Fusidic acid_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NCOA3 nuclear receptor coactivator 3 0.133036
FNDC3A fibronectin type III domain containing 3A 0.124483
VMP1 vacuole membrane protein 1 0.113661
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.105472
RPL23 ribosomal protein L23 0.0963348
CEMIP cell migration inducing protein, hyaluronan binding 0.0877779
EXT1 exostosin glycosyltransferase 1 0.0742604
INTS6 integrator complex subunit 6 0.0687083
CLTC clathrin, heavy chain (Hc) 0.0679358
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0647032
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0551176
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.054123
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0520275
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0515717
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0498081
DUSP16 dual specificity phosphatase 16 0.0497375
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.049614
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0490038
HSPA8 heat shock 70kDa protein 8 0.0487902
ATF6 activating transcription factor 6 0.047527
CSNK1A1 casein kinase 1, alpha 1 0.0471808
ADARB1 adenosine deaminase, RNA-specific, B1 0.0466131
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0465314
RCOR1 REST corepressor 1 0.0459233
SGMS1 sphingomyelin synthase 1 0.0428896
TSC22D2 TSC22 domain family, member 2 0.0417582
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0415602
RAB7A RAB7A, member RAS oncogene family 0.0412025
ALCAM activated leukocyte cell adhesion molecule 0.0404439
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0399041
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0396643
CUL3 cullin 3 0.0395716
PDLIM5 PDZ and LIM domain 5 0.0392866
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0391795
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0391785
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0381936
SLC38A2 solute carrier family 38, member 2 0.0378677
TRIO trio Rho guanine nucleotide exchange factor 0.0365549
VCL vinculin 0.0356884
FAM219A family with sequence similarity 219, member A 0.0343298
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0340969
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0336113
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0332594
SP100 SP100 nuclear antigen 0.0330465
SPAG9 sperm associated antigen 9 0.0328631
ZSWIM6 zinc finger, SWIM-type containing 6 0.0323929
ERRFI1 ERBB receptor feedback inhibitor 1 0.0323608
NAMPT nicotinamide phosphoribosyltransferase 0.0318772
MYO10 myosin X 0.0316264
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0315102
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0314865
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0306185
USP53 ubiquitin specific peptidase 53 0.0305887
STK4 serine/threonine kinase 4 0.0305304
MYO5B myosin VB 0.0304126
ATXN1 ataxin 1 0.0304114
NABP1 nucleic acid binding protein 1 0.0303216
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0302192
PPME1 protein phosphatase methylesterase 1 0.030031
GRB10 growth factor receptor-bound protein 10 0.0299554
HELZ helicase with zinc finger 0.0296811
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0292264
ANKRD11 ankyrin repeat domain 11 0.0291391
KMT2E lysine (K)-specific methyltransferase 2E 0.0290885
WWC1 WW and C2 domain containing 1 0.0290133
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0288682
USP9X ubiquitin specific peptidase 9, X-linked 0.0286823
TRA2B transformer 2 beta homolog (Drosophila) 0.0285329
SMAD3 SMAD family member 3 0.0281974
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0281932
GPATCH2L G patch domain containing 2-like 0.028127
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0275734
YAP1 Yes-associated protein 1 0.027503
FNBP1 formin binding protein 1 0.0273487
KRT86 keratin 86, type II 0.0273325
TRA2A transformer 2 alpha homolog (Drosophila) 0.0271284
MYO1B myosin IB 0.02711
ADGRG6 adhesion G protein-coupled receptor G6 0.0270684
PAWR PRKC, apoptosis, WT1, regulator 0.0269667
CELF1 CUGBP, Elav-like family member 1 0.0268371
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0268277
USP15 ubiquitin specific peptidase 15 0.0265244
MCL1 myeloid cell leukemia 1 0.0261514
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0261377
MACF1 microtubule-actin crosslinking factor 1 0.0259672
STXBP4 syntaxin binding protein 4 0.0259305
ANKRD12 ankyrin repeat domain 12 0.0258759
SEPTIN9 septin 9 0.0258082
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0256739
FMNL2 formin-like 2 0.0255532
ACTN1 actinin, alpha 1 0.0254848
RPS3 ribosomal protein S3 0.0254544
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0253857
LDHA lactate dehydrogenase A 0.0251379
WSB1 WD repeat and SOCS box containing 1 0.0251329
MYH9 myosin, heavy chain 9, non-muscle 0.0250615
MYO1E myosin IE 0.0248686
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 0.0248532
NEBL nebulette 0.0247569
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.024653

decreased expression

Symbol Name Standardized Value
ZMYND8 zinc finger, MYND-type containing 8 -0.252077
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0952449
IGFBP5 insulin-like growth factor binding protein 5 -0.0948298
ACACA acetyl-CoA carboxylase alpha -0.0908488
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0880005
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0865843
FTH1 ferritin, heavy polypeptide 1 -0.0714523
PBX1 pre-B-cell leukemia homeobox 1 -0.0666758
LASP1 LIM and SH3 protein 1 -0.0635706
CCND1 cyclin D1 -0.0626361
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0551342
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.0549636
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0532383
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0482894
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -0.0477494
FADS2 fatty acid desaturase 2 -0.0470763
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0424129
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0413819
FASN fatty acid synthase -0.0403227
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0375729
OSMR oncostatin M receptor -0.0331089
RAB6A RAB6A, member RAS oncogene family -0.0322196
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0296178
LDLR low density lipoprotein receptor -0.0289178
ZNF652 zinc finger protein 652 -0.0287868
FDPS farnesyl diphosphate synthase -0.0285513
DENND1B DENN/MADD domain containing 1B -0.0284156
BCAS1 breast carcinoma amplified sequence 1 -0.027355
CATSPERB catsper channel auxiliary subunit beta -0.0273303
TMC5 transmembrane channel-like 5 -0.027314
INSIG1 insulin induced gene 1 -0.0270915
IDI1 isopentenyl-diphosphate delta isomerase 1 -0.0269732
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0268534
TBC1D5 TBC1 domain family, member 5 -0.0265719
TMEM41B transmembrane protein 41B -0.0261492
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0260925
PTMA prothymosin, alpha -0.0259033
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0257118
CCSER1 coiled-coil serine-rich protein 1 -0.0252953
TNS3 tensin 3 -0.024973
NIPSNAP2 nipsnap homolog 2 -0.0248412
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0245227
TPM4 tropomyosin 4 -0.0242526
MSMO1 methylsterol monooxygenase 1 -0.0238537
NCOA6 nuclear receptor coactivator 6 -0.0235954
DSTN destrin (actin depolymerizing factor) -0.0235646
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0230825
MACC1 metastasis associated in colon cancer 1 -0.0217247
S100A9 S100 calcium binding protein A9 -0.0217099
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0214111
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0213979
TMEM123 transmembrane protein 123 -0.0213349
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0211575
KRT19 keratin 19, type I -0.0209516
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -0.0207228
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0205202
MMP24OS MMP24 opposite strand -0.0203993
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0202908
DHFR dihydrofolate reductase -0.01978
DNAH14 dynein, axonemal, heavy chain 14 -0.0197607
SREBF2 sterol regulatory element binding transcription factor 2 -0.0197446
MUSK muscle, skeletal, receptor tyrosine kinase -0.0197385
LOC102724023 ES1 protein homolog, mitochondrial -0.0196445
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0195819
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0195714
RAB27B RAB27B, member RAS oncogene family -0.019387
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0192516
EXOC4 exocyst complex component 4 -0.0191574
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0190897
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 -0.0190679
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0189689
TMEM165 transmembrane protein 165 -0.0188665
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0188586
AUTS2 autism susceptibility candidate 2 -0.0184057
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0183139
SBF2 SET binding factor 2 -0.0182908
RESF1 retroelement silencing factor 1 -0.0182564
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0179966
KAZN kazrin, periplakin interacting protein -0.0177696
RAI14 retinoic acid induced 14 -0.0176318
RBM47 RNA binding motif protein 47 -0.0175199
TMSB4X thymosin beta 4, X-linked -0.0174986
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0172496
THSD4 thrombospondin, type I, domain containing 4 -0.0171627
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0170775
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0170765
PHF14 PHD finger protein 14 -0.0170599
PDIA3 protein disulfide isomerase family A, member 3 -0.0169778
ESRP1 epithelial splicing regulatory protein 1 -0.0169152
MAP4 microtubule-associated protein 4 -0.0169116
ACTG1 actin gamma 1 -0.0167508
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0167185
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0164853
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 -0.0164125
ELOVL5 ELOVL fatty acid elongase 5 -0.0162746
TOB1 transducer of ERBB2, 1 -0.0161222
SPIDR scaffolding protein involved in DNA repair -0.0159534
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0157456
GNAS GNAS complex locus -0.0155788
MYADM myeloid-associated differentiation marker -0.0154949