Fusidic acid_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.232196
ATXN1 ataxin 1 0.115279
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.108847
HMGA2 high mobility group AT-hook 2 0.0938767
FAT1 FAT atypical cadherin 1 0.0892766
LMO7 LIM domain 7 0.0775293
MACF1 microtubule-actin crosslinking factor 1 0.07319
YAP1 Yes-associated protein 1 0.0698844
USP9X ubiquitin specific peptidase 9, X-linked 0.0666976
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0609751
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0600249
SMAD3 SMAD family member 3 0.0600097
DSCAM Down syndrome cell adhesion molecule 0.0511988
MYO5B myosin VB 0.0478941
EFNB2 ephrin-B2 0.0466787
ARHGAP42 Rho GTPase activating protein 42 0.0419892
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0417942
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0410335
SRRM2 serine/arginine repetitive matrix 2 0.0395415
PRELID2 PRELI domain containing 2 0.0386859
LAMA4 laminin, alpha 4 0.0386487
SNX9 sorting nexin 9 0.0385755
SEPTIN9 septin 9 0.0375814
VMP1 vacuole membrane protein 1 0.0371904
CPOX coproporphyrinogen oxidase 0.0364294
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0363945
USP6NL USP6 N-terminal like 0.0356164
ECT2 epithelial cell transforming 2 0.0351847
DSPP dentin sialophosphoprotein 0.0347653
NCEH1 neutral cholesterol ester hydrolase 1 0.0347046
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0340975
ZNRF3 zinc and ring finger 3 0.0336095
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0328438
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0321828
SFPQ splicing factor proline/glutamine-rich 0.0320357
TTC3 tetratricopeptide repeat domain 3 0.0318716
SPRED2 sprouty-related, EVH1 domain containing 2 0.0315727
PDE4B phosphodiesterase 4B, cAMP-specific 0.0314402
AREG amphiregulin 0.0314271
PCM1 pericentriolar material 1 0.0314178
MYH9 myosin, heavy chain 9, non-muscle 0.0309173
MSI2 musashi RNA-binding protein 2 0.0306643
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0306598
RCOR1 REST corepressor 1 0.030111
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0299895
RNF43 ring finger protein 43 0.0298248
SON SON DNA binding protein 0.0296247
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0294066
BCL2L1 BCL2-like 1 0.0291582
ZHX2 zinc fingers and homeoboxes 2 0.0287723
ARHGAP32 Rho GTPase activating protein 32 0.0286514
HOMER1 homer scaffolding protein 1 0.0286369
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0284616
SLTM SAFB-like, transcription modulator 0.02802
ALCAM activated leukocyte cell adhesion molecule 0.0275809
TNS3 tensin 3 0.027506
ZSWIM6 zinc finger, SWIM-type containing 6 0.0268761
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0267223
CCSER1 coiled-coil serine-rich protein 1 0.0262474
APLP2 amyloid beta (A4) precursor-like protein 2 0.0262278
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0262098
SLC30A10 solute carrier family 30, member 10 0.0261779
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0260928
DST dystonin 0.0257999
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.025583
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0254567
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0253572
ABR active BCR-related 0.0253281
EXT1 exostosin glycosyltransferase 1 0.0250522
MTUS1 microtubule associated tumor suppressor 1 0.0245421
HDAC4 histone deacetylase 4 0.0245259
DPY19L1 dpy-19-like 1 (C. elegans) 0.0245235
ZNF638 zinc finger protein 638 0.0242997
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0242593
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0242503
CSNK1A1 casein kinase 1, alpha 1 0.0241413
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0240543
KMT2C lysine (K)-specific methyltransferase 2C 0.0240179
MIDEAS mitotic deacetylase associated SANT domain protein 0.0237758
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.02365
BIRC3 baculoviral IAP repeat containing 3 0.0235361
SPATA13 spermatogenesis associated 13 0.0234909
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0230584
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0230206
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.0224989
FHL2 four and a half LIM domains 2 0.0223419
STK24 serine/threonine kinase 24 0.0221605
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0220323
NTSR1 neurotensin receptor 1 (high affinity) 0.0219465
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0218701
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0218378
CLDND1 claudin domain containing 1 0.0217361
PRRC2C proline-rich coiled-coil 2C 0.0215232
KITLG KIT ligand 0.021521
WSB1 WD repeat and SOCS box containing 1 0.0213612
CCNL1 cyclin L1 0.0213005
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0212258
FNDC3B fibronectin type III domain containing 3B 0.02108
EPHA2 EPH receptor A2 0.0208133
RPL3 ribosomal protein L3 0.0207795

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.277132
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.184609
ACTG1 actin gamma 1 -0.138908
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.134873
FRAS1 Fraser extracellular matrix complex subunit 1 -0.104305
PTMA prothymosin, alpha -0.102729
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0772774
HDAC2 histone deacetylase 2 -0.0699974
GPC5 glypican 5 -0.0650387
RPS24 ribosomal protein S24 -0.0612975
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0612489
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0579816
IER3 immediate early response 3 -0.0567505
FLOT1 flotillin 1 -0.0549482
TPT1 tumor protein, translationally-controlled 1 -0.0528645
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0517965
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0516408
IGFBP3 insulin-like growth factor binding protein 3 -0.0503709
RPS8 ribosomal protein S8 -0.0502536
VCL vinculin -0.0480233
ANXA2 annexin A2 -0.0464944
EIF1 eukaryotic translation initiation factor 1 -0.0461815
LAMB3 laminin, beta 3 -0.0453984
RPS25 ribosomal protein S25 -0.0434786
RPS6 ribosomal protein S6 -0.0430628
FERMT1 fermitin family member 1 -0.0408103
ITPKC inositol-trisphosphate 3-kinase C -0.0377805
LDHA lactate dehydrogenase A -0.0371847
FHIT fragile histidine triad -0.0368468
PERP PERP, TP53 apoptosis effector -0.0357493
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0353661
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0338205
CCND1 cyclin D1 -0.0327549
RPLP1 ribosomal protein, large, P1 -0.0326739
TPM4 tropomyosin 4 -0.0326387
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0324337
ATP5F1B ATP synthase F1 subunit beta -0.0323735
RPL34 ribosomal protein L34 -0.0323734
ANXA1 annexin A1 -0.0322972
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.032199
RPS29 ribosomal protein S29 -0.0320933
EMP1 epithelial membrane protein 1 -0.0315468
RPLP0 ribosomal protein, large, P0 -0.0314523
RPS15 ribosomal protein S15 -0.0312271
FOSL1 FOS-like antigen 1 -0.0312062
RPS5 ribosomal protein S5 -0.031052
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0308132
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0305121
SERINC5 serine incorporator 5 -0.0303605
MTAP methylthioadenosine phosphorylase -0.0303096
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.030117
UBC ubiquitin C -0.0299459
EGR1 early growth response 1 -0.0299033
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0294695
RSL1D1 ribosomal L1 domain containing 1 -0.0294664
KLF5 Kruppel-like factor 5 (intestinal) -0.0292337
S100A10 S100 calcium binding protein A10 -0.0278702
RPS23 ribosomal protein S23 -0.0272989
OSBPL3 oxysterol binding protein-like 3 -0.0271624
S100A6 S100 calcium binding protein A6 -0.0271098
CUX1 cut-like homeobox 1 -0.0262339
ANXA3 annexin A3 -0.0259863
RPL32 ribosomal protein L32 -0.0258633
RPL7A ribosomal protein L7a -0.0255013
RPS13 ribosomal protein S13 -0.02548
FTH1 ferritin, heavy polypeptide 1 -0.0254479
SBF2 SET binding factor 2 -0.0251626
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.025153
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.024896
KLF3 Kruppel-like factor 3 (basic) -0.0245519
COG5 component of oligomeric golgi complex 5 -0.0243947
LOC102724023 ES1 protein homolog, mitochondrial -0.0241616
CD36 CD36 molecule (thrombospondin receptor) -0.0241278
DENND1A DENN/MADD domain containing 1A -0.0241244
VDAC1 voltage-dependent anion channel 1 -0.0240819
RPS16 ribosomal protein S16 -0.0240473
RPL37 ribosomal protein L37 -0.0238836
SQSTM1 sequestosome 1 -0.0236615
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.0230889
INSIG1 insulin induced gene 1 -0.0230643
RPL26 ribosomal protein L26 -0.0229931
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0229314
TMSB10 thymosin beta 10 -0.0229052
RPL13A ribosomal protein L13a -0.0228903
CANX calnexin -0.0226951
AKAP12 A kinase (PRKA) anchor protein 12 -0.0225347
RPL12 ribosomal protein L12 -0.0224078
RPL31 ribosomal protein L31 -0.0223571
LMAN1 lectin, mannose-binding, 1 -0.0220928
ARF1 ADP-ribosylation factor 1 -0.0216622
RPL19 ribosomal protein L19 -0.0216574
SKAP1 src kinase associated phosphoprotein 1 -0.0215907
RPL35A ribosomal protein L35a -0.0214814
RPL7 ribosomal protein L7 -0.021391
EEF2 eukaryotic translation elongation factor 2 -0.0213516
GPHN gephyrin -0.0213468
RPL11 ribosomal protein L11 -0.0210759
PATJ PATJ crumbs cell polarity complex component -0.0208894
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.020719
RPL5 ribosomal protein L5 -0.0205418