Futibatinib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Futibatinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Futibatinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.239892
IGFBP1 insulin-like growth factor binding protein 1 0.169255
MT2A metallothionein 2A 0.12959
SVIL supervillin 0.127856
TIMP1 TIMP metallopeptidase inhibitor 1 0.118664
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.110428
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.104874
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.102247
LOC112694756 uncharaterized LOC112694756 0.0786513
AKAP12 A kinase (PRKA) anchor protein 12 0.0773776
RPLP1 ribosomal protein, large, P1 0.0674432
TPT1 tumor protein, translationally-controlled 1 0.0655082
ERRFI1 ERBB receptor feedback inhibitor 1 0.0633373
TMSB10 thymosin beta 10 0.0574763
RPS8 ribosomal protein S8 0.0566752
RPL34 ribosomal protein L34 0.055333
CCL20 chemokine (C-C motif) ligand 20 0.0527061
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0522809
RPS24 ribosomal protein S24 0.0501079
RPL23 ribosomal protein L23 0.0491853
RPS19 ribosomal protein S19 0.0480069
EXT1 exostosin glycosyltransferase 1 0.045719
FTH1 ferritin, heavy polypeptide 1 0.0452413
FOXP1 forkhead box P1 0.0444241
FAM107B family with sequence similarity 107, member B 0.0430167
SDC4 syndecan 4 0.0417889
H1-0 H1.0 linker histone 0.0382858
GRB10 growth factor receptor-bound protein 10 0.0378512
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0377413
RPL31 ribosomal protein L31 0.0373796
RPS21 ribosomal protein S21 0.0372846
RACK1 receptor for activated C kinase 1 0.0370182
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0368814
HMGA1 high mobility group AT-hook 1 0.0352723
RPS12 ribosomal protein S12 0.0350822
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0344009
NFE2L2 nuclear factor, erythroid 2-like 2 0.0341381
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0337623
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0333166
PDLIM5 PDZ and LIM domain 5 0.0329697
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0328119
RPL5 ribosomal protein L5 0.0327513
KLF6 Kruppel-like factor 6 0.0325999
KYNU kynureninase 0.0322849
RPL12 ribosomal protein L12 0.0317387
RPS27A ribosomal protein S27a 0.0316165
GPC3 glypican 3 0.0311846
PNRC1 proline-rich nuclear receptor coactivator 1 0.0303397
RPL11 ribosomal protein L11 0.0299138
FTL ferritin, light polypeptide 0.0298761
BHLHE40 basic helix-loop-helix family, member e40 0.0291398
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0287358
KIF21A kinesin family member 21A 0.0283861
RPL27 ribosomal protein L27 0.0280408
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0278197
EIF1 eukaryotic translation initiation factor 1 0.0277248
RPL37 ribosomal protein L37 0.0274922
EEF1G eukaryotic translation elongation factor 1 gamma 0.0273338
RPLP2 ribosomal protein, large, P2 0.0270058
KRT8 keratin 8, type II 0.0266128
RPL37A ribosomal protein L37a 0.0263992
FRMD5 FERM domain containing 5 0.0263761
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0261538
IQSEC1 IQ motif and Sec7 domain 1 0.0254777
RPS14 ribosomal protein S14 0.0254749
MACF1 microtubule-actin crosslinking factor 1 0.0252146
NACA nascent polypeptide-associated complex alpha subunit 0.0251044
BCL2L1 BCL2-like 1 0.0250825
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0248239
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0244845
RPLP0 ribosomal protein, large, P0 0.0244401
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0242123
ATP5F1E ATP synthase F1 subunit epsilon 0.0241808
RPS20 ribosomal protein S20 0.024148
LCN2 lipocalin 2 0.0240083
RPS2 ribosomal protein S2 0.0235929
RPL18 ribosomal protein L18 0.0233209
FERMT2 fermitin family member 2 0.0231998
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0231139
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0229017
DTNA dystrobrevin, alpha 0.0226577
DUSP16 dual specificity phosphatase 16 0.0226429
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0225725
CTNND1 catenin (cadherin-associated protein), delta 1 0.0222173
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0221202
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0220666
AGO2 argonaute RISC catalytic component 2 0.0218823
RPL4 ribosomal protein L4 0.0217383
RPS17 ribosomal protein S17 0.021207
MTSS1 metastasis suppressor 1 0.0206152
RPS16 ribosomal protein S16 0.0205689
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.0205658
RPS27 ribosomal protein S27 0.0205606
ACTN1 actinin, alpha 1 0.0204484
CTSB cathepsin B 0.0203982
SAMD4A sterile alpha motif domain containing 4A 0.0202233
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0199941
BRD4 bromodomain containing 4 0.0199884
RPL10A ribosomal protein L10a 0.0196805
DNAH17 dynein, axonemal, heavy chain 17 0.0195154

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.140592
C3 complement component 3 -0.107423
FNDC3B fibronectin type III domain containing 3B -0.10666
EML4 echinoderm microtubule associated protein like 4 -0.105314
SLC38A2 solute carrier family 38, member 2 -0.100629
PTPRM protein tyrosine phosphatase, receptor type, M -0.0898073
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0812807
TMEM123 transmembrane protein 123 -0.0798011
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0789432
EHBP1 EH domain binding protein 1 -0.0772394
LYZ lysozyme -0.0756227
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0699509
SESTD1 SEC14 and spectrin domains 1 -0.0698381
FBF1 Fas (TNFRSF6) binding factor 1 -0.0687729
PCBP2 poly(rC) binding protein 2 -0.0656488
MAML2 mastermind-like 2 (Drosophila) -0.0623646
APOA2 apolipoprotein A-II -0.0599337
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0559547
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0553824
PLIN2 perilipin 2 -0.0508693
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0502345
APOB apolipoprotein B -0.0488287
DST dystonin -0.0486262
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0482418
PEG10 paternally expressed 10 -0.047318
ADGRG6 adhesion G protein-coupled receptor G6 -0.0457757
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0451127
RBM39 RNA binding motif protein 39 -0.0440357
ARHGAP12 Rho GTPase activating protein 12 -0.0431914
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0428239
LRMDA leucine rich melanocyte differentiation associated -0.0427266
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0423239
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0418465
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0415354
VMP1 vacuole membrane protein 1 -0.041445
ELL2 elongation factor, RNA polymerase II, 2 -0.0403616
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0402891
DENND4A DENN/MADD domain containing 4A -0.0399979
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0399573
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0392667
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0390973
FMNL2 formin-like 2 -0.0388628
PTBP3 polypyrimidine tract binding protein 3 -0.0388317
FN1 fibronectin 1 -0.0387291
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.038376
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0383271
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0381796
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0380802
VEGFA vascular endothelial growth factor A -0.0370588
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0367162
GMDS GDP-mannose 4,6-dehydratase -0.0365111
CPE carboxypeptidase E -0.03554
ADAM9 ADAM metallopeptidase domain 9 -0.035492
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.034683
ITGA1 integrin, alpha 1 -0.0341557
INSIG2 insulin induced gene 2 -0.0341557
SRRM1 serine/arginine repetitive matrix 1 -0.0335762
KTN1 kinectin 1 (kinesin receptor) -0.0334516
SOD2 superoxide dismutase 2, mitochondrial -0.0328688
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0316883
COBLL1 cordon-bleu WH2 repeat protein-like 1 -0.0314365
PEG3 paternally expressed 3 -0.0312773
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0311965
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0310999
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0308654
RERE arginine-glutamic acid dipeptide (RE) repeats -0.030793
DOCK4 dedicator of cytokinesis 4 -0.0307629
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0297796
APOH apolipoprotein H (beta-2-glycoprotein I) -0.0293453
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0292708
AFDN afadin, adherens junction formation factor -0.0292346
MTUS1 microtubule associated tumor suppressor 1 -0.0286885
PCM1 pericentriolar material 1 -0.0286259
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0286184
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0285035
PARD3 par-3 family cell polarity regulator -0.0283528
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0281474
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0281121
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0280661
MALT1 MALT1 paracaspase -0.0279788
PDIA3 protein disulfide isomerase family A, member 3 -0.0279081
HELZ helicase with zinc finger -0.0279036
CYB5R3 cytochrome b5 reductase 3 -0.0278887
GOLGA4 golgin A4 -0.0278445
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0277578
KIF5B kinesin family member 5B -0.0274531
CCNL1 cyclin L1 -0.0274118
MBNL2 muscleblind-like splicing regulator 2 -0.0273073
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0271867
SOX5 SRY (sex determining region Y)-box 5 -0.0271702
CP ceruloplasmin (ferroxidase) -0.0271412
TRIM26 tripartite motif containing 26 -0.0267299
MATN3 matrilin 3 -0.0263814
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0261622
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0261248
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0260881
SCN1A sodium channel, voltage gated, type I alpha subunit -0.025799
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0255852
KIF1B kinesin family member 1B -0.0253241
DOK6 docking protein 6 -0.0250548