Fusidic acid_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in A549 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Fusidic acid_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.201838
ARHGAP26 Rho GTPase activating protein 26 0.15144
SMAD3 SMAD family member 3 0.085902
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0842264
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0775469
EPAS1 endothelial PAS domain protein 1 0.0671592
AKAP12 A kinase (PRKA) anchor protein 12 0.0665717
FNDC3B fibronectin type III domain containing 3B 0.0649517
SLC38A2 solute carrier family 38, member 2 0.0648934
KYNU kynureninase 0.0643999
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0625959
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0625814
NRIP1 nuclear receptor interacting protein 1 0.0622599
EXT1 exostosin glycosyltransferase 1 0.0611418
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0609304
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0606352
BMP6 bone morphogenetic protein 6 0.0599812
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0583603
VMP1 vacuole membrane protein 1 0.0560936
CEMIP cell migration inducing protein, hyaluronan binding 0.0524027
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0521005
ELL2 elongation factor, RNA polymerase II, 2 0.0515244
PABPC1 poly(A) binding protein, cytoplasmic 1 0.050942
FAM107B family with sequence similarity 107, member B 0.0492658
LDHA lactate dehydrogenase A 0.0489094
RND3 Rho family GTPase 3 0.0460103
ANXA2 annexin A2 0.0449503
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0436185
NAP1L1 nucleosome assembly protein 1-like 1 0.0434879
CMIP c-Maf inducing protein 0.0429325
WWOX WW domain containing oxidoreductase 0.0425114
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0409966
ASPH aspartate beta-hydroxylase 0.0409816
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0409493
DOCK4 dedicator of cytokinesis 4 0.040272
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0398262
MYH9 myosin, heavy chain 9, non-muscle 0.0393428
AKAP13 A kinase (PRKA) anchor protein 13 0.0387148
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0374699
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0371707
STAT1 signal transducer and activator of transcription 1, 91kDa 0.036395
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0360058
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.035573
RPL41 ribosomal protein L41 0.0350994
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0345881
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0341887
BASP1 brain abundant, membrane attached signal protein 1 0.0338803
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0337939
SPAG9 sperm associated antigen 9 0.0334261
KANK1 KN motif and ankyrin repeat domains 1 0.0334114
CAPRIN2 caprin family member 2 0.0334077
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0333951
AHR aryl hydrocarbon receptor 0.0331138
SMYD3 SET and MYND domain containing 3 0.0328999
DUSP16 dual specificity phosphatase 16 0.032212
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0316426
PKM pyruvate kinase, muscle 0.0314228
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0314114
CORO1C coronin, actin binding protein, 1C 0.0310528
ENO1 enolase 1, (alpha) 0.0310385
ALCAM activated leukocyte cell adhesion molecule 0.0305751
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0302724
DST dystonin 0.030186
RUNX1 runt-related transcription factor 1 0.0299212
BPTF bromodomain PHD finger transcription factor 0.029822
HSPA8 heat shock 70kDa protein 8 0.0294108
FNDC3A fibronectin type III domain containing 3A 0.0290366
MCL1 myeloid cell leukemia 1 0.0289324
TUT7 terminal uridylyl transferase 7 0.0286106
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0285158
ECT2 epithelial cell transforming 2 0.0283094
MCTP1 multiple C2 domains, transmembrane 1 0.0282379
USP9X ubiquitin specific peptidase 9, X-linked 0.0282168
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0281113
EEF2 eukaryotic translation elongation factor 2 0.0281006
RNF145 ring finger protein 145 0.0277303
ACTN4 actinin, alpha 4 0.0275294
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0273596
DSCAM Down syndrome cell adhesion molecule 0.0273267
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0272248
RBPMS RNA binding protein with multiple splicing 0.0271734
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0269441
FAT1 FAT atypical cadherin 1 0.0267747
FUS FUS RNA binding protein 0.026752
APP amyloid beta (A4) precursor protein 0.0264305
TM4SF1 transmembrane 4 L six family member 1 0.0263384
CD44 CD44 molecule (Indian blood group) 0.026146
PRKCE protein kinase C, epsilon 0.0261222
EIF4A2 eukaryotic translation initiation factor 4A2 0.0260296
CEP95 centrosomal protein 95kDa 0.0256501
MPRIP myosin phosphatase Rho interacting protein 0.0256482
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0256203
PRELID2 PRELI domain containing 2 0.0256157
TNIP1 TNFAIP3 interacting protein 1 0.0255128
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0254208
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0252392
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0251647
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0247479
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0244447
DOCK5 dedicator of cytokinesis 5 0.0243828

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.222767
NDRG1 N-myc downstream regulated 1 -0.167368
IGFBP4 insulin-like growth factor binding protein 4 -0.0990114
PDE4D phosphodiesterase 4D, cAMP-specific -0.0753365
CA12 carbonic anhydrase XII -0.0675469
EHBP1 EH domain binding protein 1 -0.0670317
LAMA5 laminin, alpha 5 -0.0628585
TNS3 tensin 3 -0.0568001
RIN2 Ras and Rab interactor 2 -0.0560002
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0559656
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0525222
TMSB10 thymosin beta 10 -0.0514471
EFNA5 ephrin-A5 -0.0506995
PTPRM protein tyrosine phosphatase, receptor type, M -0.0498957
FTH1 ferritin, heavy polypeptide 1 -0.0495518
LIMCH1 LIM and calponin homology domains 1 -0.0488102
MAP1B microtubule-associated protein 1B -0.0446723
AUTS2 autism susceptibility candidate 2 -0.0438192
GRB10 growth factor receptor-bound protein 10 -0.043534
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0432205
LTBP4 latent transforming growth factor beta binding protein 4 -0.0422671
RAD51B RAD51 paralog B -0.0414682
USP3 ubiquitin specific peptidase 3 -0.0406096
ANKRD11 ankyrin repeat domain 11 -0.0405564
RAI14 retinoic acid induced 14 -0.0402781
ANXA4 annexin A4 -0.0391639
ZBTB20 zinc finger and BTB domain containing 20 -0.0387968
GOLGA4 golgin A4 -0.0387613
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0377736
WASF2 WAS protein family, member 2 -0.0361778
ZMYND8 zinc finger, MYND-type containing 8 -0.0350455
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0349077
PARD3 par-3 family cell polarity regulator -0.0338229
SLC35F3 solute carrier family 35, member F3 -0.0331525
FA2H fatty acid 2-hydroxylase -0.0330397
IARS1 isoleucyl-tRNA synthetase 1 -0.0322005
HMGA1 high mobility group AT-hook 1 -0.0319443
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0319348
ZFHX3 zinc finger homeobox 3 -0.031219
RGS17 regulator of G-protein signaling 17 -0.031076
PRKCA protein kinase C, alpha -0.0307629
IGFBP1 insulin-like growth factor binding protein 1 -0.0304645
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0302455
MT1X metallothionein 1X -0.0301033
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0298592
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0293384
TBC1D5 TBC1 domain family, member 5 -0.0285466
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0284262
PBX1 pre-B-cell leukemia homeobox 1 -0.0282771
FLNB filamin B, beta -0.0279776
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0276769
PTBP3 polypyrimidine tract binding protein 3 -0.0276443
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0274865
SLC25A51 solute carrier family 25, member 51 -0.0273968
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0272422
MT2A metallothionein 2A -0.0271178
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0264305
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0262872
DENND1A DENN/MADD domain containing 1A -0.0262835
FAM13A family with sequence similarity 13, member A -0.0261092
PTK2 protein tyrosine kinase 2 -0.0258111
IGSF11 immunoglobulin superfamily, member 11 -0.0257507
S100A6 S100 calcium binding protein A6 -0.0256292
BIRC6 baculoviral IAP repeat containing 6 -0.02551
LAMB3 laminin, beta 3 -0.0251031
RPS19 ribosomal protein S19 -0.0249905
TPM4 tropomyosin 4 -0.0249191
ACTG1 actin gamma 1 -0.0248104
HIP1 huntingtin interacting protein 1 -0.0244088
DAPK1 death-associated protein kinase 1 -0.0242402
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0239531
SETD5 SET domain containing 5 -0.0237355
EGFR epidermal growth factor receptor -0.0236507
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 -0.0236107
AKR1C2 aldo-keto reductase family 1, member C2 -0.0233969
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0230605
PFN1 profilin 1 -0.023045
RAB27B RAB27B, member RAS oncogene family -0.0230152
SBF2 SET binding factor 2 -0.0229843
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0226322
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0225399
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.022104
PTMA prothymosin, alpha -0.0220313
VCL vinculin -0.0218886
GOLGB1 golgin B1 -0.021666
PCED1B PC-esterase domain containing 1B -0.0216569
CLMP CXADR-like membrane protein -0.0215725
DENND4A DENN/MADD domain containing 4A -0.0213489
RAB6A RAB6A, member RAS oncogene family -0.0211834
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0210766
CP ceruloplasmin (ferroxidase) -0.0209034
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0208345
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0207797
HELZ helicase with zinc finger -0.0206048
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.020566
COL7A1 collagen, type VII, alpha 1 -0.0205115
IRAK2 interleukin-1 receptor-associated kinase 2 -0.0203192
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0200588
TPM1 tropomyosin 1 (alpha) -0.0200306
RRBP1 ribosome binding protein 1 -0.0199272