Fumaric acid_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fumaric acid perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fumaric acid_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.179602
VIM vimentin 0.0732615
LOC112694756 uncharaterized LOC112694756 0.0687378
HLA-B major histocompatibility complex, class I, B 0.0682068
FAM13A family with sequence similarity 13, member A 0.0614217
SMAD3 SMAD family member 3 0.0555542
HIPK2 homeodomain interacting protein kinase 2 0.0534932
EEF2 eukaryotic translation elongation factor 2 0.0533742
TMSB10 thymosin beta 10 0.049002
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0486153
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0478474
RPL4 ribosomal protein L4 0.0472345
PLEC plectin 0.0465012
DGKD diacylglycerol kinase, delta 130kDa 0.045144
EIF1 eukaryotic translation initiation factor 1 0.0437458
HLA-A major histocompatibility complex, class I, A 0.0416598
RPL37A ribosomal protein L37a 0.0414222
PTMA prothymosin, alpha 0.0407672
TPM4 tropomyosin 4 0.0404703
MYH9 myosin, heavy chain 9, non-muscle 0.0387512
SHB Src homology 2 domain containing adaptor protein B 0.0382164
NDRG1 N-myc downstream regulated 1 0.0375258
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0366859
ANTXR2 anthrax toxin receptor 2 0.0361369
APP amyloid beta (A4) precursor protein 0.0360755
HLA-C major histocompatibility complex, class I, C 0.035759
AKAP12 A kinase (PRKA) anchor protein 12 0.0357517
BHLHE40 basic helix-loop-helix family, member e40 0.0356451
DDIT4 DNA-damage-inducible transcript 4 0.0356086
EIF4H eukaryotic translation initiation factor 4H 0.0351643
BACE2 beta-site APP-cleaving enzyme 2 0.034841
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0341883
KDM3A lysine (K)-specific demethylase 3A 0.0338962
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0335229
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0333607
ZNF841 zinc finger protein 841 0.0331678
RPL23 ribosomal protein L23 0.032978
TMSB4X thymosin beta 4, X-linked 0.0323727
MARCHF6 membrane associated ring-CH-type finger 6 0.0323399
RPL3 ribosomal protein L3 0.0320634
UBE2O ubiquitin-conjugating enzyme E2O 0.0314
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0312368
TNRC18 trinucleotide repeat containing 18 0.0310402
FLNA filamin A, alpha 0.0307595
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0302928
JUN jun proto-oncogene 0.030086
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0300597
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0298663
WDR45B WD repeat domain 45B 0.029786
CCDC9 coiled-coil domain containing 9 0.0294715
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0294228
NAV2 neuron navigator 2 0.0290309
CD59 CD59 molecule, complement regulatory protein 0.0288446
TPT1 tumor protein, translationally-controlled 1 0.028527
RPL35A ribosomal protein L35a 0.0284488
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0283325
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0277108
NPAS2 neuronal PAS domain protein 2 0.0275408
LENG8 leukocyte receptor cluster (LRC) member 8 0.0271585
JARID2 jumonji, AT rich interactive domain 2 0.0271453
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.027086
YBX1 Y box binding protein 1 0.026724
FTH1 ferritin, heavy polypeptide 1 0.0266229
ANKRD11 ankyrin repeat domain 11 0.0266216
HMGB2 high mobility group box 2 0.0265966
GPR107 G protein-coupled receptor 107 0.0264646
HOOK2 hook microtubule-tethering protein 2 0.0264614
RLIM ring finger protein, LIM domain interacting 0.026346
ARHGAP22 Rho GTPase activating protein 22 0.0262384
RAD21 RAD21 homolog (S. pombe) 0.026213
PGK1 phosphoglycerate kinase 1 0.0260605
TNIP1 TNFAIP3 interacting protein 1 0.0259336
TP53BP1 tumor protein p53 binding protein 1 0.0259152
DIDO1 death inducer-obliterator 1 0.0254133
CELF1 CUGBP, Elav-like family member 1 0.024466
COL6A2 collagen, type VI, alpha 2 0.0243097
MKI67 marker of proliferation Ki-67 0.0242783
KPNB1 karyopherin (importin) beta 1 0.0239498
NAV1 neuron navigator 1 0.0236817
B2M beta-2-microglobulin 0.0234485
ENO1 enolase 1, (alpha) 0.0233695
RPL37 ribosomal protein L37 0.0233388
RNF216 ring finger protein 216 0.0227909
RAI1 retinoic acid induced 1 0.0227646
RASA3 RAS p21 protein activator 3 0.0226483
COPG1 coatomer protein complex, subunit gamma 1 0.0225758
TMEM41B transmembrane protein 41B 0.0225282
NONO non-POU domain containing, octamer-binding 0.0223704
CEMIP cell migration inducing protein, hyaluronan binding 0.0222293
TUBB tubulin, beta class I 0.0221503
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0221403
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0219359
RACK1 receptor for activated C kinase 1 0.0218961
SFPQ splicing factor proline/glutamine-rich 0.0218326
NIBAN2 niban apoptosis regulator 2 0.0218148
MACF1 microtubule-actin crosslinking factor 1 0.0218076
FAM219A family with sequence similarity 219, member A 0.0218067
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.0217899
GOLGA3 golgin A3 0.0217552
MATR3 matrin 3 0.0216441

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.355947
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.108715
DST dystonin -0.10694
PDE4D phosphodiesterase 4D, cAMP-specific -0.101145
EGFR epidermal growth factor receptor -0.0937922
FTL ferritin, light polypeptide -0.0920614
LOX lysyl oxidase -0.0893673
IGFBP3 insulin-like growth factor binding protein 3 -0.0878105
KYNU kynureninase -0.0818538
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0778471
SDK1 sidekick cell adhesion molecule 1 -0.0753321
CD44 CD44 molecule (Indian blood group) -0.0703955
GRB10 growth factor receptor-bound protein 10 -0.0696293
ASPH aspartate beta-hydroxylase -0.0676861
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0660948
CANX calnexin -0.0654374
FN1 fibronectin 1 -0.0651148
FNDC3B fibronectin type III domain containing 3B -0.0598849
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0592693
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0569135
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0568551
INTS6 integrator complex subunit 6 -0.0557312
GOLGB1 golgin B1 -0.054851
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0525708
PDLIM5 PDZ and LIM domain 5 -0.0510837
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0503525
VCL vinculin -0.0486686
STK17A serine/threonine kinase 17a -0.0479349
TGFBI transforming growth factor, beta-induced, 68kDa -0.0477819
TENM3 teneurin transmembrane protein 3 -0.0462803
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0453202
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0453027
ZBTB20 zinc finger and BTB domain containing 20 -0.0448485
MAP4 microtubule-associated protein 4 -0.0441392
CDK13 cyclin-dependent kinase 13 -0.0431608
IARS1 isoleucyl-tRNA synthetase 1 -0.0422037
FER fer (fps/fes related) tyrosine kinase -0.040186
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0396932
FBXL17 F-box and leucine-rich repeat protein 17 -0.0391487
PALLD palladin, cytoskeletal associated protein -0.0391367
PRELID2 PRELI domain containing 2 -0.0386842
COPB1 coatomer protein complex, subunit beta 1 -0.0386731
VMP1 vacuole membrane protein 1 -0.0384227
NALF1 NALCN channel auxiliary factor 1 -0.0373895
MBNL1 muscleblind-like splicing regulator 1 -0.0371297
MAP1B microtubule-associated protein 1B -0.037116
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.036935
PDIA3 protein disulfide isomerase family A, member 3 -0.0367978
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0366139
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0365928
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0364678
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0364474
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0356908
NAMPT nicotinamide phosphoribosyltransferase -0.0356747
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0355795
GLCCI1 glucocorticoid induced 1 -0.0355693
PHF3 PHD finger protein 3 -0.0354705
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0351717
SEC24A SEC24 family member A -0.0348296
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0345294
TXNIP thioredoxin interacting protein -0.0342632
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0341143
GLS2 glutaminase 2 (liver, mitochondrial) -0.0333304
MT2A metallothionein 2A -0.0329564
EHBP1 EH domain binding protein 1 -0.0325857
MBD5 methyl-CpG binding domain protein 5 -0.032551
PTPRD protein tyrosine phosphatase, receptor type, D -0.0323529
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0323017
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0322635
NABP1 nucleic acid binding protein 1 -0.0319182
OSMR oncostatin M receptor -0.031587
KTN1 kinectin 1 (kinesin receptor) -0.0315418
TAS2R14 taste receptor, type 2, member 14 -0.0314021
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0310742
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -0.0308299
FBXO11 F-box protein 11 -0.0304119
NAV3 neuron navigator 3 -0.0303568
PSD3 pleckstrin and Sec7 domain containing 3 -0.0302519
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0302485
COMMD10 COMM domain containing 10 -0.03021
IL6ST interleukin 6 signal transducer -0.0297859
RAB1A RAB1A, member RAS oncogene family -0.0297757
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0296767
ALCAM activated leukocyte cell adhesion molecule -0.029354
WASF2 WAS protein family, member 2 -0.0292676
TENT5A terminal nucleotidyltransferase 5A -0.0292285
USP34 ubiquitin specific peptidase 34 -0.0291528
HDAC9 histone deacetylase 9 -0.0290901
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0290172
PHF14 PHD finger protein 14 -0.028733
KCTD16 potassium channel tetramerization domain containing 16 -0.0283777
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0282708
PTCHD4 patched domain containing 4 -0.0281576
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.0280982
SPAG9 sperm associated antigen 9 -0.0278298
TTC3 tetratricopeptide repeat domain 3 -0.0276961
SEC31A SEC31 homolog A (S. cerevisiae) -0.0276754
FNDC3A fibronectin type III domain containing 3A -0.0275534
DIAPH3 diaphanous-related formin 3 -0.0275317
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0272625