Fusidic acid_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.0831398
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0740642
AKAP12 A kinase (PRKA) anchor protein 12 0.0708116
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0641009
FMNL2 formin-like 2 0.0583579
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0561298
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0551106
FNDC3B fibronectin type III domain containing 3B 0.053358
CENPF centromere protein F, 350/400kDa 0.0532934
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0494738
PKM pyruvate kinase, muscle 0.0407589
TPM3 tropomyosin 3 0.0404451
FMN1 formin 1 0.0372421
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0343842
PRELID2 PRELI domain containing 2 0.0336852
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0336833
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0323238
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0319111
ASPH aspartate beta-hydroxylase 0.0318925
MSN moesin 0.031194
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0300416
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0298307
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0296994
MSI2 musashi RNA-binding protein 2 0.0288006
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0287341
MACF1 microtubule-actin crosslinking factor 1 0.0286934
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0282426
MYH9 myosin, heavy chain 9, non-muscle 0.027699
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0273384
GOLGB1 golgin B1 0.027245
CFAP20DC CFAP20 domain containing 0.0272375
AFDN afadin, adherens junction formation factor 0.0272259
AMOTL1 angiomotin like 1 0.0271288
SRRM2 serine/arginine repetitive matrix 2 0.0270269
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0263017
SYNE2 spectrin repeat containing, nuclear envelope 2 0.026156
HDAC4 histone deacetylase 4 0.0258268
NFE2L1 nuclear factor, erythroid 2-like 1 0.025607
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0255001
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.025467
RAD51B RAD51 paralog B 0.0252149
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0249141
NOTCH2 notch 2 0.024904
IVNS1ABP influenza virus NS1A binding protein 0.0247893
LINGO2 leucine rich repeat and Ig domain containing 2 0.0245624
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0243289
NAV2 neuron navigator 2 0.0240019
SPAG9 sperm associated antigen 9 0.0238146
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0236156
ATXN1 ataxin 1 0.0232191
SON SON DNA binding protein 0.0231026
EZR ezrin 0.0230803
HDAC9 histone deacetylase 9 0.0219411
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0219164
LPP LIM domain containing preferred translocation partner in lipoma 0.0218412
AKAP13 A kinase (PRKA) anchor protein 13 0.0218058
ACTN1 actinin, alpha 1 0.0216353
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0211668
VEGFA vascular endothelial growth factor A 0.0210107
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.020942
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0203454
SFPQ splicing factor proline/glutamine-rich 0.0201735
PTK2 protein tyrosine kinase 2 0.020085
EP300 E1A binding protein p300 0.0199337
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0198973
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0194042
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0193987
OSBPL10 oxysterol binding protein-like 10 0.018956
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0189517
NAV1 neuron navigator 1 0.0189334
MAML3 mastermind-like 3 (Drosophila) 0.0189002
CD109 CD109 molecule 0.0188914
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0188213
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0187995
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0187261
FN1 fibronectin 1 0.0187135
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0186843
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0184782
IGFBP3 insulin-like growth factor binding protein 3 0.0182121
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0180347
MCL1 myeloid cell leukemia 1 0.0179754
FHIT fragile histidine triad 0.0179697
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0178763
RNF213 ring finger protein 213 0.017556
ZMIZ1 zinc finger, MIZ-type containing 1 0.0175317
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0173845
MAP4 microtubule-associated protein 4 0.0172455
SEPTIN9 septin 9 0.0170061
SET SET nuclear proto-oncogene 0.0168917
SMAD3 SMAD family member 3 0.0168774
HSPA8 heat shock 70kDa protein 8 0.0168183
MEF2A myocyte enhancer factor 2A 0.0164158
KTN1 kinectin 1 (kinesin receptor) 0.0164082
ENO1 enolase 1, (alpha) 0.0159323
USP34 ubiquitin specific peptidase 34 0.0157994
BHLHE40 basic helix-loop-helix family, member e40 0.0157645
CHD1 chromodomain helicase DNA binding protein 1 0.0157403
MED13 mediator complex subunit 13 0.0157374
IQGAP3 IQ motif containing GTPase activating protein 3 0.0157246
SVIL supervillin 0.0157054

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.328075
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.305799
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.100116
FTL ferritin, light polypeptide -0.0932543
RPLP1 ribosomal protein, large, P1 -0.0891355
LSAMP limbic system-associated membrane protein -0.0829994
EIF1 eukaryotic translation initiation factor 1 -0.0789802
PTMA prothymosin, alpha -0.078006
MT2A metallothionein 2A -0.0717693
RPS6 ribosomal protein S6 -0.0703035
ACTG1 actin gamma 1 -0.0668958
SQSTM1 sequestosome 1 -0.066225
RPL35A ribosomal protein L35a -0.0657802
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0657036
CCND1 cyclin D1 -0.0624776
RPS24 ribosomal protein S24 -0.0609259
TPT1 tumor protein, translationally-controlled 1 -0.0604873
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0603222
VDAC1 voltage-dependent anion channel 1 -0.0573527
RPS23 ribosomal protein S23 -0.0567285
TMSB10 thymosin beta 10 -0.0542911
PGK1 phosphoglycerate kinase 1 -0.054247
RPL32 ribosomal protein L32 -0.0524027
RPLP2 ribosomal protein, large, P2 -0.0519208
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.051635
RPL38 ribosomal protein L38 -0.0507636
RPS8 ribosomal protein S8 -0.0507222
RPS29 ribosomal protein S29 -0.0489644
RPL31 ribosomal protein L31 -0.0485118
RPS13 ribosomal protein S13 -0.0482291
RPL34 ribosomal protein L34 -0.045479
RPL23 ribosomal protein L23 -0.0449613
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0448529
RPL11 ribosomal protein L11 -0.0448142
NLGN1 neuroligin 1 -0.0445926
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0435999
ICAM1 intercellular adhesion molecule 1 -0.0433812
RAB7A RAB7A, member RAS oncogene family -0.0418087
RPS3 ribosomal protein S3 -0.040291
RPS16 ribosomal protein S16 -0.0402526
RPL36A ribosomal protein L36a -0.0402458
GOLGA4 golgin A4 -0.0390011
RPS14 ribosomal protein S14 -0.0379291
S100A9 S100 calcium binding protein A9 -0.0374096
LOC112694756 uncharaterized LOC112694756 -0.0364616
RPL5 ribosomal protein L5 -0.0357065
RPS25 ribosomal protein S25 -0.0356879
TM4SF1 transmembrane 4 L six family member 1 -0.0354799
RPS21 ribosomal protein S21 -0.0353255
PMEL premelanosome protein -0.0349294
RPL19 ribosomal protein L19 -0.0344502
IER3 immediate early response 3 -0.0344295
KPNB1 karyopherin (importin) beta 1 -0.033723
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0335313
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0330993
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0328831
RPS15 ribosomal protein S15 -0.0327638
RPS27A ribosomal protein S27a -0.0325053
RPL28 ribosomal protein L28 -0.0320561
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0315587
RPLP0 ribosomal protein, large, P0 -0.0309962
PRAME preferentially expressed antigen in melanoma -0.0307774
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0306023
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.030415
GNAS GNAS complex locus -0.0300834
ZMYND8 zinc finger, MYND-type containing 8 -0.0298854
RPL27 ribosomal protein L27 -0.0296899
RPL12 ribosomal protein L12 -0.0296775
RPS19 ribosomal protein S19 -0.0294744
HLA-B major histocompatibility complex, class I, B -0.0293081
RPS5 ribosomal protein S5 -0.0290976
UBC ubiquitin C -0.0287653
S100A10 S100 calcium binding protein A10 -0.0286776
TFPI2 tissue factor pathway inhibitor 2 -0.0279867
CALU calumenin -0.0279564
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0279388
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0279042
RACK1 receptor for activated C kinase 1 -0.0277546
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0275148
RPS20 ribosomal protein S20 -0.0274878
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0271308
RPL36 ribosomal protein L36 -0.0269926
B2M beta-2-microglobulin -0.0265152
RPL8 ribosomal protein L8 -0.0263596
CTSD cathepsin D -0.026145
RPL7A ribosomal protein L7a -0.0254414
RPS11 ribosomal protein S11 -0.0253999
IFI6 interferon, alpha-inducible protein 6 -0.0253206
RPL15 ribosomal protein L15 -0.0251843
CA8 carbonic anhydrase VIII -0.0250484
LITAF lipopolysaccharide-induced TNF factor -0.0249475
GSTO1 glutathione S-transferase omega 1 -0.0246574
RPL9 ribosomal protein L9 -0.0244173
RHOBTB3 Rho-related BTB domain containing 3 -0.0241893
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0240051
RPL30 ribosomal protein L30 -0.0237993
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0235418
NDRG1 N-myc downstream regulated 1 -0.0235351
WDR45B WD repeat domain 45B -0.0232663
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0230764