Furosemide_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Furosemide perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Furosemide_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.129532
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0701677
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0620425
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0604619
LAMB3 laminin, beta 3 0.0482002
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0429962
VEGFA vascular endothelial growth factor A 0.0418483
ELL2 elongation factor, RNA polymerase II, 2 0.0391995
IGFBP3 insulin-like growth factor binding protein 3 0.0390747
TSC22D2 TSC22 domain family, member 2 0.0375703
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0375226
TRIO trio Rho guanine nucleotide exchange factor 0.0371191
FTH1 ferritin, heavy polypeptide 1 0.0353934
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0348907
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0326577
TXNIP thioredoxin interacting protein 0.0269854
ARRDC3 arrestin domain containing 3 0.0267754
BHLHE40 basic helix-loop-helix family, member e40 0.0267365
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0252544
FAM13A family with sequence similarity 13, member A 0.0244706
TPM3 tropomyosin 3 0.0239554
UBA6 ubiquitin-like modifier activating enzyme 6 0.0230675
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0229458
DSCAM Down syndrome cell adhesion molecule 0.0212407
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0205908
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0205478
SDC4 syndecan 4 0.0204566
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.020315
RBM25 RNA binding motif protein 25 0.0199859
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0199584
YTHDC1 YTH domain containing 1 0.019649
MSN moesin 0.0194975
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0191615
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0190442
CTSB cathepsin B 0.0181614
CCNL1 cyclin L1 0.0179388
APLP2 amyloid beta (A4) precursor-like protein 2 0.0177643
CD44 CD44 molecule (Indian blood group) 0.0174259
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0171538
ANKRD28 ankyrin repeat domain 28 0.0170909
SLMAP sarcolemma associated protein 0.0168848
RTN4 reticulon 4 0.0164025
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0163055
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0157776
AHNAK AHNAK nucleoprotein 0.0156987
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0155866
NAMPT nicotinamide phosphoribosyltransferase 0.0155115
MARCHF6 membrane associated ring-CH-type finger 6 0.0150285
F11R F11 receptor 0.0148667
MYO5B myosin VB 0.0145975
KIAA1217 KIAA1217 0.0143033
WDFY3 WD repeat and FYVE domain containing 3 0.0138429
MT2A metallothionein 2A 0.0136796
MYH9 myosin, heavy chain 9, non-muscle 0.0136408
EIF4A2 eukaryotic translation initiation factor 4A2 0.0135875
EPS8 epidermal growth factor receptor pathway substrate 8 0.0135673
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0134956
RUNX1 runt-related transcription factor 1 0.0133506
MACF1 microtubule-actin crosslinking factor 1 0.0130621
EZR ezrin 0.0130597
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0128949
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0128564
RASA2 RAS p21 protein activator 2 0.0127785
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0126609
UGCG UDP-glucose ceramide glucosyltransferase 0.0126334
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.012572
PUM1 pumilio RNA-binding family member 1 0.0125611
HSPA8 heat shock 70kDa protein 8 0.0122371
TFG TRK-fused gene 0.0119813
TMF1 TATA element modulatory factor 1 0.0119786
FLNA filamin A, alpha 0.0119585
FAM3C family with sequence similarity 3, member C 0.0118899
SMAD3 SMAD family member 3 0.0118658
HLA-A major histocompatibility complex, class I, A 0.0118503
DDIT4 DNA-damage-inducible transcript 4 0.0118491
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0117118
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0116558
MYO10 myosin X 0.0115699
KMT2E lysine (K)-specific methyltransferase 2E 0.0113659
NCKAP1 NCK-associated protein 1 0.0112994
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0112648
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0112171
CLDN4 claudin 4 0.0111864
MCTP2 multiple C2 domains, transmembrane 2 0.0111584
TJP2 tight junction protein 2 0.0111567
PLEC plectin 0.0111356
HLA-B major histocompatibility complex, class I, B 0.0110108
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0110012
FNDC3B fibronectin type III domain containing 3B 0.0109897
PCBP2 poly(rC) binding protein 2 0.0109351
FLNB filamin B, beta 0.0109083
OGA O-GlcNAcase 0.0109057
USP3 ubiquitin specific peptidase 3 0.0107504
SAMD4A sterile alpha motif domain containing 4A 0.0106307
FXR1 fragile X mental retardation, autosomal homolog 1 0.0104847
RIOK3 RIO kinase 3 0.0104753
EEF2 eukaryotic translation elongation factor 2 0.0104159
RNF145 ring finger protein 145 0.0103109
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0102998
NPTN neuroplastin 0.0102541

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0976595
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0586142
PTMA prothymosin, alpha -0.0496686
FTL ferritin, light polypeptide -0.0476489
RPLP1 ribosomal protein, large, P1 -0.0423115
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0417223
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0375755
LDHA lactate dehydrogenase A -0.0346102
EXT1 exostosin glycosyltransferase 1 -0.0344144
RPS24 ribosomal protein S24 -0.029997
S100A10 S100 calcium binding protein A10 -0.0297947
TPT1 tumor protein, translationally-controlled 1 -0.0296882
RPL34 ribosomal protein L34 -0.0296277
RPL23 ribosomal protein L23 -0.0292252
TPM4 tropomyosin 4 -0.0267679
VCL vinculin -0.0266048
FBXO32 F-box protein 32 -0.026601
CCND1 cyclin D1 -0.0265836
GNAS GNAS complex locus -0.0264271
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0257518
RPLP0 ribosomal protein, large, P0 -0.0234393
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0231157
KRT7 keratin 7, type II -0.0228065
EIF1 eukaryotic translation initiation factor 1 -0.0227949
RPS23 ribosomal protein S23 -0.0217437
LPP LIM domain containing preferred translocation partner in lipoma -0.0210279
S100A6 S100 calcium binding protein A6 -0.0209055
FBXO34 F-box protein 34 -0.0208331
RPL4 ribosomal protein L4 -0.0206595
RPS6 ribosomal protein S6 -0.0196888
RPS25 ribosomal protein S25 -0.0192824
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0191332
RPL32 ribosomal protein L32 -0.0188323
HMGA1 high mobility group AT-hook 1 -0.0186652
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0185299
ARF1 ADP-ribosylation factor 1 -0.0181895
PDLIM5 PDZ and LIM domain 5 -0.0167289
ARHGAP20 Rho GTPase activating protein 20 -0.0166253
TM4SF1 transmembrane 4 L six family member 1 -0.0163443
RPL30 ribosomal protein L30 -0.0162388
IFI16 interferon, gamma-inducible protein 16 -0.0162321
RPL19 ribosomal protein L19 -0.0160331
VIM vimentin -0.015993
ARHGAP5 Rho GTPase activating protein 5 -0.0159902
CANX calnexin -0.0159439
TKT transketolase -0.0159408
RPS20 ribosomal protein S20 -0.0158618
RACK1 receptor for activated C kinase 1 -0.0156971
BZW1 basic leucine zipper and W2 domains 1 -0.0156462
RPL35A ribosomal protein L35a -0.0154226
IFIH1 interferon induced with helicase C domain 1 -0.0153188
C15ORF48 chromosome 15 open reading frame 48 -0.0147006
CEP350 centrosomal protein 350kDa -0.0146676
PALLD palladin, cytoskeletal associated protein -0.0146526
RPL31 ribosomal protein L31 -0.0143766
ISG15 ISG15 ubiquitin-like modifier -0.0142382
RPS5 ribosomal protein S5 -0.0142211
RPS16 ribosomal protein S16 -0.0140009
F3 coagulation factor III (thromboplastin, tissue factor) -0.0139616
UBAP1 ubiquitin associated protein 1 -0.0136737
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0136731
LMO7 LIM domain 7 -0.0136265
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0136102
RPS17 ribosomal protein S17 -0.01352
RPL12 ribosomal protein L12 -0.0135104
OSBPL3 oxysterol binding protein-like 3 -0.013071
RPL27A ribosomal protein L27a -0.0130503
MCU mitochondrial calcium uniporter -0.012858
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0126332
CTSD cathepsin D -0.0125387
RPS19 ribosomal protein S19 -0.0124326
KRT18 keratin 18, type I -0.0124197
RPL11 ribosomal protein L11 -0.0121924
WARS1 tryptophanyl-tRNA synthetase 1 -0.0121168
HDLBP high density lipoprotein binding protein -0.0121038
SP100 SP100 nuclear antigen -0.01184
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0118169
RPL15 ribosomal protein L15 -0.0115703
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0115414
RPS13 ribosomal protein S13 -0.0113196
NPC2 Niemann-Pick disease, type C2 -0.0111106
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0110514
RPL8 ribosomal protein L8 -0.0107264
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0106993
EEF1G eukaryotic translation elongation factor 1 gamma -0.0106529
INTS6 integrator complex subunit 6 -0.0104549
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0103666
RIGI RNA sensor RIG-I -0.0101017
RPL9 ribosomal protein L9 -0.0100708
LAP3 leucine aminopeptidase 3 -0.0100519
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.010018
RPL26 ribosomal protein L26 -0.00986168
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.00974462
RPL7A ribosomal protein L7a -0.00972524
TAOK1 TAO kinase 1 -0.00966051
LIMCH1 LIM and calponin homology domains 1 -0.009659
FNIP1 folliculin interacting protein 1 -0.00965778
RPS4X ribosomal protein S4, X-linked -0.0096333
GOLGB1 golgin B1 -0.00950276
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.00943651