Fumaric acid_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fumaric acid perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fumaric acid_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A 0.0823103
CRH corticotropin releasing hormone 0.078738
MYH9 myosin, heavy chain 9, non-muscle 0.0681314
MSI2 musashi RNA-binding protein 2 0.0604609
SRRM2 serine/arginine repetitive matrix 2 0.0545726
PTPRK protein tyrosine phosphatase, receptor type, K 0.0544474
KDM3A lysine (K)-specific demethylase 3A 0.0535275
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0528809
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0515278
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0502204
LPIN1 lipin 1 0.0500826
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0497361
COL1A1 collagen, type I, alpha 1 0.0460058
HELZ helicase with zinc finger 0.0451528
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0445024
FXR1 fragile X mental retardation, autosomal homolog 1 0.0444845
THSD4 thrombospondin, type I, domain containing 4 0.043487
AKAP12 A kinase (PRKA) anchor protein 12 0.0425749
SEPTIN2 septin 2 0.042081
TNIP1 TNFAIP3 interacting protein 1 0.0417097
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0402909
TRIO trio Rho guanine nucleotide exchange factor 0.0396102
ZMIZ1 zinc finger, MIZ-type containing 1 0.0394343
FNDC3B fibronectin type III domain containing 3B 0.0382151
WDR45B WD repeat domain 45B 0.0379554
LOC112694756 uncharaterized LOC112694756 0.0372355
RPL3 ribosomal protein L3 0.035783
NONO non-POU domain containing, octamer-binding 0.0355477
LIMCH1 LIM and calponin homology domains 1 0.0355218
PTMA prothymosin, alpha 0.0354958
BRD4 bromodomain containing 4 0.0346578
DDIT4 DNA-damage-inducible transcript 4 0.0340983
EEF2 eukaryotic translation elongation factor 2 0.0338465
AOPEP aminopeptidase O (putative) 0.0337633
NUMA1 nuclear mitotic apparatus protein 1 0.0327205
CCNY cyclin Y 0.032186
RPL19 ribosomal protein L19 0.0321382
SSBP3 single stranded DNA binding protein 3 0.0308951
NCOR2 nuclear receptor corepressor 2 0.0306018
CEP250 centrosomal protein 250kDa 0.0305755
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.0305005
APP amyloid beta (A4) precursor protein 0.0303438
UBE2O ubiquitin-conjugating enzyme E2O 0.029824
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.029672
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0296463
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0293868
FNBP1 formin binding protein 1 0.0291994
FUS FUS RNA binding protein 0.0289386
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0289278
PSD3 pleckstrin and Sec7 domain containing 3 0.0282084
ARHGAP9 Rho GTPase activating protein 9 0.0282025
LSAMP limbic system-associated membrane protein 0.0276901
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0269722
AFDN afadin, adherens junction formation factor 0.0269496
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0260563
TBX2 T-box 2 0.025957
RPL23 ribosomal protein L23 0.0256249
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0254584
CASC3 cancer susceptibility candidate 3 0.0254559
COL18A1 collagen, type XVIII, alpha 1 0.0254148
ADGRG6 adhesion G protein-coupled receptor G6 0.0244436
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0243873
MYH10 myosin, heavy chain 10, non-muscle 0.024378
SEPTIN9 septin 9 0.0242504
RAD21 RAD21 homolog (S. pombe) 0.024103
SCG2 secretogranin II 0.0239427
HMGB2 high mobility group box 2 0.0239396
RPL35A ribosomal protein L35a 0.0238886
CABIN1 calcineurin binding protein 1 0.023863
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0236793
PHIP pleckstrin homology domain interacting protein 0.0236697
NFE2L1 nuclear factor, erythroid 2-like 1 0.023596
H3-3B H3.3 histone B 0.0235054
NRG1 neuregulin 1 0.023478
PIAS2 protein inhibitor of activated STAT, 2 0.0233795
RPL4 ribosomal protein L4 0.0233758
USP9X ubiquitin specific peptidase 9, X-linked 0.0232367
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0232191
MMP2 matrix metallopeptidase 2 0.0231494
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0231041
ADAR adenosine deaminase, RNA-specific 0.0230428
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0230298
NDRG1 N-myc downstream regulated 1 0.0229492
PLAT plasminogen activator, tissue 0.0229313
TUBB tubulin, beta class I 0.0228777
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0228385
AFF4 AF4/FMR2 family, member 4 0.0227988
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0226213
HLA-C major histocompatibility complex, class I, C 0.0225076
SON SON DNA binding protein 0.0222875
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0220759
COLEC11 collectin sub-family member 11 0.0220311
MIDEAS mitotic deacetylase associated SANT domain protein 0.0220297
CADM1 cell adhesion molecule 1 0.0218442
ZFC3H1 zinc finger, C3H1-type containing 0.0217786
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0215323
USP36 ubiquitin specific peptidase 36 0.0214943
CENPF centromere protein F, 350/400kDa 0.02147
RLIM ring finger protein, LIM domain interacting 0.0214551
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0214488

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.318512
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.205017
VCL vinculin -0.167783
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.106474
ZSWIM6 zinc finger, SWIM-type containing 6 -0.102019
IGF2 insulin-like growth factor 2 -0.101979
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0932761
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0817985
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0678516
VMP1 vacuole membrane protein 1 -0.0631579
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0609143
MCL1 myeloid cell leukemia 1 -0.0575051
LPP LIM domain containing preferred translocation partner in lipoma -0.0545539
PDIA3 protein disulfide isomerase family A, member 3 -0.0526416
SYT1 synaptotagmin I -0.0525175
JMJD1C jumonji domain containing 1C -0.0505551
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0499594
TPM1 tropomyosin 1 (alpha) -0.0497481
FN1 fibronectin 1 -0.0495149
VIM vimentin -0.048386
CANX calnexin -0.0455965
TTC17 tetratricopeptide repeat domain 17 -0.0448199
DPH6 diphthamine biosynthesis 6 -0.0423547
BCAS3 breast carcinoma amplified sequence 3 -0.0417188
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0406602
PDE4D phosphodiesterase 4D, cAMP-specific -0.0404734
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0388902
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0377673
RPS23 ribosomal protein S23 -0.0377484
EGR1 early growth response 1 -0.0360298
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0359199
FNDC3A fibronectin type III domain containing 3A -0.0358823
PDLIM5 PDZ and LIM domain 5 -0.0357746
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0356482
RPS15 ribosomal protein S15 -0.0354678
MBD5 methyl-CpG binding domain protein 5 -0.0345573
POTEF POTE ankyrin domain family, member F -0.0335933
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0335369
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0334222
GATA3 GATA binding protein 3 -0.0333724
RPLP1 ribosomal protein, large, P1 -0.0329724
RPL31 ribosomal protein L31 -0.0328403
MBNL1 muscleblind-like splicing regulator 1 -0.032614
TLE4 transducin-like enhancer of split 4 -0.0325394
UNC5C unc-5 homolog C (C. elegans) -0.0323159
SLC38A2 solute carrier family 38, member 2 -0.0321838
MYO1E myosin IE -0.0320707
GOLGB1 golgin B1 -0.0320401
RAB7A RAB7A, member RAS oncogene family -0.0318328
TNRC6B trinucleotide repeat containing 6B -0.0312368
EFNA5 ephrin-A5 -0.031095
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0308043
ACTG1 actin gamma 1 -0.0307924
GOLGA4 golgin A4 -0.0300837
KTN1 kinectin 1 (kinesin receptor) -0.029597
TPT1 tumor protein, translationally-controlled 1 -0.0293223
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0293007
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0292519
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.028326
EXT1 exostosin glycosyltransferase 1 -0.028278
PAPOLA poly(A) polymerase alpha -0.0281285
BPTF bromodomain PHD finger transcription factor -0.0280064
SCAF11 SR-related CTD-associated factor 11 -0.0279704
IARS1 isoleucyl-tRNA synthetase 1 -0.0278972
ZNF638 zinc finger protein 638 -0.0275256
LIMA1 LIM domain and actin binding 1 -0.0273274
CD36 CD36 molecule (thrombospondin receptor) -0.0269206
PLPP1 phospholipid phosphatase 1 -0.0268736
NBEAL1 neurobeachin-like 1 -0.0266131
KDM2A lysine (K)-specific demethylase 2A -0.0265357
CUX1 cut-like homeobox 1 -0.026422
BLZF1 basic leucine zipper nuclear factor 1 -0.0263638
SQSTM1 sequestosome 1 -0.0262279
GLCCI1 glucocorticoid induced 1 -0.0260846
DSTN destrin (actin depolymerizing factor) -0.0260316
PTEN phosphatase and tensin homolog -0.0259951
ADGRB3 adhesion G protein-coupled receptor B3 -0.0259177
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0256854
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0256019
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0255668
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0253423
ZBTB20 zinc finger and BTB domain containing 20 -0.0252365
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0252064
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -0.0250398
TPM4 tropomyosin 4 -0.0249658
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.0247877
CEP350 centrosomal protein 350kDa -0.0242112
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0241514
RPLP2 ribosomal protein, large, P2 -0.0241363
MEIS2 Meis homeobox 2 -0.0241325
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0235239
GPC6 glypican 6 -0.0231595
JPT1 Jupiter microtubule associated homolog 1 -0.0229833
RPS5 ribosomal protein S5 -0.0227436
PRKCA protein kinase C, alpha -0.0225132
EIF5B eukaryotic translation initiation factor 5B -0.0224381
DEK DEK proto-oncogene -0.0223157
AKAP9 A kinase (PRKA) anchor protein 9 -0.0223031
AHR aryl hydrocarbon receptor -0.0222429
MYO9A myosin IXA -0.0219276