Fusidic acid_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.375776
MYH9 myosin, heavy chain 9, non-muscle 0.119474
CD44 CD44 molecule (Indian blood group) 0.116319
ERRFI1 ERBB receptor feedback inhibitor 1 0.113426
EXT1 exostosin glycosyltransferase 1 0.0877004
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0867591
COL6A2 collagen, type VI, alpha 2 0.0826564
PRELID2 PRELI domain containing 2 0.0818873
ENO1 enolase 1, (alpha) 0.0810311
FNDC3B fibronectin type III domain containing 3B 0.0794527
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.078845
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0697414
MACF1 microtubule-actin crosslinking factor 1 0.0697361
CANX calnexin 0.0646461
TRIO trio Rho guanine nucleotide exchange factor 0.0580785
COL5A1 collagen, type V, alpha 1 0.0579426
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0577727
SAMD4A sterile alpha motif domain containing 4A 0.0562574
VEGFC vascular endothelial growth factor C 0.0547482
KYNU kynureninase 0.0536023
FAM13A family with sequence similarity 13, member A 0.0532069
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0517095
ASPH aspartate beta-hydroxylase 0.0484366
SEPTIN9 septin 9 0.0467648
CALR calreticulin 0.0462248
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0456428
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.043867
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0435803
AHNAK AHNAK nucleoprotein 0.0434418
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0431362
INSIG2 insulin induced gene 2 0.0415684
BHLHE40 basic helix-loop-helix family, member e40 0.0403632
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0395545
ANKRD11 ankyrin repeat domain 11 0.0395233
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0388632
DST dystonin 0.0386319
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0383386
LOX lysyl oxidase 0.0369759
ATXN1 ataxin 1 0.035369
SLC38A2 solute carrier family 38, member 2 0.0352637
ABLIM3 actin binding LIM protein family, member 3 0.0352167
INTS6 integrator complex subunit 6 0.0350348
ATP13A3 ATPase type 13A3 0.0350198
ZEB2 zinc finger E-box binding homeobox 2 0.0347674
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0346583
GRB10 growth factor receptor-bound protein 10 0.0345665
SND1 staphylococcal nuclease and tudor domain containing 1 0.0344793
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0344382
VMP1 vacuole membrane protein 1 0.0341945
NRXN3 neurexin 3 0.0335077
HIP1 huntingtin interacting protein 1 0.0332743
RUNX1 runt-related transcription factor 1 0.033232
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0330306
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0329915
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0321387
MYO10 myosin X 0.0312106
PKM pyruvate kinase, muscle 0.0309368
SDC4 syndecan 4 0.0307693
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0304465
ARB2A ARB2 cotranscriptional regulator A 0.0303073
TTC3 tetratricopeptide repeat domain 3 0.0302571
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0302161
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0301542
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0300443
SETBP1 SET binding protein 1 0.0299282
AOPEP aminopeptidase O (putative) 0.0298356
SMAD3 SMAD family member 3 0.0296803
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0296012
BBS9 Bardet-Biedl syndrome 9 0.0290137
BACE2 beta-site APP-cleaving enzyme 2 0.0289319
MYOF myoferlin 0.0285915
CLTC clathrin, heavy chain (Hc) 0.0285449
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0282103
GOLGB1 golgin B1 0.0280888
THBS1 thrombospondin 1 0.0278372
ELL2 elongation factor, RNA polymerase II, 2 0.027388
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0270749
PYGL phosphorylase, glycogen, liver 0.0270064
PTK2 protein tyrosine kinase 2 0.026926
GOLGA4 golgin A4 0.0268876
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0266216
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0265165
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0264813
KMT2C lysine (K)-specific methyltransferase 2C 0.0262184
ANKRD36 ankyrin repeat domain 36 0.0261655
ZNF292 zinc finger protein 292 0.0261027
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0258111
SEC24D SEC24 family member D 0.0252985
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0252728
ANO6 anoctamin 6 0.0251541
ANXA2 annexin A2 0.0249552
FAM107B family with sequence similarity 107, member B 0.0246412
ACTN4 actinin, alpha 4 0.0245188
LDHA lactate dehydrogenase A 0.0244247
HOOK2 hook microtubule-tethering protein 2 0.0243437
NAMPT nicotinamide phosphoribosyltransferase 0.0243258
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0241577
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0240905
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0238875
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.023853

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.227527
IGFBP3 insulin-like growth factor binding protein 3 -0.144374
HLA-B major histocompatibility complex, class I, B -0.118286
B2M beta-2-microglobulin -0.103911
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0945444
TMSB10 thymosin beta 10 -0.0939948
FTL ferritin, light polypeptide -0.0932085
COL1A1 collagen, type I, alpha 1 -0.0769889
MT2A metallothionein 2A -0.0663869
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0616126
VIM vimentin -0.0565272
PTMA prothymosin, alpha -0.0467398
COL6A1 collagen, type VI, alpha 1 -0.0465009
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0444152
ACTG1 actin gamma 1 -0.0428972
H3-3B H3.3 histone B -0.0420827
COL1A2 collagen, type I, alpha 2 -0.0414186
HLA-C major histocompatibility complex, class I, C -0.040975
MYADM myeloid-associated differentiation marker -0.0377081
RPS14 ribosomal protein S14 -0.0376977
HLA-A major histocompatibility complex, class I, A -0.0373342
KMT2E lysine (K)-specific methyltransferase 2E -0.0363045
BIRC6 baculoviral IAP repeat containing 6 -0.0362852
CCNI cyclin I -0.0359966
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0354649
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0352333
PDE4D phosphodiesterase 4D, cAMP-specific -0.0349791
RPL34 ribosomal protein L34 -0.0329614
ZMYND8 zinc finger, MYND-type containing 8 -0.032635
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0323434
POTEF POTE ankyrin domain family, member F -0.0321281
IL6 interleukin 6 -0.0313592
RPL28 ribosomal protein L28 -0.0300582
GCC2 GRIP and coiled-coil domain containing 2 -0.0300436
MT1X metallothionein 1X -0.0292447
LOC112694756 uncharaterized LOC112694756 -0.0284865
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0284853
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0276583
NDRG1 N-myc downstream regulated 1 -0.0275943
TNS3 tensin 3 -0.0274743
COL5A2 collagen, type V, alpha 2 -0.0272211
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0262578
BBX bobby sox homolog (Drosophila) -0.0258285
SLC38A1 solute carrier family 38, member 1 -0.0257256
RPLP1 ribosomal protein, large, P1 -0.0249182
S100A6 S100 calcium binding protein A6 -0.0246776
GNAS GNAS complex locus -0.0243035
PDIA3 protein disulfide isomerase family A, member 3 -0.0237536
FOSL1 FOS-like antigen 1 -0.0236483
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0235203
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0233955
UGP2 UDP-glucose pyrophosphorylase 2 -0.0233271
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0233069
RAB1A RAB1A, member RAS oncogene family -0.0231987
BSG basigin (Ok blood group) -0.0228578
SERF2 small EDRK-rich factor 2 -0.0227947
AK1 adenylate kinase 1 -0.0226053
MMP12 matrix metallopeptidase 12 -0.0224989
VDAC1 voltage-dependent anion channel 1 -0.0221027
PSD3 pleckstrin and Sec7 domain containing 3 -0.0216897
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0215421
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0215246
RPL9 ribosomal protein L9 -0.0213905
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -0.0213541
PTN pleiotrophin -0.0211414
SEPTIN7 septin 7 -0.0210805
RPS23 ribosomal protein S23 -0.0210521
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0208855
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0208668
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0207916
PIAS1 protein inhibitor of activated STAT, 1 -0.0207576
CST3 cystatin C -0.0206663
EFHD2 EF-hand domain family, member D2 -0.0204948
EGR1 early growth response 1 -0.0204899
S100A9 S100 calcium binding protein A9 -0.0203659
TCERG1 transcription elongation regulator 1 -0.020149
RAB22A RAB22A, member RAS oncogene family -0.0198684
NDFIP1 Nedd4 family interacting protein 1 -0.0195843
HM13 histocompatibility (minor) 13 -0.0195075
CENPE centromere protein E, 312kDa -0.0194867
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0194766
HMGB1 high mobility group box 1 -0.0194609
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0194031
TUBA1B tubulin, alpha 1b -0.0192633
C2CD2 C2 calcium-dependent domain containing 2 -0.0191277
RPL27A ribosomal protein L27a -0.0189864
EIF2A eukaryotic translation initiation factor 2A, 65kDa -0.0189175
RPS11 ribosomal protein S11 -0.0183117
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.0182779
P4HB prolyl 4-hydroxylase, beta polypeptide -0.018248
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0182083
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0182022
JARID2 jumonji, AT rich interactive domain 2 -0.0181273
ANKRD33B ankyrin repeat domain 33B -0.0178775
RPL23 ribosomal protein L23 -0.0177312
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0176503
TFPI2 tissue factor pathway inhibitor 2 -0.0175637
SRPK2 SRSF protein kinase 2 -0.0174927
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0174836
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0174774