Fusidic acid_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.25807
SMOC1 SPARC related modular calcium binding 1 0.0853832
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.077497
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0698362
SNAP25 synaptosomal-associated protein, 25kDa 0.0674895
VGF VGF nerve growth factor inducible 0.0666732
MCL1 myeloid cell leukemia 1 0.0634929
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0541498
FNDC3A fibronectin type III domain containing 3A 0.0516948
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0488373
PDE4D phosphodiesterase 4D, cAMP-specific 0.0476849
NCKAP5 NCK-associated protein 5 0.0446515
ASPH aspartate beta-hydroxylase 0.0428774
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0393159
MYH9 myosin, heavy chain 9, non-muscle 0.0384738
SLC38A2 solute carrier family 38, member 2 0.0380318
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0371686
ELL2 elongation factor, RNA polymerase II, 2 0.0358626
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0357809
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0339765
FAT1 FAT atypical cadherin 1 0.0334661
IVNS1ABP influenza virus NS1A binding protein 0.0333367
DGKD diacylglycerol kinase, delta 130kDa 0.0314984
AHR aryl hydrocarbon receptor 0.0303461
GRAMD4 GRAM domain containing 4 0.0298491
MPRIP myosin phosphatase Rho interacting protein 0.029547
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0294819
LSAMP limbic system-associated membrane protein 0.0279992
NRXN1 neurexin 1 0.0270479
APP amyloid beta (A4) precursor protein 0.0239869
TMEM255B transmembrane protein 255B 0.023983
PRELID2 PRELI domain containing 2 0.0233894
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0231587
RNF144A ring finger protein 144A 0.0230812
SIK2 salt-inducible kinase 2 0.0226711
NUP58 nucleoporin 58 0.0225767
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0225089
TOP2B topoisomerase (DNA) II beta 180kDa 0.0223179
ADARB1 adenosine deaminase, RNA-specific, B1 0.0222722
PCM1 pericentriolar material 1 0.0220074
NBAS neuroblastoma amplified sequence 0.0214072
TRIP12 thyroid hormone receptor interactor 12 0.0211322
LIMCH1 LIM and calponin homology domains 1 0.0211321
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0210627
MYO1B myosin IB 0.0210256
ANKH ANKH inorganic pyrophosphate transport regulator 0.0208482
MSN moesin 0.0207933
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0204989
SPTBN1 spectrin, beta, non-erythrocytic 1 0.019776
SFPQ splicing factor proline/glutamine-rich 0.019731
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0196752
PSD3 pleckstrin and Sec7 domain containing 3 0.0196633
PBX3 pre-B-cell leukemia homeobox 3 0.0196495
HSPA8 heat shock 70kDa protein 8 0.0195872
USP9X ubiquitin specific peptidase 9, X-linked 0.0194603
PICALM phosphatidylinositol binding clathrin assembly protein 0.0192773
PCSK1 proprotein convertase subtilisin/kexin type 1 0.0191527
AUTS2 autism susceptibility candidate 2 0.0191058
XRN2 5'-3' exoribonuclease 2 0.0190271
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0187168
YTHDC1 YTH domain containing 1 0.0185328
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0185232
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0183219
ZNF407 zinc finger protein 407 0.0181992
TENM1 teneurin transmembrane protein 1 0.0181831
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0180347
RPL4 ribosomal protein L4 0.0179872
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0179254
DST dystonin 0.0177075
RUNX1 runt-related transcription factor 1 0.0176014
IGF1R insulin-like growth factor 1 receptor 0.0174671
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0174168
ADAR adenosine deaminase, RNA-specific 0.017322
BACE2 beta-site APP-cleaving enzyme 2 0.0171336
TTC19 tetratricopeptide repeat domain 19 0.0170545
PCBP3 poly(rC) binding protein 3 0.0167493
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0167183
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0166079
ELOVL5 ELOVL fatty acid elongase 5 0.01649
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0161897
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0159905
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0159007
HYOU1 hypoxia up-regulated 1 0.0157932
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0155149
MBNL1 muscleblind-like splicing regulator 1 0.0154949
VMP1 vacuole membrane protein 1 0.0154545
PRPF8 pre-mRNA processing factor 8 0.0153152
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0152172
KDM4C lysine (K)-specific demethylase 4C 0.0151221
ADAM17 ADAM metallopeptidase domain 17 0.0150429
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0149331
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0149269
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.0149206
WDR26 WD repeat domain 26 0.0148652
ANKRD36 ankyrin repeat domain 36 0.0147177
AKAP13 A kinase (PRKA) anchor protein 13 0.014701
RIMBP2 RIMS binding protein 2 0.014689
SINHCAF SIN3-HDAC complex associated factor 0.0146075
DOT1L DOT1-like histone H3K79 methyltransferase 0.0145794
FCHSD2 FCH and double SH3 domains 2 0.0144794

decreased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 -0.19743
PTMA prothymosin, alpha -0.177987
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0892941
MT2A metallothionein 2A -0.0861339
STC1 stanniocalcin 1 -0.0857235
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0848915
IGFBP5 insulin-like growth factor binding protein 5 -0.0837782
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0825233
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0787331
SNTG1 syntrophin, gamma 1 -0.0787047
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0753805
NRG1 neuregulin 1 -0.0745007
NDRG1 N-myc downstream regulated 1 -0.0736902
PEG10 paternally expressed 10 -0.0690316
FTL ferritin, light polypeptide -0.0683712
ACTG1 actin gamma 1 -0.0671236
GPC6 glypican 6 -0.0665542
CALCA calcitonin-related polypeptide alpha -0.0661297
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0624997
GPC5 glypican 5 -0.0613401
RPL26 ribosomal protein L26 -0.0599192
ESRRG estrogen-related receptor gamma -0.0597225
SYT1 synaptotagmin I -0.0585825
RPS8 ribosomal protein S8 -0.0581621
RIMS2 regulating synaptic membrane exocytosis 2 -0.0564564
RPS21 ribosomal protein S21 -0.0564342
EGR1 early growth response 1 -0.0546627
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0540056
GNAS GNAS complex locus -0.053885
RPS6 ribosomal protein S6 -0.0534358
MAP1B microtubule-associated protein 1B -0.0511938
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.0498632
RPLP1 ribosomal protein, large, P1 -0.0462604
RPS3 ribosomal protein S3 -0.0460845
TSHZ2 teashirt zinc finger homeobox 2 -0.0460763
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0459387
S100A9 S100 calcium binding protein A9 -0.0447732
ATP5F1E ATP synthase F1 subunit epsilon -0.0439105
CNKSR3 CNKSR family member 3 -0.0436413
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0419053
RPL37A ribosomal protein L37a -0.0414928
LOC112694756 uncharaterized LOC112694756 -0.0412671
RPL5 ribosomal protein L5 -0.0403089
ADGRL2 adhesion G protein-coupled receptor L2 -0.0402131
FOXC1 forkhead box C1 -0.0398364
RPL23 ribosomal protein L23 -0.039168
RPL11 ribosomal protein L11 -0.0388923
TPT1 tumor protein, translationally-controlled 1 -0.0386822
TMSB4X thymosin beta 4, X-linked -0.0378915
ZBTB20 zinc finger and BTB domain containing 20 -0.0375205
RIT2 Ras-like without CAAX 2 -0.0373914
TMSB10 thymosin beta 10 -0.0373653
RPL12 ribosomal protein L12 -0.0372034
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0368754
RPL37 ribosomal protein L37 -0.0368519
CCDC88A coiled-coil domain containing 88A -0.0366669
CPE carboxypeptidase E -0.0361224
IFI6 interferon, alpha-inducible protein 6 -0.0358381
RPL31 ribosomal protein L31 -0.03555
PDIA3 protein disulfide isomerase family A, member 3 -0.0353365
NIPBL Nipped-B homolog (Drosophila) -0.0350692
RPL8 ribosomal protein L8 -0.0350328
RPL38 ribosomal protein L38 -0.0347441
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0345043
B2M beta-2-microglobulin -0.0339188
KPNB1 karyopherin (importin) beta 1 -0.0332899
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0331614
CHGA chromogranin A -0.0330946
ATP5F1B ATP synthase F1 subunit beta -0.0327857
RPS27A ribosomal protein S27a -0.0324631
P4HB prolyl 4-hydroxylase, beta polypeptide -0.03234
SCG2 secretogranin II -0.0322276
PGK1 phosphoglycerate kinase 1 -0.0321022
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0318817
RORA RAR-related orphan receptor A -0.0317536
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -0.0317168
RPS16 ribosomal protein S16 -0.0315244
RBM25 RNA binding motif protein 25 -0.0314764
RPS25 ribosomal protein S25 -0.0314387
SEC11C SEC11 homolog C (S. cerevisiae) -0.0313602
RACK1 receptor for activated C kinase 1 -0.0313581
RPS29 ribosomal protein S29 -0.0309621
RPL35A ribosomal protein L35a -0.0306106
RPS5 ribosomal protein S5 -0.0305087
RPS23 ribosomal protein S23 -0.0303804
KTN1 kinectin 1 (kinesin receptor) -0.0297462
RPL36A ribosomal protein L36a -0.0294949
BCL2 B-cell CLL/lymphoma 2 -0.0293049
RPLP0 ribosomal protein, large, P0 -0.0292463
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0285075
RPL36AL ribosomal protein L36a-like -0.0285043
RPS19 ribosomal protein S19 -0.0282823
RPS17 ribosomal protein S17 -0.0281975
RPLP2 ribosomal protein, large, P2 -0.027966
NIPSNAP2 nipsnap homolog 2 -0.027803
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0272539
RPL34 ribosomal protein L34 -0.0272511
RPL19 ribosomal protein L19 -0.0269535
HMGB1 high mobility group box 1 -0.0268721
ZBTB7C zinc finger and BTB domain containing 7C -0.0265768