Furosemide_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Furosemide perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Furosemide_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.120103
CCN2 cellular communication network factor 2 0.0738709
TMEM41B transmembrane protein 41B 0.0686159
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0686113
SMC4 structural maintenance of chromosomes 4 0.0594916
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0584728
MKI67 marker of proliferation Ki-67 0.0560976
MMP12 matrix metallopeptidase 12 0.0522161
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.051343
HMGA2 high mobility group AT-hook 2 0.0470791
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0469061
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0456427
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0410511
DST dystonin 0.039838
ANXA1 annexin A1 0.0374884
ATP11A ATPase, class VI, type 11A 0.0367501
NLGN1 neuroligin 1 0.0352486
TPM3 tropomyosin 3 0.035083
CENPF centromere protein F, 350/400kDa 0.0350543
JMJD1C jumonji domain containing 1C 0.0339328
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0329455
KPNB1 karyopherin (importin) beta 1 0.0326872
NAP1L1 nucleosome assembly protein 1-like 1 0.032295
NHSL1 NHS-like 1 0.0322709
PCDH7 protocadherin 7 0.032119
SPATS2 spermatogenesis associated, serine-rich 2 0.0315622
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0289753
ASPH aspartate beta-hydroxylase 0.0285438
RRM2 ribonucleotide reductase M2 0.0284783
EHBP1 EH domain binding protein 1 0.0282299
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0268335
MARCHF4 membrane associated ring-CH-type finger 4 0.0261606
ERRFI1 ERBB receptor feedback inhibitor 1 0.0260167
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0252324
AKAP12 A kinase (PRKA) anchor protein 12 0.0249669
AHNAK AHNAK nucleoprotein 0.0248769
ACTG1 actin gamma 1 0.0246923
EDARADD EDAR-associated death domain 0.0245194
HSPA8 heat shock 70kDa protein 8 0.0243706
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0240009
BIRC3 baculoviral IAP repeat containing 3 0.0239703
CALR calreticulin 0.023581
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0234156
VMP1 vacuole membrane protein 1 0.0232575
SQSTM1 sequestosome 1 0.0230641
KDM2A lysine (K)-specific demethylase 2A 0.0230333
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0226531
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0219478
NIPBL Nipped-B homolog (Drosophila) 0.0214719
HLA-A major histocompatibility complex, class I, A 0.0214309
YAP1 Yes-associated protein 1 0.0212888
ADIPOR2 adiponectin receptor 2 0.0212361
CENPE centromere protein E, 312kDa 0.0211198
MAP1B microtubule-associated protein 1B 0.0209385
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0208953
TPR translocated promoter region, nuclear basket protein 0.0206911
PACS1 phosphofurin acidic cluster sorting protein 1 0.0203176
TAS2R14 taste receptor, type 2, member 14 0.0198542
USP34 ubiquitin specific peptidase 34 0.0194886
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0194592
ANKRD36 ankyrin repeat domain 36 0.0193919
WWOX WW domain containing oxidoreductase 0.0192606
MED12L mediator complex subunit 12-like 0.0192172
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0190896
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.018812
IPO7 importin 7 0.0187911
ASXL1 additional sex combs like transcriptional regulator 1 0.0186492
CCDC88A coiled-coil domain containing 88A 0.0186143
KLF6 Kruppel-like factor 6 0.018577
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0184229
PDIA3 protein disulfide isomerase family A, member 3 0.0184141
SRRM2 serine/arginine repetitive matrix 2 0.0184041
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0182477
CANX calnexin 0.0182151
ANKRD12 ankyrin repeat domain 12 0.0181663
MTAP methylthioadenosine phosphorylase 0.0178891
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0174577
DOCK1 dedicator of cytokinesis 1 0.0173413
MSRB3 methionine sulfoxide reductase B3 0.0172578
ETV6 ets variant 6 0.0172285
CHD4 chromodomain helicase DNA binding protein 4 0.0171707
TBL1X transducin (beta)-like 1X-linked 0.0171617
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0168315
GJA1 gap junction protein, alpha 1, 43kDa 0.0165406
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0165141
NCAPD2 non-SMC condensin I complex, subunit D2 0.0162797
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0159971
DPYD dihydropyrimidine dehydrogenase 0.0159224
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0158029
BABAM2 BRISC and BRCA1 A complex member 2 0.0157468
PDE4D phosphodiesterase 4D, cAMP-specific 0.0157284
RTN4 reticulon 4 0.0156457
JUN jun proto-oncogene 0.015619
MACF1 microtubule-actin crosslinking factor 1 0.0155983
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0155825
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.0153657
NDC80 NDC80 kinetochore complex component 0.0153054
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0153024
PCM1 pericentriolar material 1 0.015282
CUX1 cut-like homeobox 1 0.0152171

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.138324
TMSB10 thymosin beta 10 -0.101242
FTL ferritin, light polypeptide -0.0487155
RPL23 ribosomal protein L23 -0.044947
TPI1 triosephosphate isomerase 1 -0.0433604
PFN1 profilin 1 -0.0346462
RPS19 ribosomal protein S19 -0.0341079
TENM3 teneurin transmembrane protein 3 -0.0327314
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0318126
CNRIP1 cannabinoid receptor interacting protein 1 -0.0316729
RPLP2 ribosomal protein, large, P2 -0.031525
RPL35A ribosomal protein L35a -0.0313739
RPS21 ribosomal protein S21 -0.0297262
RPS23 ribosomal protein S23 -0.0283283
RPLP0 ribosomal protein, large, P0 -0.0271353
RPL11 ribosomal protein L11 -0.0270374
RPL12 ribosomal protein L12 -0.026917
SLC38A2 solute carrier family 38, member 2 -0.0264809
RPL19 ribosomal protein L19 -0.026326
RPS6 ribosomal protein S6 -0.0261942
PCBP2 poly(rC) binding protein 2 -0.0250728
AREG amphiregulin -0.0249137
RPL8 ribosomal protein L8 -0.0241626
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0234781
LDHA lactate dehydrogenase A -0.0231351
EEF1G eukaryotic translation elongation factor 1 gamma -0.0226283
HMGA1 high mobility group AT-hook 1 -0.0224408
RPS24 ribosomal protein S24 -0.0219645
PUM2 pumilio RNA-binding family member 2 -0.0213073
EIF1 eukaryotic translation initiation factor 1 -0.0211229
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0208206
CELF2 CUGBP, Elav-like family member 2 -0.0205122
CXADR coxsackie virus and adenovirus receptor -0.0203714
RPLP1 ribosomal protein, large, P1 -0.020228
MGAT4C MGAT4 family, member C -0.0198656
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.019814
VCL vinculin -0.0197779
RPS14 ribosomal protein S14 -0.0197281
RPS16 ribosomal protein S16 -0.0187725
RPS8 ribosomal protein S8 -0.018691
CARD16 caspase recruitment domain family, member 16 -0.0183307
RPL26 ribosomal protein L26 -0.0176096
KLHL24 kelch-like family member 24 -0.0171618
RPS13 ribosomal protein S13 -0.0168593
RPS15 ribosomal protein S15 -0.0167264
MYL12B myosin, light chain 12B, regulatory -0.0166173
EEF2 eukaryotic translation elongation factor 2 -0.0163369
RPS20 ribosomal protein S20 -0.0162222
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0162218
RPL32 ribosomal protein L32 -0.0161354
RPS5 ribosomal protein S5 -0.0159874
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0158983
PTMA prothymosin, alpha -0.0157047
ATP5F1B ATP synthase F1 subunit beta -0.0156133
FNDC3B fibronectin type III domain containing 3B -0.0155274
POTEF POTE ankyrin domain family, member F -0.0155206
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0154891
RPL27 ribosomal protein L27 -0.0153808
RPS4X ribosomal protein S4, X-linked -0.0152885
CPOX coproporphyrinogen oxidase -0.0151102
RPL27A ribosomal protein L27a -0.0150566
GARS1 glycyl-tRNA synthetase 1 -0.0149077
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0147487
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0147314
YBX1 Y box binding protein 1 -0.0146948
CAMTA1 calmodulin binding transcription activator 1 -0.0146159
LDHB lactate dehydrogenase B -0.0144402
BRWD1 bromodomain and WD repeat domain containing 1 -0.014056
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0140192
ATP5F1E ATP synthase F1 subunit epsilon -0.0140147
TUBA1B tubulin, alpha 1b -0.0139702
RPS29 ribosomal protein S29 -0.0139282
PNN pinin, desmosome associated protein -0.01369
ARHGAP12 Rho GTPase activating protein 12 -0.0136589
RPL34 ribosomal protein L34 -0.0136344
RPS11 ribosomal protein S11 -0.0133102
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0132752
YBX3 Y box binding protein 3 -0.0132594
RPL36 ribosomal protein L36 -0.0132156
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0128544
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0128083
RPL7 ribosomal protein L7 -0.0127757
RPS3 ribosomal protein S3 -0.0127701
WDR43 WD repeat domain 43 -0.0127122
SETD5 SET domain containing 5 -0.0126266
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0123929
S100A10 S100 calcium binding protein A10 -0.0120161
CFDP1 craniofacial development protein 1 -0.0118855
VAT1 vesicle amine transport 1 -0.0118327
COX7B cytochrome c oxidase subunit VIIb -0.0117052
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0116527
RPS27 ribosomal protein S27 -0.0115709
RPL18 ribosomal protein L18 -0.0113943
AXIN2 axin 2 -0.0113486
RPL15 ribosomal protein L15 -0.0113486
S100A9 S100 calcium binding protein A9 -0.0111718
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0111362
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0111311
CLDND1 claudin domain containing 1 -0.0110935
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0110773