Fumaric acid_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fumaric acid perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fumaric acid_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.122568
ARGLU1 arginine and glutamate rich 1 0.10263
SRRM2 serine/arginine repetitive matrix 2 0.0870099
HLA-B major histocompatibility complex, class I, B 0.0819215
MLPH melanophilin 0.0757926
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.075181
PHF3 PHD finger protein 3 0.074031
LOC112694756 uncharaterized LOC112694756 0.0705809
CALR calreticulin 0.0592766
VEGFA vascular endothelial growth factor A 0.0589684
EEF2 eukaryotic translation elongation factor 2 0.0548644
DSCAM Down syndrome cell adhesion molecule 0.0540251
DSPP dentin sialophosphoprotein 0.0500425
APOL2 apolipoprotein L, 2 0.049469
APOL1 apolipoprotein L, 1 0.0489973
SMAD3 SMAD family member 3 0.0478615
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0476616
NDRG1 N-myc downstream regulated 1 0.0473447
HLA-C major histocompatibility complex, class I, C 0.0457693
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0448861
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0439014
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0438651
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0436216
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0428922
NCOR2 nuclear receptor corepressor 2 0.0409846
PTPRF protein tyrosine phosphatase, receptor type, F 0.0408134
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0402288
IFNGR1 interferon gamma receptor 1 0.0400847
NONO non-POU domain containing, octamer-binding 0.0399834
OARD1 O-acyl-ADP-ribose deacylase 1 0.0392216
STYXL2 serine/threonine/tyrosine interacting like 2 0.0385757
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0383785
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0377379
ZMYND8 zinc finger, MYND-type containing 8 0.0373355
CGN cingulin 0.0360465
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0359169
BHLHE40 basic helix-loop-helix family, member e40 0.0357934
GIGYF2 GRB10 interacting GYF protein 2 0.0357551
RPS6 ribosomal protein S6 0.0357508
MINK1 misshapen-like kinase 1 0.0348485
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.034818
RPL35A ribosomal protein L35a 0.0346009
HDAC4 histone deacetylase 4 0.0345354
EFHD2 EF-hand domain family, member D2 0.0343452
PFKP phosphofructokinase, platelet 0.0343257
ERCC5 excision repair cross-complementation group 5 0.0340191
SH3PXD2A SH3 and PX domains 2A 0.033602
RPL23 ribosomal protein L23 0.0335487
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.0335474
RPL37 ribosomal protein L37 0.0332657
FAT1 FAT atypical cadherin 1 0.0330821
TUFT1 tuftelin 1 0.032759
PRRC2C proline-rich coiled-coil 2C 0.031768
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0314332
BICRAL BICRA like chromatin remodeling complex associated protein 0.0314052
EIF1 eukaryotic translation initiation factor 1 0.0303739
GOLGA2 golgin A2 0.0300881
NIBAN2 niban apoptosis regulator 2 0.0299801
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0296367
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.029634
ADAR adenosine deaminase, RNA-specific 0.0295882
RNF43 ring finger protein 43 0.0294183
IGF1R insulin-like growth factor 1 receptor 0.0292249
CTNND1 catenin (cadherin-associated protein), delta 1 0.0289541
APP amyloid beta (A4) precursor protein 0.0289057
MPRIP myosin phosphatase Rho interacting protein 0.0287138
RPL13A ribosomal protein L13a 0.0286488
HLA-A major histocompatibility complex, class I, A 0.0285994
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0284674
RPL4 ribosomal protein L4 0.0283757
RPL37A ribosomal protein L37a 0.0280275
EPCAM epithelial cell adhesion molecule 0.0279934
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0279239
EIF4B eukaryotic translation initiation factor 4B 0.0279142
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0274885
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 0.0274829
SHB Src homology 2 domain containing adaptor protein B 0.0273826
TNIP1 TNFAIP3 interacting protein 1 0.0273264
CDK5RAP3 CDK5 regulatory subunit associated protein 3 0.0271036
RPL11 ribosomal protein L11 0.0270903
SET SET nuclear proto-oncogene 0.0270558
KRT18 keratin 18, type I 0.0270026
SLK STE20-like kinase 0.0269001
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.026604
SFTPA2 surfactant protein A2 0.0265042
CMIP c-Maf inducing protein 0.0264734
EIF4H eukaryotic translation initiation factor 4H 0.0264426
KIF16B kinesin family member 16B 0.026407
ZC3H13 zinc finger CCCH-type containing 13 0.0263554
PNPLA7 patatin-like phospholipase domain containing 7 0.0262585
ANXA11 annexin A11 0.0262484
RRBP1 ribosome binding protein 1 0.026246
OGA O-GlcNAcase 0.0260876
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0258817
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0258772
DNM2 dynamin 2 0.0257867
MYO18A myosin XVIIIA 0.0256088
NCOA3 nuclear receptor coactivator 3 0.0252387
SDC4 syndecan 4 0.025088
TMED2 transmembrane emp24 domain trafficking protein 2 0.0249595

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.164399
MACC1 metastasis associated in colon cancer 1 -0.0882993
ERBIN erbb2 interacting protein -0.0828917
PERP PERP, TP53 apoptosis effector -0.0820219
FNDC3B fibronectin type III domain containing 3B -0.0805157
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0652623
PDIA3 protein disulfide isomerase family A, member 3 -0.0642891
ANXA2 annexin A2 -0.0622284
LOC102724023 ES1 protein homolog, mitochondrial -0.0584688
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0563017
EGR1 early growth response 1 -0.0554388
GMDS GDP-mannose 4,6-dehydratase -0.0552333
EPSTI1 epithelial stromal interaction 1 (breast) -0.055161
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0535675
FNDC3A fibronectin type III domain containing 3A -0.0507297
CCNL1 cyclin L1 -0.0491087
SEC31A SEC31 homolog A (S. cerevisiae) -0.0479471
VCL vinculin -0.0470845
GCLC glutamate-cysteine ligase, catalytic subunit -0.046649
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0465412
FNIP1 folliculin interacting protein 1 -0.046107
XAF1 XIAP associated factor 1 -0.0444185
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0442444
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0435326
ZNF292 zinc finger protein 292 -0.0433739
TJP1 tight junction protein 1 -0.0431683
POTEF POTE ankyrin domain family, member F -0.0422035
MYO1E myosin IE -0.040835
SP100 SP100 nuclear antigen -0.0406046
EFNB2 ephrin-B2 -0.0400907
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0395746
LYZ lysozyme -0.039568
ABLIM1 actin binding LIM protein 1 -0.0395311
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0391104
PTBP3 polypyrimidine tract binding protein 3 -0.0390916
UFM1 ubiquitin-fold modifier 1 -0.0372164
LMO7 LIM domain 7 -0.0363155
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0362223
UBC ubiquitin C -0.0362093
AREG amphiregulin -0.0360783
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0357763
RHOBTB3 Rho-related BTB domain containing 3 -0.0356984
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0354988
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0354945
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0350894
VMP1 vacuole membrane protein 1 -0.0348748
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0343117
ZBTB20 zinc finger and BTB domain containing 20 -0.0343069
TXNIP thioredoxin interacting protein -0.0341657
RAB7A RAB7A, member RAS oncogene family -0.034013
LCN2 lipocalin 2 -0.0334377
STS steroid sulfatase (microsomal), isozyme S -0.0333412
SPDYA speedy/RINGO cell cycle regulator family member A -0.032345
S100A10 S100 calcium binding protein A10 -0.032299
PRKCA protein kinase C, alpha -0.0316844
ARHGAP26 Rho GTPase activating protein 26 -0.0311783
BLZF1 basic leucine zipper nuclear factor 1 -0.0310689
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0305674
RUNX1 runt-related transcription factor 1 -0.0305255
INTS6 integrator complex subunit 6 -0.0301018
BCLAF1 BCL2-associated transcription factor 1 -0.0300625
TRIM2 tripartite motif containing 2 -0.0300169
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0297041
HM13 histocompatibility (minor) 13 -0.0293901
NCOA7 nuclear receptor coactivator 7 -0.0292472
DLG1 discs, large homolog 1 (Drosophila) -0.0291449
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0282689
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0281523
RIGI RNA sensor RIG-I -0.0281
AKAP13 A kinase (PRKA) anchor protein 13 -0.0280492
SEC24A SEC24 family member A -0.0279631
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0277727
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0275127
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0274854
C6ORF132 chromosome 6 open reading frame 132 -0.027283
PLSCR1 phospholipid scramblase 1 -0.0270009
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0266813
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0265384
ALCAM activated leukocyte cell adhesion molecule -0.026531
RAB10 RAB10, member RAS oncogene family -0.0264736
TSC22D2 TSC22 domain family, member 2 -0.0261764
MX2 MX dynamin-like GTPase 2 -0.0259426
RABGAP1L RAB GTPase activating protein 1-like -0.0258304
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0255483
SLC38A2 solute carrier family 38, member 2 -0.0251332
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0247367
MAGT1 magnesium transporter 1 -0.0245992
KLF6 Kruppel-like factor 6 -0.0245118
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0244137
TFG TRK-fused gene -0.0241326
ETV6 ets variant 6 -0.0236457
KDM2A lysine (K)-specific demethylase 2A -0.0236324
DSTN destrin (actin depolymerizing factor) -0.0236101
MED13 mediator complex subunit 13 -0.023532
LIPH lipase, member H -0.0229181
SETD5 SET domain containing 5 -0.0225125
CATSPERB catsper channel auxiliary subunit beta -0.0224894
CCNI cyclin I -0.0224566
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0222255
IARS1 isoleucyl-tRNA synthetase 1 -0.0221258