| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Furosemide perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Furosemide_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.108104 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.100562 |
| C3 | complement component 3 | 0.080936 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0796594 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0670386 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0664837 |
| SVIL | supervillin | 0.0662293 |
| IGF2 | insulin-like growth factor 2 | 0.0638202 |
| VEGFA | vascular endothelial growth factor A | 0.0551814 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0479814 |
| DSPP | dentin sialophosphoprotein | 0.0460842 |
| FN1 | fibronectin 1 | 0.0448544 |
| MT2A | metallothionein 2A | 0.0446996 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0404585 |
| FAT1 | FAT atypical cadherin 1 | 0.0385033 |
| APOB | apolipoprotein B | 0.0380507 |
| SMAD3 | SMAD family member 3 | 0.0348201 |
| ATXN1 | ataxin 1 | 0.0341558 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.032459 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0302066 |
| RPS12 | ribosomal protein S12 | 0.0293805 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0284763 |
| RPL37A | ribosomal protein L37a | 0.0283609 |
| AHNAK | AHNAK nucleoprotein | 0.0281373 |
| AFDN | afadin, adherens junction formation factor | 0.027583 |
| INTS6 | integrator complex subunit 6 | 0.0274804 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0262751 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0261568 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0258456 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0253393 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0252363 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0249363 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0248949 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0231823 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0229562 |
| TNS1 | tensin 1 | 0.0223194 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0221267 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0218059 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0216533 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0206274 |
| ITGB5 | integrin, beta 5 | 0.020404 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0203226 |
| PLEC | plectin | 0.0198918 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0198577 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.019837 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0196434 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0196219 |
| ENO1 | enolase 1, (alpha) | 0.0192517 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0191828 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0189861 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0189367 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0188684 |
| CCN2 | cellular communication network factor 2 | 0.0186641 |
| SEPTIN9 | septin 9 | 0.018118 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0179997 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0175661 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0170687 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0168341 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.016752 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.016662 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0165908 |
| PKP4 | plakophilin 4 | 0.0164388 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0156494 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0156402 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0155979 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0155066 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0155037 |
| PRELID2 | PRELI domain containing 2 | 0.0154713 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0150639 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0149748 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0147943 |
| CTSB | cathepsin B | 0.0145916 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0143155 |
| RAD51B | RAD51 paralog B | 0.0141033 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0140618 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0139841 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0139258 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0138172 |
| BCL2L1 | BCL2-like 1 | 0.013613 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0135979 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0135899 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0134758 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0133119 |
| FLNA | filamin A, alpha | 0.0132592 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0129679 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | 0.0128108 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0127925 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0126647 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0124905 |
| YAP1 | Yes-associated protein 1 | 0.0124183 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0124105 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0122659 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0121852 |
| RPL28 | ribosomal protein L28 | 0.0121403 |
| SBF2 | SET binding factor 2 | 0.012062 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0119657 |
| AHR | aryl hydrocarbon receptor | 0.011961 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0118868 |
| JAG1 | jagged 1 | 0.0118776 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.011685 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.126067 |
| GPC3 | glypican 3 | -0.0963737 |
| TMSB10 | thymosin beta 10 | -0.0947608 |
| APOA2 | apolipoprotein A-II | -0.0798856 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0780308 |
| PLIN2 | perilipin 2 | -0.0586288 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0576171 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0574508 |
| VCL | vinculin | -0.0566084 |
| HMGA1 | high mobility group AT-hook 1 | -0.0561712 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0554103 |
| RPS24 | ribosomal protein S24 | -0.0488706 |
| CP | ceruloplasmin (ferroxidase) | -0.0477932 |
| FTL | ferritin, light polypeptide | -0.044571 |
| RPLP1 | ribosomal protein, large, P1 | -0.0440968 |
| ASPH | aspartate beta-hydroxylase | -0.043947 |
| TMEM123 | transmembrane protein 123 | -0.0429678 |
| EHBP1 | EH domain binding protein 1 | -0.0420588 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.039805 |
| NPR2 | natriuretic peptide receptor 2 | -0.0390043 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0388144 |
| TPM4 | tropomyosin 4 | -0.0375135 |
| AHSG | alpha-2-HS-glycoprotein | -0.0354403 |
| APOE | apolipoprotein E | -0.0354364 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.035323 |
| TRIM26 | tripartite motif containing 26 | -0.0343027 |
| GNAS | GNAS complex locus | -0.0342505 |
| RPLP0 | ribosomal protein, large, P0 | -0.0323412 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0315532 |
| PERP | PERP, TP53 apoptosis effector | -0.0308592 |
| LYZ | lysozyme | -0.0307449 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.030513 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0298198 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0292459 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.029055 |
| RPS6 | ribosomal protein S6 | -0.0278787 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0277947 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0276734 |
| RBM25 | RNA binding motif protein 25 | -0.0249008 |
| ITGAV | integrin, alpha V | -0.0248691 |
| LDHA | lactate dehydrogenase A | -0.0246189 |
| RPL34 | ribosomal protein L34 | -0.0244317 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0239294 |
| PTCHD4 | patched domain containing 4 | -0.0236257 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0235103 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0230143 |
| EGR1 | early growth response 1 | -0.0222602 |
| HMGA2 | high mobility group AT-hook 2 | -0.0221044 |
| RBM39 | RNA binding motif protein 39 | -0.0216064 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0206944 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0206664 |
| PEG3 | paternally expressed 3 | -0.0205304 |
| MIDN | midnolin | -0.0205287 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0203816 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0201914 |
| RPS21 | ribosomal protein S21 | -0.0201584 |
| PTMA | prothymosin, alpha | -0.0200244 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0199824 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0198682 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0198151 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0193723 |
| RPL11 | ribosomal protein L11 | -0.0192825 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.019222 |
| VDAC1 | voltage-dependent anion channel 1 | -0.018985 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0187987 |
| FILIP1L | filamin A interacting protein 1-like | -0.0187836 |
| RPL31 | ribosomal protein L31 | -0.0186081 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0185482 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0183633 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0181064 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0179983 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.017967 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0178494 |
| RPL12 | ribosomal protein L12 | -0.0177941 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0176497 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0168473 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0167241 |
| GPC6 | glypican 6 | -0.016699 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0166457 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0165342 |
| RPS5 | ribosomal protein S5 | -0.0162534 |
| WDR45B | WD repeat domain 45B | -0.0161693 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -0.016164 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0159939 |
| DNAAF9 | dynein axonemal assembly factor 9 | -0.0159297 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0158729 |
| RIGI | RNA sensor RIG-I | -0.015781 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0156897 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.015497 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0154258 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0153951 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.015385 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0150873 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0149924 |
| LAP3 | leucine aminopeptidase 3 | -0.0148873 |
| CBX3 | chromobox homolog 3 | -0.0148172 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0147909 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0147455 |
| S100A6 | S100 calcium binding protein A6 | -0.0147092 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0145952 |
