Fusidic acid_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 0.0632947
ASPH aspartate beta-hydroxylase 0.0523523
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0494157
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0474724
FNDC3B fibronectin type III domain containing 3B 0.0464764
CD44 CD44 molecule (Indian blood group) 0.0443321
VCL vinculin 0.0430221
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0429595
NAV1 neuron navigator 1 0.0426143
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0409581
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0399252
HMGA2 high mobility group AT-hook 2 0.0370434
MSN moesin 0.0369784
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0366801
GPC6 glypican 6 0.0358882
SLC38A2 solute carrier family 38, member 2 0.0343872
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0335805
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0327814
MYH9 myosin, heavy chain 9, non-muscle 0.0317521
TXNIP thioredoxin interacting protein 0.0312806
MCL1 myeloid cell leukemia 1 0.0310938
ALCAM activated leukocyte cell adhesion molecule 0.0309109
BCAR3 breast cancer anti-estrogen resistance 3 0.0307789
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0305846
PDE4D phosphodiesterase 4D, cAMP-specific 0.0296836
TPM3 tropomyosin 3 0.0296138
POTEF POTE ankyrin domain family, member F 0.0296129
TRIO trio Rho guanine nucleotide exchange factor 0.0292603
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.029061
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0290471
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0279607
PKM pyruvate kinase, muscle 0.0278671
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0273893
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0270079
PCBP2 poly(rC) binding protein 2 0.0267545
ANKRD28 ankyrin repeat domain 28 0.0265682
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0263952
DOCK5 dedicator of cytokinesis 5 0.0263056
SAMD4A sterile alpha motif domain containing 4A 0.026238
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0262179
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.02606
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.025524
FRMD6 FERM domain containing 6 0.024444
ERBIN erbb2 interacting protein 0.0243609
CALD1 caldesmon 1 0.0242956
DST dystonin 0.0241267
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0240936
AKAP13 A kinase (PRKA) anchor protein 13 0.0240689
ANO6 anoctamin 6 0.0237719
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0237149
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0236007
ZSWIM6 zinc finger, SWIM-type containing 6 0.0235869
ENO1 enolase 1, (alpha) 0.0230836
LPP LIM domain containing preferred translocation partner in lipoma 0.0226579
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0221474
KLF12 Kruppel-like factor 12 0.0221287
DNMBP dynamin binding protein 0.0217055
CENPF centromere protein F, 350/400kDa 0.0215257
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.020446
CCNL1 cyclin L1 0.0203919
DPYD dihydropyrimidine dehydrogenase 0.020237
MBNL1 muscleblind-like splicing regulator 1 0.019873
MAP1B microtubule-associated protein 1B 0.0198243
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0195229
SPATS2 spermatogenesis associated, serine-rich 2 0.0194055
BDNF brain-derived neurotrophic factor 0.0193592
TRIP12 thyroid hormone receptor interactor 12 0.0193506
NT5E 5'-nucleotidase, ecto (CD73) 0.0191347
SMAD3 SMAD family member 3 0.0191189
SFPQ splicing factor proline/glutamine-rich 0.0191106
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0190239
ATXN1 ataxin 1 0.0186986
MAML2 mastermind-like 2 (Drosophila) 0.018565
NCOR2 nuclear receptor corepressor 2 0.0185483
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0185263
SASH1 SAM and SH3 domain containing 1 0.0183349
LINGO2 leucine rich repeat and Ig domain containing 2 0.0182069
PRELID2 PRELI domain containing 2 0.0182036
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0181681
MACF1 microtubule-actin crosslinking factor 1 0.0181678
ACTN1 actinin, alpha 1 0.0181443
ITGA6 integrin, alpha 6 0.018116
ADAM19 ADAM metallopeptidase domain 19 0.0180315
SMYD3 SET and MYND domain containing 3 0.0180258
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0180031
CDK6 cyclin-dependent kinase 6 0.0179578
CCN2 cellular communication network factor 2 0.0176899
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0175658
APLP2 amyloid beta (A4) precursor-like protein 2 0.0174678
MPRIP myosin phosphatase Rho interacting protein 0.0172681
PTBP3 polypyrimidine tract binding protein 3 0.0171743
OSMR oncostatin M receptor 0.0166951
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0166358
CMIP c-Maf inducing protein 0.0166141
KDM4C lysine (K)-specific demethylase 4C 0.0165895
EXOC4 exocyst complex component 4 0.0164122
TSC22D1 TSC22 domain family, member 1 0.0162854
RIGI RNA sensor RIG-I 0.0162393
TRA2B transformer 2 beta homolog (Drosophila) 0.016223
PFN1 profilin 1 0.0161428

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.312409
VIM vimentin -0.134069
DTNA dystrobrevin, alpha -0.125237
AKAP12 A kinase (PRKA) anchor protein 12 -0.0820082
LSAMP limbic system-associated membrane protein -0.0741991
KDM3A lysine (K)-specific demethylase 3A -0.0678779
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0657597
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0647197
TPT1 tumor protein, translationally-controlled 1 -0.062619
TMSB10 thymosin beta 10 -0.0622396
ACTG1 actin gamma 1 -0.0539589
PHACTR1 phosphatase and actin regulator 1 -0.0539447
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0521693
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0517516
LOC112694756 uncharaterized LOC112694756 -0.0496105
ANXA2 annexin A2 -0.0484775
PTMA prothymosin, alpha -0.0451086
EIF1 eukaryotic translation initiation factor 1 -0.0422545
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0419769
RPLP1 ribosomal protein, large, P1 -0.0419553
PGK1 phosphoglycerate kinase 1 -0.0419291
RPS6 ribosomal protein S6 -0.0412402
RPL12 ribosomal protein L12 -0.0401107
WDR45B WD repeat domain 45B -0.0400308
RAD21 RAD21 homolog (S. pombe) -0.0375592
APP amyloid beta (A4) precursor protein -0.0370246
RPL13A ribosomal protein L13a -0.0364266
MCTP1 multiple C2 domains, transmembrane 1 -0.0356982
RLF rearranged L-myc fusion -0.0351314
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0349111
AHNAK AHNAK nucleoprotein -0.0346253
C2CD2 C2 calcium-dependent domain containing 2 -0.0334687
GNAS GNAS complex locus -0.0332717
WDR43 WD repeat domain 43 -0.0327592
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0327496
NAMPT nicotinamide phosphoribosyltransferase -0.0325221
QKI QKI, KH domain containing, RNA binding -0.0319903
SEPTIN7 septin 7 -0.0311835
RPL19 ribosomal protein L19 -0.0299866
CAVIN1 caveolae associated protein 1 -0.0294099
MARCHF6 membrane associated ring-CH-type finger 6 -0.0292961
RPL38 ribosomal protein L38 -0.0291479
RAB1A RAB1A, member RAS oncogene family -0.0290968
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0290012
PTK2 protein tyrosine kinase 2 -0.0287227
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0283941
BRWD1 bromodomain and WD repeat domain containing 1 -0.0281295
NAP1L1 nucleosome assembly protein 1-like 1 -0.0281063
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0277719
RPL6 ribosomal protein L6 -0.0277313
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.027661
CSTB cystatin B (stefin B) -0.0275107
RPL34 ribosomal protein L34 -0.0274296
RPS8 ribosomal protein S8 -0.0267237
RPL23 ribosomal protein L23 -0.0267037
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0266171
YBX3 Y box binding protein 3 -0.0258586
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0257073
RPL11 ribosomal protein L11 -0.025644
USP3 ubiquitin specific peptidase 3 -0.0250727
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.024956
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0248892
CTSB cathepsin B -0.0248613
WSB1 WD repeat and SOCS box containing 1 -0.024838
LMAN1 lectin, mannose-binding, 1 -0.0246682
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0246454
RPL35A ribosomal protein L35a -0.0245962
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0245885
RPL8 ribosomal protein L8 -0.0245875
MXI1 MAX interactor 1, dimerization protein -0.0245447
PRKG1 protein kinase, cGMP-dependent, type I -0.0243875
RPL32 ribosomal protein L32 -0.0242388
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0242223
TSC22D2 TSC22 domain family, member 2 -0.0241564
ENKUR enkurin, TRPC channel interacting protein -0.023912
CDH13 cadherin 13 -0.0238889
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0236893
MMP12 matrix metallopeptidase 12 -0.0233635
RPL7 ribosomal protein L7 -0.0233395
H1-0 H1.0 linker histone -0.0229055
RPS24 ribosomal protein S24 -0.0228083
RSL1D1 ribosomal L1 domain containing 1 -0.0225987
FGFR1 fibroblast growth factor receptor 1 -0.022471
NACA nascent polypeptide-associated complex alpha subunit -0.0222203
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -0.0221849
ESM1 endothelial cell-specific molecule 1 -0.0216428
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0215656
RACK1 receptor for activated C kinase 1 -0.0215653
RPL36A ribosomal protein L36a -0.0212648
HDAC3 histone deacetylase 3 -0.0211112
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0210499
PUM2 pumilio RNA-binding family member 2 -0.0210168
RPL37 ribosomal protein L37 -0.0208002
SPAG9 sperm associated antigen 9 -0.0205936
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0203939
NOP58 NOP58 ribonucleoprotein -0.0202812
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0201803
TEX10 testis expressed 10 -0.0201576
NTM neurotrimin -0.0201548
BTG1 B-cell translocation gene 1, anti-proliferative -0.0200666