| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Futibatinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Futibatinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.148965 |
| TMSB10 | thymosin beta 10 | 0.139099 |
| ANKRD12 | ankyrin repeat domain 12 | 0.11514 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.109746 |
| VIM | vimentin | 0.109177 |
| AREG | amphiregulin | 0.0904169 |
| NHSL1 | NHS-like 1 | 0.0897925 |
| JMJD1C | jumonji domain containing 1C | 0.0767005 |
| SMC4 | structural maintenance of chromosomes 4 | 0.075045 |
| HMGA2 | high mobility group AT-hook 2 | 0.0712838 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0677868 |
| YBX3 | Y box binding protein 3 | 0.060529 |
| MKI67 | marker of proliferation Ki-67 | 0.0599355 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0598799 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0547467 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0541348 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0538004 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0526577 |
| RRM2 | ribonucleotide reductase M2 | 0.0523013 |
| R3HDM2 | R3H domain containing 2 | 0.0504727 |
| CENPF | centromere protein F, 350/400kDa | 0.0501157 |
| PTMS | parathymosin | 0.04895 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0484804 |
| YAP1 | Yes-associated protein 1 | 0.0471163 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0469551 |
| CUX1 | cut-like homeobox 1 | 0.0468716 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0463328 |
| TMEM41B | transmembrane protein 41B | 0.0459651 |
| RPL36A | ribosomal protein L36a | 0.0452666 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0448815 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.043269 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0422056 |
| CBX3 | chromobox homolog 3 | 0.0419107 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0416758 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0415364 |
| EHBP1 | EH domain binding protein 1 | 0.0401479 |
| KLF6 | Kruppel-like factor 6 | 0.0399911 |
| KIF18B | kinesin family member 18B | 0.0382152 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0380959 |
| VMP1 | vacuole membrane protein 1 | 0.0378789 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0374886 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0371633 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0368896 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0368338 |
| H1-0 | H1.0 linker histone | 0.0367309 |
| USP34 | ubiquitin specific peptidase 34 | 0.0366439 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0361078 |
| WWOX | WW domain containing oxidoreductase | 0.0358126 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0353539 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0351795 |
| LRRC23 | leucine rich repeat containing 23 | 0.0349381 |
| PTMA | prothymosin, alpha | 0.034595 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0343677 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0342402 |
| RPL23 | ribosomal protein L23 | 0.0338729 |
| GCG | glucagon | 0.033655 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0334298 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.033413 |
| RPS8 | ribosomal protein S8 | 0.0332028 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0329018 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0322645 |
| TUBA1B | tubulin, alpha 1b | 0.0320175 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0314925 |
| ASPH | aspartate beta-hydroxylase | 0.0311105 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0310018 |
| TPX2 | TPX2, microtubule-associated | 0.0310018 |
| PDS5A | PDS5 cohesin associated factor A | 0.030785 |
| ZNF638 | zinc finger protein 638 | 0.0306826 |
| GNAS | GNAS complex locus | 0.0304671 |
| CCDC88A | coiled-coil domain containing 88A | 0.0304282 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0300628 |
| RPS26 | ribosomal protein S26 | 0.0296935 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0295323 |
| RPL34 | ribosomal protein L34 | 0.0294524 |
| RASAL2 | RAS protein activator like 2 | 0.0286479 |
| TPM3 | tropomyosin 3 | 0.0285029 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0284501 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0282279 |
| DOCK3 | dedicator of cytokinesis 3 | 0.0278614 |
| RAD23A | RAD23 homolog A (S. cerevisiae) | 0.0277325 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0275674 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0275207 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0273854 |
| PRR11 | proline rich 11 | 0.0273066 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0272841 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0269039 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0268779 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0268322 |
| ACBD6 | acyl-CoA binding domain containing 6 | 0.0267138 |
| PRKCE | protein kinase C, epsilon | 0.0263285 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0252903 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0251471 |
| TFCP2 | transcription factor CP2 | 0.025073 |
| HMGB1 | high mobility group box 1 | 0.0249605 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0246877 |
| PHACTR4 | phosphatase and actin regulator 4 | 0.0246402 |
| HDGF | hepatoma-derived growth factor | 0.0245623 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0245472 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0242216 |
| FUS | FUS RNA binding protein | 0.0241337 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.217526 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.122336 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.105098 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0831274 |
| MGAT4C | MGAT4 family, member C | -0.0815643 |
| DST | dystonin | -0.0781126 |
| LDHA | lactate dehydrogenase A | -0.0721749 |
| NLGN1 | neuroligin 1 | -0.0717119 |
| TENM3 | teneurin transmembrane protein 3 | -0.0696804 |
| EGR1 | early growth response 1 | -0.0696254 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0692307 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0631994 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0605628 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0598663 |
| LOC112694756 | uncharaterized LOC112694756 | -0.059087 |
| TPI1 | triosephosphate isomerase 1 | -0.0567821 |
| POTEF | POTE ankyrin domain family, member F | -0.0565687 |
| LDHB | lactate dehydrogenase B | -0.0535399 |
| ZNF804A | zinc finger protein 804A | -0.0533368 |
| DTNA | dystrobrevin, alpha | -0.0519591 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0518139 |
| YBX1 | Y box binding protein 1 | -0.051777 |
| PCDH7 | protocadherin 7 | -0.0509063 |
| PGK1 | phosphoglycerate kinase 1 | -0.0508654 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.049207 |
| PLK2 | polo-like kinase 2 | -0.0488202 |
| ENO1 | enolase 1, (alpha) | -0.0463861 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | -0.0462528 |
| RPL19 | ribosomal protein L19 | -0.0461971 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0440882 |
| RPS3 | ribosomal protein S3 | -0.0411417 |
| RPL37A | ribosomal protein L37a | -0.0409445 |
| PKM | pyruvate kinase, muscle | -0.0408549 |
| CCN2 | cellular communication network factor 2 | -0.040552 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0404243 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0403436 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0401529 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0378032 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0376235 |
| RPS12 | ribosomal protein S12 | -0.0375966 |
| NEK7 | NIMA-related kinase 7 | -0.037318 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0366884 |
| HLA-A | major histocompatibility complex, class I, A | -0.036168 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0358955 |
| CCNL1 | cyclin L1 | -0.0358757 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0347036 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0345363 |
| S100A11 | S100 calcium binding protein A11 | -0.0340942 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0339246 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | -0.0337459 |
| RPL11 | ribosomal protein L11 | -0.0334995 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0327405 |
| HDAC9 | histone deacetylase 9 | -0.0327063 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.0323636 |
| FAT1 | FAT atypical cadherin 1 | -0.0322686 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | -0.0318724 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0315558 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0311861 |
| CDK6 | cyclin-dependent kinase 6 | -0.0308217 |
| CPOX | coproporphyrinogen oxidase | -0.030401 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0303097 |
| RPS2 | ribosomal protein S2 | -0.0302254 |
| ANXA1 | annexin A1 | -0.0299567 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0297874 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0293573 |
| AXIN2 | axin 2 | -0.0293242 |
| RPS27A | ribosomal protein S27a | -0.0291601 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.02912 |
| TPR | translocated promoter region, nuclear basket protein | -0.0287531 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0282792 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0281821 |
| RPL13A | ribosomal protein L13a | -0.0281045 |
| NCKAP1 | NCK-associated protein 1 | -0.0279402 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | -0.0276278 |
| GOLGB1 | golgin B1 | -0.0272372 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | -0.027148 |
| UBB | ubiquitin B | -0.0271103 |
| RPL12 | ribosomal protein L12 | -0.0270992 |
| OXR1 | oxidation resistance 1 | -0.0266204 |
| AHR | aryl hydrocarbon receptor | -0.0256915 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | -0.0255146 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0253805 |
| TNPO1 | transportin 1 | -0.0252116 |
| TFG | TRK-fused gene | -0.0251087 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0249986 |
| FN1 | fibronectin 1 | -0.0246699 |
| CALD1 | caldesmon 1 | -0.0246161 |
| PCM1 | pericentriolar material 1 | -0.0245977 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.0244498 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0243394 |
| IGF2 | insulin-like growth factor 2 | -0.0243342 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.024257 |
| ZNF217 | zinc finger protein 217 | -0.0241734 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.0239982 |
| NRXN3 | neurexin 3 | -0.0237397 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0232716 |
| FASN | fatty acid synthase | -0.0227802 |
| B2M | beta-2-microglobulin | -0.022677 |
| GPR15 | G protein-coupled receptor 15 | -0.0226732 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0226532 |
