Fumaric acid_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fumaric acid perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fumaric acid_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.100312
LOC112694756 uncharaterized LOC112694756 0.0971156
SLIT2 slit homolog 2 (Drosophila) 0.0958116
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0903745
RPL3 ribosomal protein L3 0.0871086
ZNF608 zinc finger protein 608 0.0848539
SRRM2 serine/arginine repetitive matrix 2 0.0763257
USP9X ubiquitin specific peptidase 9, X-linked 0.0718288
CABIN1 calcineurin binding protein 1 0.0675958
NONO non-POU domain containing, octamer-binding 0.0626485
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0614436
DIDO1 death inducer-obliterator 1 0.0608936
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0597856
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0592067
NEBL nebulette 0.0587708
RPL11 ribosomal protein L11 0.0573132
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0567941
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0547284
EEF2 eukaryotic translation elongation factor 2 0.0539816
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0533582
SRSF4 serine/arginine-rich splicing factor 4 0.0515425
FMNL2 formin-like 2 0.0509435
HSPA8 heat shock 70kDa protein 8 0.0508387
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0481421
KDM3A lysine (K)-specific demethylase 3A 0.0480916
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0468787
ZFAND3 zinc finger, AN1-type domain 3 0.0464779
ATP11A ATPase, class VI, type 11A 0.0464211
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0457047
ADAR adenosine deaminase, RNA-specific 0.0452006
VCL vinculin 0.0448631
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0441804
SMYD3 SET and MYND domain containing 3 0.044146
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0430254
PIAS2 protein inhibitor of activated STAT, 2 0.0422369
NUMA1 nuclear mitotic apparatus protein 1 0.0409468
FUS FUS RNA binding protein 0.0408772
EIF4A2 eukaryotic translation initiation factor 4A2 0.0404958
TMSB10 thymosin beta 10 0.0401668
SOX4 SRY (sex determining region Y)-box 4 0.0400691
DBN1 drebrin 1 0.0388937
RPS21 ribosomal protein S21 0.0384884
OSBPL10 oxysterol binding protein-like 10 0.0383086
CNN2 calponin 2 0.0382923
CELF2 CUGBP, Elav-like family member 2 0.0381121
TPI1 triosephosphate isomerase 1 0.0368755
EWSR1 EWS RNA-binding protein 1 0.0366323
RAD21 RAD21 homolog (S. pombe) 0.0362888
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0355966
PUM1 pumilio RNA-binding family member 1 0.0355493
PRRC2A proline-rich coiled-coil 2A 0.034802
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.034742
RCC1 regulator of chromosome condensation 1 0.0347326
UBA1 ubiquitin-like modifier activating enzyme 1 0.0345489
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0339749
SON SON DNA binding protein 0.0338266
USP22 ubiquitin specific peptidase 22 0.0338003
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0335664
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.033461
RALY RALY heterogeneous nuclear ribonucleoprotein 0.033212
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0330228
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0330215
YBX1 Y box binding protein 1 0.0323862
YEATS2 YEATS domain containing 2 0.0323615
ANKRD11 ankyrin repeat domain 11 0.0321468
FOXO3 forkhead box O3 0.0320857
MYH9 myosin, heavy chain 9, non-muscle 0.0318277
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0313949
MACF1 microtubule-actin crosslinking factor 1 0.0313491
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.0313477
PRRC2B proline-rich coiled-coil 2B 0.0311154
DSCAM Down syndrome cell adhesion molecule 0.0310372
DENND5A DENN/MADD domain containing 5A 0.0310052
RPL37 ribosomal protein L37 0.0309723
FAT1 FAT atypical cadherin 1 0.0307545
TBCD tubulin folding cofactor D 0.0305555
SHROOM3 shroom family member 3 0.0304027
WLS wntless Wnt ligand secretion mediator 0.0303646
PLCG1 phospholipase C, gamma 1 0.0300457
CHD7 chromodomain helicase DNA binding protein 7 0.0299345
SMC1A structural maintenance of chromosomes 1A 0.0297528
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.029695
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0296877
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 0.0295186
RPS9 ribosomal protein S9 0.0292501
MPRIP myosin phosphatase Rho interacting protein 0.0290152
TENM3 teneurin transmembrane protein 3 0.0288979
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0287635
RPS4X ribosomal protein S4, X-linked 0.0286736
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0286482
KMT2D lysine (K)-specific methyltransferase 2D 0.0286221
CEP250 centrosomal protein 250kDa 0.0284411
PLEC plectin 0.0282519
CCNY cyclin Y 0.0280442
OGA O-GlcNAcase 0.0280272
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0278024
DST dystonin 0.0277829
SUN1 Sad1 and UNC84 domain containing 1 0.0276245
CAMTA1 calmodulin binding transcription activator 1 0.0275434
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0274804

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.190946
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.129888
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.116755
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.115077
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.108835
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0659811
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0601454
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0453121
CADM2 cell adhesion molecule 2 -0.045238
GNAS GNAS complex locus -0.0445867
PDIA3 protein disulfide isomerase family A, member 3 -0.0442704
GOLGA4 golgin A4 -0.0429938
TOX thymocyte selection-associated high mobility group box -0.0422141
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0393131
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0388113
PNISR PNN-interacting serine/arginine-rich protein -0.0387399
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0383872
VMP1 vacuole membrane protein 1 -0.0377784
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0371098
MBNL1 muscleblind-like splicing regulator 1 -0.0361583
ANKRD12 ankyrin repeat domain 12 -0.0359442
COL5A2 collagen, type V, alpha 2 -0.0356645
DEK DEK proto-oncogene -0.0355274
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0350331
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0348731
HMGB1 high mobility group box 1 -0.0348423
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0344371
KIF5B kinesin family member 5B -0.0337161
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0330059
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0330034
RPS2 ribosomal protein S2 -0.0326729
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0320471
RSF1 remodeling and spacing factor 1 -0.0318249
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0317675
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.030674
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0303642
TLK1 tousled-like kinase 1 -0.0300113
BRWD1 bromodomain and WD repeat domain containing 1 -0.0297449
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0289316
NOP58 NOP58 ribonucleoprotein -0.0288806
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0283903
R3HDM1 R3H domain containing 1 -0.0279511
RAD51B RAD51 paralog B -0.0274766
SCAF11 SR-related CTD-associated factor 11 -0.0273407
MAP4 microtubule-associated protein 4 -0.0269731
CDH18 cadherin 18, type 2 -0.0268167
SRSF11 serine/arginine-rich splicing factor 11 -0.0265024
CDK13 cyclin-dependent kinase 13 -0.0263399
RTN4 reticulon 4 -0.0261204
KDM2A lysine (K)-specific demethylase 2A -0.0260129
PTBP3 polypyrimidine tract binding protein 3 -0.0259058
TUT4 terminal uridylyl transferase 4 -0.0257294
AGTPBP1 ATP/GTP binding protein 1 -0.0257229
COG5 component of oligomeric golgi complex 5 -0.0256784
FCHSD2 FCH and double SH3 domains 2 -0.0255756
VEGFC vascular endothelial growth factor C -0.0251928
BCAS3 breast carcinoma amplified sequence 3 -0.0250469
CEP350 centrosomal protein 350kDa -0.0248229
LMAN1 lectin, mannose-binding, 1 -0.0246219
ZNF638 zinc finger protein 638 -0.0244773
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0244301
RPLP1 ribosomal protein, large, P1 -0.0243931
VDAC1 voltage-dependent anion channel 1 -0.0243564
ANKRD17 ankyrin repeat domain 17 -0.0242382
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0240704
STAU1 staufen double-stranded RNA binding protein 1 -0.0237513
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0236002
SMC4 structural maintenance of chromosomes 4 -0.0231254
PGAP1 post-GPI attachment to proteins 1 -0.0229337
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0228966
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0228126
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.022721
MBD5 methyl-CpG binding domain protein 5 -0.0226862
TCF12 transcription factor 12 -0.0226635
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0225442
GRID2 glutamate receptor, ionotropic, delta 2 -0.0223845
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0221932
CAMKMT calmodulin-lysine N-methyltransferase -0.0221203
TTC3 tetratricopeptide repeat domain 3 -0.0220523
WASF2 WAS protein family, member 2 -0.0220391
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0219779
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0219386
NBEAL1 neurobeachin-like 1 -0.0218164
SRP54 signal recognition particle 54kDa -0.0218085
RPS8 ribosomal protein S8 -0.0216423
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0215813
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0215522
ZNF292 zinc finger protein 292 -0.0215278
PRKCI protein kinase C, iota -0.0215154
NPEPPS aminopeptidase puromycin sensitive -0.0212293
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0210379
HIP1 huntingtin interacting protein 1 -0.0209575
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0209537
AGO3 argonaute RISC catalytic component 3 -0.0209348
ZMYM4 zinc finger, MYM-type 4 -0.0209339
FTL ferritin, light polypeptide -0.0208135
XRN1 5'-3' exoribonuclease 1 -0.0205757
MEMO1 mediator of cell motility 1 -0.0204774
HILPDA hypoxia inducible lipid droplet-associated -0.0203326
RPS12 ribosomal protein S12 -0.020299