| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fumaric acid perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Fumaric acid_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.257272 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.130986 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.111751 |
| VEGFA | vascular endothelial growth factor A | 0.111275 |
| RPL3 | ribosomal protein L3 | 0.0925135 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0918447 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0865685 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0855572 |
| MT2A | metallothionein 2A | 0.0807768 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0741807 |
| AFDN | afadin, adherens junction formation factor | 0.0714027 |
| SDC4 | syndecan 4 | 0.0644918 |
| KRT8 | keratin 8, type II | 0.0643917 |
| LOC112694756 | uncharaterized LOC112694756 | 0.063662 |
| RPL11 | ribosomal protein L11 | 0.0622779 |
| TNS1 | tensin 1 | 0.0598262 |
| NDRG1 | N-myc downstream regulated 1 | 0.0595067 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0530577 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0528823 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.051643 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0503387 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0503277 |
| PLEC | plectin | 0.0490358 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0473161 |
| RPL37A | ribosomal protein L37a | 0.046251 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0448757 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0445183 |
| INSIG2 | insulin induced gene 2 | 0.0437923 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0437678 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0431047 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.040477 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0404031 |
| RPL23 | ribosomal protein L23 | 0.0398818 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0379892 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0377031 |
| LDHA | lactate dehydrogenase A | 0.0372292 |
| EFNA1 | ephrin-A1 | 0.0371896 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0371531 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0366137 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.036427 |
| PGK1 | phosphoglycerate kinase 1 | 0.0360055 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.035521 |
| CLTB | clathrin, light chain B | 0.0351031 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0349433 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0344782 |
| TF | transferrin | 0.0340534 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0337743 |
| DTNA | dystrobrevin, alpha | 0.0337602 |
| IQSEC1 | IQ motif and Sec7 domain 1 | 0.033243 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0330305 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.033019 |
| APOA2 | apolipoprotein A-II | 0.0324959 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0313373 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0312099 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0307495 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0306205 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0304934 |
| NONO | non-POU domain containing, octamer-binding | 0.0302558 |
| TMSB10 | thymosin beta 10 | 0.0302277 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0299649 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0296799 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0292145 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0290571 |
| MYO1B | myosin IB | 0.0290359 |
| WDR45B | WD repeat domain 45B | 0.0283004 |
| RPL35A | ribosomal protein L35a | 0.0281417 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0280487 |
| RPS17 | ribosomal protein S17 | 0.0276934 |
| FLNB | filamin B, beta | 0.0275366 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0273818 |
| RPS12 | ribosomal protein S12 | 0.0273667 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0272915 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.026952 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0267129 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0260809 |
| ACTG1 | actin gamma 1 | 0.026015 |
| RPL37 | ribosomal protein L37 | 0.0260019 |
| HELZ | helicase with zinc finger | 0.0258674 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0258432 |
| DIDO1 | death inducer-obliterator 1 | 0.0258426 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.025632 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0255808 |
| SFTPA2 | surfactant protein A2 | 0.0253726 |
| BRD4 | bromodomain containing 4 | 0.0251235 |
| SMAD3 | SMAD family member 3 | 0.0250993 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0250087 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0250076 |
| PDE8A | phosphodiesterase 8A | 0.0249854 |
| YBX1 | Y box binding protein 1 | 0.0249562 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0246093 |
| ADM | adrenomedullin | 0.0243935 |
| APOA1 | apolipoprotein A-I | 0.0243467 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0240105 |
| RPS19 | ribosomal protein S19 | 0.0239122 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0238576 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.023856 |
| TOP1 | topoisomerase (DNA) I | 0.0237687 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0234807 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0234493 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0233099 |
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | -0.18705 |
| EHBP1 | EH domain binding protein 1 | -0.160499 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.146471 |
| FN1 | fibronectin 1 | -0.142165 |
| SLC38A2 | solute carrier family 38, member 2 | -0.132567 |
| IGF2 | insulin-like growth factor 2 | -0.131386 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.127808 |
| GPC6 | glypican 6 | -0.114908 |
| GPC3 | glypican 3 | -0.104719 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.103047 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0978309 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0803739 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0787184 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0690707 |
| PTCHD4 | patched domain containing 4 | -0.0657978 |
| FRMD5 | FERM domain containing 5 | -0.058614 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0583557 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0579602 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0571667 |
| TMEM123 | transmembrane protein 123 | -0.0569646 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0562795 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.055085 |
| ITGAV | integrin, alpha V | -0.0548986 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0542232 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0507018 |
| VCL | vinculin | -0.0498693 |
| DST | dystonin | -0.0463228 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0455728 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0455515 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0446661 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0442803 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.042286 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0408858 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0404351 |
| FAM135A | family with sequence similarity 135, member A | -0.0390929 |
| TRIM26 | tripartite motif containing 26 | -0.0388924 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0385442 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0381887 |
| ITGA1 | integrin, alpha 1 | -0.0374209 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.036936 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0365366 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0354805 |
| JMJD1C | jumonji domain containing 1C | -0.0341338 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0335061 |
| FOXP1 | forkhead box P1 | -0.0333979 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0329966 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.0327636 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.032339 |
| OSMR | oncostatin M receptor | -0.0318007 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0316088 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0311609 |
| C3 | complement component 3 | -0.0307126 |
| GK | glycerol kinase | -0.0306276 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0305688 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0302799 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0300396 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0298917 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0296797 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0294218 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0293925 |
| CNKSR3 | CNKSR family member 3 | -0.0290582 |
| CP | ceruloplasmin (ferroxidase) | -0.0289567 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0287772 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0285856 |
| GNAS | GNAS complex locus | -0.0284513 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0280171 |
| LYZ | lysozyme | -0.0279766 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0278164 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0278115 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0277773 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0277113 |
| DOK6 | docking protein 6 | -0.0273586 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0272667 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.027117 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0270028 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0267982 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0267461 |
| HMGA2 | high mobility group AT-hook 2 | -0.0266299 |
| CDK6 | cyclin-dependent kinase 6 | -0.0265363 |
| MAP4 | microtubule-associated protein 4 | -0.026514 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0264962 |
| PERP | PERP, TP53 apoptosis effector | -0.026249 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0261508 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0258878 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.025841 |
| FILIP1L | filamin A interacting protein 1-like | -0.0256387 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0255699 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0255657 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0255313 |
| ZNF644 | zinc finger protein 644 | -0.0254556 |
| A2M | alpha-2-macroglobulin | -0.0252343 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0250141 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0244576 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0243972 |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 | -0.0242893 |
| STK17A | serine/threonine kinase 17a | -0.0240896 |
| TCF12 | transcription factor 12 | -0.0232826 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0231099 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0231017 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.0230521 |
