Fusidic acid_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DSPP dentin sialophosphoprotein 0.119747
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.103092
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.103017
EZR ezrin 0.0981505
HSPA8 heat shock 70kDa protein 8 0.0731423
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.069548
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0685623
SAMD4A sterile alpha motif domain containing 4A 0.0643732
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0632704
FAT1 FAT atypical cadherin 1 0.0608955
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0600441
SMAD3 SMAD family member 3 0.058533
CALR calreticulin 0.0575094
GOLGB1 golgin B1 0.0574085
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0573373
NEBL nebulette 0.0568772
CANX calnexin 0.056449
MYO1E myosin IE 0.0561928
APLP2 amyloid beta (A4) precursor-like protein 2 0.0559622
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0547795
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0538205
MYH9 myosin, heavy chain 9, non-muscle 0.052659
CSNK1A1 casein kinase 1, alpha 1 0.0520515
IFRD1 interferon-related developmental regulator 1 0.0518312
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0511118
AFDN afadin, adherens junction formation factor 0.0504049
PKM pyruvate kinase, muscle 0.0501245
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0500775
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0495623
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0493892
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0488265
USP9X ubiquitin specific peptidase 9, X-linked 0.0459481
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0451969
FAM107B family with sequence similarity 107, member B 0.0448764
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0444151
TJP1 tight junction protein 1 0.0437905
NCEH1 neutral cholesterol ester hydrolase 1 0.0432999
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0423452
SPAG9 sperm associated antigen 9 0.0422691
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0405295
ZSWIM6 zinc finger, SWIM-type containing 6 0.0389936
RPS3 ribosomal protein S3 0.0388984
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.038052
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0378119
ENO1 enolase 1, (alpha) 0.0377397
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0375937
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0371862
HKDC1 hexokinase domain containing 1 0.0369262
TGFA transforming growth factor, alpha 0.036925
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0365607
KTN1 kinectin 1 (kinesin receptor) 0.0365052
LMO7 LIM domain 7 0.0364489
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0362811
AKAP9 A kinase (PRKA) anchor protein 9 0.0358231
RPL41 ribosomal protein L41 0.0357777
OSBPL10 oxysterol binding protein-like 10 0.035442
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0353968
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0353191
KMT2C lysine (K)-specific methyltransferase 2C 0.0349701
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0348063
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0345794
MACF1 microtubule-actin crosslinking factor 1 0.0342736
CEMIP cell migration inducing protein, hyaluronan binding 0.0341571
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0341306
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0337332
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0335201
CEMIP2 cell migration inducing hyaluronidase 2 0.0334532
SRRM2 serine/arginine repetitive matrix 2 0.0333877
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0331418
EXT1 exostosin glycosyltransferase 1 0.0331213
VCL vinculin 0.0330068
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.032943
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0322968
PRRC2C proline-rich coiled-coil 2C 0.0317799
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0316509
ZFC3H1 zinc finger, C3H1-type containing 0.0315191
INTS6 integrator complex subunit 6 0.0315107
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0313363
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0312034
CKAP5 cytoskeleton associated protein 5 0.0310586
XRN2 5'-3' exoribonuclease 2 0.0310408
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0310025
LDHA lactate dehydrogenase A 0.0309763
EGFR epidermal growth factor receptor 0.0306575
STC2 stanniocalcin 2 0.030594
AKAP13 A kinase (PRKA) anchor protein 13 0.0304269
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0303445
ADM adrenomedullin 0.0302577
PMM2 phosphomannomutase 2 0.03001
CTBP2 C-terminal binding protein 2 0.0297542
EIF4B eukaryotic translation initiation factor 4B 0.0295666
RNF213 ring finger protein 213 0.029407
KRT20 keratin 20, type I 0.0290879
APP amyloid beta (A4) precursor protein 0.029064
TPR translocated promoter region, nuclear basket protein 0.0289666
TTC3 tetratricopeptide repeat domain 3 0.0289352
TMF1 TATA element modulatory factor 1 0.0288695
DSCAM Down syndrome cell adhesion molecule 0.0280378
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0278922
STX3 syntaxin 3 0.0278513

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.18749
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.18594
TMSB10 thymosin beta 10 -0.110072
KRT8 keratin 8, type II -0.0955892
FTH1 ferritin, heavy polypeptide 1 -0.0885846
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0857012
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0795658
CCND1 cyclin D1 -0.0733782
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0699309
RPL28 ribosomal protein L28 -0.0632957
RPS21 ribosomal protein S21 -0.063037
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0614566
MAML2 mastermind-like 2 (Drosophila) -0.0587818
FTL ferritin, light polypeptide -0.0574498
TMEM123 transmembrane protein 123 -0.0559975
HMGA1 high mobility group AT-hook 1 -0.0495614
RPS25 ribosomal protein S25 -0.0483365
CST3 cystatin C -0.047535
S100A10 S100 calcium binding protein A10 -0.0451658
S100A6 S100 calcium binding protein A6 -0.043586
RPL32 ribosomal protein L32 -0.0420994
PERP PERP, TP53 apoptosis effector -0.0420973
RPS15 ribosomal protein S15 -0.0407297
RPLP2 ribosomal protein, large, P2 -0.0404329
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0401353
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.0400102
ITGB4 integrin, beta 4 -0.0399055
RPS6 ribosomal protein S6 -0.0398837
EGR1 early growth response 1 -0.0374139
KRT18 keratin 18, type I -0.0371011
ANKRD28 ankyrin repeat domain 28 -0.0369544
LOC112694756 uncharaterized LOC112694756 -0.0362066
ZMYND8 zinc finger, MYND-type containing 8 -0.036091
RPL23 ribosomal protein L23 -0.0359463
RPL8 ribosomal protein L8 -0.0348201
GNAS GNAS complex locus -0.03479
RPS11 ribosomal protein S11 -0.0339264
ATP5F1B ATP synthase F1 subunit beta -0.0335147
UBC ubiquitin C -0.0326968
FRMD5 FERM domain containing 5 -0.032609
RNF43 ring finger protein 43 -0.032061
PTBP3 polypyrimidine tract binding protein 3 -0.0319854
ACTG1 actin gamma 1 -0.0312144
RPS13 ribosomal protein S13 -0.0310754
LOC102724023 ES1 protein homolog, mitochondrial -0.0305551
RHEB Ras homolog enriched in brain -0.0304091
RPLP1 ribosomal protein, large, P1 -0.0303146
RPS5 ribosomal protein S5 -0.0301085
RBM39 RNA binding motif protein 39 -0.0300422
UGCG UDP-glucose ceramide glucosyltransferase -0.0293806
GSTP1 glutathione S-transferase pi 1 -0.0293453
JUP junction plakoglobin -0.0289256
ZNRF3 zinc and ring finger 3 -0.0288935
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0288883
CTSD cathepsin D -0.0278802
ACTN4 actinin, alpha 4 -0.0278307
PFN1 profilin 1 -0.0274934
RPS24 ribosomal protein S24 -0.0270437
DLG1 discs, large homolog 1 (Drosophila) -0.0268938
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0267049
DYNLRB1 dynein, light chain, roadblock-type 1 -0.026703
SETD5 SET domain containing 5 -0.026486
KMT2E lysine (K)-specific methyltransferase 2E -0.0262632
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0257184
ASTN2 astrotactin 2 -0.0255604
CDCP1 CUB domain containing protein 1 -0.0252219
SDK1 sidekick cell adhesion molecule 1 -0.0251546
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0249574
RPS14 ribosomal protein S14 -0.0247319
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0245756
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0243116
RPS16 ribosomal protein S16 -0.024028
RPS29 ribosomal protein S29 -0.0238648
RPS23 ribosomal protein S23 -0.0236905
CADPS Ca++-dependent secretion activator -0.0236039
WASF2 WAS protein family, member 2 -0.0234839
HLA-A major histocompatibility complex, class I, A -0.023061
GTF2IRD1 GTF2I repeat domain containing 1 -0.0228192
CAPN1 calpain 1, (mu/I) large subunit -0.0225325
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0223666
MIDN midnolin -0.0223193
PIAS1 protein inhibitor of activated STAT, 1 -0.0223071
RPL36A ribosomal protein L36a -0.022287
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0222866
RPL15 ribosomal protein L15 -0.02217
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.0220699
RBM27 RNA binding motif protein 27 -0.022043
PDE8A phosphodiesterase 8A -0.02186
TCERG1 transcription elongation regulator 1 -0.0214667
RPL19 ribosomal protein L19 -0.0214233
USP3 ubiquitin specific peptidase 3 -0.0213652
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0212537
BSG basigin (Ok blood group) -0.0211213
RAB22A RAB22A, member RAS oncogene family -0.0209116
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0207901
RPL5 ribosomal protein L5 -0.0207244
HMGB1 high mobility group box 1 -0.0207185
ZNF207 zinc finger protein 207 -0.0203867
SNX9 sorting nexin 9 -0.0202406
TFG TRK-fused gene -0.0202156