Furosemide_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Furosemide perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

121 genes differentially expressed following the Furosemide_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.143306
ELL2 elongation factor, RNA polymerase II, 2 0.124169
PDE4D phosphodiesterase 4D, cAMP-specific 0.084837
PDE10A phosphodiesterase 10A 0.0812646
LAMB3 laminin, beta 3 0.0712279
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0703297
P3H2 prolyl 3-hydroxylase 2 0.0667486
PSD3 pleckstrin and Sec7 domain containing 3 0.0626465
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0613024
ANXA2 annexin A2 0.056316
TXNRD1 thioredoxin reductase 1 0.0492521
EXT1 exostosin glycosyltransferase 1 0.0478286
EGFR epidermal growth factor receptor 0.0465183
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0460814
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0386802
EPS8 epidermal growth factor receptor pathway substrate 8 0.0378229
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0346221
FNDC3B fibronectin type III domain containing 3B 0.0332128
GRAMD1B GRAM domain containing 1B 0.0325195
LAMA4 laminin, alpha 4 0.0314565
TRIO trio Rho guanine nucleotide exchange factor 0.027541
TPT1 tumor protein, translationally-controlled 1 0.0257202
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0256853
PTK2 protein tyrosine kinase 2 0.0244728
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0243859
NDRG1 N-myc downstream regulated 1 0.0243576
PHF3 PHD finger protein 3 0.0231032
GLS2 glutaminase 2 (liver, mitochondrial) 0.0229104
PRKCA protein kinase C, alpha 0.0228707
STC1 stanniocalcin 1 0.0223537
EXOC4 exocyst complex component 4 0.0210318
PRRC2C proline-rich coiled-coil 2C 0.0201361
FMNL2 formin-like 2 0.0190434
ATXN1 ataxin 1 0.0181802
RPL19 ribosomal protein L19 0.0175241
ZNF609 zinc finger protein 609 0.0171105
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0154397
RORA RAR-related orphan receptor A 0.0153222
RAP1B RAP1B, member of RAS oncogene family 0.0134166
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0131319
RPL23 ribosomal protein L23 0.0109305
ARHGAP26 Rho GTPase activating protein 26 0.00993878
NAMPT nicotinamide phosphoribosyltransferase 0.00957616
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.00917222
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00703701
RPL26 ribosomal protein L26 0.00676909
OSMR oncostatin M receptor 0.00585925
RPS6 ribosomal protein S6 0.00448985

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.166494
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.155617
PKM pyruvate kinase, muscle -0.123267
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.10323
TMSB10 thymosin beta 10 -0.0896886
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0842494
AKAP12 A kinase (PRKA) anchor protein 12 -0.0829638
COL5A2 collagen, type V, alpha 2 -0.0813848
RIGI RNA sensor RIG-I -0.0802098
VIM vimentin -0.0773481
HMGA2 high mobility group AT-hook 2 -0.0764927
NF1 neurofibromin 1 -0.0664911
PGK1 phosphoglycerate kinase 1 -0.065615
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0638291
NAP1L1 nucleosome assembly protein 1-like 1 -0.06069
RPL35A ribosomal protein L35a -0.0600159
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0592657
B2M beta-2-microglobulin -0.0590081
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0547398
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0540919
GPC6 glypican 6 -0.0521159
MAP4 microtubule-associated protein 4 -0.0512072
SLC38A2 solute carrier family 38, member 2 -0.0510168
COL6A3 collagen, type VI, alpha 3 -0.0503789
LMO7 LIM domain 7 -0.0489648
RPL11 ribosomal protein L11 -0.0488118
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0482386
TAS2R14 taste receptor, type 2, member 14 -0.0472542
MAP1B microtubule-associated protein 1B -0.0453966
ANKRD11 ankyrin repeat domain 11 -0.045084
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0360375
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0341277
RNF213 ring finger protein 213 -0.0335794
RPS8 ribosomal protein S8 -0.0312938
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0311991
NAV1 neuron navigator 1 -0.0294808
CCNI cyclin I -0.0293067
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0256893
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0249079
RPS3 ribosomal protein S3 -0.0246952
LDHA lactate dehydrogenase A -0.0243405
PRELID2 PRELI domain containing 2 -0.0228803
FOXP1 forkhead box P1 -0.0217215
RPL34 ribosomal protein L34 -0.0210547
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0192339
RUNX1 runt-related transcription factor 1 -0.0192234
AKAP13 A kinase (PRKA) anchor protein 13 -0.0187533
NKD1 naked cuticle homolog 1 (Drosophila) -0.0182745
JARID2 jumonji, AT rich interactive domain 2 -0.017103
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0161197
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0158311
FTH1 ferritin, heavy polypeptide 1 -0.0141763
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0132157
FLNB filamin B, beta -0.0132088
PTMA prothymosin, alpha -0.0125174
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0122416
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0116634
NALF1 NALCN channel auxiliary factor 1 -0.0114011
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0101394
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.00908789
TBC1D22A TBC1 domain family, member 22A -0.00897801
MYO1E myosin IE -0.00831377
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.00811624
HLA-B major histocompatibility complex, class I, B -0.00774593
NCOA3 nuclear receptor coactivator 3 -0.00743115
JMJD1C jumonji domain containing 1C -0.00683603
AHNAK AHNAK nucleoprotein -0.00608695
MYO10 myosin X -0.00558621
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.00553777
IGFBP3 insulin-like growth factor binding protein 3 -0.00256539
ZBTB20 zinc finger and BTB domain containing 20 -0.00128016
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -8.3808E-4
ASPH aspartate beta-hydroxylase -6.08542E-4