Fumaric acid_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fumaric acid perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fumaric acid_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.147379
PLEC plectin 0.131594
MYH9 myosin, heavy chain 9, non-muscle 0.123083
MSN moesin 0.10818
PODXL podocalyxin-like 0.0975972
TGM2 transglutaminase 2 0.0831135
TRIO trio Rho guanine nucleotide exchange factor 0.0732297
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0687835
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0678292
NCOR2 nuclear receptor corepressor 2 0.0671757
B2M beta-2-microglobulin 0.0651682
MEF2A myocyte enhancer factor 2A 0.0645049
LAMA5 laminin, alpha 5 0.0611076
LOC112694756 uncharaterized LOC112694756 0.0603222
BHLHE40 basic helix-loop-helix family, member e40 0.0602779
PGK1 phosphoglycerate kinase 1 0.0586615
KRT17 keratin 17, type I 0.0583764
FOSL1 FOS-like antigen 1 0.0577658
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0574221
TNIP1 TNFAIP3 interacting protein 1 0.0531131
MT2A metallothionein 2A 0.0503654
HSPG2 heparan sulfate proteoglycan 2 0.0485208
EFHD2 EF-hand domain family, member D2 0.0468218
HLA-B major histocompatibility complex, class I, B 0.0446456
EEF2 eukaryotic translation elongation factor 2 0.0446106
CD59 CD59 molecule, complement regulatory protein 0.0445943
PCDH1 protocadherin 1 0.0445663
RPL3 ribosomal protein L3 0.0436021
EPHA2 EPH receptor A2 0.0432889
SMAD3 SMAD family member 3 0.0427811
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0421312
ACTN4 actinin, alpha 4 0.041915
SLK STE20-like kinase 0.0415859
KRT14 keratin 14, type I 0.0406084
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0402601
LMNA lamin A/C 0.0388127
TPM3 tropomyosin 3 0.0386853
APLP2 amyloid beta (A4) precursor-like protein 2 0.038408
BCL2L1 BCL2-like 1 0.0379764
FLNB filamin B, beta 0.0379114
FLNA filamin A, alpha 0.0378679
YBX1 Y box binding protein 1 0.0373551
KDM6A lysine (K)-specific demethylase 6A 0.0361568
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0354982
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0349587
SH3PXD2A SH3 and PX domains 2A 0.0346269
RPS21 ribosomal protein S21 0.0344267
UBA6 ubiquitin-like modifier activating enzyme 6 0.0343851
MEGF6 multiple EGF-like-domains 6 0.0342602
MYO10 myosin X 0.0334469
ANKRD11 ankyrin repeat domain 11 0.0332274
SRRM2 serine/arginine repetitive matrix 2 0.0326984
PLS3 plastin 3 0.0326199
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0326108
NONO non-POU domain containing, octamer-binding 0.0324182
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0320545
POTEF POTE ankyrin domain family, member F 0.0313552
ARRDC3 arrestin domain containing 3 0.0313402
TMSB10 thymosin beta 10 0.0312387
YBX3 Y box binding protein 3 0.0312308
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0311951
IFITM3 interferon induced transmembrane protein 3 0.0309242
ZMIZ1 zinc finger, MIZ-type containing 1 0.0301277
ARGLU1 arginine and glutamate rich 1 0.0299053
ESYT2 extended synaptotagmin-like protein 2 0.0298191
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0297107
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0296761
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0295752
PKM pyruvate kinase, muscle 0.0294651
GUK1 guanylate kinase 1 0.0291505
ANGPTL4 angiopoietin-like 4 0.0288766
CEP250 centrosomal protein 250kDa 0.0288508
PICALM phosphatidylinositol binding clathrin assembly protein 0.0284105
NUMA1 nuclear mitotic apparatus protein 1 0.0283802
ACTN1 actinin, alpha 1 0.0281997
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0278182
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0276393
BCL9L B-cell CLL/lymphoma 9-like 0.0275375
RICTOR RPTOR independent companion of MTOR, complex 2 0.0274068
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0273979
DIDO1 death inducer-obliterator 1 0.0273199
CYB5R3 cytochrome b5 reductase 3 0.027226
PFN1 profilin 1 0.0270373
RPL11 ribosomal protein L11 0.0269331
OGA O-GlcNAcase 0.0269223
MT1X metallothionein 1X 0.0268272
VEGFA vascular endothelial growth factor A 0.0267072
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0264911
RPS6 ribosomal protein S6 0.026489
GRB10 growth factor receptor-bound protein 10 0.0264537
IFI6 interferon, alpha-inducible protein 6 0.0261225
ITGB4 integrin, beta 4 0.0260679
AKAP13 A kinase (PRKA) anchor protein 13 0.0259722
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0258693
LDHA lactate dehydrogenase A 0.0255175
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0252989
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0251053
ADM adrenomedullin 0.0241042
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0241014
MPRIP myosin phosphatase Rho interacting protein 0.0240697

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.321957
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.164755
TIMP3 TIMP metallopeptidase inhibitor 3 -0.105295
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0993342
AHNAK AHNAK nucleoprotein -0.0843201
DPYD dihydropyrimidine dehydrogenase -0.0798764
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0772478
RAI14 retinoic acid induced 14 -0.0664436
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0638755
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0628066
CANX calnexin -0.0614139
SEC31A SEC31 homolog A (S. cerevisiae) -0.0573294
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0573266
PDLIM5 PDZ and LIM domain 5 -0.0556693
PALLD palladin, cytoskeletal associated protein -0.0537573
SULF1 sulfatase 1 -0.0525408
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0515087
HM13 histocompatibility (minor) 13 -0.0481483
ABI3BP ABI family, member 3 (NESH) binding protein -0.0480167
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0460276
MECOM MDS1 and EVI1 complex locus -0.045995
ALCAM activated leukocyte cell adhesion molecule -0.0449903
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0440197
NRIP1 nuclear receptor interacting protein 1 -0.0428363
HMGA2 high mobility group AT-hook 2 -0.0411548
INTS6 integrator complex subunit 6 -0.0409134
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0380869
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0378958
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0378202
CDK13 cyclin-dependent kinase 13 -0.0378075
FN1 fibronectin 1 -0.0378053
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0375948
OSMR oncostatin M receptor -0.037374
GOLGB1 golgin B1 -0.0367815
IARS1 isoleucyl-tRNA synthetase 1 -0.036777
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0352736
COPB1 coatomer protein complex, subunit beta 1 -0.0347227
HLA-E major histocompatibility complex, class I, E -0.0342419
RABGAP1L RAB GTPase activating protein 1-like -0.0333159
EFNA5 ephrin-A5 -0.0332268
TTC3 tetratricopeptide repeat domain 3 -0.0316544
DLG1 discs, large homolog 1 (Drosophila) -0.0312006
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0311796
TPT1 tumor protein, translationally-controlled 1 -0.0311751
DGKH diacylglycerol kinase, eta -0.0311223
EHBP1 EH domain binding protein 1 -0.0307738
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0306687
PIBF1 progesterone immunomodulatory binding factor 1 -0.0305238
LMO7 LIM domain 7 -0.0300708
ZEB1 zinc finger E-box binding homeobox 1 -0.0300211
LMAN1 lectin, mannose-binding, 1 -0.0298256
EGFR epidermal growth factor receptor -0.0298154
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0295744
PRSS23 protease, serine, 23 -0.029338
CNTNAP3 contactin associated protein-like 3 -0.0293259
CDK6 cyclin-dependent kinase 6 -0.0292316
PDE4D phosphodiesterase 4D, cAMP-specific -0.0290196
CALU calumenin -0.0288572
GARS1 glycyl-tRNA synthetase 1 -0.0287436
EXOC4 exocyst complex component 4 -0.0286804
CAVIN1 caveolae associated protein 1 -0.0284242
EXOC6B exocyst complex component 6B -0.0283989
THBD thrombomodulin -0.0281212
HDLBP high density lipoprotein binding protein -0.0280647
NRG1 neuregulin 1 -0.0278995
MAP4 microtubule-associated protein 4 -0.0278495
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0278361
ATM ATM serine/threonine kinase -0.0278323
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0277742
EXT1 exostosin glycosyltransferase 1 -0.0276526
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0272296
FAM114A1 family with sequence similarity 114, member A1 -0.0271702
TMEM263 transmembrane protein 263 -0.0271534
BZW1 basic leucine zipper and W2 domains 1 -0.0270453
SLC35F3 solute carrier family 35, member F3 -0.0268486
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0267562
GNAS GNAS complex locus -0.0265111
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0264403
CLDN1 claudin 1 -0.026095
MBNL1 muscleblind-like splicing regulator 1 -0.026042
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0256857
FSCN1 fascin actin-bundling protein 1 -0.0256289
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0252804
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0251976
ZMYND8 zinc finger, MYND-type containing 8 -0.0248312
ERAP2 endoplasmic reticulum aminopeptidase 2 -0.024743
NIPBL Nipped-B homolog (Drosophila) -0.0246964
SAMD9 sterile alpha motif domain containing 9 -0.0245336
FNIP1 folliculin interacting protein 1 -0.0244157
IFI16 interferon, gamma-inducible protein 16 -0.0236788
MBD5 methyl-CpG binding domain protein 5 -0.023589
MTSS1 metastasis suppressor 1 -0.0235601
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0233353
RB1 retinoblastoma 1 -0.0233161
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0232205
COG6 component of oligomeric golgi complex 6 -0.0231923
FNDC3A fibronectin type III domain containing 3A -0.0227508
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.022601
UTRN utrophin -0.0225997
MON2 MON2 homolog (S. cerevisiae) -0.0224515