Fusidic acid_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

151 genes differentially expressed following the Fusidic acid_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
YAP1 Yes-associated protein 1 0.150459
NEBL nebulette 0.136168
GLIS3 GLIS family zinc finger 3 0.128338
NAP1L1 nucleosome assembly protein 1-like 1 0.110659
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.107688
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.103584
SLC38A2 solute carrier family 38, member 2 0.0999996
PDE4D phosphodiesterase 4D, cAMP-specific 0.095525
BRWD1 bromodomain and WD repeat domain containing 1 0.0937148
RAD51B RAD51 paralog B 0.0913776
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0891002
EZR ezrin 0.0887038
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0854221
JMJD1C jumonji domain containing 1C 0.0848101
TXNRD1 thioredoxin reductase 1 0.0824433
AKAP12 A kinase (PRKA) anchor protein 12 0.0818856
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0794479
NAV1 neuron navigator 1 0.0785889
TENM3 teneurin transmembrane protein 3 0.072129
FNDC3A fibronectin type III domain containing 3A 0.069796
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0691025
ABI1 abl-interactor 1 0.0681405
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0666867
RPL11 ribosomal protein L11 0.0646445
OSMR oncostatin M receptor 0.0643307
MED13L mediator complex subunit 13-like 0.0633083
NF1 neurofibromin 1 0.062934
EGFR epidermal growth factor receptor 0.0627429
SLIT2 slit homolog 2 (Drosophila) 0.060951
MAP4 microtubule-associated protein 4 0.0607135
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0573286
VMP1 vacuole membrane protein 1 0.055809
EFNA5 ephrin-A5 0.0523641
TJP1 tight junction protein 1 0.051885
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0497344
DSCAM Down syndrome cell adhesion molecule 0.0493487
MPRIP myosin phosphatase Rho interacting protein 0.0488856
EPS8 epidermal growth factor receptor pathway substrate 8 0.0477428
FN1 fibronectin 1 0.0476448
RORA RAR-related orphan receptor A 0.0476002
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0457814
LOC102724023 ES1 protein homolog, mitochondrial 0.0435633
UVRAG UV radiation resistance associated 0.0431626
RPL26 ribosomal protein L26 0.0427737
RUNX1 runt-related transcription factor 1 0.0427512
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0424069
SNX9 sorting nexin 9 0.0420361
KIF2A kinesin heavy chain member 2A 0.0411884
CCNI cyclin I 0.0407186
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0390998
NCKAP5 NCK-associated protein 5 0.0377411
ZCCHC7 zinc finger, CCHC domain containing 7 0.0362429
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0359439
FNDC3B fibronectin type III domain containing 3B 0.0341767
AHNAK AHNAK nucleoprotein 0.0318176
PRELID2 PRELI domain containing 2 0.0316688
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.029979
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0296534
PKM pyruvate kinase, muscle 0.0296441
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0286081
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0281242
SLTM SAFB-like, transcription modulator 0.0280576
ANXA2 annexin A2 0.0280259
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0274188
PRRC2C proline-rich coiled-coil 2C 0.0254508
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0250435
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0242807
FNBP1L formin binding protein 1-like 0.0241087
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0239613
TMEM123 transmembrane protein 123 0.0239356
POTEF POTE ankyrin domain family, member F 0.023445
SMYD3 SET and MYND domain containing 3 0.023014
USP34 ubiquitin specific peptidase 34 0.0230055
KMT2C lysine (K)-specific methyltransferase 2C 0.0217059
PDE10A phosphodiesterase 10A 0.0215459
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0210911
ANKRD12 ankyrin repeat domain 12 0.0207467
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0180702
RBM25 RNA binding motif protein 25 0.0165125
MAP1B microtubule-associated protein 1B 0.0155342
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0129229
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0127154
LDHA lactate dehydrogenase A 0.0103044
AFDN afadin, adherens junction formation factor 0.0095497
MACF1 microtubule-actin crosslinking factor 1 0.00612834
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.00252034
FLNB filamin B, beta 0.00115022
NRG1 neuregulin 1 7.38872E-4

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.200752
TPT1 tumor protein, translationally-controlled 1 -0.181723
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.169629
EXT1 exostosin glycosyltransferase 1 -0.163408
NAV2 neuron navigator 2 -0.142876
HMGA2 high mobility group AT-hook 2 -0.140805
VIM vimentin -0.114463
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.113635
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.109787
CDH13 cadherin 13 -0.106731
CXCL8 chemokine (C-X-C motif) ligand 8 -0.104386
MT2A metallothionein 2A -0.101567
IGF2 insulin-like growth factor 2 -0.101141
COL5A1 collagen, type V, alpha 1 -0.0969991
PSD3 pleckstrin and Sec7 domain containing 3 -0.0879285
NALF1 NALCN channel auxiliary factor 1 -0.0849176
RPS19 ribosomal protein S19 -0.084197
SAMD4A sterile alpha motif domain containing 4A -0.0835975
RPS12 ribosomal protein S12 -0.0817087
RAP1B RAP1B, member of RAS oncogene family -0.0788192
TRIO trio Rho guanine nucleotide exchange factor -0.0785335
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0736847
IGFBP3 insulin-like growth factor binding protein 3 -0.0735094
RPS25 ribosomal protein S25 -0.0732341
LMO7 LIM domain 7 -0.0684184
RPL23 ribosomal protein L23 -0.0671549
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0627742
PTMA prothymosin, alpha -0.0589909
NAMPT nicotinamide phosphoribosyltransferase -0.0581743
NKD1 naked cuticle homolog 1 (Drosophila) -0.0572852
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0527556
LAMB3 laminin, beta 3 -0.0501591
MYO1E myosin IE -0.0488106
ENO1 enolase 1, (alpha) -0.0448029
STC1 stanniocalcin 1 -0.0412881
RPL35A ribosomal protein L35a -0.0404886
NDRG1 N-myc downstream regulated 1 -0.0399895
H3-3B H3.3 histone B -0.0391536
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0389511
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.038892
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0380369
AKAP13 A kinase (PRKA) anchor protein 13 -0.0379871
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0378791
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0353344
TMSB10 thymosin beta 10 -0.0343424
ANKRD11 ankyrin repeat domain 11 -0.0323317
RPS8 ribosomal protein S8 -0.0309251
B2M beta-2-microglobulin -0.0295354
ASPH aspartate beta-hydroxylase -0.0233306
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0228523
PGK1 phosphoglycerate kinase 1 -0.0207309
ZBTB20 zinc finger and BTB domain containing 20 -0.0206773
RPS6 ribosomal protein S6 -0.0148817
MCL1 myeloid cell leukemia 1 -0.0141115
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0124763
FTL ferritin, light polypeptide -0.0124659
VCL vinculin -0.00885651
GOLGA4 golgin A4 -0.00767534
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0042795
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.00420223
PICALM phosphatidylinositol binding clathrin assembly protein -0.00389291
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.00208018
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.00164346