Fusidic acid_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.358853
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.151141
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.147627
SMAD3 SMAD family member 3 0.132126
SPTBN1 spectrin, beta, non-erythrocytic 1 0.131822
EXT1 exostosin glycosyltransferase 1 0.10739
RUNX1 runt-related transcription factor 1 0.1036
FNDC3B fibronectin type III domain containing 3B 0.0973378
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.093397
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0832135
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0713668
SQSTM1 sequestosome 1 0.0690127
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0654902
ITGA6 integrin, alpha 6 0.0648391
KYNU kynureninase 0.0641656
DST dystonin 0.0629335
MSI2 musashi RNA-binding protein 2 0.0598364
EFNB2 ephrin-B2 0.058648
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0524298
MBNL2 muscleblind-like splicing regulator 2 0.0523483
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0510347
CALR calreticulin 0.0506129
FNIP2 folliculin interacting protein 2 0.0490427
ABHD2 abhydrolase domain containing 2 0.048238
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.047388
CTBP2 C-terminal binding protein 2 0.0456801
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0455819
PADI1 peptidyl arginine deiminase, type I 0.04377
TOX3 TOX high mobility group box family member 3 0.0434303
DSPP dentin sialophosphoprotein 0.042902
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0424292
MLPH melanophilin 0.0424053
TRIM2 tripartite motif containing 2 0.0416035
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0415296
PRELID2 PRELI domain containing 2 0.0413155
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0412877
KIAA1217 KIAA1217 0.0405577
GMDS GDP-mannose 4,6-dehydratase 0.040502
CXCL8 chemokine (C-X-C motif) ligand 8 0.040397
MACC1 metastasis associated in colon cancer 1 0.0399604
FNDC3A fibronectin type III domain containing 3A 0.0390465
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0387876
AFF1 AF4/FMR2 family, member 1 0.0382793
SLK STE20-like kinase 0.0382491
AKAP13 A kinase (PRKA) anchor protein 13 0.038216
HKDC1 hexokinase domain containing 1 0.0381648
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0381101
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0376161
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0371147
EPS8 epidermal growth factor receptor pathway substrate 8 0.0368769
EHF ets homologous factor 0.0364955
ASPH aspartate beta-hydroxylase 0.0363515
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0359905
DUSP16 dual specificity phosphatase 16 0.0356207
YAP1 Yes-associated protein 1 0.0351177
MYO1E myosin IE 0.0350944
SPAG9 sperm associated antigen 9 0.0346696
MED13 mediator complex subunit 13 0.0344678
RRBP1 ribosome binding protein 1 0.034389
MACF1 microtubule-actin crosslinking factor 1 0.0338541
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0332993
MYH9 myosin, heavy chain 9, non-muscle 0.0331821
LAMB3 laminin, beta 3 0.0330455
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0328673
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0324793
USP9X ubiquitin specific peptidase 9, X-linked 0.032479
TMPRSS4 transmembrane protease, serine 4 0.0323562
NEBL nebulette 0.0323234
CEMIP cell migration inducing protein, hyaluronan binding 0.0322119
ARHGAP26 Rho GTPase activating protein 26 0.0321439
RNF43 ring finger protein 43 0.0320037
CANX calnexin 0.0314853
LURAP1L leucine rich adaptor protein 1-like 0.0313885
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0312009
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0308328
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0299172
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0297584
EPHB2 EPH receptor B2 0.0295406
ENO1 enolase 1, (alpha) 0.0294761
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0293137
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.02904
SDC4 syndecan 4 0.0284434
USP54 ubiquitin specific peptidase 54 0.0279762
TC2N tandem C2 domains, nuclear 0.027786
SOD2 superoxide dismutase 2, mitochondrial 0.0276148
AFF4 AF4/FMR2 family, member 4 0.0275146
TPR translocated promoter region, nuclear basket protein 0.0271754
PDZD8 PDZ domain containing 8 0.0270982
ABLIM1 actin binding LIM protein 1 0.0270432
OGA O-GlcNAcase 0.0268045
H1-0 H1.0 linker histone 0.0265927
HYOU1 hypoxia up-regulated 1 0.026506
GCLC glutamate-cysteine ligase, catalytic subunit 0.0264188
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0262024
ERRFI1 ERBB receptor feedback inhibitor 1 0.02607
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0258499
RDH10 retinol dehydrogenase 10 (all-trans) 0.0257839
MUC13 mucin 13, cell surface associated 0.0255213
HDAC4 histone deacetylase 4 0.0253531
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0251036

decreased expression

Symbol Name Standardized Value
EGR1 early growth response 1 -0.12098
LYZ lysozyme -0.11417
VCL vinculin -0.109437
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0905588
PHF3 PHD finger protein 3 -0.0858775
NPSR1 neuropeptide S receptor 1 -0.0734364
STAT1 signal transducer and activator of transcription 1, 91kDa -0.071292
B2M beta-2-microglobulin -0.0655864
SP100 SP100 nuclear antigen -0.065586
PLSCR2 phospholipid scramblase 2 -0.0639315
RIGI RNA sensor RIG-I -0.058802
EPSTI1 epithelial stromal interaction 1 (breast) -0.0578299
XAF1 XIAP associated factor 1 -0.0549725
PLSCR1 phospholipid scramblase 1 -0.054417
ANXA2 annexin A2 -0.0532754
TNS4 tensin 4 -0.0527293
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.050286
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0493951
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0487892
BTBD9 BTB (POZ) domain containing 9 -0.0464815
TPT1 tumor protein, translationally-controlled 1 -0.0451042
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0447149
RPL7L1 ribosomal protein L7-like 1 -0.042997
MX1 MX dynamin-like GTPase 1 -0.0429748
TM4SF19 transmembrane 4 L six family member 19 -0.0429656
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0426673
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0417851
MX2 MX dynamin-like GTPase 2 -0.0417421
POU2F2 POU class 2 homeobox 2 -0.0400987
TXNIP thioredoxin interacting protein -0.0400036
RAB7A RAB7A, member RAS oncogene family -0.0398189
IGFBP3 insulin-like growth factor binding protein 3 -0.038342
ACTG1 actin gamma 1 -0.0380105
IFI6 interferon, alpha-inducible protein 6 -0.0377994
C6ORF132 chromosome 6 open reading frame 132 -0.0372925
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0369802
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.036223
NCKAP5 NCK-associated protein 5 -0.0361046
RPS6 ribosomal protein S6 -0.035758
ZNF609 zinc finger protein 609 -0.0355579
PMP22 peripheral myelin protein 22 -0.0353342
MCL1 myeloid cell leukemia 1 -0.0352466
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0347761
PIAS1 protein inhibitor of activated STAT, 1 -0.034211
PTMA prothymosin, alpha -0.0341862
MAP7 microtubule-associated protein 7 -0.0333387
RABGAP1L RAB GTPase activating protein 1-like -0.0330339
ZMYND8 zinc finger, MYND-type containing 8 -0.0326228
OARD1 O-acyl-ADP-ribose deacylase 1 -0.0301218
NDRG1 N-myc downstream regulated 1 -0.030022
AHI1 Abelson helper integration site 1 -0.029942
C6ORF62 chromosome 6 open reading frame 62 -0.0298343
INTS6 integrator complex subunit 6 -0.0284956
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0284343
TM4SF1 transmembrane 4 L six family member 1 -0.0283077
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0275203
LAP3 leucine aminopeptidase 3 -0.0265607
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0264948
PATJ PATJ crumbs cell polarity complex component -0.0258559
GPATCH8 G patch domain containing 8 -0.0257499
FBXO39 F-box protein 39 -0.0253528
IFI27 interferon, alpha-inducible protein 27 -0.0253283
TRIM25 tripartite motif containing 25 -0.0252696
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0250729
TRIM56 tripartite motif containing 56 -0.0247665
FOSL1 FOS-like antigen 1 -0.024529
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0244984
ADAR adenosine deaminase, RNA-specific -0.0243515
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0241988
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0238947
STS steroid sulfatase (microsomal), isozyme S -0.0237455
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0236776
ZNF207 zinc finger protein 207 -0.0231838
AREG amphiregulin -0.0228644
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0228325
LRRC8A leucine rich repeat containing 8 family, member A -0.0225038
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0221241
THOC2 THO complex 2 -0.0220259
EIF1 eukaryotic translation initiation factor 1 -0.0219218
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0217853
LPP LIM domain containing preferred translocation partner in lipoma -0.0216457
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0215703
RAD51B RAD51 paralog B -0.021192
GOSR2 golgi SNAP receptor complex member 2 -0.0210854
EPCAM epithelial cell adhesion molecule -0.0210185
GOLGB1 golgin B1 -0.0210038
RPS8 ribosomal protein S8 -0.0209578
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0208622
CCND3 cyclin D3 -0.0208481
OASL 2'-5'-oligoadenylate synthetase-like -0.0208384
TNPO3 transportin 3 -0.0207557
SPIDR scaffolding protein involved in DNA repair -0.0206995
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0206958
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0205798
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0204907
HSH2D hematopoietic SH2 domain containing -0.0202117
MAML2 mastermind-like 2 (Drosophila) -0.0202104
LOC112694756 uncharaterized LOC112694756 -0.0200688
APOL6 apolipoprotein L, 6 -0.0200225
IRF9 interferon regulatory factor 9 -0.0199707