Fusidic acid_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.164885
EXT1 exostosin glycosyltransferase 1 0.149811
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0843661
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0724494
NTN4 netrin 4 0.0712665
SMAD3 SMAD family member 3 0.066389
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0661449
VCL vinculin 0.0615364
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0600007
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0591379
AKAP12 A kinase (PRKA) anchor protein 12 0.0590684
ENO1 enolase 1, (alpha) 0.0573056
FNDC3B fibronectin type III domain containing 3B 0.0571344
HIPK2 homeodomain interacting protein kinase 2 0.0551719
STC2 stanniocalcin 2 0.0506034
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0500792
GRB10 growth factor receptor-bound protein 10 0.0491837
MYH9 myosin, heavy chain 9, non-muscle 0.0463141
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0450323
FNDC3A fibronectin type III domain containing 3A 0.0442291
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0432771
PDLIM5 PDZ and LIM domain 5 0.0423465
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0410382
DST dystonin 0.0408815
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0407705
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0407671
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0407443
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.040329
TXNIP thioredoxin interacting protein 0.0396684
SVIL supervillin 0.039099
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0388107
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0384715
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0378864
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0375915
TPR translocated promoter region, nuclear basket protein 0.0370726
WWTR1 WW domain containing transcription regulator 1 0.0365435
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0352566
LTBP1 latent transforming growth factor beta binding protein 1 0.0352507
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0351996
PTK2 protein tyrosine kinase 2 0.0346689
MYOF myoferlin 0.0340501
TRIO trio Rho guanine nucleotide exchange factor 0.0339318
ZSWIM6 zinc finger, SWIM-type containing 6 0.0339225
TPM3 tropomyosin 3 0.0333165
FAT1 FAT atypical cadherin 1 0.0328757
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0324282
GPATCH2L G patch domain containing 2-like 0.0322309
AFDN afadin, adherens junction formation factor 0.0320307
VEGFC vascular endothelial growth factor C 0.0317186
MACF1 microtubule-actin crosslinking factor 1 0.0314918
PKM pyruvate kinase, muscle 0.0307552
NRIP1 nuclear receptor interacting protein 1 0.0307254
SPAG9 sperm associated antigen 9 0.030016
ACTN1 actinin, alpha 1 0.0294262
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.029423
RAB31 RAB31, member RAS oncogene family 0.029242
PRELID2 PRELI domain containing 2 0.0284945
RASAL2 RAS protein activator like 2 0.0283467
MCL1 myeloid cell leukemia 1 0.0277279
ITGA1 integrin, alpha 1 0.027415
PRRC2C proline-rich coiled-coil 2C 0.0270464
NPAS2 neuronal PAS domain protein 2 0.0263711
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0262564
EZR ezrin 0.0256247
MBNL1 muscleblind-like splicing regulator 1 0.0254619
DOCK5 dedicator of cytokinesis 5 0.0254276
APLP2 amyloid beta (A4) precursor-like protein 2 0.0251754
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.024873
CAPN2 calpain 2, (m/II) large subunit 0.0246247
RPS3 ribosomal protein S3 0.0243718
AKAP13 A kinase (PRKA) anchor protein 13 0.024345
RAI14 retinoic acid induced 14 0.0237928
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0236018
CALR calreticulin 0.0235184
CTNND1 catenin (cadherin-associated protein), delta 1 0.0234998
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0232146
MLPH melanophilin 0.0231926
SFPQ splicing factor proline/glutamine-rich 0.0230808
RNF213 ring finger protein 213 0.0230739
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0229396
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0229176
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0228427
KIAA1217 KIAA1217 0.0227629
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0227351
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0226879
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0225053
FLNA filamin A, alpha 0.0216231
ERRFI1 ERBB receptor feedback inhibitor 1 0.0215758
PALLD palladin, cytoskeletal associated protein 0.0215512
RBPMS RNA binding protein with multiple splicing 0.0215445
WDR1 WD repeat domain 1 0.0212835
GPC6 glypican 6 0.0211409
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0209787
ZNF638 zinc finger protein 638 0.020885
WSB1 WD repeat and SOCS box containing 1 0.0205116
CLIP2 CAP-GLY domain containing linker protein 2 0.0204532
CTBP2 C-terminal binding protein 2 0.020399
JMJD1C jumonji domain containing 1C 0.0203968
IFI44 interferon-induced protein 44 0.0203537
NFE2L1 nuclear factor, erythroid 2-like 1 0.0203278

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.381615
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.152534
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.111359
FTH1 ferritin, heavy polypeptide 1 -0.0719841
SQSTM1 sequestosome 1 -0.0625807
NRG1 neuregulin 1 -0.0508575
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0430326
MT2A metallothionein 2A -0.0391635
FTL ferritin, light polypeptide -0.038594
FN1 fibronectin 1 -0.0385888
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.038359
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0352727
RPS6 ribosomal protein S6 -0.0339123
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0324631
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0324259
RPLP1 ribosomal protein, large, P1 -0.0305685
ATP5F1B ATP synthase F1 subunit beta -0.029782
RPS5 ribosomal protein S5 -0.0289715
RPS15 ribosomal protein S15 -0.0280608
RPS25 ribosomal protein S25 -0.0280261
WDR45B WD repeat domain 45B -0.0270422
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0268917
S100A6 S100 calcium binding protein A6 -0.0255469
HLA-B major histocompatibility complex, class I, B -0.0250578
ETV1 ets variant 1 -0.0248637
RPS23 ribosomal protein S23 -0.0243823
EIF1 eukaryotic translation initiation factor 1 -0.0234694
ARF4 ADP-ribosylation factor 4 -0.0231205
GNAS GNAS complex locus -0.0225204
PDIA3 protein disulfide isomerase family A, member 3 -0.0219231
MAP1B microtubule-associated protein 1B -0.0219179
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0212877
FOSL1 FOS-like antigen 1 -0.0210013
COG5 component of oligomeric golgi complex 5 -0.0209723
SCFD2 sec1 family domain containing 2 -0.0208388
SUCO SUN domain containing ossification factor -0.0206906
SETD5 SET domain containing 5 -0.020462
RPS11 ribosomal protein S11 -0.0203536
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0202717
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0201064
UBC ubiquitin C -0.0200963
ACBD3 acyl-CoA binding domain containing 3 -0.0199725
RPL28 ribosomal protein L28 -0.0197623
CDCP1 CUB domain containing protein 1 -0.0196631
TFPI2 tissue factor pathway inhibitor 2 -0.0195464
NAMPT nicotinamide phosphoribosyltransferase -0.0194874
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0187377
UGCG UDP-glucose ceramide glucosyltransferase -0.018176
NKTR natural killer cell triggering receptor -0.0180703
RHEB Ras homolog enriched in brain -0.01803
MIS18BP1 MIS18 binding protein 1 -0.0175582
DNM1L dynamin 1-like -0.0174331
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0174205
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0173087
LRRC23 leucine rich repeat containing 23 -0.0172255
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0171943
KRT81 keratin 81, type II -0.017168
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0168585
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0167408
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0166629
RPS19 ribosomal protein S19 -0.016551
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0164828
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0164715
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0164648
RPS16 ribosomal protein S16 -0.0163523
NUP58 nucleoporin 58 -0.0163475
FDPS farnesyl diphosphate synthase -0.0162269
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0160908
SOX5 SRY (sex determining region Y)-box 5 -0.0159024
SMOX spermine oxidase -0.0158178
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -0.0157319
HMGA1 high mobility group AT-hook 1 -0.0156083
POU2F1 POU class 2 homeobox 1 -0.0154861
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0154811
AFTPH aftiphilin -0.0154055
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0153751
KDM5B lysine (K)-specific demethylase 5B -0.0152821
LDHB lactate dehydrogenase B -0.014934
SAMD8 sterile alpha motif domain containing 8 -0.0148454
RAP1B RAP1B, member of RAS oncogene family -0.0148185
RAB7A RAB7A, member RAS oncogene family -0.0147944
RACK1 receptor for activated C kinase 1 -0.0146781
APOLD1 apolipoprotein L domain containing 1 -0.0145925
VIM vimentin -0.0145827
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0145395
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0145241
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0144922
DSTN destrin (actin depolymerizing factor) -0.0144411
WTAP Wilms tumor 1 associated protein -0.0143579
PIBF1 progesterone immunomodulatory binding factor 1 -0.0143044
RPS24 ribosomal protein S24 -0.0143018
S100A10 S100 calcium binding protein A10 -0.0142469
RPS29 ribosomal protein S29 -0.0142142
FKBP1A FK506 binding protein 1A, 12kDa -0.013913
RPL32 ribosomal protein L32 -0.0138854
PLAG1 pleiomorphic adenoma gene 1 -0.0138078
ATN1 atrophin 1 -0.0138043
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0137937
GAS2L3 growth arrest-specific 2 like 3 -0.0137342
RPLP0 ribosomal protein, large, P0 -0.0136666