Furosemide_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Furosemide perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Furosemide_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.114618
PALM2AKAP2 PALM2 and AKAP2 fusion 0.064731
MACF1 microtubule-actin crosslinking factor 1 0.0630578
IGFBP3 insulin-like growth factor binding protein 3 0.0603955
FNDC3B fibronectin type III domain containing 3B 0.0577385
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0546325
ATXN1 ataxin 1 0.0533885
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0520907
SMAD3 SMAD family member 3 0.0519975
CD44 CD44 molecule (Indian blood group) 0.0467862
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0432079
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0413059
SMYD3 SET and MYND domain containing 3 0.0397553
DSCAM Down syndrome cell adhesion molecule 0.0393961
NAV2 neuron navigator 2 0.0387674
PRELID2 PRELI domain containing 2 0.0383077
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0379385
ANKRD11 ankyrin repeat domain 11 0.037227
SVIL supervillin 0.033996
PRKCA protein kinase C, alpha 0.0336515
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0334096
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0328458
NT5E 5'-nucleotidase, ecto (CD73) 0.0323603
ASPH aspartate beta-hydroxylase 0.0322648
TRIO trio Rho guanine nucleotide exchange factor 0.03218
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0314377
DST dystonin 0.0314184
INTS6 integrator complex subunit 6 0.0307016
ANO6 anoctamin 6 0.0299983
PBX3 pre-B-cell leukemia homeobox 3 0.0293846
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0279301
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.027863
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0272418
AHNAK2 AHNAK nucleoprotein 2 0.0272157
LPP LIM domain containing preferred translocation partner in lipoma 0.0269123
RAD51B RAD51 paralog B 0.0261655
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0261133
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0252392
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0249629
CAPRIN2 caprin family member 2 0.0245955
YAP1 Yes-associated protein 1 0.0245093
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.024492
IL1RAP interleukin 1 receptor accessory protein 0.0243071
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0236843
IQGAP1 IQ motif containing GTPase activating protein 1 0.0236576
MYH9 myosin, heavy chain 9, non-muscle 0.0236177
FLNB filamin B, beta 0.0234815
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0233243
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0232578
MKI67 marker of proliferation Ki-67 0.0230995
ERCC6L2 excision repair cross-complementation group 6-like 2 0.0226794
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0226095
ZFAND3 zinc finger, AN1-type domain 3 0.0224817
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0224783
SQSTM1 sequestosome 1 0.0220791
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0220344
APLP2 amyloid beta (A4) precursor-like protein 2 0.0218443
SLC38A2 solute carrier family 38, member 2 0.0218001
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.021733
MBD5 methyl-CpG binding domain protein 5 0.0213303
BCAR3 breast cancer anti-estrogen resistance 3 0.0211485
ZSWIM6 zinc finger, SWIM-type containing 6 0.0210784
LOC112694756 uncharaterized LOC112694756 0.0210629
EEF2 eukaryotic translation elongation factor 2 0.0205587
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0203869
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0202586
NBEA neurobeachin 0.0202103
AKAP12 A kinase (PRKA) anchor protein 12 0.0196953
CCDC91 coiled-coil domain containing 91 0.0196856
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0194455
ANKRD28 ankyrin repeat domain 28 0.0191528
STXBP1 syntaxin binding protein 1 0.0190883
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0190736
PDE4D phosphodiesterase 4D, cAMP-specific 0.019061
FMNL2 formin-like 2 0.0190213
BICD1 bicaudal D homolog 1 (Drosophila) 0.0189896
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0188664
SON SON DNA binding protein 0.0186341
FER fer (fps/fes related) tyrosine kinase 0.0185806
VMP1 vacuole membrane protein 1 0.0185084
FLNA filamin A, alpha 0.0184901
ELL2 elongation factor, RNA polymerase II, 2 0.018138
FBXL7 F-box and leucine-rich repeat protein 7 0.0180632
WWTR1 WW domain containing transcription regulator 1 0.0180082
BABAM2 BRISC and BRCA1 A complex member 2 0.0179679
APP amyloid beta (A4) precursor protein 0.0178488
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0178176
ACTN1 actinin, alpha 1 0.0177385
DGKD diacylglycerol kinase, delta 130kDa 0.0177002
PYGL phosphorylase, glycogen, liver 0.0176861
TJP1 tight junction protein 1 0.017615
SEPTIN9 septin 9 0.0175174
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0174066
FAM168A family with sequence similarity 168, member A 0.0174056
CKAP5 cytoskeleton associated protein 5 0.0173757
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0170321
GOLGB1 golgin B1 0.01697
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0168765
VCL vinculin 0.0167678
BHLHE40 basic helix-loop-helix family, member e40 0.0167388

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.0801734
TMSB10 thymosin beta 10 -0.0789224
PTMA prothymosin, alpha -0.0318357
RPLP1 ribosomal protein, large, P1 -0.0278281
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0268955
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0255081
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0250324
LDHA lactate dehydrogenase A -0.0236814
RPS23 ribosomal protein S23 -0.0227486
TPT1 tumor protein, translationally-controlled 1 -0.0209083
B2M beta-2-microglobulin -0.0206612
HILPDA hypoxia inducible lipid droplet-associated -0.0193676
NALCN sodium leak channel, non selective -0.0192207
EIF1 eukaryotic translation initiation factor 1 -0.0190169
GNAS GNAS complex locus -0.0184815
RACK1 receptor for activated C kinase 1 -0.0180869
BTG1 B-cell translocation gene 1, anti-proliferative -0.0179942
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0179752
FTL ferritin, light polypeptide -0.0173067
RPLP0 ribosomal protein, large, P0 -0.0169933
VDAC1 voltage-dependent anion channel 1 -0.016936
RPL32 ribosomal protein L32 -0.0166495
GOLGA4 golgin A4 -0.0160376
RPL15 ribosomal protein L15 -0.0152487
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0147603
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0145552
RPL11 ribosomal protein L11 -0.0145486
RPL12 ribosomal protein L12 -0.0143508
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0141056
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0139855
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0137645
RPS21 ribosomal protein S21 -0.0137541
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0136877
HMGA1 high mobility group AT-hook 1 -0.0135906
RPL36 ribosomal protein L36 -0.0132439
PFN1 profilin 1 -0.0130335
RPS28 ribosomal protein S28 -0.0130017
RPS6 ribosomal protein S6 -0.0128944
RPL35A ribosomal protein L35a -0.0128827
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -0.012837
S100A6 S100 calcium binding protein A6 -0.0127251
IER3 immediate early response 3 -0.0125441
ENO2 enolase 2 (gamma, neuronal) -0.0123947
RPL9 ribosomal protein L9 -0.0123648
RPS16 ribosomal protein S16 -0.0122584
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0121387
TPI1 triosephosphate isomerase 1 -0.0120726
ISG15 ISG15 ubiquitin-like modifier -0.0120053
WARS1 tryptophanyl-tRNA synthetase 1 -0.0119317
RPS20 ribosomal protein S20 -0.0118444
NPR2 natriuretic peptide receptor 2 -0.0118165
RPS15 ribosomal protein S15 -0.0116855
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0116585
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0114247
IGFBP4 insulin-like growth factor binding protein 4 -0.0112865
PARD3 par-3 family cell polarity regulator -0.0112859
RPS24 ribosomal protein S24 -0.0111256
RPL19 ribosomal protein L19 -0.010817
RPS19 ribosomal protein S19 -0.0107057
IFITM3 interferon induced transmembrane protein 3 -0.0106672
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0104811
RPL31 ribosomal protein L31 -0.0104378
NACA nascent polypeptide-associated complex alpha subunit -0.0103787
RBM25 RNA binding motif protein 25 -0.0103176
WDR45B WD repeat domain 45B -0.0102586
RPS8 ribosomal protein S8 -0.0102282
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0102258
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0102154
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.010116
GGNBP2 gametogenetin binding protein 2 -0.0100056
ENKUR enkurin, TRPC channel interacting protein -0.00980256
LMO7 LIM domain 7 -0.00974873
RPL23 ribosomal protein L23 -0.00974747
RPS25 ribosomal protein S25 -0.00966354
NDUFA4 NDUFA4, mitochondrial complex associated -0.00966248
MYL12B myosin, light chain 12B, regulatory -0.00959024
TMEM161B transmembrane protein 161B -0.00956855
TM4SF1 transmembrane 4 L six family member 1 -0.00952425
RPS14 ribosomal protein S14 -0.00944861
SAR1A secretion associated, Ras related GTPase 1A -0.00942865
RBM39 RNA binding motif protein 39 -0.0094231
ZEB2 zinc finger E-box binding homeobox 2 -0.00941912
TTK TTK protein kinase -0.00941505
RPS17 ribosomal protein S17 -0.00940383
PLIN2 perilipin 2 -0.00923579
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.00917506
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -0.00909461
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.00907658
RPL30 ribosomal protein L30 -0.00904266
CAPNS1 calpain, small subunit 1 -0.00902245
TSPAN4 tetraspanin 4 -0.00897899
NPEPPS aminopeptidase puromycin sensitive -0.00892874
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.00892339
PDLIM5 PDZ and LIM domain 5 -0.00891866
NPC2 Niemann-Pick disease, type C2 -0.00891801
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 -0.00891044
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0089013
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.00885706
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.00859267
CFH complement factor H -0.00858467