Furosemide_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Furosemide perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Furosemide_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.0821069
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0666034
NAMPT nicotinamide phosphoribosyltransferase 0.0628822
CD44 CD44 molecule (Indian blood group) 0.0605927
CLU clusterin 0.0593229
MEF2A myocyte enhancer factor 2A 0.0583643
ANXA2 annexin A2 0.0489462
TMSB4X thymosin beta 4, X-linked 0.0476932
MYOF myoferlin 0.0472252
BHLHE40 basic helix-loop-helix family, member e40 0.0463254
AHNAK AHNAK nucleoprotein 0.0461808
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0441636
FTH1 ferritin, heavy polypeptide 1 0.0426593
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0420027
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0390393
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0384918
ENO1 enolase 1, (alpha) 0.0372466
KIAA1217 KIAA1217 0.0366083
EMP1 epithelial membrane protein 1 0.0352952
DSCAM Down syndrome cell adhesion molecule 0.0348854
ESYT2 extended synaptotagmin-like protein 2 0.0343515
ARRDC3 arrestin domain containing 3 0.0340509
MBNL1 muscleblind-like splicing regulator 1 0.032114
SMAD3 SMAD family member 3 0.0316202
H1-0 H1.0 linker histone 0.0303875
CUL4B cullin 4B 0.0299985
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0296663
HLA-A major histocompatibility complex, class I, A 0.0281256
KMT2E lysine (K)-specific methyltransferase 2E 0.0274833
EZR ezrin 0.0273105
FOXO1 forkhead box O1 0.0271957
AHNAK2 AHNAK nucleoprotein 2 0.02662
TXNIP thioredoxin interacting protein 0.0260668
ZNF292 zinc finger protein 292 0.0260647
TGM2 transglutaminase 2 0.0259041
YBX3 Y box binding protein 3 0.0258118
OSMR oncostatin M receptor 0.0255266
LIFR leukemia inhibitory factor receptor alpha 0.024346
MARCHF6 membrane associated ring-CH-type finger 6 0.0239954
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.023874
TPM3 tropomyosin 3 0.0233321
RIN2 Ras and Rab interactor 2 0.0233118
MEGF6 multiple EGF-like-domains 6 0.0225791
HLA-C major histocompatibility complex, class I, C 0.0225353
PRELID2 PRELI domain containing 2 0.0224912
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0220105
CEMIP cell migration inducing protein, hyaluronan binding 0.0217594
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0215094
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0209132
ASPH aspartate beta-hydroxylase 0.0208968
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0208165
KLF5 Kruppel-like factor 5 (intestinal) 0.0207541
KDM3A lysine (K)-specific demethylase 3A 0.0207489
RB1CC1 RB1-inducible coiled-coil 1 0.0200988
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0197472
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0194406
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.01935
ZNFX1 zinc finger, NFX1-type containing 1 0.0190504
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0189413
HLA-B major histocompatibility complex, class I, B 0.0187481
AFAP1 actin filament associated protein 1 0.0187065
PLAT plasminogen activator, tissue 0.0181843
AOPEP aminopeptidase O (putative) 0.0180877
PLEC plectin 0.017966
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0179305
ANGPTL4 angiopoietin-like 4 0.017901
PDGFB platelet-derived growth factor beta polypeptide 0.0178541
DUSP6 dual specificity phosphatase 6 0.017827
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0176648
STAU1 staufen double-stranded RNA binding protein 1 0.0173034
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.017215
RIPK2 receptor-interacting serine-threonine kinase 2 0.0170873
HOOK2 hook microtubule-tethering protein 2 0.0168489
IGF2 insulin-like growth factor 2 0.0168383
SLK STE20-like kinase 0.0167112
SYNJ2 synaptojanin 2 0.0164936
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0163901
ANXA11 annexin A11 0.0163276
RPS3 ribosomal protein S3 0.0162812
CSNK1A1 casein kinase 1, alpha 1 0.0162713
MTSS1 metastasis suppressor 1 0.0161987
LOC112694756 uncharaterized LOC112694756 0.0161867
EEF2 eukaryotic translation elongation factor 2 0.016131
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.016128
EPHA2 EPH receptor A2 0.0160927
NAP1L1 nucleosome assembly protein 1-like 1 0.0160012
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.015971
SLTM SAFB-like, transcription modulator 0.0158506
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0157978
BCL2L1 BCL2-like 1 0.0157658
RIOK3 RIO kinase 3 0.0156788
GBP4 guanylate binding protein 4 0.015653
PODXL podocalyxin-like 0.015437
NTSR1 neurotensin receptor 1 (high affinity) 0.0152743
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0152143
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.015159
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0150863
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0150727
FNIP1 folliculin interacting protein 1 0.0150133
PHF21A PHD finger protein 21A 0.0149024

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.103175
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0837548
TMSB10 thymosin beta 10 -0.0769707
ALCAM activated leukocyte cell adhesion molecule -0.0642244
PTMA prothymosin, alpha -0.0613739
PDLIM5 PDZ and LIM domain 5 -0.0567301
INTS6 integrator complex subunit 6 -0.0556621
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0537763
DPYD dihydropyrimidine dehydrogenase -0.0510686
POTEF POTE ankyrin domain family, member F -0.050093
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0486361
PLS3 plastin 3 -0.0429392
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0429267
RPS6 ribosomal protein S6 -0.0407648
PALLD palladin, cytoskeletal associated protein -0.0398182
HSPG2 heparan sulfate proteoglycan 2 -0.038443
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0377133
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0375249
LDHA lactate dehydrogenase A -0.0374676
RPLP1 ribosomal protein, large, P1 -0.0358728
SLC35F3 solute carrier family 35, member F3 -0.0355355
UTRN utrophin -0.034568
ANO1 anoctamin 1, calcium activated chloride channel -0.0332386
FTL ferritin, light polypeptide -0.0328851
ITGA6 integrin, alpha 6 -0.0319448
ZMYND8 zinc finger, MYND-type containing 8 -0.0302751
CDK6 cyclin-dependent kinase 6 -0.0295352
DGKH diacylglycerol kinase, eta -0.0293692
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0292976
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0292116
PSD3 pleckstrin and Sec7 domain containing 3 -0.0290141
RPS25 ribosomal protein S25 -0.0288595
FLNB filamin B, beta -0.0280814
TPM4 tropomyosin 4 -0.0272473
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0267849
HMGA2 high mobility group AT-hook 2 -0.0258947
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0257008
RPS23 ribosomal protein S23 -0.0252164
RPL31 ribosomal protein L31 -0.0251264
PKM pyruvate kinase, muscle -0.0248402
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0244737
KRT17 keratin 17, type I -0.0237315
S100A10 S100 calcium binding protein A10 -0.0229609
RASAL2 RAS protein activator like 2 -0.0229486
SULF2 sulfatase 2 -0.0228551
ENO2 enolase 2 (gamma, neuronal) -0.0223272
VDAC1 voltage-dependent anion channel 1 -0.0219021
WASF2 WAS protein family, member 2 -0.0212755
CYB5R3 cytochrome b5 reductase 3 -0.0210412
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0208116
RPS24 ribosomal protein S24 -0.0202932
RPL11 ribosomal protein L11 -0.0199438
RPS29 ribosomal protein S29 -0.0197674
RCOR1 REST corepressor 1 -0.0197084
SULF1 sulfatase 1 -0.0196535
S100A2 S100 calcium binding protein A2 -0.0196218
PRSS23 protease, serine, 23 -0.0194462
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.0193719
RPLP2 ribosomal protein, large, P2 -0.0193228
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.019197
RPL23 ribosomal protein L23 -0.0189006
HMGA1 high mobility group AT-hook 1 -0.0188834
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0187982
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.0185949
HM13 histocompatibility (minor) 13 -0.0184908
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0184492
C4BPB complement component 4 binding protein, beta -0.0177791
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0177664
RAP1B RAP1B, member of RAS oncogene family -0.0176839
IARS1 isoleucyl-tRNA synthetase 1 -0.0176078
KIAA1671 KIAA1671 -0.0175282
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0174367
DOCK9 dedicator of cytokinesis 9 -0.0173199
MDK midkine (neurite growth-promoting factor 2) -0.0172873
IFI27 interferon, alpha-inducible protein 27 -0.0172296
EGFR epidermal growth factor receptor -0.0171194
NCKAP5 NCK-associated protein 5 -0.0171017
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.01703
RPS13 ribosomal protein S13 -0.0169596
F3 coagulation factor III (thromboplastin, tissue factor) -0.0168715
RAB2A RAB2A, member RAS oncogene family -0.016871
EFHD2 EF-hand domain family, member D2 -0.016317
RPL34 ribosomal protein L34 -0.0163014
DLG1 discs, large homolog 1 (Drosophila) -0.016265
GUK1 guanylate kinase 1 -0.0162642
S100A11 S100 calcium binding protein A11 -0.0159281
FSCN1 fascin actin-bundling protein 1 -0.0158817
TAGLN2 transgelin 2 -0.0158091
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.0157034
ITSN1 intersectin 1 (SH3 domain protein) -0.0155618
PDS5B PDS5 cohesin associated factor B -0.0155199
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0155094
RABGAP1L RAB GTPase activating protein 1-like -0.0155044
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.015472
FRMD6 FERM domain containing 6 -0.0154037
FBXO11 F-box protein 11 -0.0150932
RPS14 ribosomal protein S14 -0.0150216
RPS17 ribosomal protein S17 -0.0148357
GNAS GNAS complex locus -0.0148017
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.014767