Fusidic acid_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.238124
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.118365
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.111381
VEGFA vascular endothelial growth factor A 0.111268
TRIO trio Rho guanine nucleotide exchange factor 0.0866074
PDE10A phosphodiesterase 10A 0.0847676
FGFR1 fibroblast growth factor receptor 1 0.0730204
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0709856
FNDC3B fibronectin type III domain containing 3B 0.0687002
MYOF myoferlin 0.0682704
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0676337
PDE4B phosphodiesterase 4B, cAMP-specific 0.0614571
BCOR BCL6 corepressor 0.0585801
ANO6 anoctamin 6 0.057671
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0573375
TMSB4X thymosin beta 4, X-linked 0.0556723
PRELID2 PRELI domain containing 2 0.0541018
SPAG9 sperm associated antigen 9 0.0540128
FRMD6 FERM domain containing 6 0.053221
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.050329
AFF4 AF4/FMR2 family, member 4 0.0496929
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0496787
TOP2B topoisomerase (DNA) II beta 180kDa 0.0489595
TSHZ2 teashirt zinc finger homeobox 2 0.048715
NGLY1 N-glycanase 1 0.0470158
PKM pyruvate kinase, muscle 0.0463308
SFPQ splicing factor proline/glutamine-rich 0.0462427
KDM6A lysine (K)-specific demethylase 6A 0.0458321
IPO7 importin 7 0.0439912
FNIP1 folliculin interacting protein 1 0.0434531
DSCAM Down syndrome cell adhesion molecule 0.0428044
EEF2 eukaryotic translation elongation factor 2 0.0422676
GSE1 Gse1 coiled-coil protein 0.0420557
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0395494
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0394277
CTBP2 C-terminal binding protein 2 0.0390082
USP9X ubiquitin specific peptidase 9, X-linked 0.0387896
ATP11A ATPase, class VI, type 11A 0.0381273
ZMIZ1 zinc finger, MIZ-type containing 1 0.0376843
KDM4C lysine (K)-specific demethylase 4C 0.0356319
TSC22D1 TSC22 domain family, member 1 0.0352978
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.035094
GIGYF2 GRB10 interacting GYF protein 2 0.0349641
NUP58 nucleoporin 58 0.0342972
MACF1 microtubule-actin crosslinking factor 1 0.0340968
RPL3 ribosomal protein L3 0.0339708
PHF3 PHD finger protein 3 0.0333768
APLP2 amyloid beta (A4) precursor-like protein 2 0.0315839
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0314765
KMT2C lysine (K)-specific methyltransferase 2C 0.0312437
CLTC clathrin, heavy chain (Hc) 0.0311356
ZNF516 zinc finger protein 516 0.0310142
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0307412
GMDS GDP-mannose 4,6-dehydratase 0.0299223
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0294618
ZNF638 zinc finger protein 638 0.0293257
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0291359
HSPA8 heat shock 70kDa protein 8 0.0291096
BBX bobby sox homolog (Drosophila) 0.0286755
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0286351
ADM adrenomedullin 0.0286294
CAMTA1 calmodulin binding transcription activator 1 0.0283588
RAD51B RAD51 paralog B 0.028324
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0282102
CKAP5 cytoskeleton associated protein 5 0.0281668
IGF2R insulin-like growth factor 2 receptor 0.0280828
CDK19 cyclin-dependent kinase 19 0.0279353
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0277568
PICALM phosphatidylinositol binding clathrin assembly protein 0.0276465
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.027539
WNK1 WNK lysine deficient protein kinase 1 0.0274879
KANK1 KN motif and ankyrin repeat domains 1 0.0267537
EIF4B eukaryotic translation initiation factor 4B 0.0266669
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0265032
ZNF608 zinc finger protein 608 0.0262532
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0261975
YAP1 Yes-associated protein 1 0.0261566
ENO1 enolase 1, (alpha) 0.0260819
PPME1 protein phosphatase methylesterase 1 0.0257755
DENND5A DENN/MADD domain containing 5A 0.0255928
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0255926
NCKAP1 NCK-associated protein 1 0.0252208
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.0251966
PCM1 pericentriolar material 1 0.0251435
TMEM41B transmembrane protein 41B 0.0251318
SMC1A structural maintenance of chromosomes 1A 0.0250219
ANKRD36 ankyrin repeat domain 36 0.0250124
TPR translocated promoter region, nuclear basket protein 0.0246813
TNIP1 TNFAIP3 interacting protein 1 0.0246722
DDIT4 DNA-damage-inducible transcript 4 0.0245994
HYOU1 hypoxia up-regulated 1 0.0245748
ARRDC3 arrestin domain containing 3 0.0244976
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0244968
MYH9 myosin, heavy chain 9, non-muscle 0.0244054
DMXL1 Dmx-like 1 0.0242581
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0242417
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0242337
CDC73 cell division cycle 73 0.0240131
SMAP1 small ArfGAP 1 0.0238662
HOXA3 homeobox A3 0.0237106

decreased expression

Symbol Name Standardized Value
CADM2 cell adhesion molecule 2 -0.191843
VIM vimentin -0.157486
PRKG1 protein kinase, cGMP-dependent, type I -0.143626
PTMA prothymosin, alpha -0.136405
PEG10 paternally expressed 10 -0.133351
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.123397
MGP matrix Gla protein -0.109559
MEOX2 mesenchyme homeobox 2 -0.103192
TPK1 thiamin pyrophosphokinase 1 -0.0955937
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0924701
MEST mesoderm specific transcript -0.0768099
RPS6 ribosomal protein S6 -0.0750626
COL1A2 collagen, type I, alpha 2 -0.0656547
RPS24 ribosomal protein S24 -0.0602214
DLG1 discs, large homolog 1 (Drosophila) -0.0565721
ACTG1 actin gamma 1 -0.0562727
TMSB10 thymosin beta 10 -0.0561651
NFIA nuclear factor I/A -0.0518226
MAP1B microtubule-associated protein 1B -0.0492588
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0473882
NFIB nuclear factor I/B -0.0472184
RPLP1 ribosomal protein, large, P1 -0.0462832
RPL35A ribosomal protein L35a -0.0458782
RPS23 ribosomal protein S23 -0.0448044
RPL31 ribosomal protein L31 -0.0418764
SEPTIN11 septin 11 -0.0400991
RPL34 ribosomal protein L34 -0.0395035
RPS8 ribosomal protein S8 -0.0386838
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0385755
RPL12 ribosomal protein L12 -0.0372658
PDIA3 protein disulfide isomerase family A, member 3 -0.0362674
ATP5F1B ATP synthase F1 subunit beta -0.0361327
BTBD3 BTB (POZ) domain containing 3 -0.0360374
RPLP2 ribosomal protein, large, P2 -0.0355779
MTDH metadherin -0.0355331
FTL ferritin, light polypeptide -0.0342716
HMGB1 high mobility group box 1 -0.0338075
PDGFC platelet derived growth factor C -0.033048
SHROOM3 shroom family member 3 -0.0329722
CALD1 caldesmon 1 -0.0329022
TPM4 tropomyosin 4 -0.0323715
RPL23 ribosomal protein L23 -0.0318929
RPS14 ribosomal protein S14 -0.0316722
ZEB1 zinc finger E-box binding homeobox 1 -0.0316473
RHOBTB3 Rho-related BTB domain containing 3 -0.03084
RPL19 ribosomal protein L19 -0.0307338
COTL1 coactosin-like F-actin binding protein 1 -0.0306728
RPS15 ribosomal protein S15 -0.0305958
VCL vinculin -0.0304533
SOX4 SRY (sex determining region Y)-box 4 -0.0304155
RPS13 ribosomal protein S13 -0.0299267
RPL28 ribosomal protein L28 -0.0294042
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0293241
KDM5B lysine (K)-specific demethylase 5B -0.0290449
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0281547
RPS19 ribosomal protein S19 -0.0280272
RACK1 receptor for activated C kinase 1 -0.0275266
RPL37 ribosomal protein L37 -0.0275001
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0273499
SRPK1 SRSF protein kinase 1 -0.0272385
RPS29 ribosomal protein S29 -0.0270329
UBE2B ubiquitin-conjugating enzyme E2B -0.0262917
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0262842
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0262329
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0260777
RPS25 ribosomal protein S25 -0.0256485
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0255993
FOXC1 forkhead box C1 -0.0255855
MAML2 mastermind-like 2 (Drosophila) -0.025438
DSTN destrin (actin depolymerizing factor) -0.025429
DUSP6 dual specificity phosphatase 6 -0.0253762
TUBA1B tubulin, alpha 1b -0.0253664
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0251459
RPS5 ribosomal protein S5 -0.0249389
RPS21 ribosomal protein S21 -0.024886
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0248733
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0243535
RPL8 ribosomal protein L8 -0.023995
CENPE centromere protein E, 312kDa -0.0239089
RPL30 ribosomal protein L30 -0.0238199
DEK DEK proto-oncogene -0.0236194
RPL5 ribosomal protein L5 -0.0236168
ACACA acetyl-CoA carboxylase alpha -0.0233358
RPS11 ribosomal protein S11 -0.0231325
CDK6 cyclin-dependent kinase 6 -0.0230938
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0229366
MEIS2 Meis homeobox 2 -0.0229184
RPS10 ribosomal protein S10 -0.0226984
SEPTIN7 septin 7 -0.0226572
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0225109
GNAS GNAS complex locus -0.0224171
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0223098
NT5C2 5'-nucleotidase, cytosolic II -0.0221441
VEZT vezatin, adherens junctions transmembrane protein -0.0220671
LARP1 La ribonucleoprotein domain family, member 1 -0.0220527
ATAD5 ATPase family, AAA domain containing 5 -0.021806
LMNA lamin A/C -0.0216296
LOC112694756 uncharaterized LOC112694756 -0.0213841
CLINT1 clathrin interactor 1 -0.0213403
VDAC1 voltage-dependent anion channel 1 -0.0212625