Fusidic acid_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in RKO cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Fusidic acid_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FRMD6 FERM domain containing 6 0.176925
ZEB1 zinc finger E-box binding homeobox 1 0.105924
ZNF438 zinc finger protein 438 0.0943787
ARHGAP22 Rho GTPase activating protein 22 0.09237
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0846299
EXT1 exostosin glycosyltransferase 1 0.0748399
SGMS2 sphingomyelin synthase 2 0.0723289
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.067374
HMGA2 high mobility group AT-hook 2 0.0640705
MCL1 myeloid cell leukemia 1 0.0595746
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0595097
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0579579
CAPRIN2 caprin family member 2 0.0550192
RCOR1 REST corepressor 1 0.0540789
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0520738
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.047687
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0470943
AGO2 argonaute RISC catalytic component 2 0.0441566
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.043683
CORO1C coronin, actin binding protein, 1C 0.040092
SFPQ splicing factor proline/glutamine-rich 0.0397613
INTS6 integrator complex subunit 6 0.0393532
SP100 SP100 nuclear antigen 0.0392447
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0378101
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0375301
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0367534
FRMD4A FERM domain containing 4A 0.0366627
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0350703
IFI16 interferon, gamma-inducible protein 16 0.0335665
ASPH aspartate beta-hydroxylase 0.0334751
SLC38A2 solute carrier family 38, member 2 0.0333448
ANK2 ankyrin 2, neuronal 0.0326019
WNT2B wingless-type MMTV integration site family, member 2B 0.0324727
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.0321324
AKAP12 A kinase (PRKA) anchor protein 12 0.0315683
XRN2 5'-3' exoribonuclease 2 0.030623
RPS3 ribosomal protein S3 0.0304826
RPS12 ribosomal protein S12 0.0294447
SRRM2 serine/arginine repetitive matrix 2 0.0286705
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0282532
EFNB2 ephrin-B2 0.0282191
RAD51B RAD51 paralog B 0.0281996
LRMDA leucine rich melanocyte differentiation associated 0.027679
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0275629
PRELID2 PRELI domain containing 2 0.0275572
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0273733
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0261947
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0257984
TPM3 tropomyosin 3 0.0253671
RPL41 ribosomal protein L41 0.0250734
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.025035
YBX3 Y box binding protein 3 0.024928
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.024874
SERBP1 SERPINE1 mRNA binding protein 1 0.0247819
ACTN1 actinin, alpha 1 0.024526
TRIP12 thyroid hormone receptor interactor 12 0.0241378
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0236387
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0233313
ADTRP androgen-dependent TFPI-regulating protein 0.0231379
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0231223
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0230815
ZSWIM6 zinc finger, SWIM-type containing 6 0.022616
EGFR epidermal growth factor receptor 0.0224428
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0223062
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0221745
TRIB1 tribbles pseudokinase 1 0.0221022
PUM3 pumilio RNA binding family member 3 0.0219721
PKM pyruvate kinase, muscle 0.0216774
EIF5 eukaryotic translation initiation factor 5 0.0216429
SMYD3 SET and MYND domain containing 3 0.0213082
PHF14 PHD finger protein 14 0.0211349
ENO1 enolase 1, (alpha) 0.0209907
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0206382
ANKRD17 ankyrin repeat domain 17 0.0205184
IARS1 isoleucyl-tRNA synthetase 1 0.0204632
FBXL17 F-box and leucine-rich repeat protein 17 0.0204462
NAV3 neuron navigator 3 0.0204408
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.0203714
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0202771
VMP1 vacuole membrane protein 1 0.0202486
ARHGAP31 Rho GTPase activating protein 31 0.0202407
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0200838
SND1 staphylococcal nuclease and tudor domain containing 1 0.0199206
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 0.019884
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0198788
GTPBP2 GTP binding protein 2 0.0197794
RAP1B RAP1B, member of RAS oncogene family 0.0196666
PMM2 phosphomannomutase 2 0.0195735
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0194591
RIGI RNA sensor RIG-I 0.0194107
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0192396
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0192036
GDI2 GDP dissociation inhibitor 2 0.0190642
MT2A metallothionein 2A 0.0190485
MCTP1 multiple C2 domains, transmembrane 1 0.0187037
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0186562
COL27A1 collagen, type XXVII, alpha 1 0.018607
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0183158
ASXL1 additional sex combs like transcriptional regulator 1 0.0182627
NEMP2 nuclear envelope integral membrane protein 2 0.0182213

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.181414
ACTG1 actin gamma 1 -0.177977
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127105
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.119673
DLC1 DLC1 Rho GTPase activating protein -0.106679
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0833713
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0684466
LOC112694756 uncharaterized LOC112694756 -0.0658379
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0608251
RAD21 RAD21 homolog (S. pombe) -0.0600367
LAMB3 laminin, beta 3 -0.0562112
RPL7A ribosomal protein L7a -0.0560159
KDM3A lysine (K)-specific demethylase 3A -0.0559332
AHNAK AHNAK nucleoprotein -0.05567
RPLP1 ribosomal protein, large, P1 -0.053176
TXNRD1 thioredoxin reductase 1 -0.0525085
PRRC2B proline-rich coiled-coil 2B -0.0507242
TPD52 tumor protein D52 -0.0496186
PDIA3 protein disulfide isomerase family A, member 3 -0.0485756
TTR transthyretin -0.0480638
ELL2 elongation factor, RNA polymerase II, 2 -0.0478467
EEF2 eukaryotic translation elongation factor 2 -0.0476078
RLF rearranged L-myc fusion -0.0470117
UBC ubiquitin C -0.0463467
TPT1 tumor protein, translationally-controlled 1 -0.0462299
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0454572
TRIO trio Rho guanine nucleotide exchange factor -0.0453674
RPL8 ribosomal protein L8 -0.0449049
OGA O-GlcNAcase -0.0446548
PTK2 protein tyrosine kinase 2 -0.0443737
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0429093
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0427728
CANX calnexin -0.0419332
RPS16 ribosomal protein S16 -0.0414572
PARD3 par-3 family cell polarity regulator -0.0409963
RPS6 ribosomal protein S6 -0.0409373
PGK1 phosphoglycerate kinase 1 -0.0408294
DIAPH3 diaphanous-related formin 3 -0.0404651
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0392727
USP3 ubiquitin specific peptidase 3 -0.0388859
SEPTIN7 septin 7 -0.0382346
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0380761
RPL13A ribosomal protein L13a -0.0372481
ZNF292 zinc finger protein 292 -0.0370222
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0369955
TPM4 tropomyosin 4 -0.0365667
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0363828
STC1 stanniocalcin 1 -0.0362212
RBM39 RNA binding motif protein 39 -0.035896
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0358639
MARCHF6 membrane associated ring-CH-type finger 6 -0.0355722
EIF1 eukaryotic translation initiation factor 1 -0.0351133
DEK DEK proto-oncogene -0.0346453
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0345428
FOXO3 forkhead box O3 -0.0339111
SBF2 SET binding factor 2 -0.0338646
RPL30 ribosomal protein L30 -0.0337733
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0336038
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0332085
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0328339
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0327087
PHIP pleckstrin homology domain interacting protein -0.0325642
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0325373
NIPBL Nipped-B homolog (Drosophila) -0.0324788
CALU calumenin -0.0318484
RPS23 ribosomal protein S23 -0.0311249
HMGA1 high mobility group AT-hook 1 -0.0308983
RPS15 ribosomal protein S15 -0.0307858
MTDH metadherin -0.0306855
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0306746
BIRC6 baculoviral IAP repeat containing 6 -0.0305201
GLG1 golgi glycoprotein 1 -0.0302922
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0301353
GNAS GNAS complex locus -0.0298443
RAB1A RAB1A, member RAS oncogene family -0.0286299
HLA-A major histocompatibility complex, class I, A -0.028538
GOLGA4 golgin A4 -0.0284546
PNISR PNN-interacting serine/arginine-rich protein -0.0282553
LMAN1 lectin, mannose-binding, 1 -0.0281685
MIS18BP1 MIS18 binding protein 1 -0.0280014
NPEPPS aminopeptidase puromycin sensitive -0.0277843
RPS27A ribosomal protein S27a -0.0277553
RPS20 ribosomal protein S20 -0.0276926
RPL32 ribosomal protein L32 -0.027594
WDR45B WD repeat domain 45B -0.0275759
RPL19 ribosomal protein L19 -0.0274509
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0274352
RNMT RNA (guanine-7-) methyltransferase -0.0273557
RPS29 ribosomal protein S29 -0.0269611
RPS24 ribosomal protein S24 -0.0267886
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0265763
HLA-C major histocompatibility complex, class I, C -0.0261987
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.026188
MATR3 matrin 3 -0.0260856
RPL7 ribosomal protein L7 -0.0260784
RPL10A ribosomal protein L10a -0.0260023
NAMPT nicotinamide phosphoribosyltransferase -0.0259865
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0259734
NUP58 nucleoporin 58 -0.0259731
MKI67 marker of proliferation Ki-67 -0.0258961