Furosemide_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Furosemide perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Furosemide_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.31223
AKAP12 A kinase (PRKA) anchor protein 12 0.0875365
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0718435
LSAMP limbic system-associated membrane protein 0.0641099
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0539719
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0520719
FNBP1 formin binding protein 1 0.0474136
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0449721
TRIO trio Rho guanine nucleotide exchange factor 0.044297
CENPF centromere protein F, 350/400kDa 0.0438615
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0376574
SMYD3 SET and MYND domain containing 3 0.0367557
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0356549
NDRG1 N-myc downstream regulated 1 0.0351491
BPTF bromodomain PHD finger transcription factor 0.0348793
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0339726
VEGFA vascular endothelial growth factor A 0.0315632
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0306869
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0306459
ZMIZ1 zinc finger, MIZ-type containing 1 0.0296565
MTDH metadherin 0.028968
ANTXR1 anthrax toxin receptor 1 0.0284302
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0280947
RPS3 ribosomal protein S3 0.0280811
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0276048
TRIB2 tribbles pseudokinase 2 0.0274681
IGFBP3 insulin-like growth factor binding protein 3 0.0264735
RUNX1 runt-related transcription factor 1 0.0257538
RPS8 ribosomal protein S8 0.02535
ATXN1 ataxin 1 0.0250965
RPL37A ribosomal protein L37a 0.0248229
USP34 ubiquitin specific peptidase 34 0.0248005
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0244789
RNF213 ring finger protein 213 0.0241906
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0239018
ADGRB3 adhesion G protein-coupled receptor B3 0.0235947
B2M beta-2-microglobulin 0.0231995
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0231014
MBTD1 mbt domain containing 1 0.0230914
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0229798
EXT1 exostosin glycosyltransferase 1 0.0226968
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0219483
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0218957
NPAS2 neuronal PAS domain protein 2 0.0218192
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0217116
PARD3 par-3 family cell polarity regulator 0.0215738
DST dystonin 0.0215427
RPS27A ribosomal protein S27a 0.0210728
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0209332
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0206791
PACS1 phosphofurin acidic cluster sorting protein 1 0.0205794
SBF2 SET binding factor 2 0.020491
SRRM2 serine/arginine repetitive matrix 2 0.0200412
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0200338
YTHDC1 YTH domain containing 1 0.0197682
RAB1A RAB1A, member RAS oncogene family 0.0193538
NFIB nuclear factor I/B 0.0193229
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0193214
IGF1R insulin-like growth factor 1 receptor 0.0192069
RSF1 remodeling and spacing factor 1 0.0190133
SRP72 signal recognition particle 72kDa 0.0189927
NKTR natural killer cell triggering receptor 0.018961
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0189248
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0188859
TENM4 teneurin transmembrane protein 4 0.0188617
FTH1 ferritin, heavy polypeptide 1 0.0188529
CEP112 centrosomal protein 112kDa 0.0186483
LPP LIM domain containing preferred translocation partner in lipoma 0.0184468
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0183779
N4BP2L2 NEDD4 binding protein 2-like 2 0.0183664
ANGPTL4 angiopoietin-like 4 0.0183621
DNAH14 dynein, axonemal, heavy chain 14 0.018345
MKI67 marker of proliferation Ki-67 0.0183224
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0182873
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.018248
LCORL ligand dependent nuclear receptor corepressor-like 0.0182168
TRIM25 tripartite motif containing 25 0.018154
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0180698
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0179621
PCBP3 poly(rC) binding protein 3 0.0178827
EZR ezrin 0.0177763
SMAD9 SMAD family member 9 0.0177098
GLI2 GLI family zinc finger 2 0.0176382
MEF2A myocyte enhancer factor 2A 0.0175724
XRN1 5'-3' exoribonuclease 1 0.0175236
DNMBP dynamin binding protein 0.0175112
CCDC47 coiled-coil domain containing 47 0.0173551
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0172484
LAMA4 laminin, alpha 4 0.0171444
CXCL8 chemokine (C-X-C motif) ligand 8 0.0171409
FAM13A family with sequence similarity 13, member A 0.0170851
SET SET nuclear proto-oncogene 0.0167133
AHNAK AHNAK nucleoprotein 0.0166958
CADM1 cell adhesion molecule 1 0.0166569
KANSL1 KAT8 regulatory NSL complex subunit 1 0.016628
JUN jun proto-oncogene 0.0162811
XRN2 5'-3' exoribonuclease 2 0.0162464
ADAM10 ADAM metallopeptidase domain 10 0.0161622
FER fer (fps/fes related) tyrosine kinase 0.0160865
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0160784

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.264772
VCL vinculin -0.0564886
NRG1 neuregulin 1 -0.0491862
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0490292
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0404721
PRKCA protein kinase C, alpha -0.034727
ITPRID2 ITPR interacting domain containing 2 -0.0338524
ZMYM2 zinc finger, MYM-type 2 -0.0322856
VMP1 vacuole membrane protein 1 -0.0308718
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0268099
NREP neuronal regeneration related protein -0.0265009
SIK2 salt-inducible kinase 2 -0.0264657
TMSB10 thymosin beta 10 -0.0255875
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0255006
NPEPPS aminopeptidase puromycin sensitive -0.0252327
RPLP1 ribosomal protein, large, P1 -0.0238994
RPLP0 ribosomal protein, large, P0 -0.0225235
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0222926
TENT5A terminal nucleotidyltransferase 5A -0.0222805
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0219709
MAP1B microtubule-associated protein 1B -0.0215631
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0215325
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0214719
RPL23 ribosomal protein L23 -0.0209158
SCG2 secretogranin II -0.0205068
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0204219
BICD1 bicaudal D homolog 1 (Drosophila) -0.0201986
FAM107B family with sequence similarity 107, member B -0.0199944
CADM2 cell adhesion molecule 2 -0.0195805
NBEA neurobeachin -0.0194199
RCOR3 REST corepressor 3 -0.0193316
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0190834
PTEN phosphatase and tensin homolog -0.0189858
COL4A5 collagen, type IV, alpha 5 -0.0188469
BCAS3 breast carcinoma amplified sequence 3 -0.0179768
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -0.0177489
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0175818
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0174139
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0173344
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0172824
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0168397
FTL ferritin, light polypeptide -0.0163549
THBS1 thrombospondin 1 -0.0162678
SDC2 syndecan 2 -0.0162187
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0161466
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0160244
STXBP4 syntaxin binding protein 4 -0.0159899
SIK3 SIK family kinase 3 -0.0156554
KLHL13 kelch-like family member 13 -0.0156462
ZC3H11A zinc finger CCCH-type containing 11A -0.0155491
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0154494
RPS24 ribosomal protein S24 -0.0153151
UNK unkempt family zinc finger -0.0152518
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0151098
COL3A1 collagen, type III, alpha 1 -0.0150218
PLAT plasminogen activator, tissue -0.0149785
ACBD3 acyl-CoA binding domain containing 3 -0.0145092
ARHGAP24 Rho GTPase activating protein 24 -0.0144833
RPS19 ribosomal protein S19 -0.0143176
RGS5 regulator of G-protein signaling 5 -0.0142359
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0141263
STK38L serine/threonine kinase 38 like -0.0140677
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0140661
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0140565
WDR36 WD repeat domain 36 -0.0138955
TRAM1 translocation associated membrane protein 1 -0.0137205
FBXL20 F-box and leucine-rich repeat protein 20 -0.013718
PCDH9 protocadherin 9 -0.0137031
ITGAV integrin, alpha V -0.0136437
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0136277
GREM2 gremlin 2, DAN family BMP antagonist -0.0136077
RPS5 ribosomal protein S5 -0.0134475
SLIT2 slit homolog 2 (Drosophila) -0.0134218
NEMF nuclear export mediator factor -0.0133628
DISP1 dispatched homolog 1 (Drosophila) -0.0132986
ABLIM1 actin binding LIM protein 1 -0.0132874
DSTN destrin (actin depolymerizing factor) -0.0132598
NRP1 neuropilin 1 -0.013252
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0132383
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.0131631
COL4A6 collagen, type IV, alpha 6 -0.0129813
BSG basigin (Ok blood group) -0.0128967
PTPRK protein tyrosine phosphatase, receptor type, K -0.0128834
ZBTB20 zinc finger and BTB domain containing 20 -0.0128508
TM9SF3 transmembrane 9 superfamily member 3 -0.0127473
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0127275
SSBP2 single-stranded DNA binding protein 2 -0.0127083
CTBP2 C-terminal binding protein 2 -0.0126523
IARS1 isoleucyl-tRNA synthetase 1 -0.0126398
KDM4C lysine (K)-specific demethylase 4C -0.0126014
COL6A1 collagen, type VI, alpha 1 -0.0125956
BMERB1 bMERB domain containing 1 -0.0125854
NCAM2 neural cell adhesion molecule 2 -0.0125787
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 -0.0125443
TPM4 tropomyosin 4 -0.0124703
HMGA1 high mobility group AT-hook 1 -0.0124275
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0124222
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0123675
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0123079
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0122997