Furosemide_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Furosemide perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Furosemide_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.193713
TGFBI transforming growth factor, beta-induced, 68kDa 0.112069
NDRG1 N-myc downstream regulated 1 0.103937
COL6A3 collagen, type VI, alpha 3 0.101272
VEGFA vascular endothelial growth factor A 0.0857878
FTH1 ferritin, heavy polypeptide 1 0.0839331
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0631287
MT2A metallothionein 2A 0.0586957
ERRFI1 ERBB receptor feedback inhibitor 1 0.05839
ELL2 elongation factor, RNA polymerase II, 2 0.0583258
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.05666
HLA-A major histocompatibility complex, class I, A 0.0546996
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0510371
ARRDC3 arrestin domain containing 3 0.0493696
NAMPT nicotinamide phosphoribosyltransferase 0.046742
FAM13A family with sequence similarity 13, member A 0.0455383
RUNX1 runt-related transcription factor 1 0.0448268
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0430005
NRXN3 neurexin 3 0.041964
STC1 stanniocalcin 1 0.0397011
AKAP9 A kinase (PRKA) anchor protein 9 0.0382646
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0355239
SHB Src homology 2 domain containing adaptor protein B 0.0349521
RAB1A RAB1A, member RAS oncogene family 0.0314945
COL5A1 collagen, type V, alpha 1 0.0309682
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0307606
TTC3 tetratricopeptide repeat domain 3 0.0304934
ADM adrenomedullin 0.029703
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0295192
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0281914
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0278739
EXT1 exostosin glycosyltransferase 1 0.0274908
TRIO trio Rho guanine nucleotide exchange factor 0.0274466
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0271547
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0264151
HLA-C major histocompatibility complex, class I, C 0.0263468
GOLGA4 golgin A4 0.0261449
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.025776
TMEM165 transmembrane protein 165 0.0254145
LOXL2 lysyl oxidase-like 2 0.0252474
SMAD3 SMAD family member 3 0.0251582
RTN4 reticulon 4 0.025154
CD44 CD44 molecule (Indian blood group) 0.0250267
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0249216
AKAP12 A kinase (PRKA) anchor protein 12 0.0246285
JARID2 jumonji, AT rich interactive domain 2 0.02461
MARCHF6 membrane associated ring-CH-type finger 6 0.0241424
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0239685
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0234282
GOLGB1 golgin B1 0.0232023
ESYT2 extended synaptotagmin-like protein 2 0.0230315
BHLHE40 basic helix-loop-helix family, member e40 0.0227064
ATXN1 ataxin 1 0.0225531
ATP13A3 ATPase type 13A3 0.0223902
NBAS neuroblastoma amplified sequence 0.0222205
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0214717
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.021208
BACE2 beta-site APP-cleaving enzyme 2 0.0211095
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0210394
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0208148
RNF24 ring finger protein 24 0.0207357
HILPDA hypoxia inducible lipid droplet-associated 0.0206997
SEPTIN9 septin 9 0.0206689
PRELID2 PRELI domain containing 2 0.0205133
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.020257
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0201724
SPAG9 sperm associated antigen 9 0.0200927
COPA coatomer protein complex, subunit alpha 0.020072
PTK2 protein tyrosine kinase 2 0.0200645
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0199477
MAML2 mastermind-like 2 (Drosophila) 0.0197143
HOOK2 hook microtubule-tethering protein 2 0.0196965
SEC31A SEC31 homolog A (S. cerevisiae) 0.0196335
TRA2A transformer 2 alpha homolog (Drosophila) 0.0196071
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0195847
FNDC3B fibronectin type III domain containing 3B 0.0195051
DDIT4 DNA-damage-inducible transcript 4 0.0194684
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0194409
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.019438
RICTOR RPTOR independent companion of MTOR, complex 2 0.0194301
DSCAM Down syndrome cell adhesion molecule 0.0192729
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0192487
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0190404
GSE1 Gse1 coiled-coil protein 0.0189759
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0186412
CLMP CXADR-like membrane protein 0.0186202
TFPI2 tissue factor pathway inhibitor 2 0.0185455
EEF2 eukaryotic translation elongation factor 2 0.0184957
CDK19 cyclin-dependent kinase 19 0.0182534
TPM3 tropomyosin 3 0.0181334
EGFR epidermal growth factor receptor 0.0180921
ZNF292 zinc finger protein 292 0.0178747
ANKHD1 ankyrin repeat and KH domain containing 1 0.0174168
ZBTB20 zinc finger and BTB domain containing 20 0.0172754
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0171321
ANXA2 annexin A2 0.0170545
FNIP1 folliculin interacting protein 1 0.0166253
CSNK1A1 casein kinase 1, alpha 1 0.0166146
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0166032
MON2 MON2 homolog (S. cerevisiae) 0.0165005

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.134612
VIM vimentin -0.0724422
FN1 fibronectin 1 -0.0657145
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0468136
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0463319
POTEF POTE ankyrin domain family, member F -0.0407393
CDH13 cadherin 13 -0.0405007
FTL ferritin, light polypeptide -0.0400708
COL1A2 collagen, type I, alpha 2 -0.0376907
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0336992
PTMA prothymosin, alpha -0.0301626
LDHA lactate dehydrogenase A -0.0301065
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0298116
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0267183
COL1A1 collagen, type I, alpha 1 -0.0260613
PRSS23 protease, serine, 23 -0.0255187
TNS3 tensin 3 -0.0247016
LOX lysyl oxidase -0.0236229
TPM4 tropomyosin 4 -0.0229208
COL5A2 collagen, type V, alpha 2 -0.0222437
RPLP1 ribosomal protein, large, P1 -0.0209783
VDAC1 voltage-dependent anion channel 1 -0.0199325
PDE10A phosphodiesterase 10A -0.0195529
TUBB tubulin, beta class I -0.0191743
TM4SF1 transmembrane 4 L six family member 1 -0.0190967
S100A6 S100 calcium binding protein A6 -0.0187392
RAB31 RAB31, member RAS oncogene family -0.017901
SOD2 superoxide dismutase 2, mitochondrial -0.0172691
VCL vinculin -0.0171943
MAP1B microtubule-associated protein 1B -0.0167134
CCND1 cyclin D1 -0.016594
RPS24 ribosomal protein S24 -0.016344
TMSB4X thymosin beta 4, X-linked -0.0161434
TNNC1 troponin C type 1 (slow) -0.0160557
ANLN anillin, actin binding protein -0.0154898
PDE4D phosphodiesterase 4D, cAMP-specific -0.0154547
TM9SF3 transmembrane 9 superfamily member 3 -0.0152569
TPM1 tropomyosin 1 (alpha) -0.0149422
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0148
RPL12 ribosomal protein L12 -0.0147046
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.014555
SLC38A2 solute carrier family 38, member 2 -0.0143971
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0141267
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.013916
CTSD cathepsin D -0.013778
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0137384
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0136045
SEPTIN7 septin 7 -0.0135132
CST3 cystatin C -0.0135129
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0134685
CLIC4 chloride intracellular channel 4 -0.0133961
CKAP4 cytoskeleton-associated protein 4 -0.0133757
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0133195
CAV1 caveolin 1, caveolae protein, 22kDa -0.0133124
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0133077
RPL31 ribosomal protein L31 -0.013292
RPS19 ribosomal protein S19 -0.0126912
TUBA1B tubulin, alpha 1b -0.0126564
CBX3 chromobox homolog 3 -0.0125662
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0125476
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase -0.0123872
RPL37 ribosomal protein L37 -0.0122258
FBN1 fibrillin 1 -0.0119871
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0117563
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0115758
TPI1 triosephosphate isomerase 1 -0.0115268
PDLIM5 PDZ and LIM domain 5 -0.0114821
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0113725
RPL5 ribosomal protein L5 -0.0112998
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0111687
RAD51B RAD51 paralog B -0.0109649
RRBP1 ribosome binding protein 1 -0.0108563
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0107457
PKM pyruvate kinase, muscle -0.0106504
SDK1 sidekick cell adhesion molecule 1 -0.0105766
SPDYA speedy/RINGO cell cycle regulator family member A -0.0105414
FRMD4A FERM domain containing 4A -0.0104928
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0104153
PLCB4 phospholipase C, beta 4 -0.01035
PALLD palladin, cytoskeletal associated protein -0.0103285
IFI16 interferon, gamma-inducible protein 16 -0.0102104
RAB6A RAB6A, member RAS oncogene family -0.0102
HMGB1 high mobility group box 1 -0.0101125
DST dystonin -0.0100169
ATP5F1B ATP synthase F1 subunit beta -0.00998334
GOLGA3 golgin A3 -0.00995813
NAV3 neuron navigator 3 -0.00989946
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.00974299
GPX8 glutathione peroxidase 8 (putative) -0.00969535
GNAS GNAS complex locus -0.00955977
RBM6 RNA binding motif protein 6 -0.00952034
NFE2L2 nuclear factor, erythroid 2-like 2 -0.00926672
THBS1 thrombospondin 1 -0.00924045
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0092233
LMAN2 lectin, mannose-binding 2 -0.00921001
ARL4C ADP-ribosylation factor-like 4C -0.00920205
ARHGAP21 Rho GTPase activating protein 21 -0.00918245
UBC ubiquitin C -0.00915507
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.00915238
KHSRP KH-type splicing regulatory protein -0.00909606