Fusidic acid_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.126186
CEMIP cell migration inducing protein, hyaluronan binding 0.113819
LMO7 LIM domain 7 0.102031
ASPH aspartate beta-hydroxylase 0.100181
MYO1E myosin IE 0.086834
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0740396
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0699613
MACF1 microtubule-actin crosslinking factor 1 0.0683541
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0682582
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0649966
ONECUT3 one cut homeobox 3 0.0638912
MUC13 mucin 13, cell surface associated 0.0634974
NEBL nebulette 0.0626473
KLF5 Kruppel-like factor 5 (intestinal) 0.0613162
EXT1 exostosin glycosyltransferase 1 0.0603414
MYH9 myosin, heavy chain 9, non-muscle 0.0586917
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0569607
DSPP dentin sialophosphoprotein 0.0522288
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0517194
EGFR epidermal growth factor receptor 0.0515274
HSPA8 heat shock 70kDa protein 8 0.0503936
AREG amphiregulin 0.0484988
USP53 ubiquitin specific peptidase 53 0.0462568
RPS12 ribosomal protein S12 0.045993
CEMIP2 cell migration inducing hyaluronidase 2 0.0443349
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0438783
RPS3 ribosomal protein S3 0.0426729
PDE10A phosphodiesterase 10A 0.0414352
ENO1 enolase 1, (alpha) 0.0414199
FNDC3B fibronectin type III domain containing 3B 0.0407376
CALR calreticulin 0.0390711
CTBP2 C-terminal binding protein 2 0.0383049
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0380058
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0378827
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0375744
GMDS GDP-mannose 4,6-dehydratase 0.0373756
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0365152
SLC38A2 solute carrier family 38, member 2 0.0351848
PDLIM5 PDZ and LIM domain 5 0.0350601
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0350507
PRELID2 PRELI domain containing 2 0.0349296
PKM pyruvate kinase, muscle 0.034391
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0333119
MPRIP myosin phosphatase Rho interacting protein 0.0327678
VCL vinculin 0.0327315
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0326859
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0324846
SRRM2 serine/arginine repetitive matrix 2 0.0314603
POF1B premature ovarian failure, 1B 0.0311632
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0305515
PDIA4 protein disulfide isomerase family A, member 4 0.0304945
DUSP16 dual specificity phosphatase 16 0.030353
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0302566
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0302169
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.030143
MCL1 myeloid cell leukemia 1 0.0287098
PLEC plectin 0.028494
FHIT fragile histidine triad 0.0281662
VMP1 vacuole membrane protein 1 0.028108
MT2A metallothionein 2A 0.0270926
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0268723
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0265312
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0262636
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0262453
SOX9 SRY (sex determining region Y)-box 9 0.0262064
DUSP4 dual specificity phosphatase 4 0.0260327
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0258592
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0256052
ARL15 ADP-ribosylation factor-like 15 0.0255391
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.0251742
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0247932
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0245765
ITPRID2 ITPR interacting domain containing 2 0.024441
RPS2 ribosomal protein S2 0.0243517
EREG epiregulin 0.0243047
CD44 CD44 molecule (Indian blood group) 0.0242724
MBNL1 muscleblind-like splicing regulator 1 0.0242186
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0241851
SMYD3 SET and MYND domain containing 3 0.0239078
TNRC18 trinucleotide repeat containing 18 0.0230514
MED13 mediator complex subunit 13 0.0229857
H1-0 H1.0 linker histone 0.0220755
ADARB1 adenosine deaminase, RNA-specific, B1 0.0219512
WWOX WW domain containing oxidoreductase 0.0219068
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0219055
ARHGAP42 Rho GTPase activating protein 42 0.0217829
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0217609
TACC2 transforming, acidic coiled-coil containing protein 2 0.0216817
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0216717
DPY19L1 dpy-19-like 1 (C. elegans) 0.0215679
SATB2 SATB homeobox 2 0.0214502
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0213821
CMIP c-Maf inducing protein 0.0213227
PLAUR plasminogen activator, urokinase receptor 0.02105
TPM3 tropomyosin 3 0.0210447
ADGRV1 adhesion G protein-coupled receptor V1 0.0205973
JARID2 jumonji, AT rich interactive domain 2 0.020594
CATSPERB catsper channel auxiliary subunit beta 0.020534
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0204494
OSBPL10 oxysterol binding protein-like 10 0.020439

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.207458
MUC6 mucin 6, oligomeric mucus/gel-forming -0.186536
PTMA prothymosin, alpha -0.161775
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.150182
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.098198
ITGA6 integrin, alpha 6 -0.096629
TMSB10 thymosin beta 10 -0.0827975
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0827049
ANXA2 annexin A2 -0.0814414
GPHN gephyrin -0.0812704
RPS6 ribosomal protein S6 -0.080667
NALF1 NALCN channel auxiliary factor 1 -0.0799529
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0673122
AHNAK AHNAK nucleoprotein -0.0670486
GCC2 GRIP and coiled-coil domain containing 2 -0.0660287
PIGR polymeric immunoglobulin receptor -0.059494
S100A6 S100 calcium binding protein A6 -0.0570102
EZR ezrin -0.0537402
CALB1 calbindin 1, 28kDa -0.0489796
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0454009
ATP5F1B ATP synthase F1 subunit beta -0.0450962
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0446317
HMGA1 high mobility group AT-hook 1 -0.043806
CCNY cyclin Y -0.0437
MUC17 mucin 17, cell surface associated -0.0423002
EMP1 epithelial membrane protein 1 -0.0417888
KIF5B kinesin family member 5B -0.0417729
TFF3 trefoil factor 3 (intestinal) -0.0405446
EPCAM epithelial cell adhesion molecule -0.0404029
GOLGA4 golgin A4 -0.0390594
LOC112694756 uncharaterized LOC112694756 -0.0388714
FTH1 ferritin, heavy polypeptide 1 -0.0386729
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0379048
ACTG1 actin gamma 1 -0.0378332
LOC102724023 ES1 protein homolog, mitochondrial -0.0378261
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0372011
PDIA3 protein disulfide isomerase family A, member 3 -0.0368867
DSTN destrin (actin depolymerizing factor) -0.0364115
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0362705
DEK DEK proto-oncogene -0.0351711
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0348399
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0344974
RTN4 reticulon 4 -0.0343999
SBF2 SET binding factor 2 -0.0343272
ANKRD28 ankyrin repeat domain 28 -0.0341615
TPM4 tropomyosin 4 -0.0341513
TXNIP thioredoxin interacting protein -0.0337286
GREB1L growth regulation by estrogen in breast cancer-like -0.033675
RPS25 ribosomal protein S25 -0.0336406
ALCAM activated leukocyte cell adhesion molecule -0.0332372
RIN2 Ras and Rab interactor 2 -0.0331154
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0330941
SSH2 slingshot protein phosphatase 2 -0.0325237
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0314647
AGR2 anterior gradient 2 -0.0304403
RPS8 ribosomal protein S8 -0.0302503
GNAS GNAS complex locus -0.0297583
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0296017
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0291621
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0290521
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0289417
NCOR1 nuclear receptor corepressor 1 -0.0284783
SREBF2 sterol regulatory element binding transcription factor 2 -0.0284074
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.028196
CCND1 cyclin D1 -0.0281883
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0281148
DLG1 discs, large homolog 1 (Drosophila) -0.0280755
CDK6 cyclin-dependent kinase 6 -0.0278614
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0277304
KDM7A lysine (K)-specific demethylase 7A -0.0277103
S100A10 S100 calcium binding protein A10 -0.0276062
TMEM135 transmembrane protein 135 -0.0275884
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0275878
WDR45B WD repeat domain 45B -0.0275051
ITGB4 integrin, beta 4 -0.0274943
PLCB4 phospholipase C, beta 4 -0.0274782
RAD21 RAD21 homolog (S. pombe) -0.0273578
RPS23 ribosomal protein S23 -0.0271274
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0269584
RPS16 ribosomal protein S16 -0.026711
COBL cordon-bleu WH2 repeat protein -0.0264712
KRT18 keratin 18, type I -0.0264698
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0264238
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0263339
SOX4 SRY (sex determining region Y)-box 4 -0.0262338
PTPRR protein tyrosine phosphatase, receptor type, R -0.0261364
RPL13A ribosomal protein L13a -0.0260443
PGK1 phosphoglycerate kinase 1 -0.0259545
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0259496
INSIG1 insulin induced gene 1 -0.0259161
LGALS4 lectin, galactoside-binding, soluble, 4 -0.0257999
RPLP1 ribosomal protein, large, P1 -0.0256686
MXI1 MAX interactor 1, dimerization protein -0.0256526
PNISR PNN-interacting serine/arginine-rich protein -0.0253938
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0253614
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0253397
FNBP1L formin binding protein 1-like -0.0252558
TMEM123 transmembrane protein 123 -0.0252146
JMJD1C jumonji domain containing 1C -0.0252135
RPL5 ribosomal protein L5 -0.0248688