Fumaric acid_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fumaric acid perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Fumaric acid_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.148123
GRB10 growth factor receptor-bound protein 10 0.140633
PCBP2 poly(rC) binding protein 2 0.134985
SMAD3 SMAD family member 3 0.131605
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.12968
NAV2 neuron navigator 2 0.120646
SDK1 sidekick cell adhesion molecule 1 0.108512
TMSB10 thymosin beta 10 0.0986447
TRIO trio Rho guanine nucleotide exchange factor 0.0974996
VEGFA vascular endothelial growth factor A 0.0949488
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0895131
EEF2 eukaryotic translation elongation factor 2 0.0890943
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0889581
VIM vimentin 0.0854411
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0842145
MYH9 myosin, heavy chain 9, non-muscle 0.0759336
TNIP1 TNFAIP3 interacting protein 1 0.0646946
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0646476
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.060516
TMSB4X thymosin beta 4, X-linked 0.0602735
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0568987
LOC112694756 uncharaterized LOC112694756 0.0568112
NDRG1 N-myc downstream regulated 1 0.0557687
PFKP phosphofructokinase, platelet 0.0548916
FAM13A family with sequence similarity 13, member A 0.0530955
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0530286
RPL3 ribosomal protein L3 0.052025
SOD2 superoxide dismutase 2, mitochondrial 0.0481924
FNDC3B fibronectin type III domain containing 3B 0.048055
CNOT12 CCR4-NOT transcription complex subunit 12 0.0477827
ANKRD11 ankyrin repeat domain 11 0.0475412
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.047536
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0471778
BHLHE40 basic helix-loop-helix family, member e40 0.0464147
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0455097
MCL1 myeloid cell leukemia 1 0.0451456
SIK3 SIK family kinase 3 0.0449034
APLP2 amyloid beta (A4) precursor-like protein 2 0.0443443
MSN moesin 0.0435106
PKM pyruvate kinase, muscle 0.0434942
YBX1 Y box binding protein 1 0.0430762
SFTPA2 surfactant protein A2 0.0423962
CEP250 centrosomal protein 250kDa 0.0411746
PRELID2 PRELI domain containing 2 0.040938
MAP2K1 mitogen-activated protein kinase kinase 1 0.0406502
SRRM2 serine/arginine repetitive matrix 2 0.0404417
RUNX1 runt-related transcription factor 1 0.040238
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0401918
ANXA1 annexin A1 0.0390783
NBAS neuroblastoma amplified sequence 0.0385948
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0382572
TIMP1 TIMP metallopeptidase inhibitor 1 0.0382418
HELZ helicase with zinc finger 0.0382139
ATXN1 ataxin 1 0.0380163
PARD3 par-3 family cell polarity regulator 0.037906
FLNB filamin B, beta 0.0375988
B2M beta-2-microglobulin 0.0372255
CDH13 cadherin 13 0.0371214
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0367882
KMT2C lysine (K)-specific methyltransferase 2C 0.0360252
MIDEAS mitotic deacetylase associated SANT domain protein 0.0357941
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0356615
ACTG1 actin gamma 1 0.0352815
CABIN1 calcineurin binding protein 1 0.0349521
NCOR2 nuclear receptor corepressor 2 0.0347552
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0346271
RPL11 ribosomal protein L11 0.0344468
USP34 ubiquitin specific peptidase 34 0.0342953
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0342674
RPL23 ribosomal protein L23 0.0341577
DTNA dystrobrevin, alpha 0.0340464
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0333721
INTS1 integrator complex subunit 1 0.0330561
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0328876
APP amyloid beta (A4) precursor protein 0.0328515
YBX3 Y box binding protein 3 0.0325835
KTN1 kinectin 1 (kinesin receptor) 0.0322503
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0320911
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0318794
DIDO1 death inducer-obliterator 1 0.0318297
KDM2A lysine (K)-specific demethylase 2A 0.0317951
AMPD3 adenosine monophosphate deaminase 3 0.0317299
EZR ezrin 0.0313673
FTL ferritin, light polypeptide 0.0309809
ADAM17 ADAM metallopeptidase domain 17 0.0308922
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0306447
CCNY cyclin Y 0.0305972
NONO non-POU domain containing, octamer-binding 0.030475
EFNA5 ephrin-A5 0.0303318
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0301431
MACF1 microtubule-actin crosslinking factor 1 0.0300593
CPNE1 copine I 0.0296832
ZFAND3 zinc finger, AN1-type domain 3 0.0294756
RPS6 ribosomal protein S6 0.029109
ANGPTL4 angiopoietin-like 4 0.0288019
TGM2 transglutaminase 2 0.028758
FAM120A family with sequence similarity 120A 0.028575
FOSL1 FOS-like antigen 1 0.0284805
SND1 staphylococcal nuclease and tudor domain containing 1 0.0282289
PTK2 protein tyrosine kinase 2 0.0281272

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.150643
LOX lysyl oxidase -0.147978
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.123985
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0902271
GLCCI1 glucocorticoid induced 1 -0.0842529
CD44 CD44 molecule (Indian blood group) -0.0807407
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0711738
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.070779
OSMR oncostatin M receptor -0.0678847
LMAN1 lectin, mannose-binding, 1 -0.0598887
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0590051
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0543107
NCOA7 nuclear receptor coactivator 7 -0.0542125
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0540252
PDE4D phosphodiesterase 4D, cAMP-specific -0.0517501
KYNU kynureninase -0.0515204
NTN4 netrin 4 -0.0490692
CANX calnexin -0.0471186
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0449345
EHBP1 EH domain binding protein 1 -0.0447286
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0441383
RNF24 ring finger protein 24 -0.0433852
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0429345
RAI14 retinoic acid induced 14 -0.0415239
GCC2 GRIP and coiled-coil domain containing 2 -0.0414543
ZEB2 zinc finger E-box binding homeobox 2 -0.0413866
ZC3H12C zinc finger CCCH-type containing 12C -0.041168
GOLGA4 golgin A4 -0.0396439
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0395526
VCL vinculin -0.0389227
IER3 immediate early response 3 -0.038886
ZNF804A zinc finger protein 804A -0.0377833
WSB1 WD repeat and SOCS box containing 1 -0.0373043
FN1 fibronectin 1 -0.0354109
ZBTB20 zinc finger and BTB domain containing 20 -0.0353611
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0350981
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0341673
TM4SF1 transmembrane 4 L six family member 1 -0.0337911
TMEM263 transmembrane protein 263 -0.032311
SAMD9 sterile alpha motif domain containing 9 -0.0321651
C15ORF48 chromosome 15 open reading frame 48 -0.0306622
EGFR epidermal growth factor receptor -0.0305757
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0298319
RAP1B RAP1B, member of RAS oncogene family -0.0297971
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0297272
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0296696
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0294997
AHNAK AHNAK nucleoprotein -0.0293133
BASP1 brain abundant, membrane attached signal protein 1 -0.0285491
ARHGAP5 Rho GTPase activating protein 5 -0.0283838
TAS2R14 taste receptor, type 2, member 14 -0.0283506
IFI16 interferon, gamma-inducible protein 16 -0.0282391
OXSR1 oxidative stress responsive 1 -0.0278921
ZBTB38 zinc finger and BTB domain containing 38 -0.0273559
AOPEP aminopeptidase O (putative) -0.0270627
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0264477
H1-0 H1.0 linker histone -0.0263968
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0255742
CDK13 cyclin-dependent kinase 13 -0.0255722
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0255104
BPTF bromodomain PHD finger transcription factor -0.0250436
NPC1 Niemann-Pick disease, type C1 -0.0249206
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0245471
MBD5 methyl-CpG binding domain protein 5 -0.0244321
WASF2 WAS protein family, member 2 -0.0242638
BZW1 basic leucine zipper and W2 domains 1 -0.0240257
ETV6 ets variant 6 -0.0236595
ANTXR2 anthrax toxin receptor 2 -0.0234669
PHF3 PHD finger protein 3 -0.023315
KSR1 kinase suppressor of ras 1 -0.0232073
TNNC1 troponin C type 1 (slow) -0.0229798
HMGA2 high mobility group AT-hook 2 -0.0223759
NRG1 neuregulin 1 -0.0217333
AADAC arylacetamide deacetylase -0.0216764
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0215014
CAVIN1 caveolae associated protein 1 -0.0211117
STAT5B signal transducer and activator of transcription 5B -0.021087
PTMA prothymosin, alpha -0.0209674
CLIP1 CAP-GLY domain containing linker protein 1 -0.0208148
EVA1C eva-1 homolog C (C. elegans) -0.0207083
ANKRD17 ankyrin repeat domain 17 -0.0206325
ATM ATM serine/threonine kinase -0.0204359
DMXL1 Dmx-like 1 -0.0204151
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0203589
KMT2E lysine (K)-specific methyltransferase 2E -0.0202567
AHI1 Abelson helper integration site 1 -0.0202353
MON2 MON2 homolog (S. cerevisiae) -0.020234
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.020026
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0197032
FNDC3A fibronectin type III domain containing 3A -0.0196295
PCNX4 pecanex 4 -0.0196077
ZMYND8 zinc finger, MYND-type containing 8 -0.019602
PTGIS prostaglandin I2 (prostacyclin) synthase -0.0195949
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0195758
PTPRK protein tyrosine phosphatase, receptor type, K -0.0194319
DAAM1 dishevelled associated activator of morphogenesis 1 -0.0193822
GOSR1 golgi SNAP receptor complex member 1 -0.0191987
TUT7 terminal uridylyl transferase 7 -0.0191884
BMERB1 bMERB domain containing 1 -0.0188329
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0185436