Fusidic acid_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.134474
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0998466
GRAMD1B GRAM domain containing 1B 0.0926404
AKAP12 A kinase (PRKA) anchor protein 12 0.0926305
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0838236
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0833779
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0751016
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0750069
ERRFI1 ERBB receptor feedback inhibitor 1 0.0746107
TPM3 tropomyosin 3 0.0702665
MYH9 myosin, heavy chain 9, non-muscle 0.0634084
MCL1 myeloid cell leukemia 1 0.062517
COPA coatomer protein complex, subunit alpha 0.0587257
ZCCHC7 zinc finger, CCHC domain containing 7 0.0585047
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0527427
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.052651
ELL2 elongation factor, RNA polymerase II, 2 0.0522563
HSPA8 heat shock 70kDa protein 8 0.0514535
TXNRD1 thioredoxin reductase 1 0.0476731
SFPQ splicing factor proline/glutamine-rich 0.0474128
ATP11A ATPase, class VI, type 11A 0.0460112
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0452953
VMP1 vacuole membrane protein 1 0.0432658
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0427204
DOCK5 dedicator of cytokinesis 5 0.0413632
INTS6 integrator complex subunit 6 0.041264
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0409339
CLTC clathrin, heavy chain (Hc) 0.0404784
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.040154
CAPRIN2 caprin family member 2 0.0394803
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0391514
FMNL2 formin-like 2 0.0385239
USP9X ubiquitin specific peptidase 9, X-linked 0.0383744
EEF2 eukaryotic translation elongation factor 2 0.037364
CSNK1A1 casein kinase 1, alpha 1 0.0372017
YAP1 Yes-associated protein 1 0.0371066
TRIO trio Rho guanine nucleotide exchange factor 0.0370638
WNK1 WNK lysine deficient protein kinase 1 0.0356733
HOMER1 homer scaffolding protein 1 0.0355389
ATP13A3 ATPase type 13A3 0.0351171
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0347164
DSPP dentin sialophosphoprotein 0.0346364
PDLIM5 PDZ and LIM domain 5 0.0340472
ZSWIM6 zinc finger, SWIM-type containing 6 0.0340244
SND1 staphylococcal nuclease and tudor domain containing 1 0.0338976
TMEM41B transmembrane protein 41B 0.0337591
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0336161
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0333414
ANKRD36 ankyrin repeat domain 36 0.0325673
RPL3 ribosomal protein L3 0.032241
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0313306
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0312905
SNAP25 synaptosomal-associated protein, 25kDa 0.0312067
THSD4 thrombospondin, type I, domain containing 4 0.0309546
NRG1 neuregulin 1 0.0307979
ADAR adenosine deaminase, RNA-specific 0.0300087
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0298022
SPAG9 sperm associated antigen 9 0.0296127
ATF6 activating transcription factor 6 0.0293687
ACTN1 actinin, alpha 1 0.0289976
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0288066
RPL41 ribosomal protein L41 0.0282892
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0282227
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0273896
ZFC3H1 zinc finger, C3H1-type containing 0.02718
TRIP12 thyroid hormone receptor interactor 12 0.0271124
CD164 CD164 molecule, sialomucin 0.0269844
WWTR1 WW domain containing transcription regulator 1 0.0269443
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.026646
PDE10A phosphodiesterase 10A 0.0266189
TLN1 talin 1 0.0265569
GOLGB1 golgin B1 0.0262714
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.026144
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0259421
HYOU1 hypoxia up-regulated 1 0.0257968
PRPF8 pre-mRNA processing factor 8 0.025673
DCAF8 DDB1 and CUL4 associated factor 8 0.0255863
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0253848
WDR26 WD repeat domain 26 0.0253516
SEC31A SEC31 homolog A (S. cerevisiae) 0.0252989
ZNF638 zinc finger protein 638 0.0252276
PRKCE protein kinase C, epsilon 0.0251909
RNF145 ring finger protein 145 0.0250963
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0250883
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.024821
PKM pyruvate kinase, muscle 0.0246944
WWOX WW domain containing oxidoreductase 0.0243449
YBX3 Y box binding protein 3 0.0242361
ANO6 anoctamin 6 0.0241034
PRELID2 PRELI domain containing 2 0.0236861
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0236784
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0236615
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0236382
BIRC3 baculoviral IAP repeat containing 3 0.0236252
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0236019
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0234601
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0232961
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0232672
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0231795
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0231331

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.409428
TMSB10 thymosin beta 10 -0.144141
PTMA prothymosin, alpha -0.111434
TFPI2 tissue factor pathway inhibitor 2 -0.094165
VIM vimentin -0.0901509
EGR1 early growth response 1 -0.0680548
RPS15 ribosomal protein S15 -0.064893
MT2A metallothionein 2A -0.0591037
HLA-B major histocompatibility complex, class I, B -0.0556891
RPLP1 ribosomal protein, large, P1 -0.0527822
RPL35A ribosomal protein L35a -0.0516887
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0482063
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0476723
RPS29 ribosomal protein S29 -0.0467327
ATP5F1B ATP synthase F1 subunit beta -0.0453025
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.045127
NCOA7 nuclear receptor coactivator 7 -0.044777
RPL19 ribosomal protein L19 -0.0444944
RPS21 ribosomal protein S21 -0.0442347
RPS19 ribosomal protein S19 -0.044144
RPL38 ribosomal protein L38 -0.0437786
FTL ferritin, light polypeptide -0.0434308
TPI1 triosephosphate isomerase 1 -0.0427718
ACTG1 actin gamma 1 -0.0425116
RPL12 ribosomal protein L12 -0.0416909
RPL37 ribosomal protein L37 -0.040849
RYR3 ryanodine receptor 3 -0.0397307
RPL5 ribosomal protein L5 -0.0394593
RPL23 ribosomal protein L23 -0.0392812
MYL12B myosin, light chain 12B, regulatory -0.0390579
RPL8 ribosomal protein L8 -0.0387877
CCND1 cyclin D1 -0.0386526
RPS10 ribosomal protein S10 -0.0384667
S100A10 S100 calcium binding protein A10 -0.0380305
DEK DEK proto-oncogene -0.0372117
LDHB lactate dehydrogenase B -0.0367816
RPL34 ribosomal protein L34 -0.0367389
ZMYND8 zinc finger, MYND-type containing 8 -0.0367314
RPS27 ribosomal protein S27 -0.0364944
RPS8 ribosomal protein S8 -0.0364189
RPL32 ribosomal protein L32 -0.0360441
SEPTIN7 septin 7 -0.0356842
RPS6 ribosomal protein S6 -0.0353443
IGF2 insulin-like growth factor 2 -0.0347031
RPL31 ribosomal protein L31 -0.0344515
RPL36 ribosomal protein L36 -0.0340876
RPL11 ribosomal protein L11 -0.0338597
GNAS GNAS complex locus -0.0337698
CAVIN1 caveolae associated protein 1 -0.0335976
ZBTB20 zinc finger and BTB domain containing 20 -0.0330943
OSMR oncostatin M receptor -0.0323984
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0320159
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0319357
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0318012
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0315646
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0313088
S100A6 S100 calcium binding protein A6 -0.0312701
RPL37A ribosomal protein L37a -0.0308336
VDAC1 voltage-dependent anion channel 1 -0.0306367
TM4SF1 transmembrane 4 L six family member 1 -0.0305252
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0299878
RPL9 ribosomal protein L9 -0.0298265
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.02863
TUBA1B tubulin, alpha 1b -0.0284592
BASP1 brain abundant, membrane attached signal protein 1 -0.0282881
RPS14 ribosomal protein S14 -0.0280506
EIF5B eukaryotic translation initiation factor 5B -0.0276061
STC1 stanniocalcin 1 -0.0272051
RPLP2 ribosomal protein, large, P2 -0.0271113
TPM4 tropomyosin 4 -0.0268155
RTN4 reticulon 4 -0.0267989
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0266121
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.026601
RPL36A ribosomal protein L36a -0.026522
PNISR PNN-interacting serine/arginine-rich protein -0.0263672
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0260843
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0259901
FMN1 formin 1 -0.0258415
RPL28 ribosomal protein L28 -0.0257246
KPNB1 karyopherin (importin) beta 1 -0.0256859
NACA nascent polypeptide-associated complex alpha subunit -0.025617
IER3 immediate early response 3 -0.0255822
RPLP0 ribosomal protein, large, P0 -0.0250665
MARCKS myristoylated alanine-rich protein kinase C substrate -0.02505
ANKRD12 ankyrin repeat domain 12 -0.0250361
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0244475
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0242081
HMGA1 high mobility group AT-hook 1 -0.0241755
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0238969
RPS24 ribosomal protein S24 -0.0237033
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.023584
TUBB4B tubulin, beta 4B class IVb -0.0231084
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0228439
RPS25 ribosomal protein S25 -0.0227534
PHF21A PHD finger protein 21A -0.0226754
ENOSF1 enolase superfamily member 1 -0.0225583
RPS23 ribosomal protein S23 -0.022524
PFN1 profilin 1 -0.0223953
EML4 echinoderm microtubule associated protein like 4 -0.0222998
BSG basigin (Ok blood group) -0.0221282