Fusidic acid_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.429765
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.132588
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0825485
FNDC3B fibronectin type III domain containing 3B 0.0729443
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0717101
ASPH aspartate beta-hydroxylase 0.0716322
KYNU kynureninase 0.0607077
DST dystonin 0.0605809
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0496063
AKAP12 A kinase (PRKA) anchor protein 12 0.0485771
CANX calnexin 0.0483465
PRELID2 PRELI domain containing 2 0.0451892
FAM13A family with sequence similarity 13, member A 0.0423084
SMAD3 SMAD family member 3 0.0416484
MACF1 microtubule-actin crosslinking factor 1 0.0402837
RUNX1 runt-related transcription factor 1 0.0379097
AHNAK AHNAK nucleoprotein 0.0373282
MYH9 myosin, heavy chain 9, non-muscle 0.034398
WWTR1 WW domain containing transcription regulator 1 0.034347
LOX lysyl oxidase 0.0339963
APP amyloid beta (A4) precursor protein 0.0337216
NFE2L1 nuclear factor, erythroid 2-like 1 0.0333353
SEPTIN9 septin 9 0.0328594
MCTP2 multiple C2 domains, transmembrane 2 0.0311342
BACE2 beta-site APP-cleaving enzyme 2 0.031108
PTPRD protein tyrosine phosphatase, receptor type, D 0.0307192
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0297718
PHF3 PHD finger protein 3 0.0294787
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0293002
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0291109
GLIS3 GLIS family zinc finger 3 0.0290469
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0287122
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0285032
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0277836
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0277066
GRAMD1B GRAM domain containing 1B 0.0273377
VEGFC vascular endothelial growth factor C 0.0264577
ERRFI1 ERBB receptor feedback inhibitor 1 0.0264323
PLEC plectin 0.02641
LOXL2 lysyl oxidase-like 2 0.0256889
ANO6 anoctamin 6 0.0255144
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0254468
ELL2 elongation factor, RNA polymerase II, 2 0.0252217
ATXN1 ataxin 1 0.0248649
YEATS2 YEATS domain containing 2 0.0244948
NAMPT nicotinamide phosphoribosyltransferase 0.0241879
COL5A1 collagen, type V, alpha 1 0.0241554
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0240027
ZNF841 zinc finger protein 841 0.0236207
AOPEP aminopeptidase O (putative) 0.0234553
HSPA8 heat shock 70kDa protein 8 0.0232162
MYO10 myosin X 0.0227457
DOCK5 dedicator of cytokinesis 5 0.0226332
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0224727
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0221244
ANKRD36 ankyrin repeat domain 36 0.0218452
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0218259
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0217315
ZNF638 zinc finger protein 638 0.0217009
HYOU1 hypoxia up-regulated 1 0.0216928
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.021606
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0214093
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0211865
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0211478
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0209616
ATP13A3 ATPase type 13A3 0.0205368
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0202507
ANKRD11 ankyrin repeat domain 11 0.0199652
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0198943
CLTC clathrin, heavy chain (Hc) 0.019713
EGFR epidermal growth factor receptor 0.0196724
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0194613
PKM pyruvate kinase, muscle 0.0192275
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0190213
FBXL17 F-box and leucine-rich repeat protein 17 0.0188884
CALR calreticulin 0.0185412
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0184529
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.018362
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0181912
PCBP3 poly(rC) binding protein 3 0.0179888
TRIO trio Rho guanine nucleotide exchange factor 0.0179849
SLC35F5 solute carrier family 35, member F5 0.0179242
DGKD diacylglycerol kinase, delta 130kDa 0.0179125
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.017885
ZBTB38 zinc finger and BTB domain containing 38 0.0175059
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0174367
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0173189
CORO1C coronin, actin binding protein, 1C 0.0173175
SAMD4A sterile alpha motif domain containing 4A 0.017134
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0170647
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0170369
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0170086
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0169841
CALN1 calneuron 1 0.016907
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0168166
MYO1B myosin IB 0.0167615
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0165061
EEF2 eukaryotic translation elongation factor 2 0.0164565
HELZ helicase with zinc finger 0.0164189
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.016161

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.359524
VIM vimentin -0.219595
TMSB10 thymosin beta 10 -0.200132
FTL ferritin, light polypeptide -0.103631
TPM4 tropomyosin 4 -0.0872555
PTMA prothymosin, alpha -0.0860419
MT2A metallothionein 2A -0.0807015
B2M beta-2-microglobulin -0.0783938
HLA-B major histocompatibility complex, class I, B -0.0663099
POTEF POTE ankyrin domain family, member F -0.0620983
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0581305
RPS6 ribosomal protein S6 -0.0552482
HLA-A major histocompatibility complex, class I, A -0.0527969
IGF2 insulin-like growth factor 2 -0.0515071
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0490761
FN1 fibronectin 1 -0.0485294
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0468433
ENO2 enolase 2 (gamma, neuronal) -0.0449464
TPI1 triosephosphate isomerase 1 -0.0438445
ACTG1 actin gamma 1 -0.0428056
RPL35A ribosomal protein L35a -0.042586
RPS8 ribosomal protein S8 -0.0403078
IGFBP5 insulin-like growth factor binding protein 5 -0.0399085
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0394307
GNAS GNAS complex locus -0.0392212
HMGA1 high mobility group AT-hook 1 -0.0388989
MAP1B microtubule-associated protein 1B -0.0387611
GRB10 growth factor receptor-bound protein 10 -0.0387209
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0377601
NDRG1 N-myc downstream regulated 1 -0.0376274
S100A6 S100 calcium binding protein A6 -0.0376252
CALD1 caldesmon 1 -0.0362591
EGR1 early growth response 1 -0.0360929
RPLP1 ribosomal protein, large, P1 -0.0357871
RAB7A RAB7A, member RAS oncogene family -0.035677
TPT1 tumor protein, translationally-controlled 1 -0.035414
TUBA1B tubulin, alpha 1b -0.0339444
RPS13 ribosomal protein S13 -0.0335826
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0334979
RTN4 reticulon 4 -0.0326968
IGFBP3 insulin-like growth factor binding protein 3 -0.0318139
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0315532
EIF1 eukaryotic translation initiation factor 1 -0.0313187
S100A10 S100 calcium binding protein A10 -0.0307637
RPLP2 ribosomal protein, large, P2 -0.029861
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0295253
RPL9 ribosomal protein L9 -0.0294921
LMNA lamin A/C -0.0292253
PDIA3 protein disulfide isomerase family A, member 3 -0.0291486
SEC61G Sec61 gamma subunit -0.0289423
PLAUR plasminogen activator, urokinase receptor -0.0287881
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0284247
RPS19 ribosomal protein S19 -0.0283396
SBF2 SET binding factor 2 -0.0280055
ATP5F1B ATP synthase F1 subunit beta -0.0273201
RPS23 ribosomal protein S23 -0.0272494
CCND1 cyclin D1 -0.0271585
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0267716
TUBB4B tubulin, beta 4B class IVb -0.0265657
CYB5R3 cytochrome b5 reductase 3 -0.0262763
PFN1 profilin 1 -0.0259571
CKAP4 cytoskeleton-associated protein 4 -0.0258202
TUBA1C tubulin, alpha 1c -0.0257477
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0253151
S100A9 S100 calcium binding protein A9 -0.0251436
CD99 CD99 molecule -0.0250675
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.025003
FOSL1 FOS-like antigen 1 -0.0248958
RPL37A ribosomal protein L37a -0.0245732
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.0243973
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0241996
NAV3 neuron navigator 3 -0.0239614
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0233694
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0232345
ZNF804A zinc finger protein 804A -0.0231108
RPLP0 ribosomal protein, large, P0 -0.0228004
RPS24 ribosomal protein S24 -0.0227784
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0227669
TIMP1 TIMP metallopeptidase inhibitor 1 -0.022738
SEPTIN7 septin 7 -0.0227069
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0225834
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0225461
RPL28 ribosomal protein L28 -0.0223913
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0222995
RPL27A ribosomal protein L27a -0.0221109
KPNB1 karyopherin (importin) beta 1 -0.0218908
RPL7A ribosomal protein L7a -0.0218788
RPL11 ribosomal protein L11 -0.0213775
PRSS23 protease, serine, 23 -0.0213084
H3-3B H3.3 histone B -0.0209495
CLMP CXADR-like membrane protein -0.0209135
LMAN1 lectin, mannose-binding, 1 -0.0206611
VDAC1 voltage-dependent anion channel 1 -0.0205027
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0201453
CD151 CD151 molecule (Raph blood group) -0.0198179
RPL23 ribosomal protein L23 -0.019736
ACBD3 acyl-CoA binding domain containing 3 -0.0195785
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0195593
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0193617
RPL12 ribosomal protein L12 -0.0193561