Fumaric acid_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fumaric acid perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Fumaric acid_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.121143
NDRG1 N-myc downstream regulated 1 0.112336
MYH9 myosin, heavy chain 9, non-muscle 0.111271
LOC112694756 uncharaterized LOC112694756 0.103976
MT2A metallothionein 2A 0.0952936
PLEC plectin 0.082886
SRRM2 serine/arginine repetitive matrix 2 0.0762102
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0687448
ARGLU1 arginine and glutamate rich 1 0.0679583
TNIP1 TNFAIP3 interacting protein 1 0.0646545
MCL1 myeloid cell leukemia 1 0.0615158
SMAD3 SMAD family member 3 0.0604257
PTPRJ protein tyrosine phosphatase, receptor type, J 0.055545
PTMA prothymosin, alpha 0.0542675
FAM13A family with sequence similarity 13, member A 0.0518153
EEF2 eukaryotic translation elongation factor 2 0.0516854
MSN moesin 0.0512399
KRT18 keratin 18, type I 0.0501015
RPL3 ribosomal protein L3 0.0483228
SEC61G Sec61 gamma subunit 0.0478526
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0465935
HSPA8 heat shock 70kDa protein 8 0.046165
IGFBP3 insulin-like growth factor binding protein 3 0.0458084
ACTG1 actin gamma 1 0.0455728
RPL35A ribosomal protein L35a 0.0446726
LAMC2 laminin, gamma 2 0.043864
GRB10 growth factor receptor-bound protein 10 0.0438474
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0437293
HYOU1 hypoxia up-regulated 1 0.043536
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0434013
CEMIP cell migration inducing protein, hyaluronan binding 0.0428342
MACF1 microtubule-actin crosslinking factor 1 0.0416962
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0415113
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0408275
ANKRD11 ankyrin repeat domain 11 0.0404392
GRAMD1B GRAM domain containing 1B 0.0383572
GSK3B glycogen synthase kinase 3 beta 0.0381462
GUK1 guanylate kinase 1 0.0369986
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0368299
SMTN smoothelin 0.0362142
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0350797
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0349931
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0349834
LAMB3 laminin, beta 3 0.0343672
TSC22D2 TSC22 domain family, member 2 0.0343244
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0332441
KMT2D lysine (K)-specific methyltransferase 2D 0.0327244
FTL ferritin, light polypeptide 0.0325484
RPL37 ribosomal protein L37 0.0319094
KRT8 keratin 8, type II 0.0318698
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.031693
CSNK1E casein kinase 1, epsilon 0.0308823
PDE8A phosphodiesterase 8A 0.0306716
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0306254
VEGFA vascular endothelial growth factor A 0.0304673
PYGL phosphorylase, glycogen, liver 0.0303844
THSD4 thrombospondin, type I, domain containing 4 0.0302495
BHLHE40 basic helix-loop-helix family, member e40 0.0297403
FTH1 ferritin, heavy polypeptide 1 0.0296906
RPL11 ribosomal protein L11 0.028853
UBA6 ubiquitin-like modifier activating enzyme 6 0.0287965
APLP2 amyloid beta (A4) precursor-like protein 2 0.0286172
PKM pyruvate kinase, muscle 0.0284465
DDIT4 DNA-damage-inducible transcript 4 0.0282767
EEF1G eukaryotic translation elongation factor 1 gamma 0.0280964
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0280634
FNDC3B fibronectin type III domain containing 3B 0.0275048
MXD1 MAX dimerization protein 1 0.0273475
MPRIP myosin phosphatase Rho interacting protein 0.0272814
NONO non-POU domain containing, octamer-binding 0.0271844
RPS27 ribosomal protein S27 0.0269474
RPL37A ribosomal protein L37a 0.0267881
SHB Src homology 2 domain containing adaptor protein B 0.0266972
BCL9L B-cell CLL/lymphoma 9-like 0.0263491
EIF4A2 eukaryotic translation initiation factor 4A2 0.0260283
CIB1 calcium and integrin binding 1 (calmyrin) 0.0258616
ERRFI1 ERBB receptor feedback inhibitor 1 0.0257597
MT1X metallothionein 1X 0.0254998
S100P S100 calcium binding protein P 0.0254743
AKAP13 A kinase (PRKA) anchor protein 13 0.0248468
PGK1 phosphoglycerate kinase 1 0.0247913
RPS17 ribosomal protein S17 0.0244165
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.024369
ARRDC3 arrestin domain containing 3 0.0240803
TPM3 tropomyosin 3 0.0239514
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0236615
RPS3 ribosomal protein S3 0.0236134
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.023456
SDC1 syndecan 1 0.0233431
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.0231881
EPHA2 EPH receptor A2 0.0231803
CCNY cyclin Y 0.0230917
ELL2 elongation factor, RNA polymerase II, 2 0.0227328
RPS19 ribosomal protein S19 0.0226189
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0225921
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0225095
ADAM17 ADAM metallopeptidase domain 17 0.0224278
SPAG9 sperm associated antigen 9 0.0224153
RPL23 ribosomal protein L23 0.0223951
TBC1D22A TBC1 domain family, member 22A 0.0221488

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.30662
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.232215
TXNRD1 thioredoxin reductase 1 -0.181697
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0681063
AKR1C1 aldo-keto reductase family 1, member C1 -0.0677375
LRP1B low density lipoprotein receptor-related protein 1B -0.0672343
EFNA5 ephrin-A5 -0.0545097
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0460648
OSMR oncostatin M receptor -0.0433172
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0430881
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0430808
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0429929
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0421337
PATJ PATJ crumbs cell polarity complex component -0.039816
CANX calnexin -0.0391226
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0376718
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0363495
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0357921
GCLC glutamate-cysteine ligase, catalytic subunit -0.0325447
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0324773
ZBTB20 zinc finger and BTB domain containing 20 -0.0321264
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0310175
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0302606
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0301306
CCND1 cyclin D1 -0.0292493
NAMPT nicotinamide phosphoribosyltransferase -0.0291031
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0286018
EGFR epidermal growth factor receptor -0.0281217
MGST1 microsomal glutathione S-transferase 1 -0.0278498
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0275826
SLC38A2 solute carrier family 38, member 2 -0.0275012
MCTP1 multiple C2 domains, transmembrane 1 -0.0271866
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0267757
PAPOLA poly(A) polymerase alpha -0.0258395
CAV1 caveolin 1, caveolae protein, 22kDa -0.025742
AHNAK AHNAK nucleoprotein -0.0257027
BRWD1 bromodomain and WD repeat domain containing 1 -0.0255366
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0251901
MGAT4C MGAT4 family, member C -0.0251264
LMO7 LIM domain 7 -0.0250183
ABLIM1 actin binding LIM protein 1 -0.0246227
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0245502
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0241577
TAS2R14 taste receptor, type 2, member 14 -0.0240324
SCLT1 sodium channel and clathrin linker 1 -0.0240315
ZMYND8 zinc finger, MYND-type containing 8 -0.0240158
ANKRD10 ankyrin repeat domain 10 -0.0235487
SP100 SP100 nuclear antigen -0.0234732
FAAH2 fatty acid amide hydrolase 2 -0.0234648
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0229136
NIPBL Nipped-B homolog (Drosophila) -0.0226936
LPP LIM domain containing preferred translocation partner in lipoma -0.0223931
GPHN gephyrin -0.0223154
USP34 ubiquitin specific peptidase 34 -0.0222919
MBD5 methyl-CpG binding domain protein 5 -0.0222247
BIRC3 baculoviral IAP repeat containing 3 -0.0221863
GOLGB1 golgin B1 -0.0221662
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0220101
JMJD1C jumonji domain containing 1C -0.021898
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0216929
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0216113
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0214295
NCOA7 nuclear receptor coactivator 7 -0.0213533
MON2 MON2 homolog (S. cerevisiae) -0.0211174
RAB1A RAB1A, member RAS oncogene family -0.0210405
REL v-rel avian reticuloendotheliosis viral oncogene homolog -0.0209432
SEC31A SEC31 homolog A (S. cerevisiae) -0.0208847
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0205569
KMT2A lysine (K)-specific methyltransferase 2A -0.020515
FNIP1 folliculin interacting protein 1 -0.0202786
PDIA3 protein disulfide isomerase family A, member 3 -0.0202649
SEC24D SEC24 family member D -0.0200012
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0196954
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0195919
UGDH UDP-glucose 6-dehydrogenase -0.0194291
RIMS2 regulating synaptic membrane exocytosis 2 -0.0193849
TMEM263 transmembrane protein 263 -0.0188982
RAB10 RAB10, member RAS oncogene family -0.0188403
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0186984
TLK1 tousled-like kinase 1 -0.0186574
CEP350 centrosomal protein 350kDa -0.0186469
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0184939
TNRC6B trinucleotide repeat containing 6B -0.0184623
GM2A GM2 ganglioside activator -0.0183881
USP53 ubiquitin specific peptidase 53 -0.0183468
BZW1 basic leucine zipper and W2 domains 1 -0.0180675
BPTF bromodomain PHD finger transcription factor -0.0179936
LRP12 low density lipoprotein receptor-related protein 12 -0.0179144
KDM2A lysine (K)-specific demethylase 2A -0.0178656
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0172482
EHBP1 EH domain binding protein 1 -0.0170708
RIGI RNA sensor RIG-I -0.0170113
PDE4D phosphodiesterase 4D, cAMP-specific -0.0169877
TPT1 tumor protein, translationally-controlled 1 -0.0168425
SPDYA speedy/RINGO cell cycle regulator family member A -0.016842
NABP1 nucleic acid binding protein 1 -0.0168006
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0167281
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0166996
NBEAL1 neurobeachin-like 1 -0.0166878
SMIM14 small integral membrane protein 14 -0.0166808