Fusidic acid_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.217178
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.152426
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.149262
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.10799
VCL vinculin 0.0934122
VIM vimentin 0.0757607
ENO1 enolase 1, (alpha) 0.0757543
MACF1 microtubule-actin crosslinking factor 1 0.0752797
DST dystonin 0.0743419
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0741998
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0728478
FBL fibrillarin 0.067636
PKM pyruvate kinase, muscle 0.0651929
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0622534
TRIO trio Rho guanine nucleotide exchange factor 0.0600671
PTMA prothymosin, alpha 0.0589013
CANX calnexin 0.0549339
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.054107
APLP2 amyloid beta (A4) precursor-like protein 2 0.0532042
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0529986
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0528877
BIRC3 baculoviral IAP repeat containing 3 0.0516888
SEPTIN9 septin 9 0.0500511
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0492213
NAP1L1 nucleosome assembly protein 1-like 1 0.046766
LDHA lactate dehydrogenase A 0.0460118
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0456117
JUN jun proto-oncogene 0.0449389
RPL35A ribosomal protein L35a 0.044742
RPS3 ribosomal protein S3 0.0446784
SRRM2 serine/arginine repetitive matrix 2 0.0446212
ASPH aspartate beta-hydroxylase 0.0440162
ADM adrenomedullin 0.0435254
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0431305
CENPF centromere protein F, 350/400kDa 0.0423402
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0412791
ANKRD11 ankyrin repeat domain 11 0.0401093
SQSTM1 sequestosome 1 0.0394267
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0386192
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0381907
CALR calreticulin 0.0377959
AHNAK AHNAK nucleoprotein 0.0376351
TPM3 tropomyosin 3 0.0375953
HDAC9 histone deacetylase 9 0.0368007
MYH9 myosin, heavy chain 9, non-muscle 0.0367074
RIGI RNA sensor RIG-I 0.035826
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0354356
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0354233
KTN1 kinectin 1 (kinesin receptor) 0.0342697
TPM1 tropomyosin 1 (alpha) 0.0336827
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.032585
PRELID2 PRELI domain containing 2 0.0319987
AFDN afadin, adherens junction formation factor 0.0314214
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0312474
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0312322
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0306177
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0305821
TRIP12 thyroid hormone receptor interactor 12 0.0305808
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0304167
INTS6 integrator complex subunit 6 0.0302822
FNDC3B fibronectin type III domain containing 3B 0.0300579
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0299391
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0297434
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0297265
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0294484
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0293181
HSPA8 heat shock 70kDa protein 8 0.0291568
GARS1 glycyl-tRNA synthetase 1 0.029155
MCL1 myeloid cell leukemia 1 0.0287314
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0286724
ANO6 anoctamin 6 0.0282427
APP amyloid beta (A4) precursor protein 0.0281977
TPR translocated promoter region, nuclear basket protein 0.0280736
GOLGB1 golgin B1 0.0280606
SEPTIN7 septin 7 0.0277954
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0277126
MT2A metallothionein 2A 0.0276785
LARS1 leucyl-tRNA synthetase 1 0.0273973
SFTPA2 surfactant protein A2 0.0273931
RPL37A ribosomal protein L37a 0.0272779
CA8 carbonic anhydrase VIII 0.0271637
CSNK1A1 casein kinase 1, alpha 1 0.0269296
MYO1E myosin IE 0.0268092
SET SET nuclear proto-oncogene 0.0267266
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0266509
RPS12 ribosomal protein S12 0.0263671
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0261009
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0258348
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0258049
RPS27A ribosomal protein S27a 0.0257362
KPNB1 karyopherin (importin) beta 1 0.0256639
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0256386
CARS1 cysteinyl-tRNA synthetase 1 0.0256179
MYO10 myosin X 0.0254239
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.025296
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0252256
TPT1 tumor protein, translationally-controlled 1 0.0250567
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0248843
SMAD3 SMAD family member 3 0.0248255
SERBP1 SERPINE1 mRNA binding protein 1 0.0247629

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.131111
ZFP36 ZFP36 ring finger protein -0.0545272
ACTN4 actinin, alpha 4 -0.0412623
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0409376
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0377839
RPS16 ribosomal protein S16 -0.0367039
ARHGAP29 Rho GTPase activating protein 29 -0.0290808
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0287411
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0287111
WWTR1 WW domain containing transcription regulator 1 -0.0272078
CARD18 caspase recruitment domain family, member 18 -0.0236785
RPL28 ribosomal protein L28 -0.0219496
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0219333
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.0219217
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0217908
SLC35F3 solute carrier family 35, member F3 -0.0212705
AFAP1 actin filament associated protein 1 -0.020294
MON2 MON2 homolog (S. cerevisiae) -0.0198603
HSPG2 heparan sulfate proteoglycan 2 -0.0193983
SBF2 SET binding factor 2 -0.0191826
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.019043
CD44 CD44 molecule (Indian blood group) -0.0187936
ANKRD28 ankyrin repeat domain 28 -0.0185217
TMEM123 transmembrane protein 123 -0.0184244
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0183984
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.01745
LOC112694756 uncharaterized LOC112694756 -0.0171199
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0163544
TMEM41B transmembrane protein 41B -0.0154756
LAMA5 laminin, alpha 5 -0.0153949
RUSC2 RUN and SH3 domain containing 2 -0.0153073
PTEN phosphatase and tensin homolog -0.0149948
ZNF331 zinc finger protein 331 -0.0148896
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.014731
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0146798
DHFR dihydrofolate reductase -0.0143644
HM13 histocompatibility (minor) 13 -0.0143465
MBNL2 muscleblind-like splicing regulator 2 -0.0142397
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.0142374
NCEH1 neutral cholesterol ester hydrolase 1 -0.0142097
CDCP1 CUB domain containing protein 1 -0.0139253
PYGB phosphorylase, glycogen; brain -0.013872
TMEM165 transmembrane protein 165 -0.0134655
R3HDM1 R3H domain containing 1 -0.013361
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0133372
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0133215
ADGRG6 adhesion G protein-coupled receptor G6 -0.0132998
WASF2 WAS protein family, member 2 -0.013177
BIRC6 baculoviral IAP repeat containing 6 -0.0130977
RPS25 ribosomal protein S25 -0.0130882
DENND4A DENN/MADD domain containing 4A -0.012922
EPAS1 endothelial PAS domain protein 1 -0.0128393
NPC1 Niemann-Pick disease, type C1 -0.0126453
AXL AXL receptor tyrosine kinase -0.012381
FHL2 four and a half LIM domains 2 -0.0122108
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0122033
NPAS2 neuronal PAS domain protein 2 -0.0121298
ZBTB20 zinc finger and BTB domain containing 20 -0.0120871
UGCG UDP-glucose ceramide glucosyltransferase -0.0119224
AOPEP aminopeptidase O (putative) -0.0118568
SEC14L1 SEC14-like 1 (S. cerevisiae) -0.0117021
SRP54 signal recognition particle 54kDa -0.0116695
SREBF2 sterol regulatory element binding transcription factor 2 -0.0116308
ARHGAP26 Rho GTPase activating protein 26 -0.0115801
ZNF207 zinc finger protein 207 -0.0115478
UBASH3B ubiquitin associated and SH3 domain containing B -0.0115056
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0115045
MECP2 methyl CpG binding protein 2 -0.0112957
GLCCI1 glucocorticoid induced 1 -0.0112315
STAT5B signal transducer and activator of transcription 5B -0.0111701
IRAK2 interleukin-1 receptor-associated kinase 2 -0.0111104
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0110488
RASAL2 RAS protein activator like 2 -0.0108505
TAPBP TAP binding protein (tapasin) -0.0107514
TNRC18 trinucleotide repeat containing 18 -0.0106822
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.010664
AGRN agrin -0.010353
FAM3C family with sequence similarity 3, member C -0.010302
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0102038
THSD4 thrombospondin, type I, domain containing 4 -0.0100349
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -0.00993737
LIMD1 LIM domains containing 1 -0.00993111
PTBP3 polypyrimidine tract binding protein 3 -0.00989615
ANTXR1 anthrax toxin receptor 1 -0.00987926
ARRDC3 arrestin domain containing 3 -0.00977151
TBC1D23 TBC1 domain family, member 23 -0.0096592
RNF13 ring finger protein 13 -0.00963138
BMERB1 bMERB domain containing 1 -0.00951413
ACTG1 actin gamma 1 -0.00947023
NFE2L2 nuclear factor, erythroid 2-like 2 -0.00937012
PIAS1 protein inhibitor of activated STAT, 1 -0.00923421
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -0.00908996
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.00906764
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.00888384
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.00888159
AVL9 AVL9 homolog (S. cerevisiase) -0.00888047
RARS2 arginyl-tRNA synthetase 2, mitochondrial -0.00880389
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.00877328
LENG8 leukocyte receptor cluster (LRC) member 8 -0.00869327
ZNF875 zinc finger protein 875 -0.00866345