Futibatinib_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Futibatinib perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Futibatinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0867818
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0784356
FTH1 ferritin, heavy polypeptide 1 0.0766762
C6ORF132 chromosome 6 open reading frame 132 0.0654481
SMAD3 SMAD family member 3 0.0640127
AREG amphiregulin 0.0561198
LCN2 lipocalin 2 0.0518299
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0501967
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0442407
MLPH melanophilin 0.0439983
INTS6 integrator complex subunit 6 0.0421026
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0393457
SHB Src homology 2 domain containing adaptor protein B 0.0380264
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0374067
FTL ferritin, light polypeptide 0.037389
SOX9 SRY (sex determining region Y)-box 9 0.0373854
EFNB2 ephrin-B2 0.0366465
RPS6 ribosomal protein S6 0.0364577
DSCAM Down syndrome cell adhesion molecule 0.0356191
RNF43 ring finger protein 43 0.0350732
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.034892
SRRM2 serine/arginine repetitive matrix 2 0.0344408
CTNND1 catenin (cadherin-associated protein), delta 1 0.0341739
NRIP1 nuclear receptor interacting protein 1 0.0341331
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0330849
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0328663
MT2A metallothionein 2A 0.0324832
RPS8 ribosomal protein S8 0.0324707
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0319695
BRD4 bromodomain containing 4 0.0319633
RPL23 ribosomal protein L23 0.0313047
NCOR2 nuclear receptor corepressor 2 0.0309493
RPL9 ribosomal protein L9 0.0300419
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0300077
SPRED1 sprouty-related, EVH1 domain containing 1 0.0291304
RPS12 ribosomal protein S12 0.0289057
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0277448
ARGLU1 arginine and glutamate rich 1 0.0274338
LIMA1 LIM domain and actin binding 1 0.0273381
RPS3 ribosomal protein S3 0.0267597
PDZD8 PDZ domain containing 8 0.0265018
PKM pyruvate kinase, muscle 0.0260586
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0260218
AKAP13 A kinase (PRKA) anchor protein 13 0.0259464
YAP1 Yes-associated protein 1 0.0255362
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0251602
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0246666
TUFT1 tuftelin 1 0.0239854
IFNGR1 interferon gamma receptor 1 0.0235381
VCL vinculin 0.0228664
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0224866
HLA-A major histocompatibility complex, class I, A 0.0224357
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0224051
RPL37A ribosomal protein L37a 0.0220774
RPLP1 ribosomal protein, large, P1 0.0218931
RBM25 RNA binding motif protein 25 0.0217691
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0208421
RPL26 ribosomal protein L26 0.0207699
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0204195
STK24 serine/threonine kinase 24 0.0202935
VEGFA vascular endothelial growth factor A 0.0201751
RPL21 ribosomal protein L21 0.0199901
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0196353
ZNF703 zinc finger protein 703 0.0195634
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.0192466
EREG epiregulin 0.0189732
RPS17 ribosomal protein S17 0.018958
HSPH1 heat shock 105kDa/110kDa protein 1 0.0189417
UBAP2 ubiquitin associated protein 2 0.0188993
DIAPH1 diaphanous-related formin 1 0.0186292
JUP junction plakoglobin 0.0181077
TRIM25 tripartite motif containing 25 0.0180501
TACSTD2 tumor-associated calcium signal transducer 2 0.0177942
ZC3H13 zinc finger CCCH-type containing 13 0.0177827
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0176978
N4BP2L2 NEDD4 binding protein 2-like 2 0.0172883
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0172519
ZNFX1 zinc finger, NFX1-type containing 1 0.0172217
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0170624
RPS2 ribosomal protein S2 0.0169449
BCLAF1 BCL2-associated transcription factor 1 0.0165964
CSNK1A1 casein kinase 1, alpha 1 0.0165114
TSC22D2 TSC22 domain family, member 2 0.0164962
BCL2L1 BCL2-like 1 0.0164657
MAP7 microtubule-associated protein 7 0.0163513
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0156697
RPL30 ribosomal protein L30 0.0153779
CLOCK clock circadian regulator 0.0153239
RPL31 ribosomal protein L31 0.0153196
ZFP36L1 ZFP36 ring finger protein-like 1 0.0152331
CDK5RAP3 CDK5 regulatory subunit associated protein 3 0.0151371
EEF2 eukaryotic translation elongation factor 2 0.0150905
USP36 ubiquitin specific peptidase 36 0.014986
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0148823
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0148687
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0148091
UBAP1 ubiquitin associated protein 1 0.0147422
CELF1 CUGBP, Elav-like family member 1 0.0146359
BRD2 bromodomain containing 2 0.0146084
DCAF7 DDB1 and CUL4 associated factor 7 0.0144915

decreased expression

Symbol Name Standardized Value
GMDS GDP-mannose 4,6-dehydratase -0.129067
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.123547
ZMYND8 zinc finger, MYND-type containing 8 -0.120744
LYZ lysozyme -0.115936
STAT1 signal transducer and activator of transcription 1, 91kDa -0.11326
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.109919
EPSTI1 epithelial stromal interaction 1 (breast) -0.108031
BTBD9 BTB (POZ) domain containing 9 -0.105679
MBNL2 muscleblind-like splicing regulator 2 -0.0978954
SPATA13 spermatogenesis associated 13 -0.0970483
ARHGAP26 Rho GTPase activating protein 26 -0.0914843
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0873496
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0845094
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0838841
NPSR1 neuropeptide S receptor 1 -0.0810281
ITGA6 integrin, alpha 6 -0.0754581
RIGI RNA sensor RIG-I -0.0703096
ZBTB20 zinc finger and BTB domain containing 20 -0.0699528
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0667555
TPT1 tumor protein, translationally-controlled 1 -0.0662105
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0661256
SQSTM1 sequestosome 1 -0.0653197
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.060326
MX1 MX dynamin-like GTPase 1 -0.0582158
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.058035
PTMA prothymosin, alpha -0.0570652
PRKCA protein kinase C, alpha -0.0542405
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0538823
CANX calnexin -0.0513838
MAML2 mastermind-like 2 (Drosophila) -0.0505329
TSHZ2 teashirt zinc finger homeobox 2 -0.050492
HLA-E major histocompatibility complex, class I, E -0.0496403
TRIO trio Rho guanine nucleotide exchange factor -0.0491596
PATJ PATJ crumbs cell polarity complex component -0.049055
PLSCR1 phospholipid scramblase 1 -0.0486651
XAF1 XIAP associated factor 1 -0.0485058
SP100 SP100 nuclear antigen -0.0479785
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0476891
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0462956
PHF3 PHD finger protein 3 -0.0460947
MECOM MDS1 and EVI1 complex locus -0.0454855
PDIA3 protein disulfide isomerase family A, member 3 -0.0450589
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0450394
GOLGB1 golgin B1 -0.0445203
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0428905
RAD51B RAD51 paralog B -0.0420092
FNDC3A fibronectin type III domain containing 3A -0.0419279
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0416224
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0413868
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0411896
ABLIM1 actin binding LIM protein 1 -0.041042
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0406257
FNDC3B fibronectin type III domain containing 3B -0.0406115
IGF1R insulin-like growth factor 1 receptor -0.0394156
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0392908
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0391057
MX2 MX dynamin-like GTPase 2 -0.0390798
NCOA7 nuclear receptor coactivator 7 -0.0390208
HLA-B major histocompatibility complex, class I, B -0.0388321
GRK3 G protein-coupled receptor kinase 3 -0.0380595
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.037283
EZR ezrin -0.0370802
MUC20 mucin 20, cell surface associated -0.0366688
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0361739
H1-0 H1.0 linker histone -0.0360764
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0354941
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0344352
RHOBTB3 Rho-related BTB domain containing 3 -0.034168
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0341669
LMO7 LIM domain 7 -0.0340246
LAMA4 laminin, alpha 4 -0.0339629
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0333682
IGFBP3 insulin-like growth factor binding protein 3 -0.0333372
TFRC transferrin receptor -0.032877
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.032855
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0326987
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.032661
STS steroid sulfatase (microsomal), isozyme S -0.0324943
RABGAP1L RAB GTPase activating protein 1-like -0.0317623
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0313982
RAB7A RAB7A, member RAS oncogene family -0.0310383
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0309551
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0308695
KIF16B kinesin family member 16B -0.0307284
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0306561
LCORL ligand dependent nuclear receptor corepressor-like -0.0302626
CALR calreticulin -0.029924
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.0297232
BRCA2 breast cancer 2, early onset -0.0296258
MKI67 marker of proliferation Ki-67 -0.0294884
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0292414
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0290814
CCDC146 coiled-coil domain containing 146 -0.0290612
SAMD9L sterile alpha motif domain containing 9-like -0.0288828
MXD1 MAX dimerization protein 1 -0.0287189
FNIP1 folliculin interacting protein 1 -0.0287145
SEC31A SEC31 homolog A (S. cerevisiae) -0.0286567
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0281721
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.028169
JAK1 Janus kinase 1 -0.0280377