Fumaric acid_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fumaric acid perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fumaric acid_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT8 keratin 8, type II 0.137088
NKD1 naked cuticle homolog 1 (Drosophila) 0.13641
KRT18 keratin 18, type I 0.128846
MYH9 myosin, heavy chain 9, non-muscle 0.128418
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.112076
PLEC plectin 0.11126
NONO non-POU domain containing, octamer-binding 0.106129
RPL35A ribosomal protein L35a 0.0988063
NAV2 neuron navigator 2 0.0865951
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0819701
ARGLU1 arginine and glutamate rich 1 0.0783451
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0776622
TMSB10 thymosin beta 10 0.0735433
HDAC4 histone deacetylase 4 0.0664779
RPL3 ribosomal protein L3 0.0644288
EEF2 eukaryotic translation elongation factor 2 0.0597944
TMSB4X thymosin beta 4, X-linked 0.0506216
NUMA1 nuclear mitotic apparatus protein 1 0.0474235
ACTG1 actin gamma 1 0.0453359
HSPA8 heat shock 70kDa protein 8 0.0449082
KIZ kizuna centrosomal protein 0.0448592
SRRM2 serine/arginine repetitive matrix 2 0.0429348
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0428106
RPL37 ribosomal protein L37 0.0421044
LOC112694756 uncharaterized LOC112694756 0.041342
RPL37A ribosomal protein L37a 0.0381041
ACTN1 actinin, alpha 1 0.0377401
PTMA prothymosin, alpha 0.0360666
EEF1G eukaryotic translation elongation factor 1 gamma 0.0354023
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0343742
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0336203
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0334776
MPRIP myosin phosphatase Rho interacting protein 0.0330975
RPL23 ribosomal protein L23 0.0330004
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0326482
MINK1 misshapen-like kinase 1 0.0322749
CDH13 cadherin 13 0.0314917
TNIP1 TNFAIP3 interacting protein 1 0.0306625
CEP250 centrosomal protein 250kDa 0.0305864
MACF1 microtubule-actin crosslinking factor 1 0.0302571
BHLHE40 basic helix-loop-helix family, member e40 0.03024
CPNE1 copine I 0.0301986
AKAP12 A kinase (PRKA) anchor protein 12 0.0301319
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0296783
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0292969
RPL13A ribosomal protein L13a 0.0289022
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0284657
DST dystonin 0.0284555
RPL11 ribosomal protein L11 0.0281355
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 0.0279597
IGFBP3 insulin-like growth factor binding protein 3 0.0277274
EIF4H eukaryotic translation initiation factor 4H 0.0275851
FLNA filamin A, alpha 0.0275397
RPS19 ribosomal protein S19 0.0274761
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 0.0272319
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0270941
PRELID3B PRELI domain containing 3B 0.0268148
NACA nascent polypeptide-associated complex alpha subunit 0.0262191
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.0259304
CD9 CD9 molecule 0.0248148
EWSR1 EWS RNA-binding protein 1 0.0244627
NCOR2 nuclear receptor corepressor 2 0.0243867
SET SET nuclear proto-oncogene 0.0243443
LMNA lamin A/C 0.0243061
TRIO trio Rho guanine nucleotide exchange factor 0.0238915
KMT2D lysine (K)-specific methyltransferase 2D 0.0237319
EIF4B eukaryotic translation initiation factor 4B 0.0236832
H1-2 H1.2 linker histone, cluster member 0.0233924
IGF1R insulin-like growth factor 1 receptor 0.0233771
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0231225
INCENP inner centromere protein antigens 135/155kDa 0.0229562
FLNB filamin B, beta 0.0228364
PPL periplakin 0.022413
RPL31 ribosomal protein L31 0.0220134
RPL38 ribosomal protein L38 0.0219203
SDK1 sidekick cell adhesion molecule 1 0.021838
HRNR hornerin 0.0210747
MSN moesin 0.0210422
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0210022
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0209911
RASA3 RAS p21 protein activator 3 0.0207777
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0207224
RLIM ring finger protein, LIM domain interacting 0.0205344
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0204477
ITGB4 integrin, beta 4 0.0201385
RPL41 ribosomal protein L41 0.0197411
EFHD2 EF-hand domain family, member D2 0.0195787
CEMIP cell migration inducing protein, hyaluronan binding 0.0195702
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0194928
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0193553
CMIP c-Maf inducing protein 0.0192616
RPL35 ribosomal protein L35 0.0189946
ACIN1 apoptotic chromatin condensation inducer 1 0.0188115
SHB Src homology 2 domain containing adaptor protein B 0.0185473
CLTA clathrin, light chain A 0.0184569
CAPRIN1 cell cycle associated protein 1 0.0183894
YBX1 Y box binding protein 1 0.0183119
SMAD3 SMAD family member 3 0.018294
MTCL1 microtubule crosslinking factor 1 0.018142
BACE2 beta-site APP-cleaving enzyme 2 0.0180976

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.3804
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.152696
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0832584
SYT1 synaptotagmin I -0.0733058
JMJD1C jumonji domain containing 1C -0.0568362
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0529345
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0513754
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0512419
SLC38A2 solute carrier family 38, member 2 -0.0463276
TMEM123 transmembrane protein 123 -0.0426685
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0420542
UBC ubiquitin C -0.0412124
OXR1 oxidation resistance 1 -0.039956
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0399349
VMP1 vacuole membrane protein 1 -0.0380942
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0375787
POTEF POTE ankyrin domain family, member F -0.0373734
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0370466
PCBP2 poly(rC) binding protein 2 -0.0356957
HMGA1 high mobility group AT-hook 1 -0.0355843
DIAPH3 diaphanous-related formin 3 -0.0344121
FNDC3A fibronectin type III domain containing 3A -0.0341612
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0339131
GOLGA4 golgin A4 -0.0335116
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0334399
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0334391
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0334145
NF1 neurofibromin 1 -0.0332126
GLG1 golgi glycoprotein 1 -0.0330961
NIPBL Nipped-B homolog (Drosophila) -0.0328911
SMC4 structural maintenance of chromosomes 4 -0.0325096
PIBF1 progesterone immunomodulatory binding factor 1 -0.0323121
SCAF11 SR-related CTD-associated factor 11 -0.0315488
IARS1 isoleucyl-tRNA synthetase 1 -0.0314547
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0313943
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0312185
GPHN gephyrin -0.0308799
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0306432
COG5 component of oligomeric golgi complex 5 -0.0305848
TXNIP thioredoxin interacting protein -0.0305393
SBF2 SET binding factor 2 -0.0304723
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0301225
KMT2E lysine (K)-specific methyltransferase 2E -0.0300943
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0298834
DEK DEK proto-oncogene -0.0297969
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0289091
WASF2 WAS protein family, member 2 -0.0286117
RPS23 ribosomal protein S23 -0.0285557
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0284989
ZMYM2 zinc finger, MYM-type 2 -0.0281006
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0280509
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0279559
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0278151
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.027361
PTBP3 polypyrimidine tract binding protein 3 -0.0272647
IPO7 importin 7 -0.0272396
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0271939
ZFP36L1 ZFP36 ring finger protein-like 1 -0.027044
BPTF bromodomain PHD finger transcription factor -0.0270274
USP34 ubiquitin specific peptidase 34 -0.0268618
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0265163
RPS15 ribosomal protein S15 -0.0263368
AKAP9 A kinase (PRKA) anchor protein 9 -0.0262927
FAF1 Fas (TNFRSF6) associated factor 1 -0.0262347
PDIA3 protein disulfide isomerase family A, member 3 -0.0262271
DSTN destrin (actin depolymerizing factor) -0.0261951
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0256899
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0256869
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0256494
PHIP pleckstrin homology domain interacting protein -0.0256007
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.025465
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0254603
TUBA1B tubulin, alpha 1b -0.0252658
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0249775
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0249528
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0248935
RPL21 ribosomal protein L21 -0.0248324
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0246631
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0246244
STAU1 staufen double-stranded RNA binding protein 1 -0.0243882
DLG1 discs, large homolog 1 (Drosophila) -0.024195
ETNK1 ethanolamine kinase 1 -0.0240956
KMT2C lysine (K)-specific methyltransferase 2C -0.0239955
CBX3 chromobox homolog 3 -0.0239634
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0239115
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0239021
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0238404
RAB7A RAB7A, member RAS oncogene family -0.0237645
PDE4D phosphodiesterase 4D, cAMP-specific -0.0237183
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0236714
NIPSNAP2 nipsnap homolog 2 -0.0234492
RTN4 reticulon 4 -0.0233436
YME1L1 YME1-like 1 ATPase -0.0233262
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0232783
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0230951
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0230779
SNX9 sorting nexin 9 -0.023034
ERBIN erbb2 interacting protein -0.0230331
RPS5 ribosomal protein S5 -0.0229313
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0229274