Fusidic acid_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.146584
GPC6 glypican 6 0.126214
ASPH aspartate beta-hydroxylase 0.123105
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0953137
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0916773
PRELID2 PRELI domain containing 2 0.086719
NLGN1 neuroligin 1 0.0821761
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0765049
SETBP1 SET binding protein 1 0.0742714
DST dystonin 0.0742315
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0638781
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.057974
EXOC4 exocyst complex component 4 0.0577746
ACTN1 actinin, alpha 1 0.0559828
PDIA4 protein disulfide isomerase family A, member 4 0.0538686
LRMDA leucine rich melanocyte differentiation associated 0.0538194
MACF1 microtubule-actin crosslinking factor 1 0.053795
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0534765
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0520537
FMNL2 formin-like 2 0.0513909
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0510356
ATXN1 ataxin 1 0.0500616
TMEM178B transmembrane protein 178B 0.049009
TLE4 transducin-like enhancer of split 4 0.0486386
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0477618
CEMIP2 cell migration inducing hyaluronidase 2 0.04736
BACE2 beta-site APP-cleaving enzyme 2 0.0461223
IFRD1 interferon-related developmental regulator 1 0.0443752
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0441698
FMN1 formin 1 0.0433359
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0413601
PAX3 paired box 3 0.0378833
CTTNBP2 cortactin binding protein 2 0.0374264
ZSWIM6 zinc finger, SWIM-type containing 6 0.0371551
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0370962
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0368921
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0364887
IGF1R insulin-like growth factor 1 receptor 0.0361644
PDLIM5 PDZ and LIM domain 5 0.0359285
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0353184
EFCAB13 EF-hand calcium binding domain 13 0.0352058
GLS2 glutaminase 2 (liver, mitochondrial) 0.0342452
NAV1 neuron navigator 1 0.03398
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0334151
UTRN utrophin 0.0332373
UBASH3B ubiquitin associated and SH3 domain containing B 0.032974
COPA coatomer protein complex, subunit alpha 0.0322811
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0322454
ZMIZ1 zinc finger, MIZ-type containing 1 0.0317282
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0315877
EXT1 exostosin glycosyltransferase 1 0.0313575
MYO1E myosin IE 0.0313499
TPR translocated promoter region, nuclear basket protein 0.0312869
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0310965
SMYD3 SET and MYND domain containing 3 0.0305073
SND1 staphylococcal nuclease and tudor domain containing 1 0.0301929
VCL vinculin 0.0299926
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0299791
IVNS1ABP influenza virus NS1A binding protein 0.0296684
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0294673
AFDN afadin, adherens junction formation factor 0.0290861
SDC2 syndecan 2 0.0288594
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0288432
PTK2 protein tyrosine kinase 2 0.0288404
TBC1D22A TBC1 domain family, member 22A 0.0288371
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0278192
MYH9 myosin, heavy chain 9, non-muscle 0.0276784
SEPTIN9 septin 9 0.027573
SAMD4A sterile alpha motif domain containing 4A 0.0272801
ANK2 ankyrin 2, neuronal 0.0266542
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0264379
MAML3 mastermind-like 3 (Drosophila) 0.0260424
KDM3A lysine (K)-specific demethylase 3A 0.0259705
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.025937
APLP2 amyloid beta (A4) precursor-like protein 2 0.0254301
CTBP2 C-terminal binding protein 2 0.0252618
EFR3B EFR3 homolog B (S. cerevisiae) 0.0251986
EYA1 EYA transcriptional coactivator and phosphatase 1 0.024304
RAD51B RAD51 paralog B 0.0242979
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0242806
CALU calumenin 0.0239832
PCDH7 protocadherin 7 0.0238974
RNF213 ring finger protein 213 0.0235516
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0234365
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0233402
ZNF638 zinc finger protein 638 0.0230729
INTS6 integrator complex subunit 6 0.022617
MCL1 myeloid cell leukemia 1 0.0225021
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0224534
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0223545
WDR1 WD repeat domain 1 0.0223524
PARVB parvin, beta 0.0221891
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.022114
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0219623
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0218906
SYNM synemin, intermediate filament protein 0.0217286
DOCK4 dedicator of cytokinesis 4 0.02165
CLIC4 chloride intracellular channel 4 0.0215229
LPP LIM domain containing preferred translocation partner in lipoma 0.0213328
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0212083

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.492315
VIM vimentin -0.202404
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.123533
NDRG1 N-myc downstream regulated 1 -0.0871003
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0765779
GDF15 growth differentiation factor 15 -0.0704057
TMSB10 thymosin beta 10 -0.0681498
MT2A metallothionein 2A -0.0655186
VGF VGF nerve growth factor inducible -0.0649407
DCT dopachrome tautomerase -0.0638759
NAMPT nicotinamide phosphoribosyltransferase -0.0602666
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.059799
HLA-B major histocompatibility complex, class I, B -0.0591548
S100A6 S100 calcium binding protein A6 -0.0581862
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0557357
KMT2E lysine (K)-specific methyltransferase 2E -0.0543772
PTMA prothymosin, alpha -0.0502853
PGK1 phosphoglycerate kinase 1 -0.047622
RNF145 ring finger protein 145 -0.0467544
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0457389
ACTG1 actin gamma 1 -0.043111
LOC112694756 uncharaterized LOC112694756 -0.0423485
IFI16 interferon, gamma-inducible protein 16 -0.0421843
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.039482
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0389675
FTL ferritin, light polypeptide -0.0385537
RPLP1 ribosomal protein, large, P1 -0.0381217
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0369832
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0367754
TMEM123 transmembrane protein 123 -0.0367592
GNAS GNAS complex locus -0.0335141
CDC73 cell division cycle 73 -0.0332998
FN1 fibronectin 1 -0.0332242
WDR45B WD repeat domain 45B -0.0328461
S100A9 S100 calcium binding protein A9 -0.0326183
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0310605
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.030597
ICAM1 intercellular adhesion molecule 1 -0.0296935
HILPDA hypoxia inducible lipid droplet-associated -0.0293802
A2M alpha-2-macroglobulin -0.0282526
IER3 immediate early response 3 -0.0277822
RPS19 ribosomal protein S19 -0.0274309
PDIA3 protein disulfide isomerase family A, member 3 -0.0265792
SETD5 SET domain containing 5 -0.0264768
RPS8 ribosomal protein S8 -0.0263797
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0263543
FAM162A family with sequence similarity 162, member A -0.0259432
CHSY1 chondroitin sulfate synthase 1 -0.0256181
RPS6 ribosomal protein S6 -0.0253572
PLIN2 perilipin 2 -0.0253502
LGALS1 lectin, galactoside-binding, soluble, 1 -0.025272
RPLP2 ribosomal protein, large, P2 -0.0248771
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0246986
IFITM3 interferon induced transmembrane protein 3 -0.0246041
FOXJ3 forkhead box J3 -0.0242507
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0242092
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0242079
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0240182
NPEPPS aminopeptidase puromycin sensitive -0.0240143
VDAC1 voltage-dependent anion channel 1 -0.0237075
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0232659
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0231726
UBC ubiquitin C -0.0230759
FOSL1 FOS-like antigen 1 -0.0230468
MTPN myotrophin -0.0229701
RPL35A ribosomal protein L35a -0.0228139
RPL37A ribosomal protein L37a -0.0226921
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0225806
CTSD cathepsin D -0.022548
MTDH metadherin -0.0222651
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0219507
RPLP0 ribosomal protein, large, P0 -0.0219075
ANXA2 annexin A2 -0.0214545
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0211726
TPI1 triosephosphate isomerase 1 -0.0208686
RPL11 ribosomal protein L11 -0.0207975
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0207012
EIF1 eukaryotic translation initiation factor 1 -0.0205764
RPL19 ribosomal protein L19 -0.0205538
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0204008
RPL34 ribosomal protein L34 -0.0203326
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0200281
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0199947
IFITM2 interferon induced transmembrane protein 2 -0.0198442
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.019833
HSPB1 heat shock 27kDa protein 1 -0.0195408
CD63 CD63 molecule -0.019379
RNF24 ring finger protein 24 -0.0193614
SSH1 slingshot protein phosphatase 1 -0.0192334
RHEB Ras homolog enriched in brain -0.0190604
PNISR PNN-interacting serine/arginine-rich protein -0.0188015
ZNF292 zinc finger protein 292 -0.018691
TPT1 tumor protein, translationally-controlled 1 -0.0186707
S100A10 S100 calcium binding protein A10 -0.0185806
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0183793
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0182863
LOC102724023 ES1 protein homolog, mitochondrial -0.0179987
KLHDC10 kelch domain containing 10 -0.0179588
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0179335
RPS13 ribosomal protein S13 -0.0177639