Fusidic acid_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.162879
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.140836
FNDC3B fibronectin type III domain containing 3B 0.139832
ASPH aspartate beta-hydroxylase 0.136871
SPTBN1 spectrin, beta, non-erythrocytic 1 0.130557
EFNA5 ephrin-A5 0.119607
MYOF myoferlin 0.0928594
APOL1 apolipoprotein L, 1 0.0900684
LMO7 LIM domain 7 0.0867685
SMAD3 SMAD family member 3 0.0782757
EXT1 exostosin glycosyltransferase 1 0.0759455
CANX calnexin 0.0752174
BICC1 BicC family RNA binding protein 1 0.0750666
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0746145
APP amyloid beta (A4) precursor protein 0.0718483
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.069848
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0662649
NAMPT nicotinamide phosphoribosyltransferase 0.0617918
ENO1 enolase 1, (alpha) 0.0617294
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.061329
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0595814
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0581485
ALCAM activated leukocyte cell adhesion molecule 0.0565504
MMP7 matrix metallopeptidase 7 0.0540208
SLC38A2 solute carrier family 38, member 2 0.0536848
PHF3 PHD finger protein 3 0.0523526
FAM3C family with sequence similarity 3, member C 0.0519535
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0516615
CD2AP CD2-associated protein 0.0499162
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0495535
ZSWIM6 zinc finger, SWIM-type containing 6 0.0486896
JAK1 Janus kinase 1 0.0466223
EPAS1 endothelial PAS domain protein 1 0.046525
DST dystonin 0.0465051
AREG amphiregulin 0.0464512
SEC31A SEC31 homolog A (S. cerevisiae) 0.046241
APLP2 amyloid beta (A4) precursor-like protein 2 0.0460778
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0460432
LDHA lactate dehydrogenase A 0.0456329
SGMS2 sphingomyelin synthase 2 0.0438868
UBASH3B ubiquitin associated and SH3 domain containing B 0.0437152
SP100 SP100 nuclear antigen 0.0437122
PDIA4 protein disulfide isomerase family A, member 4 0.0436418
KYNU kynureninase 0.0435356
NRIP1 nuclear receptor interacting protein 1 0.0433923
SAMD4A sterile alpha motif domain containing 4A 0.0430688
ACTN1 actinin, alpha 1 0.041841
PKM pyruvate kinase, muscle 0.0417973
FUS FUS RNA binding protein 0.0412493
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0406687
TGFB2 transforming growth factor, beta 2 0.0402774
DOCK5 dedicator of cytokinesis 5 0.039895
PRELID2 PRELI domain containing 2 0.0395054
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0390153
KIF13B kinesin family member 13B 0.0387377
SH3KBP1 SH3-domain kinase binding protein 1 0.0380924
CALR calreticulin 0.0379854
MYO1E myosin IE 0.0379139
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0376663
FAAH2 fatty acid amide hydrolase 2 0.0375912
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0365979
NRG3 neuregulin 3 0.0357946
SLC35F5 solute carrier family 35, member F5 0.0357543
MX1 MX dynamin-like GTPase 1 0.035408
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0352217
KIAA1217 KIAA1217 0.0351763
MYH9 myosin, heavy chain 9, non-muscle 0.0351533
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0350404
CMIP c-Maf inducing protein 0.0350311
TMSB4X thymosin beta 4, X-linked 0.0349777
VMP1 vacuole membrane protein 1 0.0346795
LAMA4 laminin, alpha 4 0.034193
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0341702
TXNIP thioredoxin interacting protein 0.0341436
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0341176
GOLGB1 golgin B1 0.0338056
CXCL8 chemokine (C-X-C motif) ligand 8 0.0336419
RNF213 ring finger protein 213 0.0335344
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0331731
FAM107B family with sequence similarity 107, member B 0.0330422
STC2 stanniocalcin 2 0.0329855
EPS8 epidermal growth factor receptor pathway substrate 8 0.0328792
EHF ets homologous factor 0.0327938
BIRC3 baculoviral IAP repeat containing 3 0.0327721
TGM2 transglutaminase 2 0.0324517
RIGI RNA sensor RIG-I 0.0322826
WWTR1 WW domain containing transcription regulator 1 0.0320801
RAD51B RAD51 paralog B 0.0320677
SHROOM3 shroom family member 3 0.0319611
IGFBP3 insulin-like growth factor binding protein 3 0.0311891
INTS6 integrator complex subunit 6 0.0311464
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.031112
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0310969
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0310428
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0307865
KRT19 keratin 19, type I 0.0306715
SMYD3 SET and MYND domain containing 3 0.0306194
DSCAM Down syndrome cell adhesion molecule 0.0301614
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0300451
SAMD9 sterile alpha motif domain containing 9 0.0298456

decreased expression

Symbol Name Standardized Value
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.125762
DTNA dystrobrevin, alpha -0.0836932
HMGA1 high mobility group AT-hook 1 -0.0691377
PARD3 par-3 family cell polarity regulator -0.0648543
RCOR1 REST corepressor 1 -0.0613893
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0580622
EIF1 eukaryotic translation initiation factor 1 -0.0578646
NDRG1 N-myc downstream regulated 1 -0.0573556
AGRN agrin -0.0566099
FLNB filamin B, beta -0.0541449
TMEM165 transmembrane protein 165 -0.0538951
LAMA5 laminin, alpha 5 -0.0487762
TMSB10 thymosin beta 10 -0.0481242
S100A6 S100 calcium binding protein A6 -0.0480397
HLA-A major histocompatibility complex, class I, A -0.0467042
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0441774
POTEF POTE ankyrin domain family, member F -0.0432223
FTH1 ferritin, heavy polypeptide 1 -0.0425393
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0416423
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0416303
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -0.0409749
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0395193
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0389483
GNAS GNAS complex locus -0.0388904
ESYT2 extended synaptotagmin-like protein 2 -0.0387425
JUP junction plakoglobin -0.0373033
HSPG2 heparan sulfate proteoglycan 2 -0.034943
GRB10 growth factor receptor-bound protein 10 -0.0348132
CAPN2 calpain 2, (m/II) large subunit -0.0347664
RAP1B RAP1B, member of RAS oncogene family -0.0340027
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0334619
SREBF2 sterol regulatory element binding transcription factor 2 -0.0332725
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.033031
PTMA prothymosin, alpha -0.0324569
WASF2 WAS protein family, member 2 -0.0322763
FOXO3 forkhead box O3 -0.0318696
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0317188
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.030814
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0302898
ACTG1 actin gamma 1 -0.0301807
ISG15 ISG15 ubiquitin-like modifier -0.029771
PLAU plasminogen activator, urokinase -0.0297258
HLA-B major histocompatibility complex, class I, B -0.0295891
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0293715
KDM2A lysine (K)-specific demethylase 2A -0.0291276
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0289901
KLF6 Kruppel-like factor 6 -0.028901
NPC1 Niemann-Pick disease, type C1 -0.0288873
ITGA6 integrin, alpha 6 -0.0287954
RAB7A RAB7A, member RAS oncogene family -0.0286778
RREB1 ras responsive element binding protein 1 -0.0284457
KMT2C lysine (K)-specific methyltransferase 2C -0.0275402
B2M beta-2-microglobulin -0.0273618
FOSL1 FOS-like antigen 1 -0.0272553
TAPBP TAP binding protein (tapasin) -0.0270944
MXD1 MAX dimerization protein 1 -0.0264183
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0262377
ITPRID2 ITPR interacting domain containing 2 -0.0260285
HLA-E major histocompatibility complex, class I, E -0.0259539
ITGB4 integrin, beta 4 -0.0258777
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0258736
EGR1 early growth response 1 -0.0258689
VIM vimentin -0.0258316
LAMB3 laminin, beta 3 -0.0257443
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0254095
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0253793
PDE4D phosphodiesterase 4D, cAMP-specific -0.0253625
RPS25 ribosomal protein S25 -0.0251563
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0250734
ATP11B ATPase, class VI, type 11B -0.0250505
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0250287
FA2H fatty acid 2-hydroxylase -0.025021
RPS23 ribosomal protein S23 -0.0246041
LAMC2 laminin, gamma 2 -0.0241269
UGCG UDP-glucose ceramide glucosyltransferase -0.023821
MT1E metallothionein 1E -0.0237601
CP ceruloplasmin (ferroxidase) -0.0235569
TRIO trio Rho guanine nucleotide exchange factor -0.0235242
ZNF292 zinc finger protein 292 -0.0235174
POM121 POM121 transmembrane nucleoporin -0.0233788
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0228133
NT5C2 5'-nucleotidase, cytosolic II -0.0227874
JMJD1C jumonji domain containing 1C -0.0227262
RTN4 reticulon 4 -0.0226775
AXL AXL receptor tyrosine kinase -0.022508
MAP1B microtubule-associated protein 1B -0.0224843
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0222364
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0221824
KDM5B lysine (K)-specific demethylase 5B -0.0221598
NCKAP5 NCK-associated protein 5 -0.0221273
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0219006
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0217703
CCNY cyclin Y -0.0217306
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.021534
TNS4 tensin 4 -0.0213826
INSIG1 insulin induced gene 1 -0.021349
ARHGAP21 Rho GTPase activating protein 21 -0.0213227
FDPS farnesyl diphosphate synthase -0.0213142
TLK2 tousled-like kinase 2 -0.0210566
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0210557