Fusidic acid_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fusidic acid perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fusidic acid_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.142337
NKD1 naked cuticle homolog 1 (Drosophila) 0.0956593
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0775656
NAV2 neuron navigator 2 0.0719165
WWOX WW domain containing oxidoreductase 0.0659942
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0639762
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0639482
YAP1 Yes-associated protein 1 0.0631746
SYT1 synaptotagmin I 0.0613899
INTS6 integrator complex subunit 6 0.0598484
MSI2 musashi RNA-binding protein 2 0.0571236
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0537446
TNS3 tensin 3 0.0518986
SMAD3 SMAD family member 3 0.0512841
RAD51B RAD51 paralog B 0.0508978
SFPQ splicing factor proline/glutamine-rich 0.0506399
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0465437
ACTN1 actinin, alpha 1 0.045709
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0455219
ACTN4 actinin, alpha 4 0.0441879
SAMD4A sterile alpha motif domain containing 4A 0.0437352
MYH9 myosin, heavy chain 9, non-muscle 0.0424833
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0424012
MACF1 microtubule-actin crosslinking factor 1 0.0415114
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0410359
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0406244
PDE4D phosphodiesterase 4D, cAMP-specific 0.0399982
ASPH aspartate beta-hydroxylase 0.0385592
DST dystonin 0.0381176
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.03808
LMO7 LIM domain 7 0.0377418
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0367969
HDAC4 histone deacetylase 4 0.0365082
PRELID2 PRELI domain containing 2 0.0364762
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0364132
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0360276
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0359278
SLC38A2 solute carrier family 38, member 2 0.0351957
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0346358
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0337648
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0335844
DSPP dentin sialophosphoprotein 0.0334998
GLI3 GLI family zinc finger 3 0.0334742
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0330207
PDLIM5 PDZ and LIM domain 5 0.0314092
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0308921
EGFR epidermal growth factor receptor 0.0304962
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0299457
LRMDA leucine rich melanocyte differentiation associated 0.0294378
ZNRF3 zinc and ring finger 3 0.0293939
FAT1 FAT atypical cadherin 1 0.0292484
RUNX1 runt-related transcription factor 1 0.0290627
MCC mutated in colorectal cancers 0.0290587
EXOC4 exocyst complex component 4 0.0289371
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0284513
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0279833
SMYD3 SET and MYND domain containing 3 0.0269503
NOP56 NOP56 ribonucleoprotein 0.0267956
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0265041
SEPTIN9 septin 9 0.0264024
BMP5 bone morphogenetic protein 5 0.0261926
DOCK5 dedicator of cytokinesis 5 0.0259927
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0257097
PCLO piccolo presynaptic cytomatrix protein 0.0255739
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0254486
ARGLU1 arginine and glutamate rich 1 0.0250593
SDK1 sidekick cell adhesion molecule 1 0.0249755
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.02496
FHIT fragile histidine triad 0.024178
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0239593
ADAM19 ADAM metallopeptidase domain 19 0.0236819
ECT2 epithelial cell transforming 2 0.0236242
RNF43 ring finger protein 43 0.0235925
CEMIP cell migration inducing protein, hyaluronan binding 0.023191
STK38L serine/threonine kinase 38 like 0.0227188
CEP112 centrosomal protein 112kDa 0.0226007
CENPF centromere protein F, 350/400kDa 0.0224891
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.022394
SYK spleen tyrosine kinase 0.0223613
CTBP2 C-terminal binding protein 2 0.0222884
MYO1D myosin ID 0.022279
RPL41 ribosomal protein L41 0.0221407
GMDS GDP-mannose 4,6-dehydratase 0.022119
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0221149
TRIO trio Rho guanine nucleotide exchange factor 0.0219169
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.021794
TIAM1 T-cell lymphoma invasion and metastasis 1 0.021597
VMP1 vacuole membrane protein 1 0.021526
COMMD10 COMM domain containing 10 0.0215244
DOCK1 dedicator of cytokinesis 1 0.0213565
CEP128 centrosomal protein 128kDa 0.0213148
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0210674
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0210632
AFAP1L2 actin filament associated protein 1-like 2 0.0210068
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0209597
MT2A metallothionein 2A 0.0208789
MYO10 myosin X 0.0207625
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0206132
CPNE1 copine I 0.0203395
TRA2B transformer 2 beta homolog (Drosophila) 0.0202596

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.239879
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.108916
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0793792
AKAP12 A kinase (PRKA) anchor protein 12 -0.0783714
ANXA2 annexin A2 -0.0651028
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0582758
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0579836
RPS6 ribosomal protein S6 -0.0568954
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0520564
KRT18 keratin 18, type I -0.0509207
PGK1 phosphoglycerate kinase 1 -0.0506596
KRT8 keratin 8, type II -0.050496
TPM4 tropomyosin 4 -0.0491773
EIF1 eukaryotic translation initiation factor 1 -0.0462868
EEF2 eukaryotic translation elongation factor 2 -0.045566
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0452356
HMGA1 high mobility group AT-hook 1 -0.0447674
CCND1 cyclin D1 -0.0439011
VIM vimentin -0.0431698
PERP PERP, TP53 apoptosis effector -0.0427727
PDGFA platelet-derived growth factor alpha polypeptide -0.0426446
ACTG1 actin gamma 1 -0.0410962
ESYT2 extended synaptotagmin-like protein 2 -0.0409955
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0402292
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0375713
ITGA6 integrin, alpha 6 -0.0375032
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0372287
LOC112694756 uncharaterized LOC112694756 -0.036546
ITGB4 integrin, beta 4 -0.0359082
S100A10 S100 calcium binding protein A10 -0.0355858
EGR1 early growth response 1 -0.0347178
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0344268
EZR ezrin -0.0334971
GOLGA4 golgin A4 -0.0333632
MORF4L2 mortality factor 4 like 2 -0.0332997
FTH1 ferritin, heavy polypeptide 1 -0.0331714
NDRG1 N-myc downstream regulated 1 -0.0320821
GLG1 golgi glycoprotein 1 -0.0311784
RACK1 receptor for activated C kinase 1 -0.0302347
EMP1 epithelial membrane protein 1 -0.0297866
GNAS GNAS complex locus -0.0296203
RPLP0 ribosomal protein, large, P0 -0.0294733
ATP5F1B ATP synthase F1 subunit beta -0.0286885
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0286131
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0285665
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0285311
AHNAK AHNAK nucleoprotein -0.0284698
RPS25 ribosomal protein S25 -0.0282448
ARF4 ADP-ribosylation factor 4 -0.0277992
NIPSNAP2 nipsnap homolog 2 -0.027431
CANX calnexin -0.027105
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0268166
RPS24 ribosomal protein S24 -0.0266059
WASF2 WAS protein family, member 2 -0.0260948
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0260176
BIRC6 baculoviral IAP repeat containing 6 -0.0259777
TMEM123 transmembrane protein 123 -0.0259299
RAB1A RAB1A, member RAS oncogene family -0.0256045
CDH13 cadherin 13 -0.0254149
LDHA lactate dehydrogenase A -0.0252574
ANO1 anoctamin 1, calcium activated chloride channel -0.0251795
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0251265
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0246199
GCC2 GRIP and coiled-coil domain containing 2 -0.0245708
ZFR zinc finger RNA binding protein -0.0243142
RLF rearranged L-myc fusion -0.0241819
ZMYND8 zinc finger, MYND-type containing 8 -0.0240234
SEC31A SEC31 homolog A (S. cerevisiae) -0.02402
TMEM41B transmembrane protein 41B -0.0239184
DSTN destrin (actin depolymerizing factor) -0.0239132
RPL39 ribosomal protein L39 -0.02371
RPLP1 ribosomal protein, large, P1 -0.0236705
PIBF1 progesterone immunomodulatory binding factor 1 -0.0235291
PDIA3 protein disulfide isomerase family A, member 3 -0.0234598
MON2 MON2 homolog (S. cerevisiae) -0.0234594
KRT19 keratin 19, type I -0.0233424
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0232794
GARS1 glycyl-tRNA synthetase 1 -0.02322
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0231866
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0230112
RPL27A ribosomal protein L27a -0.0229407
UBC ubiquitin C -0.0229261
RPL37 ribosomal protein L37 -0.0227719
KDM3A lysine (K)-specific demethylase 3A -0.0224479
RPL12 ribosomal protein L12 -0.022253
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0222079
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0221881
RIOK3 RIO kinase 3 -0.0221053
EPB41 erythrocyte membrane protein band 4.1 -0.022002
SKAP1 src kinase associated phosphoprotein 1 -0.0217346
RPS5 ribosomal protein S5 -0.0216872
RPL7 ribosomal protein L7 -0.0216096
RPL11 ribosomal protein L11 -0.0216044
COPB1 coatomer protein complex, subunit beta 1 -0.0215958
RPL36A ribosomal protein L36a -0.0215232
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0214884
DDIT4 DNA-damage-inducible transcript 4 -0.0214775
BTG1 B-cell translocation gene 1, anti-proliferative -0.0213899
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0213805
TMSB4X thymosin beta 4, X-linked -0.0213297