, AAA domain containing 2B | 0.75 |
| RBIS | ribosomal biogenesis factor | 0.74 |
| OBSL1 | obscurin-like 1 | 0.74 |
| RBMXL2 | RNA binding motif protein, X-linked-like 2 | 0.72 |
| DFFB | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 0.71 |
| ZNF593 | zinc finger protein 593 | 0.71 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | 0.67 |
| AEN | apoptosis enhancing nuclease | 0.65 |
| TMEM134 | transmembrane protein 134 | 0.65 |
| ATP8B2 | ATPase, aminophospholipid transporter, class I, type 8B, member 2 | 0.65 |
| MRAS | muscle RAS oncogene homolog | 0.64 |
| F8 | coagulation factor VIII, procoagulant component | 0.63 |
| ALPK3 | alpha-kinase 3 | 0.59 |
| TMLHE | trimethyllysine hydroxylase, epsilon | 0.55 |
| GNL2 | guanine nucleotide binding protein-like 2 (nucleolar) | 0.54 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 0.53 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.5 |
| IFT22 | intraflagellar transport 22 | 0.5 |
| MYH7B | myosin, heavy chain 7B, cardiac muscle, beta | 0.49 |
| IFRD1 | interferon-related developmental regulator 1 | 0.49 |
| CCNDBP1 | cyclin D-type binding-protein 1 | 0.48 |
| GDF15 | growth differentiation factor 15 | 0.47 |
| RPP21 | ribonuclease P/MRP 21kDa subunit | 0.47 |
| MAP2 | microtubule-associated protein 2 | 0.47 |
| SATB1 | SATB homeobox 1 | 0.46 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.45 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 0.45 |
| FHIT | fragile histidine triad | 0.43 |
| CPN1 | carboxypeptidase N, polypeptide 1 | 0.42 |
| DCHS2 | dachsous cadherin-related 2 | 0.42 |
| DCLRE1C | DNA cross-link repair 1C | 0.41 |
| RAB30 | RAB30, member RAS oncogene family | 0.39 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | 0.39 |
| PDCD7 | programmed cell death 7 | 0.39 |
| HSBP1 | heat shock factor binding protein 1 | 0.39 |
| HCFC2 | host cell factor C2 | 0.38 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.38 |
| NOP53 | NOP53 ribosome biogenesis factor | 0.37 |
| DST | dystonin | 0.37 |
| HBS1L | HBS1-like translational GTPase | 0.36 |
| RITA1 | RBPJ interacting and tubulin associated 1 | 0.36 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | 0.36 |
| USP43 | ubiquitin specific peptidase 43 | 0.36 |
| XAB2 | XPA binding protein 2 | 0.36 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.35 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.35 |
| NOSIP | nitric oxide synthase interacting protein | 0.35 |
| CNTN1 | contactin 1 | 0.35 |
| PPHLN1 | periphilin 1 | 0.35 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 0.35 |
| RSL24D1 | ribosomal L24 domain containing 1 | 0.34 |
| WDR53 | WD repeat domain 53 | 0.34 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.34 |
| DMWD | dystrophia myotonica, WD repeat containing | 0.34 |
| FDXR | ferredoxin reductase | 0.34 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.34 |
| CLSTN3 | calsyntenin 3 | 0.33 |
| PMF1 | polyamine-modulated factor 1 | 0.33 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | 0.33 |
| H3C1 | H3 clustered histone 1 | 0.33 |
| RNASE4 | ribonuclease, RNase A family, 4 | 0.33 |
| FZD7 | frizzled class receptor 7 | 0.33 |
| GRTP1 | growth hormone regulated TBC protein 1 | 0.33 |
| BORCS6 | BLOC-1 related complex subunit 6 | 0.33 |
| MIPOL1 | mirror-image polydactyly 1 | 0.33 |
| CEP83 | centrosomal protein 83kDa | 0.32 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | 0.32 |
| TMEM248 | transmembrane protein 248 | 0.31 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.31 |
| ASNSD1 | asparagine synthetase domain containing 1 | 0.31 |
| CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 | 0.31 |
| PEX16 | peroxisomal biogenesis factor 16 | 0.3 |
| GTF3C6 | general transcription factor IIIC, polypeptide 6, alpha 35kDa | 0.3 |
| PLEKHO2 | pleckstrin homology domain containing, family O member 2 | 0.3 |
| RAB29 | RAB29, member RAS oncogene family | 0.3 |
| ALKBH3 | alkB, alkylation repair homolog 3 (E. coli) | 0.29 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.29 |
| PIR | pirin (iron-binding nuclear protein) | 0.29 |
| NOP16 | NOP16 nucleolar protein | 0.29 |
| NLRC3 | NLR family, CARD domain containing 3 | 0.29 |
| PTRHD1 | peptidyl-tRNA hydrolase domain containing 1 | 0.29 |
| GPRASP2 | G protein-coupled receptor associated sorting protein 2 | 0.29 |
| ACTR8 | ARP8 actin-related protein 8 homolog (yeast) | 0.29 |
| ING4 | inhibitor of growth family, member 4 | 0.29 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 0.28 |
| C8ORF76 | chromosome 8 open reading frame 76 | 0.28 |
| FAS | Fas cell surface death receptor | 0.28 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | -2.98 |
| LIX1L | Lix1 homolog (chicken) like | -0.98 |
| BMERB1 | bMERB domain containing 1 | -0.92 |
| SARS | seryl-tRNA synthetase | -0.88 |
| ZNF428 | zinc finger protein 428 | -0.87 |
| BHLHA15 | basic helix-loop-helix family, member a15 | -0.87 |
| FAM241B | family with sequence similarity 241 member B | -0.85 |
| ZNF460 | zinc finger protein 460 | -0.79 |
| ZBTB45 | zinc finger and BTB domain containing 45 | -0.79 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.78 |
| ATF6B | activating transcription factor 6 beta | -0.74 |
| STC2 | stanniocalcin 2 | -0.72 |
| HEXIM2 | hexamethylene bis-acetamide inducible 2 | -0.71 |
| RIOK3 | RIO kinase 3 | -0.69 |
| BACH1 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | -0.66 |
| RTTN | rotatin | -0.65 |
| IGF1R | insulin-like growth factor 1 receptor | -0.65 |
| MTA1 | metastasis associated 1 | -0.63 |
| CHPF | chondroitin polymerizing factor | -0.61 |
| HOXB9 | homeobox B9 | -0.6 |
| PRXL2A | peroxiredoxin like 2A | -0.6 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | -0.6 |
| TATDN2 | TatD DNase domain containing 2 | -0.6 |
| BAG1 | BCL2-associated athanogene | -0.58 |
| AAMP | angio-associated, migratory cell protein | -0.58 |
| RNF149 | ring finger protein 149 | -0.58 |
| TRERF1 | transcriptional regulating factor 1 | -0.57 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.55 |
| KCTD2 | potassium channel tetramerization domain containing 2 | -0.55 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.54 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | -0.54 |
| CCDC25 | coiled-coil domain containing 25 | -0.53 |
| TMEM98 | transmembrane protein 98 | -0.53 |
| MT2A | metallothionein 2A | -0.52 |
| CHTF8 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) | -0.51 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.51 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | -0.51 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | -0.51 |
| REX1BD | required for excision 1-B domain containing | -0.51 |
| EXPH5 | exophilin 5 | -0.5 |
| AMACR | alpha-methylacyl-CoA racemase | -0.5 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.5 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.49 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | -0.47 |
| ZNF417 | zinc finger protein 417 | -0.47 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | -0.47 |
| RMND5B | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | -0.47 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.46 |
| TPCN1 | two pore segment channel 1 | -0.46 |
| TLL2 | tolloid-like 2 | -0.46 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.45 |
| CPA4 | carboxypeptidase A4 | -0.44 |
| DIXDC1 | DIX domain containing 1 | -0.44 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.44 |
| CEP70 | centrosomal protein 70kDa | -0.44 |
| OSBPL7 | oxysterol binding protein-like 7 | -0.43 |
| THAP4 | THAP domain containing 4 | -0.43 |
| AP5Z1 | adaptor-related protein complex 5, zeta 1 subunit | -0.43 |
| SLC38A9 | solute carrier family 38, member 9 | -0.43 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.43 |
| FAM171B | family with sequence similarity 171, member B | -0.43 |
| PRR11 | proline rich 11 | -0.43 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.43 |
| OSTF1 | osteoclast stimulating factor 1 | -0.42 |
| FAM110C | family with sequence similarity 110, member C | -0.42 |
| RNF141 | ring finger protein 141 | -0.42 |
| FSTL3 | follistatin-like 3 (secreted glycoprotein) | -0.42 |
| SLC12A5 | solute carrier family 12 (potassium/chloride transporter), member 5 | -0.41 |
| FSD1L | fibronectin type III and SPRY domain containing 1-like | -0.41 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | -0.41 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | -0.41 |
| TMEM126B | transmembrane protein 126B | -0.41 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.41 |
| CDC25A | cell division cycle 25A | -0.41 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.41 |
| SIK2 | salt-inducible kinase 2 | -0.41 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | -0.41 |
| ZNF367 | zinc finger protein 367 | -0.4 |
| DZIP3 | DAZ interacting zinc finger protein 3 | -0.4 |
| CDCA3 | cell division cycle associated 3 | -0.4 |
| SRP9 | signal recognition particle 9kDa | -0.4 |
| UNC13D | unc-13 homolog D (C. elegans) | -0.4 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.4 |
| AMOTL1 | angiomotin like 1 | -0.39 |
| N4BP2 | NEDD4 binding protein 2 | -0.39 |
| RNF26 | ring finger protein 26 | -0.39 |
| UBN2 | ubinuclein 2 | -0.38 |
| DIAPH3 | diaphanous-related formin 3 | -0.38 |
| SPTLC2 | serine palmitoyltransferase, long chain base subunit 2 | -0.38 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.38 |
| SAYSD1 | SAYSVFN motif domain containing 1 | -0.38 |
| PCLAF | PCNA clamp associated factor | -0.37 |
| WHAMM | WAS protein homolog associated with actin, golgi membranes and microtubules | -0.37 |
| GRAMD1A | GRAM domain containing 1A | -0.37 |
| SEPHS2 | selenophosphate synthetase 2 | -0.37 |
| SH3BP1 | SH3-domain binding protein 1 | -0.37 |
| SLC43A3 | solute carrier family 43, member 3 | -0.37 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | -0.37 |
| CDCA4 | cell division cycle associated 4 | -0.36 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | -0.36 |
