Futibatinib_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Futibatinib perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Futibatinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.221469
VIM vimentin 0.211959
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.133474
LMNA lamin A/C 0.109296
CSTB cystatin B (stefin B) 0.100613
S100A6 S100 calcium binding protein A6 0.0871584
NDRG1 N-myc downstream regulated 1 0.0839819
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0816181
PTMA prothymosin, alpha 0.0741614
BHLHE40 basic helix-loop-helix family, member e40 0.0727299
FTH1 ferritin, heavy polypeptide 1 0.0637646
SQSTM1 sequestosome 1 0.0586807
CALR calreticulin 0.0571703
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0569083
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0563008
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0559147
RHOBTB3 Rho-related BTB domain containing 3 0.0557203
DLG1 discs, large homolog 1 (Drosophila) 0.0547339
TMSB4X thymosin beta 4, X-linked 0.0543243
HLA-B major histocompatibility complex, class I, B 0.0512836
EIF1 eukaryotic translation initiation factor 1 0.0505535
S100A10 S100 calcium binding protein A10 0.0496677
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0479744
P4HB prolyl 4-hydroxylase, beta polypeptide 0.045983
RAI1 retinoic acid induced 1 0.0451937
CD99 CD99 molecule 0.044769
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.044027
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0434543
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0428839
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0407987
TPT1 tumor protein, translationally-controlled 1 0.0406549
ZFP36L1 ZFP36 ring finger protein-like 1 0.0405303
OGA O-GlcNAcase 0.0376821
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.036011
GARS1 glycyl-tRNA synthetase 1 0.0356242
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0346885
AHNAK AHNAK nucleoprotein 0.0345673
RPL23 ribosomal protein L23 0.0345375
PRRC2C proline-rich coiled-coil 2C 0.0326208
CLIP2 CAP-GLY domain containing linker protein 2 0.0324075
HSPB1 heat shock 27kDa protein 1 0.0322397
COL3A1 collagen, type III, alpha 1 0.031955
RRBP1 ribosome binding protein 1 0.0318586
S100A4 S100 calcium binding protein A4 0.031815
RPL34 ribosomal protein L34 0.0314965
RPL12 ribosomal protein L12 0.0307467
HIP1 huntingtin interacting protein 1 0.0304961
LOXL2 lysyl oxidase-like 2 0.0301817
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.0290043
MNT MAX network transcriptional repressor 0.0288561
UBC ubiquitin C 0.0288282
DDIT4 DNA-damage-inducible transcript 4 0.027853
RPLP1 ribosomal protein, large, P1 0.027849
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0276018
GNAS GNAS complex locus 0.0272815
TM4SF1 transmembrane 4 L six family member 1 0.0267775
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0266649
MYADM myeloid-associated differentiation marker 0.0263254
CELF1 CUGBP, Elav-like family member 1 0.0262784
RND3 Rho family GTPase 3 0.0262683
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.0252407
THBS2 thrombospondin 2 0.0247334
KLF6 Kruppel-like factor 6 0.0246746
NAV2 neuron navigator 2 0.0246527
GTF2IRD1 GTF2I repeat domain containing 1 0.0240556
CANX calnexin 0.0239902
MYL12B myosin, light chain 12B, regulatory 0.0239064
RPL28 ribosomal protein L28 0.0235864
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0234924
RPS24 ribosomal protein S24 0.0232723
BSG basigin (Ok blood group) 0.0231685
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0231453
TPM4 tropomyosin 4 0.0229574
RPS3 ribosomal protein S3 0.0228538
IL32 interleukin 32 0.0227281
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.022718
RPL26 ribosomal protein L26 0.0227009
NEFL neurofilament, light polypeptide 0.0225662
CBX3 chromobox homolog 3 0.0222572
PFN1 profilin 1 0.0222518
PLAUR plasminogen activator, urokinase receptor 0.0219261
SEPTIN2 septin 2 0.0217982
KDM6B lysine (K)-specific demethylase 6B 0.0215994
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0215907
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0213692
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0212371
LY6E lymphocyte antigen 6 complex, locus E 0.0210163
TGFB1 transforming growth factor, beta 1 0.0208596
RPLP2 ribosomal protein, large, P2 0.0207835
GOLGA4 golgin A4 0.020643
FOSL1 FOS-like antigen 1 0.0205995
BACE2 beta-site APP-cleaving enzyme 2 0.0205524
MIDN midnolin 0.0203986
WDFY1 WD repeat and FYVE domain containing 1 0.0203262
CAVIN1 caveolae associated protein 1 0.0201727
MT1X metallothionein 1X 0.0201311
ELL2 elongation factor, RNA polymerase II, 2 0.0201251
FTL ferritin, light polypeptide 0.0199387
MYO9B myosin IXB 0.019766
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0197027

decreased expression

Symbol Name Standardized Value
PODXL podocalyxin-like -0.16332
COL5A1 collagen, type V, alpha 1 -0.116153
IGFBP3 insulin-like growth factor binding protein 3 -0.11104
POTEF POTE ankyrin domain family, member F -0.103977
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0924446
CDH13 cadherin 13 -0.073573
COL8A1 collagen, type VIII, alpha 1 -0.0724786
LOX lysyl oxidase -0.0700628
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.067852
TRIO trio Rho guanine nucleotide exchange factor -0.0659847
FN1 fibronectin 1 -0.061679
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0615792
PRSS23 protease, serine, 23 -0.0588077
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0582698
LDHA lactate dehydrogenase A -0.0570004
EGFR epidermal growth factor receptor -0.0567132
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0530562
PLAT plasminogen activator, tissue -0.0517458
PKM pyruvate kinase, muscle -0.0514405
CD44 CD44 molecule (Indian blood group) -0.0473329
RIGI RNA sensor RIG-I -0.0464434
DST dystonin -0.0461239
PDE4D phosphodiesterase 4D, cAMP-specific -0.0459812
FNDC3B fibronectin type III domain containing 3B -0.0455368
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0427655
GLIS3 GLIS family zinc finger 3 -0.0422359
MAP1B microtubule-associated protein 1B -0.0421425
SAMD9 sterile alpha motif domain containing 9 -0.0406975
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0393591
ASPH aspartate beta-hydroxylase -0.0388759
TPM1 tropomyosin 1 (alpha) -0.0388107
RUNX1 runt-related transcription factor 1 -0.0387914
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0386222
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0372345
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0368941
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0368819
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0346673
MACF1 microtubule-actin crosslinking factor 1 -0.0346251
VCL vinculin -0.033335
EFNA5 ephrin-A5 -0.0332673
OASL 2'-5'-oligoadenylate synthetase-like -0.0328351
PLXNA2 plexin A2 -0.0325452
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0324522
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0320787
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.031934
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0303159
ENO1 enolase 1, (alpha) -0.0298394
CDK6 cyclin-dependent kinase 6 -0.0298345
PGK1 phosphoglycerate kinase 1 -0.0290832
NALF1 NALCN channel auxiliary factor 1 -0.0286142
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0280727
NAV1 neuron navigator 1 -0.0264017
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0262569
FAT1 FAT atypical cadherin 1 -0.0257179
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0255951
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.025391
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0245619
S100A11 S100 calcium binding protein A11 -0.0245143
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0238803
MCL1 myeloid cell leukemia 1 -0.0238782
MBNL1 muscleblind-like splicing regulator 1 -0.0236075
SVIL supervillin -0.0234244
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0225889
MED13L mediator complex subunit 13-like -0.0223012
PDE10A phosphodiesterase 10A -0.0217411
MYOF myoferlin -0.0216354
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0215449
SETX senataxin -0.0214581
TENM3 teneurin transmembrane protein 3 -0.021307
RAD51B RAD51 paralog B -0.0212244
FBN1 fibrillin 1 -0.0209828
IFITM3 interferon induced transmembrane protein 3 -0.0205276
IFI44 interferon-induced protein 44 -0.0203395
SORBS2 sorbin and SH3 domain containing 2 -0.0202981
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0202915
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0201761
AEBP2 AE binding protein 2 -0.0201566
MX2 MX dynamin-like GTPase 2 -0.0200419
JAZF1 JAZF zinc finger 1 -0.0199212
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0196957
FNDC3A fibronectin type III domain containing 3A -0.0196333
SP100 SP100 nuclear antigen -0.019587
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0194521
IPO9 importin 9 -0.0193927
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.0192687
INTS6 integrator complex subunit 6 -0.0192589
PRELID2 PRELI domain containing 2 -0.0191818
GOLGB1 golgin B1 -0.0191053
ADAM19 ADAM metallopeptidase domain 19 -0.0189552
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.018556
PSD3 pleckstrin and Sec7 domain containing 3 -0.0185233
MPRIP myosin phosphatase Rho interacting protein -0.0181134
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0180333
RNF144A ring finger protein 144A -0.017885
SDK1 sidekick cell adhesion molecule 1 -0.0177452
EXT1 exostosin glycosyltransferase 1 -0.0177341
DOCK5 dedicator of cytokinesis 5 -0.0176849
TNS3 tensin 3 -0.0176641
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0173178
ADAM9 ADAM metallopeptidase domain 9 -0.0170744