Fusidic acid_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PKM pyruvate kinase, muscle 0.144821
PDE4D phosphodiesterase 4D, cAMP-specific 0.113999
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0685571
PRELID2 PRELI domain containing 2 0.0672648
TMSB4X thymosin beta 4, X-linked 0.0668308
ENO1 enolase 1, (alpha) 0.0651752
ADAM10 ADAM metallopeptidase domain 10 0.0626561
SOX6 SRY (sex determining region Y)-box 6 0.0527799
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0469542
MACROD2 MACRO domain containing 2 0.0452125
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0417414
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0403295
BMP10 bone morphogenetic protein 10 0.039878
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0393291
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0386156
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0382739
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0371854
ZNF608 zinc finger protein 608 0.0348506
SEPTIN9 septin 9 0.0338045
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0333803
EIF4B eukaryotic translation initiation factor 4B 0.0331178
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0325857
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.0323953
PCM1 pericentriolar material 1 0.0323381
ANLN anillin, actin binding protein 0.0318796
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0318695
MYO5C myosin VC 0.0313479
RPL41 ribosomal protein L41 0.0313111
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0312983
SDK1 sidekick cell adhesion molecule 1 0.0309131
DST dystonin 0.030898
HSPA8 heat shock 70kDa protein 8 0.0298999
AHNAK AHNAK nucleoprotein 0.0290131
TSC22D1 TSC22 domain family, member 1 0.0276871
ZEB1 zinc finger E-box binding homeobox 1 0.0264585
BPTF bromodomain PHD finger transcription factor 0.0263487
ABI1 abl-interactor 1 0.0262619
EGFR epidermal growth factor receptor 0.0261727
CEP112 centrosomal protein 112kDa 0.0258429
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0242203
PDGFC platelet derived growth factor C 0.0236972
EIF4A2 eukaryotic translation initiation factor 4A2 0.0234417
MYO9A myosin IXA 0.0233395
TPM4 tropomyosin 4 0.0228414
FMN1 formin 1 0.0227858
RPS3 ribosomal protein S3 0.0227631
MACF1 microtubule-actin crosslinking factor 1 0.0226296
CEP250 centrosomal protein 250kDa 0.0223536
CASC3 cancer susceptibility candidate 3 0.0222848
GLI3 GLI family zinc finger 3 0.0218494
NFE2L1 nuclear factor, erythroid 2-like 1 0.0218461
ANKRD36C ankyrin repeat domain 36C 0.0216886
STX18 syntaxin 18 0.0214195
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0210723
CLSTN1 calsyntenin 1 0.0210073
WAC WW domain containing adaptor with coiled-coil 0.0208175
MTA3 metastasis associated 1 family, member 3 0.0207336
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0207125
GPATCH2L G patch domain containing 2-like 0.0206561
IQGAP1 IQ motif containing GTPase activating protein 1 0.0203903
RYK receptor-like tyrosine kinase 0.0202946
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0201401
TAS2R14 taste receptor, type 2, member 14 0.0201325
SMAD6 SMAD family member 6 0.0196265
SCARB2 scavenger receptor class B, member 2 0.0196245
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.019607
DSPP dentin sialophosphoprotein 0.0196012
PCCA propionyl CoA carboxylase, alpha polypeptide 0.019525
RPS18 ribosomal protein S18 0.019486
CKAP5 cytoskeleton associated protein 5 0.0193553
SPRY2 sprouty homolog 2 (Drosophila) 0.0192546
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0191744
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0190531
KIAA1328 KIAA1328 0.0188417
RPL4 ribosomal protein L4 0.0188161
RPL3 ribosomal protein L3 0.0187491
RB1 retinoblastoma 1 0.0186491
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0186288
OSBPL8 oxysterol binding protein-like 8 0.0186136
CAMTA1 calmodulin binding transcription activator 1 0.0185703
PIAS1 protein inhibitor of activated STAT, 1 0.0184777
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0184648
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0183929
MINDY2 MINDY lysine 48 deubiquitinase 2 0.018276
RC3H2 ring finger and CCCH-type domains 2 0.0181442
IFI16 interferon, gamma-inducible protein 16 0.0181231
GIGYF2 GRB10 interacting GYF protein 2 0.0180572
PDIA6 protein disulfide isomerase family A, member 6 0.0179432
PLXNA1 plexin A1 0.0179264
TASP1 taspase, threonine aspartase, 1 0.0178943
EEF2 eukaryotic translation elongation factor 2 0.0178047
CUL4B cullin 4B 0.0176417
TBC1D5 TBC1 domain family, member 5 0.0175876
EFR3A EFR3 homolog A (S. cerevisiae) 0.0174555
KLC1 kinesin light chain 1 0.0174152
KIF11 kinesin family member 11 0.0173296
CKAP2L cytoskeleton associated protein 2-like 0.0172939
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 0.017233
ARGLU1 arginine and glutamate rich 1 0.0172243
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0172232

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.388326
PTMA prothymosin, alpha -0.151846
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.104965
GOLGA4 golgin A4 -0.100871
FLNB filamin B, beta -0.0895142
ACTG1 actin gamma 1 -0.0836397
DLG1 discs, large homolog 1 (Drosophila) -0.0801335
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0782736
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0755416
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0722033
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0643115
BIRC6 baculoviral IAP repeat containing 6 -0.0636123
RPS8 ribosomal protein S8 -0.0619033
EVI5 ecotropic viral integration site 5 -0.0606673
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0602649
RPL11 ribosomal protein L11 -0.0596798
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0596412
RBM39 RNA binding motif protein 39 -0.0587133
NFIA nuclear factor I/A -0.0574342
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0573716
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0569163
IARS1 isoleucyl-tRNA synthetase 1 -0.0566455
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0566446
LOC112694756 uncharaterized LOC112694756 -0.0557829
RPLP0 ribosomal protein, large, P0 -0.0556703
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0546213
RTN4 reticulon 4 -0.0538015
EFNA5 ephrin-A5 -0.0529355
S100A6 S100 calcium binding protein A6 -0.0526627
PDE4B phosphodiesterase 4B, cAMP-specific -0.0523235
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0516733
NF1 neurofibromin 1 -0.050873
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0497449
GNAS GNAS complex locus -0.0477888
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0452801
NPAS2 neuronal PAS domain protein 2 -0.0447561
FNDC3B fibronectin type III domain containing 3B -0.0440649
RHBDD1 rhomboid domain containing 1 -0.0437762
SLC38A2 solute carrier family 38, member 2 -0.0436503
AHI1 Abelson helper integration site 1 -0.0429988
RPS19 ribosomal protein S19 -0.0421889
RPL5 ribosomal protein L5 -0.0416479
SETD5 SET domain containing 5 -0.0412248
GARS1 glycyl-tRNA synthetase 1 -0.0411641
TMEM41B transmembrane protein 41B -0.0410004
RAB7A RAB7A, member RAS oncogene family -0.0405653
TJP1 tight junction protein 1 -0.0404793
FOXP1 forkhead box P1 -0.0403864
GLI2 GLI family zinc finger 2 -0.0401252
ENO2 enolase 2 (gamma, neuronal) -0.0400656
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0399718
RPL35A ribosomal protein L35a -0.0393686
LPP LIM domain containing preferred translocation partner in lipoma -0.0389643
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0389561
RUSC2 RUN and SH3 domain containing 2 -0.0378981
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.03763
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0375668
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0373273
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0372813
SEC31A SEC31 homolog A (S. cerevisiae) -0.0364775
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0356477
PFN1 profilin 1 -0.0354357
NCOR1 nuclear receptor corepressor 1 -0.0348928
HM13 histocompatibility (minor) 13 -0.0347702
BRWD1 bromodomain and WD repeat domain containing 1 -0.034552
MON2 MON2 homolog (S. cerevisiae) -0.0345204
EML4 echinoderm microtubule associated protein like 4 -0.0344841
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0343263
ANK2 ankyrin 2, neuronal -0.0342606
CENPF centromere protein F, 350/400kDa -0.0341897
CCND1 cyclin D1 -0.0340324
FKBP10 FK506 binding protein 10, 65 kDa -0.0336058
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0335422
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0334204
RPS23 ribosomal protein S23 -0.0329969
HSPA4L heat shock 70kDa protein 4-like -0.0328711
RPS25 ribosomal protein S25 -0.0328497
GPHN gephyrin -0.0324273
ATP5F1B ATP synthase F1 subunit beta -0.0323599
HSPB1 heat shock 27kDa protein 1 -0.032338
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0323309
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.031686
S100A10 S100 calcium binding protein A10 -0.031461
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0314259
CALU calumenin -0.0311971
RPS6 ribosomal protein S6 -0.0311353
PNISR PNN-interacting serine/arginine-rich protein -0.0310509
EPB41 erythrocyte membrane protein band 4.1 -0.0309451
NBAS neuroblastoma amplified sequence -0.0307901
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0307175
MBNL1 muscleblind-like splicing regulator 1 -0.0307121
NEBL nebulette -0.0302573
PRRC2B proline-rich coiled-coil 2B -0.0300584
GLS2 glutaminase 2 (liver, mitochondrial) -0.0287955
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0287118
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0281555
TMEM39A transmembrane protein 39A -0.0280837
EIF5B eukaryotic translation initiation factor 5B -0.027844
MED13 mediator complex subunit 13 -0.0277171
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.027714